This study aims to identify the degree of the major selection motivation, self-efficacy, resilience, social support, academic stress, and college life adjustment of nursing students who experienced the COVID-19 pandemic, and to identify the correlations between variables and factors affecting college life adjustment. The data of this study was collected from May 14, 2024 to June 20, 2024 through a Google online questionnaire targeting 182 nursing students in Seoul and the metropolitan area and descriptive statistics, Student's t-test, one-way ANOVA, Pearson's Correlation, and linear multiple regression were conducted using SPSS Statistics 25.0. The results of the difference analysis by general characteristics showed that there was a significant difference in college life adjustment by age (F=10.602, p=.000) and grade (t=-2.334, p=.021). College life adjustment showed a significant positive (+) correlation with major selection motivation (r=.581, p<.010), self-efficacy (r=.551, p<.010), resilience (r=.699, p<.010), and social support (r=.557, p<.010), but a significant negative (-) correlation with academic stress (r=-.495, p<.010). The variables that affected college life adjustment were identified as resilience (𝛽=.366, p<.01), academic stress (𝛽=-.183, p<.05), motivation for choosing a major (𝛽=.168, p<.05), and age (𝛽=.117, p<.05), and the explanatory power for college life adjustment was 56.7%. The finding of this study can be used as basic data for developing strategies to enhanced the college life adjustment of nursing students.