• Title/Summary/Keyword: critical evidence

Search Result 651, Processing Time 0.02 seconds

Rites of Zhou Core Values of City Building and Critical Review of Flat Conformational Analysis through Its Annotations (『주례(周禮)』 주(注)·소(疏)를 통해 논의된 도성건설(都城建設)의 핵심과 평면적 형태해석의 비판적 검토)

  • Kang, Seo-Yeon
    • Journal of architectural history
    • /
    • v.25 no.3
    • /
    • pp.7-22
    • /
    • 2016
  • Of all the annotations of Rites of Zhou for 2,000 years, there is no single line of history of ore contents related to city building in its current perspective. This is because the definitive evidence of the interpretation of related phrases is regarded as top-level guidelines called "辨方正位(Byeonbang-Jeongwi)", and their specific contents have been discussed in '匠人建國(Jangin-Geonguk)'. The phrases of '匠人營國(Jangin-Yeongguk)', considered to be the key buzzword related to city building, must be reconsidered for these reasons. As such, this paper strives to analyze the system of logic formed by consistent interpretation that flowed for 2,000 years from Han to Qing dynasties, and to discover the principles of city building used in Confucian classics.

Mitochondrial noncoding RNA transport

  • Kim, Kyoung Mi;Noh, Ji Heon;Abdelmohsen, Kotb;Gorospe, Myriam
    • BMB Reports
    • /
    • v.50 no.4
    • /
    • pp.164-174
    • /
    • 2017
  • Mitochondria are cytosolic organelles essential for generating energy and maintaining cell homeostasis. Despite their critical function, the handful of proteins expressed by the mitochondrial genome is insufficient to maintain mitochondrial structure or activity. Accordingly, mitochondrial metabolism is fully dependent on factors encoded by the nuclear DNA, including many proteins synthesized in the cytosol and imported into mitochondria via established mechanisms. However, there is growing evidence that mammalian mitochondria can also import cytosolic noncoding RNA via poorly understood processes. Here, we summarize our knowledge of mitochondrial RNA, discuss recent progress in understanding the molecular mechanisms and functional impact of RNA import into mitochondria, and identify rising challenges and opportunities in this rapidly evolving field.

The Effect of Marketing Mix on the Formatoin of Fashion Brand Equity (마케팅 믹스 요소가 의류 브랜드 자산 형성에 미치는 영향)

  • Choi, Sun-Hyung
    • The Research Journal of the Costume Culture
    • /
    • v.13 no.1
    • /
    • pp.174-187
    • /
    • 2005
  • Recently the issue of brand equity has emerged as one of the most critical areas for fashion marketing management. Despite strong interest in the subject, there is little evidence of how brand equity is created by marketing mix elements and what their effects are. This study explores the influences of marketing mix elements on the brand equity of apparel products. Based on a literature review, a conceptual model for the quality, design, price, advertisements, and brand leadership on consumer's view on brand equity through brand identification and brand values was formulated and tested. For comparative purposes, two basic casual brands are tested, one is Polo and the other is Giodano. The subjects were Korean .50 college women living in Seoul and Daejeon. Results showed that brand equity of casual brand is affected by quality, brand leadership, design, price, advertisements. Therefore marketers should develop the core element to position its brand strategy to create competitive advantages.

  • PDF

A Study on the SCM Partnerships Factors and Business Performance (섬유산업의 SCM 파트너십 요인과 사업성과에 관한 연구)

  • Kim, Chang-Bong;Kwon, Seung-Ha
    • International Commerce and Information Review
    • /
    • v.10 no.3
    • /
    • pp.221-238
    • /
    • 2008
  • This paper examined the supply chain management partnerships factors and business performance in textile industry. To build a global network, we should consider the following critical factors such as lead-time reduction, information sharing, and inventory management. The purpose of this study is to focus on QR (Quick Response) of SCM in textile industries to clarify which of the SCM factors contribute to business performance for the SCM firms. Based on the analysis of eighth-six cases, the following results were found. First, partnerships factors of supply chain management have a positively significant influence on responsiveness of supply chain management. Second, partnerships factors of supply chain management have a positively significant influence on flexibility of supply chain management. This study suggests that partnerships are main factors for the business performance. Especially, our empirical evidence shows that capacity of firms practicing SCM, information techniques, and partnerships make the firms' business performance more responsive and flexible.

  • PDF

Geological Safety Evaluation and Monitoring of Nuclear Facility Sites in South Korea

  • Lee, Hyunwoo;Woo, Hyeon Dong;Chun, Hyun Ju;Im, Chang-Bock
    • The Journal of Engineering Geology
    • /
    • v.24 no.4
    • /
    • pp.609-613
    • /
    • 2014
  • The Korean Peninsula, located at the southeastern tip of the Eurasian Plate, is known to be tectonically stable, and no critical evidence has yet been found that would override the safety design of nuclear facilities in South Korea. Because a nuclear power plant, like other major social overhead capital facilities, could cause great damage to both the environment and society through an unexpected tectonic event, even one of extremely low probability, like the Fukushima accident, a defense-in-depth safety approach is required in geological and geotechnical site safety evaluation for nuclear projects. This paper introduces the regulatory procedures that are in place to confirm nuclear site safety and site monitoring (e.g., earthquakes and groundwater) systems applied to nuclear facilities in order to reduce inherent uncertainties within the site safety review of geological and seismological issues related with a NPP project.

Protein Kinase D1, a New Molecular Player in VEGF Signaling and Angiogenesis

  • Ha, Chang Hoon;Jin, Zheng Gen
    • Molecules and Cells
    • /
    • v.28 no.1
    • /
    • pp.1-5
    • /
    • 2009
  • Vascular endothelial growth factor (VEGF) is essential for many angiogenic processes both in normal and pathological conditions. However, the signaling pathways involved in VEGF-induced angiogenesis are incompletely understood. The protein kinase D1 (PKD1), a newly described calcium/calmodulin-dependent serine/threonine kinase, has been implicated in cell migration, proliferation and membrane trafficking. Increasing evidence suggests critical roles for PKD1-mediated signaling pathways in endothelial cells, particularly in the regulation of VEGF-induced angiogenesis. Recent studies show that class IIa histone deacetylases (HDACs) are PKD1 substrates and VEGF signal-responsive repressors of myocyte enhancer factor-2 (MEF2) transcriptional activation in endothelial cells. This review provides a guide to PKD1 signaling pathways and the direct downstream targets of PKD1 in VEGF signaling, and suggests important functions of PKD1 in angiogenesis.

PIWI Proteins and piRNAs in the Nervous System

  • Kim, Kyung Won
    • Molecules and Cells
    • /
    • v.42 no.12
    • /
    • pp.828-835
    • /
    • 2019
  • PIWI Argonaute proteins and Piwi-interacting RNAs (piRNAs) are expressed in all animal species and play a critical role in cellular defense by inhibiting the activation of transposable elements in the germline. Recently, new evidence suggests that PIWI proteins and piRNAs also play important roles in various somatic tissues, including neurons. This review summarizes the neuronal functions of the PIWI-piRNA pathway in multiple animal species, including their involvement in axon regeneration, behavior, memory formation, and transgenerational epigenetic inheritance of adaptive memory. This review also discusses the consequences of dysregulation of neuronal PIWI-piRNA pathways in certain neurological disorders, including neurodevelopmental and neurodegenerative diseases. A full understanding of neuronal PIWI-piRNA pathways will ultimately provide novel insights into small RNA biology and could potentially provide precise targets for therapeutic applications.

An Overview of Group Sequential Procedures (집단축차검정법들에 관한 고찰)

  • Jae Won Lee
    • The Korean Journal of Applied Statistics
    • /
    • v.7 no.2
    • /
    • pp.35-51
    • /
    • 1994
  • For ethical and economic reasons, clinicla trials must be repeatedly monitored for evidence of treatment benefit or harm. Repeated testing at conventional critical values can substantially inflate the overal type I error rate. To maintain acceptable levels, group sequential procedures have been developed for clinical trials. This article gives a brief overview of the group sequential procedures.

  • PDF

Post-discharge Nutrition (미숙아의 퇴원 후 영양)

  • Kim, Ee-Kyung
    • Neonatal Medicine
    • /
    • v.16 no.2
    • /
    • pp.131-136
    • /
    • 2009
  • Preterm infants are frequently discharged from the hospital with growth retardation. Given the potentially lifelong effects of growth impairmnet during a critical time of development, considerable effort should be focused on improving growth after discharge. Growth monitoring must be based on regular measurements of weight, length, and head circumference to identify those preterm infants with poor growth that may need additional nutritional support. Although prior studies vary in design and the intervention used, the evidence supports the use of fortified formulas in formula-fed preterm infants after discharge. The situation for infants fed human milk is much less clear, it seems prudent to concentrate our efforts on the encouragement of breast-feeding in this population. Catch up growth may have many benefits, and may lead to improved development. However, its long-term metabolic consequences are currently unclear. Understanding the optimal means of providing nutrition after discharge is an ongoing process.

Home Care Nursing: An Economic Analysis (가정간호의 경제성 평가에 관한 문헌분석)

  • Lim, Ji Young;Kim, Ji Young
    • Journal of Home Health Care Nursing
    • /
    • v.20 no.2
    • /
    • pp.141-151
    • /
    • 2013
  • Purpose: The purpose of this study was to examine the economic effectiveness of by conducting a literature review of published articles, masters theses, and doctoral dissertations. Method: Prior to the literature review, inclusion-exclusion criteria were established. We then reviewed 1,029 CINAHL, MEDLINE, and Cochrane DB papers, and 153 RISS papers collected between Results: A total of 12 studies met the inclusion-exclusion criteria.-effectiveness: 6 cost-effectiveness studies, 1 cost-utility studies, and 5 cost-benefit studies. Each of the 12 reviewed studies concluded that home care nursing had greater economic benefits than other compared healthcare services. Conclusion: Home care nursing has significant economic benefits in multi health care service settings and for various patient groups. Therefore these results will be used a critical evidence for the development of economically effective home based health care systems for future policy making.

  • PDF