• Title/Summary/Keyword: critical means

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Shedding; towards a new paradigm of syndecan function in cancer

  • Choi, So-Joong;Lee, Ha-Won;Choi, Jung-Ran;Oh, Eok-Soo
    • BMB Reports
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    • v.43 no.5
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    • pp.305-310
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    • 2010
  • Syndecans, cell surface heparansulfate proteoglycans, have been proposed to act as cell surface receptors and/or coreceptors to play critical roles in multiple cellular functions. However, recent reports suggest that the function of syndecans can be further extended through shedding, a cleavage of extracellular domain. Shedding constitutes an additional level for controlling the function of syndecans, providing a means to attenuate and/or regulate amplitude and duration of syndecan signals by modulating the activity of syndecans as cell surface receptors. Whether these remaining cleavage products are still capable of functioning as cell surface receptors to efficiently transduce signals inside of cells is not clear. However, shedding transforms cell surface receptor syndecans into soluble forms, which, like growth factors, may act as novel ligands to induce cellular responses by association with other cell surface receptors. It is becoming interestingly evident that shed syndecans also contribute significantly to syndecan functions in cancer biology. This review presents current knowledge about syndecan shedding and its functional significance, particularly in the context of cancer.

The Analysis of The Transport Current Property Depend on The Fault Angle of BSCCO HTS Cable (초전도 케이블용 BSCCO의 사고각에 따른 통전특성 분석)

  • Lee, Dong-Hyeok;Du, Ho-Ik;Doo, Seung-Gyu;Kim, Min-Ju;Kim, Yong-Jin;Han, Byoung-Sung
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2009.06a
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    • pp.367-368
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    • 2009
  • BSCCO HTS(High Temperature Superconductor) could be applied to superconducting cable, magnet and motor, using its hight critical properties. Especially, superconducting cable has a hight possibility of practical use due to the possibility of low voltage and high capacity transmission caused by its lower power loss than copper cable. In this paper, the transport characteristics of BSCCO superconducting cable, according to the change of BSCCO superconducting cable's accident point at phase $0^{\circ}$ and $45^{\circ}C$, were analyzed and compared each other. Consequently, when the accident was occur the resistance of the HTS was higher at the point phase $0^{\circ}$ than $45^{\circ}$ which means it will cause much higher load on the HTS.

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A Study on the Uniform Design for Postmen (집배원 유니폼 디자인 개발에 관한 연구 -2000년도 착용 유니폼을 중심으로-)

  • 신혜영
    • Journal of the Korean Society of Costume
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    • v.50 no.7
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    • pp.33-46
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    • 2000
  • Uniform is the dress of distinctive design or fashion worn by members of a particular group or serving as a means of identification. The postman's uniform of Ministry of Communication should be distinctive or characteristic clothing to provide high functionality and symbolization of job characteristics, cost effectiveness and esthetic. In order to design the postman's new uniform available in 2000, there has been a satisfaction survey to 1,116 postmen. A thorough analysis of survey and informal and face-to-face discussion with postmen give the direction of design concept. One of the most important things in the design concept is to make the uniform high quality & refinement. The style is a refined jumper suit in consideration of form stability, wearing satisfaction, convenience in activity. The basic colors selected are navy and medium gray. The colors of jumper are MOC red ; C.I color Green : a representative color of youth, white : a symbolic color of bright future. All three colors are plaid on a basic nary color. In the selection of the textile, synthetic fiber (Polyester 65%, rayon 35%) equipped with UV cutting as well as water resistance etc. was recommended. In the uniform design process, the effective communication with user (postman) is critical to find the requirements and needs of uniform user (postman). Also. the uniform designer should reflect the above four key factors in design development. Therefore, the uniform should provide the user with high job performance and job pride in wearing the uniform.

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Development of Automatic Visual Inspection System for Micro Needle (미세 탐침의 비전 자동 검사 시스템 개발)

  • Kang, Su-Min;Han, Kwang-Hee;Huh, Kyung-Moo
    • Journal of the Institute of Electronics Engineers of Korea SC
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    • v.45 no.6
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    • pp.16-25
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    • 2008
  • The micro needle means the ultrafine probe of 'Probe Card'. The size of micro needle is so minute that it is difficult to minute that it is difficult to inspect it with eyes. On the other hand it is very critical if there is a defect in micro needle of probe card. In this study, we developed an automatic visual inspection system for finding defect status in probe angle, tip length and diameter. Through the experimental results, we could find that our proposed method is better than human-eyes inspection method in accuracy and inspection speed, and also in robustness to lighting circumstances.

Effect of Thermomechanical Treatment on the Phase Transformation and Superelasticity in Ti-Ni-Cu Shape Memory Alloy (Ti-Ni-Cu 형상기억합금의 상변태 및 초탄성에 미치는 가공열처리의 영향)

  • Lee, O.Y.;Park, Y.K.;Chun, B.S.
    • Journal of the Korean Society for Heat Treatment
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    • v.7 no.4
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    • pp.253-261
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    • 1994
  • Transformation behavior and superelastic behavior of Ti-Ni-Cu alloys with various Cu content has been investigated by means of electrical resistivity measurement, X-ray diffraction, tensile test and transmission electron microscopy. Two types of heat treatment are given to the specimens: i) Solutions treatment. ii) thermo-mechanical treatment. The transformation sequence in solution treated Ti-Ni-Cu Alloys substituted by Cu for Ni up to 5at.% occurs to $B2{\rightleftarrows}B19^{\prime}$ and it proceeds in two stages by addition of 10at.%Cu, i. e, $B2{\rightleftarrows}B19{\rightleftarrows}B19^{\prime}$. Also, it has been found that Ti-30Ni-20Cu alloy transformed in one stage : $B2{\rightleftarrows}B19$. The thermo-mechanically treated Ti-47Ni-3Cu alloy transformed in two stages: B2${\rightleftarrows}$rhomboheral phase${\rightleftarrows}B19^{\prime}$, while transformation sequence in Ti-45Ni-5Cu and Ti-40Ni-10Cu alloy transformed as same as solution treated specimens. The critical stress for inducing slip deformation in solution treated and thermo-mechanically treated Ti-40Ni-10Cu alloy is about 90MPa and 320Mpa respectively.

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Host Responses from Innate to Adaptive Immunity after Vaccination: Molecular and Cellular Events

  • Kang, Sang-Moo;Compans, Richard W.
    • Molecules and Cells
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    • v.27 no.1
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    • pp.5-14
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    • 2009
  • The availability of effective vaccines has had the most profound positive effect on improving the quality of public health by preventing infectious diseases. Despite many successful vaccines, there are still old and new emerging pathogens against which there is no vaccine available. A better understanding of how vaccines work for providing protection will help to improve current vaccines as well as to develop effective vaccines against pathogens for which we do not have a proper means to control. Recent studies have focused on innate immunity as the first line of host defense and its role in inducing adaptive immunity; such studies have been an intense area of research, which will reveal the immunological mechanisms how vaccines work for protection. Toll-like receptors (TLRs), a family of receptors for pathogen-associated molecular patterns on cells of the innate immune system, play a critical role in detecting and responding to microbial infections. Importantly, the innate immune system modulates the quantity and quality of long-term T and B cell memory and protective immune responses to pathogens. Limited studies suggest that vaccines which mimic natural infection and/or the structure of pathogens seem to be effective in inducing long-term protective immunity. A better understanding of the similarities and differences of the molecular and cellular events in host responses to vaccination and pathogen infection would enable the rationale for design of novel preventive measures against many challenging pathogens.

A simple phenotyping method for deep-rooting rice grown in pots

  • Han, Jae-Hyuk;Shin, Na-Hyun;Moon, Jae-Hoon;Chin, Joong Hyoun;Yoo, Soo-Cheul
    • Journal of Plant Biotechnology
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    • v.43 no.4
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    • pp.444-449
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    • 2016
  • Deep rooting, which enables plants to extract water from greater soil depths, is a critical strategy for improving plant survival under water-deficient conditions. However, as it is difficult to observe intact root systems belowground, several techniques have been developed to screen deep- and shallow-rooting phenotypes in rice. Here, we introduce a simple and convenient method for deep- and shallow-rooting phenotyping using a unique combination of sand, soil, and plastic mesh netting. Vandana, a drought-tolerant rice variety, and Dongjin, a Korean japonica rice variety, were used to analyze root phenotypes. No significant differences in root length were observed in rice grown under irrigated conditions regardless of net position, whereas roots were significantly longer, and ratio of deep root (RDR) values were significantly higher in Vandana rice grown under semi-drought conditions. In summary, this simple and useful method represents a low-cost means of phenotyping the roots of rice and other crops grown in various-sized pots and at multiple plant growth stages.

A numerical deformation analysis of micro elements by stamping orders (스탬핑 순서가 미치는 미세요소 변형 수치해석)

  • Lee, Chang-Hee;Kim, Yong-Yun
    • Journal of the Korean Society for Precision Engineering
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    • v.22 no.12 s.177
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    • pp.156-162
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    • 2005
  • In this paper, we study the mechanism of lead deformation by numerically simulating the stamping process by means of a commercial finite element code. It is very important to analyze effects that the lead shape makes on the lead deformation, because the lead shape is often modified in order to minimize the deformation or to increase the buckling critical load of the punch. Therefore the stamping process, first, numerically simulated by considering as a quasi-static problem. Second, the effect on the lead deformation due to the lead shape variation, a linear lead geometry and a bent lead, was numerically analyzed and discussed. Finally, the punching order was optimized fur multi-lead generating stamping process. The results show that the bent lead is little bit more shifted than the linear lead after the punching process. But the bent lead is vertically less deformed than the linear lead. The punching order to successively generate the lead is good to keep the lead space uniform. The results will be very effectively applied for the design of the blanking or punching dies in industry.

Test Results of the Mechanical Face Seal for a Turbopump

  • Kwak, Hyun-D.;Jeon, Seong-Min;Kim, Jin-Han
    • KSTLE International Journal
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    • v.8 no.1
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    • pp.11-15
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    • 2007
  • The mechanical face seal has been tested in Korea Aerospace Research Institute (KARl) for turbopump applications. In the turbopump under current development, the mechanical face seal is installed between fuel pump and turbine to prevent a mixture of fuel and combustion gas. Generally the mechanical face seal in turbopump is exposed to severe environment because of great rotational speed, high temperature of combustion gas and high level of pressure difference. Thus a series of tests were performed to guarantee the reliability of mechanical face seal by means of simulating the practical operating conditions. The tests were conducted up to 20,000 rpm with pressure difference of 800 kPa and temperature of 620 K In addition several carbon materials for mechanical face seal were conducted to the tests to compare the life time. During the tests, the performance against leakage was monitored and the carbon wear was also measured to estimate the life of a mechanical face seal The results show that the leakage flow rates of mechanical face seal is ignorable compared to an overall flow rate of fuel pump. The carbon material which has the finest wear resistance was found during the tests. Lastly no critical failure of mechanical face seal was found during the tests and the reliability of mechanical face seal for turbopump was successfully proved.

Role of corporate culture in shaping up innovative, strategy-driven corporation (혁신적 전략기업 형성을 위한 기업문화의 역할)

  • 이원창;서의호
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 2000.10a
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    • pp.22-25
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    • 2000
  • With the dawn of the 21st century, the corporate business environment started to witness the unprecedented, intense competition on global basis. As a result, the kind of corporate business activity that can respond swiftly to the new changes emerged as one of the most critical factors to increase corporate competitiveness. Being reborn as a strategy-focused organization means seeking innovation. And the strategy not involving innovation is just meaningless. It is this innovation that lies at the heart of the corporate strategy, and that is the only way for continuation of the corporation. The most important pending issue facing companies today is to bolster corporate competencies fit for new business environment, to develop corporate culture required for getting competitiveness edge back, and ultimately to put the company on the continued growth path. Corporate culture, as the very underlying belief and philosophy, is not just woven into the fabric of the corporate management strategy and into the way the company is doing its business. It also, as a regulation and norm for its employees to stick by, affects the way they think and behave. This paper aims at presenting the role of the corporate culture in working out problems encountered by companies today, like corporate innovation, instilling vitality to the organization, beefing up the underlying corporate capabilities, and making transformation required by the changing business environment.

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