• The Korean Journal of Pain
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• 제31권4호
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• pp.235-243
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• 2018

Postherpetic neuralgia (PHN) is the most troublesome side effect of Herpes Zoster (HZ), which mainly affects the elderly and immunocompromised populations. Despite the current advancement of treatments, PHN persists in many individuals influencing their daily activities and reducing their quality of life. Anticonvulsants, antidepressants, topical therapies including lidocaine and capsaicin, and opioids, are the most widely used therapies for the treatment of PHN. These medications come with their adverse effects, so they should be used carefully with the elderly or with patients with significant comorbidities. Other measures like botulinum toxin, nerve blocks, spinal cord stimulation, and radiofrequency have also contributed significantly to the management of PHN. However, the efficacy, safety, and tolerability of these invasive methods need to be carefully monitored when administering them. Early diagnosis and early initiation of treatment can reduce the burden associated with PHN. The zoster vaccine has effectively reduced the incidence of HZ and PHN. In this article, we discuss the treatment options available for the management of PHN, mainly focusing on the efficacy and safety of different therapeutic modalities.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2001년도 학술대회지
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• pp.175-183
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• 2001

오늘날 국내 기업들의 관심은 업종을 가리지 않고 정보기술(IT)로 집중하여 고객관계관리(CRM), SCM, ERP등과 같은 다양한 기법들을 도입하지 않으면 경쟁에서 도태될 것 같은 분위기로 전환되고 있으며, 이러한 사항은 건설산업에서도 나타나고 있다. 그러나 국내 건설기업들의 홈페이지에는 단순히 자사의 홍보나 시스템 활용부문에 한정된 구성을 취하고 있으며, 고객들의 참여유도 역시 낮은 수준을 유지하고 있는 실정으로 조사되었다. 이에 본 연구는 타 산업의 구축사례와 건설관련자들의 설문조사를 분석하여 고객관계관리(CRM) 개념을 기반으로 한 건설기업들의 웹사이트 활성화를 위한 기초자료를 제시한다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제13권1호
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• pp.79-86
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• 2013

We describe a neural stimulator front-end with arbitrary stimulation waveform generator and adaptive supply regulator (ASR) for visual prosthesis. Each pixel circuit generates arbitrary current waveform with 5 bit programmable amplitude. The ASR provides the internal supply voltage regulated to the minimum required voltage for stimulation. The prototype is implemented in $0.35{\mu}m$ CMOS with HV option and occupies $2.94mm^2$ including I/Os.

• Clinical and Experimental Reproductive Medicine
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• 제40권4호
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• pp.143-147
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• 2013

Oocyte in vitro maturation (IVM) is an assisted reproductive technology in which oocytes are retrieved from the antral follicles of unstimulated or minimally stimulated ovaries. IVM of human oocytes has emerged as a promising procedure. This new technology has advantages over controlled ovarian stimulation such as reduction of costs, simplicity, and elimination of ovarian hyperstimulation syndrome. By elimination or reduction of gonadotropin stimulation, IVM offers eligible infertile couples a safe and convenient form of treatment, and IVM outcomes are currently comparable in safety and efficacy to those of conventional in vitro fertilization. IVM has been applied mainly in patients with polycystic ovary syndrome or ultrasound-only polycystic ovaries, but with time, the indications for IVM have expanded to other uncommon situations such as fertility preservation, as well as to normal responders. In this review, the current clinical experiences with IVM will be described.

• Journal of Korean Neurosurgical Society
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• 제64권4호
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• pp.486-494
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• 2021

The growth of pulsed electromagnetic field (PEMF) therapy and its progress over the years for use in post-operative bone growth has been revolutionary in its effect on bone tissue proliferation and vascular flow. However, further progress in PEMF therapy has been difficult due to lack of more evidence-based understanding of its mechanism of action. Our objective was to review the current understanding of bone growth physiology, the mechanism of PEMF therapy action along with its application in spinal surgery and associated outcomes. The authors of this review examined multiple controlled, comparative, and cohort studies to compare fusion rates of patients undergoing PEMF stimulation. Examining spinal fusion rates, a rounded comparison of post-fusion outcomes with and without bone stimulator was performed. Results showed that postoperative spinal surgery PEMF stimulation had higher rates of fusion than control groups. Though PEMF therapy was proven more effective, multiple factors contributed to difficulty in patient compliance for use. Extended timeframe of treatment and cost of treatment were the main obstacles to full compliance. This review showed that PEMF therapy presented an increased rate of recovery in patients, supporting the use of these devices as an effective post-surgical aid. Given the recent advances in the development of PEMF devices, affordability and access will be much easier suited to the patient population, allowing for more readily available treatment options.

• 한국산학기술학회논문지
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• 제15권11호
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• pp.6767-6773
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• 2014

본 연구는 고유수용성신경근촉진법의 체간 패턴 운동을 병행한 경두개직류자극이 뇌졸중 환자의 하지 근 활성도와 균형 능력, 보행 속도에 어떠한 영향을 미치는지 알아보기 위하여 실시하였다. 본 연구에는 총 31명의 뇌졸중 환자가 참여하였으며, 대상자들은 무작위 추출법을 통해서 실험군 15명과 대조군 16명으로 각각 배정되었다. 모든 대상자들은 고유수용성 신경근촉진법의 체간 패턴 운동을 6주 동안, 주 3회 20분 씩 시행하였고, 실험군에는 추가적으로 경두개직류자극을 20분 간 시행하였다. 연구 결과 실험군이 대조군에 비해 마비측 하지의 비복근, 전경골근의 활성도와 균형 능력에서 유의한 차이를 보였다(p<.05). 이러한 결과는 고유수용성신경근촉진법의 체간 패턴 운동을 병행한 경두개직류자극이 뇌졸중 환자의 하지 기능 회복에 긍정적인 효과를 가져다 준 것으로 사료된다.

• International Journal of Contents
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• 제8권1호
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• pp.74-81
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• 2012

The aim is to investigate the analgesic effect of transcranial direct current stimulation(tDCS) on central neuropathic pain(CNP) in spinal cord contusive rat model. Twenty Sprague-Dawley rats($250{\pm}50$ g, male) were used. Thoracic spinal cord(T10) was contused using New York University(NYU) spinal cord impactor. The animals were randomly assigned to two groups; GroupI: Non-treatment after SCI induction(n=10), GroupII: application of tDCS(0.1 mA, 20 min/time, 2 times/day, 5 days/6week) after SCI induction(n=10). Assess the effect of tDCS using the Basso Beattie Bresnahan(BBB) locomotor rating scales, Touch $test^{TM}$ sensory evaluator(TTSE), Plantar test$^{\circledR}$after contusion at the $2^{nd}$, $3^{rd}$, $4^{th}$, $5^{th}$, $6^{th}$ week and the immunohistochemistric response of c-fos in the thalamus, cerebral cortex after contusion at the $3^{rd}$, $6^{th}$ week after SCI. The scores of BBB scales were significantly different from $3^{rd}$week. TTSE were different significantly over time, but there were no differences at each evaluation times on between-measure time effects. Plantar test were different significantly over time and there were difference at the $4^{th}$, $6^{th}$ week after SCI on between-measure time effects. Also, immunohistochemistric response of c-fos was reduced significantly from $3^{rd}$, $6^{th}$ week after SCI in tDCS group compared with control group in thalamus and cortex. These results identified that tDCS of non-invasive therapeutic method may have beneficial analgesic effect on CNP after SCI with behavioral test and immunohistochemical test.

• 한국한의학연구원논문집
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• 제9권2호
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• pp.121-130
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• 2003

The goal of this study is construction and efficacy evaluation of MPC-25 (Magnetic Pain Control-25), a medical device using magnetic stimulation. MPC-25 consists of a main body containing power supply and control module and a bed containing magnetic core and coil. In distinction from electric pain control medical devices, magnetic pain control system is non-contact, so the patients need not take off their clothes to be treated. High amplitude current pulses are applied to a magnetic coil and induce time varying magnetic field generating eddy current in a conductor like human body. Clinical efficacy test was performed in patients suffering from musculoskeletal pain of lumbar, shoulder and joint. Degree of pain before and after treatment for 30 minutes was compared using Visual Analogous Scale. As a result, 14 cases out of 20 showed decreased pain perception, so the rate of efficacy is 70%. Reduction of pain perception was statistically significant (P=0.001 by Wilcoxon Signed Rank Test).

• The Journal of Korean Physical Therapy
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• 제26권6호
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• pp.436-441
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• 2014

Purpose: The objective of this study was to offer clinical primary data that it's aims to examine effects of transcranial direct current stimulation (tDCS) on cognitive function and biochemical change of rat with alzheimer's disease(AD) induced by injecting scopolamine. Methods: Subjects were instructed cognitive dysfunction model, rat of Sprague-Dawley system was injected with scopolamine and each experimental group was classified into three; group I (n=16) is non-treatment groups; group II (n=16) is applied with the tacrine; group III (n=16) is applied with the tDCS. The ziggurat task test was conducted to observe behavioral changes and cognitive function ability and 7, 14, 21, 28 days after the model. Acetylcholine Esterase (Ach E) activity was examined for biochemical assessment of which the results are followed. Results: Participants showed as to behavioral change, tacrine application group was the most significantly responded, following tDCS application group. As to biochemical change, same as above, tacrine application group was the most significantly responded, following tDCS application group. Conclusion: From these results, confirm that tDCS application to rat with alzheimer's disease leads to positive effects on behavioral, cognitive function changes, and biochemical changes, lasting for certain period of time. This study, in particular, tDCS, which can change excitability of brain cells non-invasively, could provide basic data that is useful as a new treatment way for the patients with cognitive dysfunction.

• 대한한방소아과학회지
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• 제36권3호
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• pp.1-18
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• 2022

Objectives The purpose of this study was to investigate the current status of interventional clinical trial registration for children with precocious puberty and to secure basic data for the design of clinical trials for traditional Korean medicine treatment of precocious puberty. Methods The following resources were used to search for data: Clinicaltrial.gov, World Health Organization International Clinical Trials Registry Platform (WHO ICTRP), and Clinical Research Information Service (CRIS), using the search terms, 'Precocious puberty', 'child'. All clinical trials which were registered as of June 2022 were used. Results For the intervention and clinical trial design, gonadotropin releasing hormone (GnRH) analog was reported in 41.7% of trials, and single group assignment was performed in 66.7% of the studies. Prior consent had not been reported in 50% of the studies. Tanner stage and GnRH stimulation tests were reported by multiple trials as inclusion criteria, and prior treatment experiences for trial drugs were reported as exclusion criteria. The peak serum concentration of luteinizing hormone following GnRH stimulation test was used as a primary outcome in 45.8% of clinical trials, and other growth-related indicators such as growth rate, height, and predicted adult height were also reported. Conclusions In consideration of the design, eligibility criteria, and outcome measurement of the existing clinical trials identified in this study, it should be referred to in the design of clinical trials for traditional Korean medicine treatment of precocious puberty.