• Tuberculosis and Respiratory Diseases
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• 제82권3호
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• pp.251-260
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• 2019

Background: Beyond its current function as a rescue therapy in acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO) may be applied in ARDS patients with less severe hypoxemia to facilitate lung protective ventilation. The purpose of this study was to evaluate the efficacy of extended ECMO use in ARDS patients. Methods: This study reviewed 223 adult patients who had been admitted to the intensive care units of 11 hospitals in Korea and subsequently treated using ECMO. Among them, the 62 who required ECMO for ARDS were analyzed. The patients were divided into two groups according to pre-ECMO arterial blood gas: an extended group (n=14) and a conventional group (n=48). Results: Baseline characteristics were not different between the groups. The median arterial carbon dioxide tension/fraction of inspired oxygen ($FiO_2$) ratio was higher (97 vs. 61, p<0.001) while the median $FiO_2$ was lower (0.8 vs. 1.0, p<0.001) in the extended compared to the conventional group. The 60-day mortality was 21% in the extended group and 54% in the conventional group (p=0.03). Multivariate analysis indicated that the extended use of ECMO was independently associated with reduced 60-day mortality (odds ratio, 0.10; 95% confidence interval, 0.02-0.64; p=0.02). Lower median peak inspiratory pressure and median dynamic driving pressure were observed in the extended group 24 hours after ECMO support. Conclusion: Extended indications of ECMO implementation coupled with protective ventilator settings may improve the clinical outcome of patients with ARDS.

• Structural Engineering and Mechanics
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• 제17권2호
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• pp.167-186
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• 2004

The design load-carrying capacities of wooden shores depend on factors, such as the wood species and properties, and construction methods. This paper focuses on the construction methods, including an upright single shore, group of upright shores, group of inclined shores, butt connections and lap connections. This paper reports experiments to obtain critical loads and then developed an empirical equation based on Euler' formula for the critical loads and design load-carrying capacities. The test results show that the critical loads for an upright single wooden shore are greater than the average values for a group of upright shores, and the latter are greater than the average values for a group of inclined shores. Test results also show that the critical loads become smaller when butt or lap connections are used, butt connections possessing greater critical loads than lap connections. Groups of inclined shores are very popular at work sites because they have some practical advantages even though they actually possess inferior critical loads. This paper presents an improved setup for constructing groups of inclined shores. With this method, the inclined shores have larger critical loads than upright shores. The design load-carrying capacities were obtained by multiplying the average critical loads by a resistance factor (or strength reduction factor, ${\phi}$) that were all smaller than 1. This article preliminarily suggests ${\phi}$ factors based on the test results for the reference of engineers or specification committees.

• Tuberculosis and Respiratory Diseases
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• 제85권4호
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• pp.332-340
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• 2022

Background: Cardiac dysfunction patients have long been considered at high risk of reintubation. However, it is based on past studies in which only conventional oxygen therapy was applied after extubation. We investigated association between cardiac dysfunction and reintubation rate in situation where high-flow nasal cannula (HFNC) was widely used during post-extubation period. Methods: We conducted a retrospective observational cohort study of patients treated with HFNC after planned extubation in medical intensive care unit of single tertiary center. Patients were divided into normal function group (ejection fraction [EF] ≥45%) and cardiac dysfunction group (EF <45%). The primary outcome was reintubation rate within 72 hours following extubation. Results: Of 270 patients, 35 (13%) had cardiac dysfunction. Baseline characteristics were similar in both groups. There were no differences in the changes in vital signs between the two groups during the first 12 hours after extubation except diastolic blood pressure. The reintubation rates were 20% and 17% for cardiac dysfunction group and normal function group, respectively (p=0.637). In a multivariate Cox regression analysis, cardiac dysfunction was not associated with an increased risk of reintubation within 72 hours following extubation (hazard ratio, 1.56; p=0.292). Conclusion: Cardiac dysfunction was not associated with increased reintubation rate within 72 hours when HFNC is immediately applied after planned extubation.

• Tuberculosis and Respiratory Diseases
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• 제84권3호
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• pp.217-225
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• 2021

Background: Despite the proven benefits of dexamethasone in hospitalized coronavirus disease 2019 (COVID-19) patients, the optimum time for the administration of dexamethasone is unknown. We investigated the progression of COVID-19 pneumonia based on the timing of dexamethasone administration. Methods: A single-center, retrospective cohort study based on medical record reviews was conducted between June 10 and September 21, 2020. We compared the risk of severe COVID-19, defined as the use of a high-flow nasal cannula or a mechanical ventilator, between groups that received dexamethasone either within 24 hours of hypoxemia (early dexamethasone group) or 24 hours after hypoxemia (late dexamethasone group). Hypoxemia was defined as room-air SpO₂ <90%. Results: Among 59 patients treated with dexamethasone for COVID-19 pneumonia, 30 were in the early dexamethasone group and 29 were in the late dexamethasone group. There was no significant difference in baseline characteristics, the time interval from symptom onset to diagnosis or hospitalization, or the use of antiviral or antibacterial agents between the two groups. The early dexamethasone group showed a significantly lower rate of severe COVID-19 compared to the control group (75.9% vs. 40.0%, p=0.012). Further, the early dexamethasone group showed a significantly shorter total duration of oxygen supplementation (10.45 days vs. 21.61 days, p=0.003) and length of stay in the hospital (19.76 days vs. 27.21 days, p=0.013). However, extracorporeal membrane oxygenation and in-hospital mortality rates were not significantly different between the two groups. Conclusion: Early administration of dexamethasone may prevent the progression of COVID-19 to a severe disease, without increased mortality.

• 대한족부족관절학회지
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• 제28권1호
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• pp.8-14
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• 2024

Purpose: Ankle fracture fixation is the gold standard of treatment but it does have its own complications. There is inadequate data regarding the comparative effectiveness of early vs. delayed fixation for open ankle fracture outcomes. This study compares the clinical and functional outcomes of open ankle fractures treated by early or delayed definitive fixation and identifies the limitations of both methods. Materials and Methods: All 73 patients enrolled in the study underwent surgical intervention within 24 hours of injury. The early fixation group (group A) consisting of 39 patients underwent definitive fixation as an index procedure, while the delayed fixation group (group B) consisted of 34 patients who underwent debridement and external fixator application as an index procedure and definitive fixation when soft tissue condition was conducive. All patients were evaluated at 2, 6, and 12 weeks postoperatively and then three monthly for a year. Results: Enneking and American Orthopaedic Foot and Ankle Society scores were markedly higher in the early fixation group at 6 months postoperatively (p-values <0.001 and 0.011, respectively). However, no discernible intergroup difference was evident at 12 months postoperatively. Between 6 and 12 months, group functional outcome scores were significantly different. At 6 months, there was a substantial difference in dorsiflexion between the two groups (p-values 0.001 and <0.001, respectively), but no difference was observed at 12 months postoperatively. At 6 and 12 months, group average plantar flexions were non-significantly different. Conclusion: Early definitive fixation of complex ankle fractures using a targeted approach produced promising results for lower grade open fractures (grades 1 and 2), and delayed definitive fixation, after initial external fixation to allow for soft tissue stabilization, produced promising results for higher grade open fractures (grades 3A and 3B). At 12-month follow-ups, clinical and functional outcomes achieved using these strategies were equivalent.

• Tuberculosis and Respiratory Diseases
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• 제57권4호
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• pp.311-319
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• 2004

연구배경 : 기관지 확장증(BE)이 NTM 폐질환의 선행 요건임은 잘 알려져 왔으나 최근 결절이 동반된 BE의 경우 NTM 폐질환의 결과일 가능성이 제시되어 흉부 CT상 BE 소견이 있는 환자들을 대상으로 NTM폐질환의 유병률을 살펴보고자 하였다. 방 법 : 2002년 1년간 서울아산병원에서 흉부 CT를 시행하여 BE소견이 있는 1244명 중 항산균검사를 1회 이상 시행한 866명을 대상으로 하였고(BE군), BE소견이 없고 객담항산균 검사를 1회 이상 시행한 292명을 대조군으로 하였다. BE군은 흉부 CT소견상 주로 우중엽, 설상엽 및 하엽에 양측성으로 분포하는 BE군(1군), 상엽의 공동 및 석회화 등 전통적으로 폐결핵 치료후의 병변으로 알려진 소견을 동반한 BE군(2군), 기타 BE군(3군)으로 구분하였고, 1군은 다발성 소결절 동반 유무에 따라 1-결절군 및 1-비결절군으로 구분하였다. 각 군에서 객담 항산균 도말, 배양, 및 동정결과와 임상상 및 방사선학적 소견을 비교 분석하였다. 결 과 : 1-결절군은 다른 모든 군과 비교하여 유의하게 NTM 동정률이 높았다(24.2%, p<0.05). ATS 기준에 따른 NTM 폐질환 예도 1-결절군(5/62, 8.1%)에서 대조군, 2군, 3군에 비하여 유의하게 높았다(p<0.05). 균주 별로는 MAC이 11예(55%), M. abscessus 5예(25%)로 가장 많았다. 결 론 : 주로 우중엽, 좌 설상엽 및 하엽의 양측성의 BE와 동반된 소결절들의 소견은 NTM 폐 감염의 가능성을 시사하는 소견이다. 그러나 이러한 소견을 가진 많은 환자에서는 NTM이 동정 되지 않아 이들이 임상 전단계 (subclinical stage)의 NTM증인지 아니면 별개의 다른 질환군 인지 확인되지 않았다. 추후 장기간의 추적관찰 및 조직검사를 통한 규명이 필요하리라 사료된다.

• 중환자간호학회지
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• 제1권1호
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• pp.59-71
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• 2008

Purpose: This study was to identify the effects of simulation-based training for advanced cardic life support on the competence of nurses in critical care settings. Methods: In this study, a nonequivalent control pretest-post test quasi-experimental design was used. Data were collected from May 1 to June 1, 2006 at one general hospital in W city. Among 40 nurses in critical care settings, twenty were assigned to the experimental group and twenty to the control group. Nurses in the experimental group received simulation-based training for advanced cardiac life support. Measurement tool were ACLS related knowledge and skills developed by AHA & Mega Code (2005) and some items were modified. The collected data were statistically processed using SPSS version 12.0 for Windows, and analyzed using descriptive statistics, $X^2$test, t-test, paired ttest, Pearson correlation coefficients. Results: 1) Hypothesis 1“: Nurses who received simulationbased training would have more knowledge of advanced cardiac life support than nurses who received traditional training”, was supported (t=11.51, p=.00). 2) Hypothesis 2: “Nurses who received simulation-based training would have better advanced cardiac life support skills than nurses who received traditional training”, was supported (t=2.38, p=.00). Conclusion: Simulation-based training for advanced cardiac life support is an effective strategy for increasing the competence of nurses in advanced cardiac life support in critical care settings.

• 한국간호교육학회지
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• 제22권1호
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• pp.42-50
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• 2016

Purpose: The purpose of this study was to investigate the effects of action learning on critical thinking disposition, communicative competence, and problem-solving ability in nursing students. Methods: The design for this was a nonequivalent control group pretest-posttest design was used for identification of the effects of lessons using action learning. The consenting participants were 184 fourth-year nursing students in D-city (Experimental group=95, Control group=89). Data was collected and the program was conducted from May 2 to July 19, 2015. Data was analyzed with an ${\chi}^2-test$, a t-test, and a paired t-test and utilized the SPSS win 21.0 program. Results: There were significant differences in critical thinking ability (t=5.00, p<.001), problem-solving ability (t=4.52, p<.001), and communicative competence (t=4.97, p<.001) in the experimental group compared to the control group. Conclusion: The study findings suggest that action-learning programs have proven to be an effective educational program for improving the critical thinking ability, problem solving ability, and communicative competence of nursing students. Action learning can be an effective teaching strategy.

• 한국간호교육학회지
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• 제22권4호
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• pp.567-576
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• 2016

Purpose: This study was conducted to test the effects of flipped learning for undergraduate nursing students. Methods: The study was a nonequivalent control group pretest-posttest design. Participants were 140 nursing students (experimental group=70, control group=70). The flipped learning was provided for 6 times (18 hours). Data were collected between March 7 and May 30, 2016. Data were analyzed using Chi-square, t-test, paired t-test with SPSS/WIN 22.0. Results: The results showed that self-efficacy (t=4.67, p<.001), critical thinking disposition (t=6.55, p<.001), and communication competence (t=3.57, p=.001) were significantly higher than in the experimental group than in the control group. Conclusion: The study findings suggest that the flipped learning has proven to be influential educational program for improving the self-efficacy, critical thinking disposition, and communication competence of nursing students. The flipped learning was an effective teaching program for nursing student, and need to develop other nursing major subjects.

• 한국환경교육학회지:환경교육
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• 제13권1호
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• pp.44-52
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• 2000

In this study, the effects of structured controversy strategy, individual learning, and traditional learning on the learning of environmental unit in ‘General Science’ were compared. One hundred and forty-three 10th-graders had been taught about environmental issues-self purification, biological concentration, acid rain, greenhouse effect, noise, and radioactivity-for 6 class hours. Prior to the instructions, environmental attitudes test and self-esteem test were administered. After the instructions, their achievements, critical thinking, environmental attitudes. self-esteem, and views on Science-Technology-Society were examined. The results of 2-way ANCOVA and/or Kruskal-Wallis test revealed that there were no significant main effects in the scores of the achievement test and the critical thinking test. The environmental attitudes test scores tended to be highest in the structured controversy group, and lowest in the traditional learning group. Self-esteem scores of the structured controversy group and the individual learning group were higher than those of the traditional learning group. Significant differences by students' prior achievement level in students' critical thinking, environmental attitudes, and views on Science-Technology-Society were also found.