• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2004년도 유체기계 연구개발 발표회 논문집
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• pp.180-186
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• 2004

Average Bi-directional flow tube was suggested to measure single and two phase flow rate. Its working principle is similar with Pilot tube, however, it makes it possible to eliminate the cooling system which is normally needed to prevent from flashing in the pressure impulse line of Pilot tube when it is used in the depressurization condition. 3-dimensional steady state flow analyses using FLUENT 5.4 code were performed to validate the application of the averagebi-directional flow tube in case of water and air flow In this study, sensitivity studies have been performed to optimize the design features of the average hi-directional flow tube which can be applied for the various experimental conditions. For Re numbers above 1000, the k values are nearly constant regardless of the Re numbers and flow types and calculation results and experimental data coincides quite well. The current FLUENT calculation results suggest that linearity of the k values in various design features of the average BDFT is highly promising, which means that it is quite reasonable to select the typical design of the average BDFT for the convenience of the experimental conditions.

• Bulletin of the Korean Chemical Society
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• 제35권2호
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• pp.557-561
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• 2014

The aim of the present study was to improve dosing of lacosamide, a functionalized amino acid used as an antiepileptic agent, from twice daily to once daily for the convenience of patients. A sustained-release lacosamide tablet was developed and dissolution testing was employed to determine in vitro release behavior using water or buffer solutions at pH 1.2, 4.0, or 6.8. Lacosamide was released for 12 h from the sustainedrelease (SR) tablet, as compared to complete release within 1 h from an immediate-release $Vimpat^{(R)}$ tablet. Each formulation (100 mg) was orally administered to six beagle dogs and six mini-pigs under fasted conditions, and pharmacokinetic parameters such as the area under the concentration time curve ($AUC_t$), the maximum plasma concentration ($C_{max}$), and the time at which this occurred ($T_{max}$) were calculated. These results showed similar values for $AUC_t$, $C_{max}$, and $T_{max}$ following oral administration of immediate-release ($Vimpat^{(R)}$) and SR lacosamide tablets.

• 여성건강간호학회지
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• 제20권3호
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• pp.215-224
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• 2014

Purpose: The study was to survey personal hygiene practice related to genito-urinary tract and menstrual hygiene management in female adolescents in order to obtain basic information for health education. Methods: With a descriptive survey design, 389 adolescents were recruited via convenience sampling in Korea. Survey instrument was the feminine and menstrual hygiene practice and perception of vaginal douching. Data were collected from a self-administered structured questionnaire. Results: Mean age of adolescents was 16.09 and menarche was at 13.21. While washing hands after urination/defecation was highly performed, wipe front to back and wash with soap and water were reported as being not well done. Twenty-eight percent reported douching habit. More positive beliefs about douching were reported by adolescents who practiced douching. Menstrual hygiene management was very appropriate with changing sanitary pads regularly with hand washing; but less performed for limiting bathing activity during menstrual periods and washing hands after activity of genito-urinary area. Conclusion: Some adolescents practiced inadequate hygiene practices especially for body cleansing during menstrual period and vaginal douching. It is important to develop and implement school health education programs on feminine and personal hygiene for adolescents to help them perform adequate health behaviors.

• 대한기계학회논문집B
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• 제33권8호
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• pp.596-603
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• 2009

The performance of proton exchange membrane fuel cell (PEMFC) is seriously changed by the humidification condition which is intrinsic characteristics of the PEMFC. Typically, the humidification of fuel cell is carried out with internal or external humidifier. A membrane humidifier is applied to the external humidification of residential power generation fuel cell due to its convenience and high performance. In this study, a simple static model is constructed to understand the physical phenomena of the membrane humidifier in terms of geometric parameters and operating parameters. The model utilizes the concept of shell and tube heat exchanger but the model is also able to estimate the mass transport through the membrane. Model is constructed with FORTRAN under Matlab/$Simulink^{(R)}$ $\Box$environment to keep consistency with other components model which we already developed. Results shows that the humidity of wet gas and membrane thickness are critical parameters to improve the performance of the humidifier.

• Bulletin of the Korean Chemical Society
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• 제22권4호
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• pp.337-348
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• 2001

This article gives an overview of a recently developed channel system, frit-inlet asymmetrical flow field-flow fractionation (FI-AFlFFF), which can be applied for the separation of nanoparticles, proteins, and water soluble polymers. A conventiona l asymmetrical flow FFF channel has been modified into a frit-inlet asymmetrical type by introducing a small inlet frit near the injection point and the system operation of the FI-AFlFFF channel can be made with a great convenience. Since sample components injected into the FI-AFlFFF channel are hydrodynamically relaxed, sample injection and separation processes proceed without interruption of the migration flow. Therefore in FI-AFlFFF, there is no requirement for a valve operation to switch the direction of the migration flow that is normally achieved during the focusing/relaxation process in a conventional asymmetrical channel. In this report, principles of the hydrodynamic relaxation in FI-AFlFFF channel are described with equations to predict the retention time and to calculate the complicated flow variations in the developed channel. The retention and resolving power of FI-AFlFFF system are demonstrated with standard nanospheres and protreins. An attempt to elucidate the capability of FI-AFlFFF system for the separation and size characterization of nanoparticles is made with a fumed silica particle sample. In FI-AFlFFF, field programming can be easily applied to improve separation speed and resolution for a highly retaining component (very large MW) by using flow circulation method. Programmed FI-AFlFFF separations are demonstrated with polystyrene sulfonate standards and pululans and the dynamic separation range of molecular weight is successfully expanded.

• 한국기계가공학회지
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• 제21권1호
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• pp.49-55
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• 2022

Recently, the automobile industry has continued to demand lighter materials owing to international environmental regulations and increased convenience. To address this demand, aluminum parts have increased in popularity and are mainly developed and produced through hot forging and cold pressing. However, because this method has low yield and low production efficiency, a new manufacturing method is desirable. In this study, the water capacity efficiency of an aluminum inner tie rod socket was investigated using cold forging that provided a high yield and excellent production efficiency. Mechanical properties were derived through tensile testing of 6110A aluminum materials, and critical fracture factor and process analysis based on experimental data were carried out. The optimized process was applied as a prototype using cold multi-stage forging, and based on the derived results, the formability, productivity, and material efficiency of aluminum inner tie rod socket parts using this cold forging process was verified.

• 한국수자원학회논문집
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• 제32권5호
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• pp.557-564
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• 1999

지하수 수질 감시를 위한 관측망의 설치는 지하수자원의 보호를 위해 매우 중요하다. 그러나 현재 지하수 수질 관측망의 설계는 합리적인 방법보다는 현장전문가의 경험과 직관에 의존하는 경우가 많다. 본 논문에서는 3차원 수질모의와 최적화를 이용하는 지하수질 관측망의 설계방법론을 제안하였다. 설계과정은 다음의 세 가지 경우로 정형화되었다. (Ⅰ) 평균농도를 감시하는 위치를 선정하되 관측정의 수기 제한되는 경우, (2) 최대농도를 감시하는 위치를 선정하되 관측정의 수가 제한되는 경우, (3) 평균농도를 감시하는 위치를 선정하되 예산상 제약이 있는 경우. 이와 같은 설계문제를 매립장 현장에 적용하고 0-1 정수계획법으로 해결하였다. 관측망의 설치목적, 운영기간, 제약조건 등에 따라 관측망의 구성이 다르게 결정됨을 보이고 그 의미를 해석하였다.

• 전기학회논문지
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• 제67권7호
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• pp.946-953
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• 2018

Photo-plethysmography (PPG), which measures changes in the peripheral blood flow of a human body using difference in absorption rate of light, is a measurement method that is studied and used in clinical and various applications due to its simple circuit configuration and measurement convenience. Magneto-plethysmography (MPG), which is newly developed by our team, is a method of measuring changes in the conductivity of biological tissues by using a eddy current induced by a time-varying magnetic field, and is not subject to optical interference. In this study, we investigated the detection characteristics of MPG according to the change of the conductivity of the object and fluid to be measured by simultaneously measuring PPG and MPG. In order to control the speed of fluid known in advance, a blood flow simulator was implemented and used. The fluid used in the experiment was general mineral water and physiological saline (0.9% NaCl) solution. Experimental results show that the amplitude change of the measured PPG was 0.3% in normal water and saline solution, and that of MPG was 77.3%. Therefore, it is considered that the magneto-plethysmography (MPG) has a strong correlation with the conductivity of the fluid.

• 한국건축시공학회지
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• 제16권6호
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• pp.561-569
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• 2016

콘크리트는 현재까지 사용되는 건축재료 양호한 품질을 지니고 있으며, 시멘트의 화학조성이 지표상의 화학조성과 유사하여 가장 쉽게 얻을 있는 재료 중 하나이다. 하지만 약한 결합력과 낮은 결합에너지로 변형에 취약하여 균열이 발생하게 된다. 건조수축 균열 저감을 위해 본 연구에서는 AE제, 감수제, 수축저감제 등을 각각 사용하는 기존연구와 달리 작업의 편리성 향상을 위하여 수축저감제 및 감수제의 혼합 형태인 수축저감형 혼화제(Superplasticizer for Reduction of Shrinkage, 이하 SRS로 칭함)를 이용하였다. 현재 레미콘사에서 일반적으로 사용되고 있는 콘크리트와 모르타르의 배합으로 계획하였으며, SRS 혼입률 변경과 혼화재 치환에 따른 기초적 실험을 진행하였다. 강도와 길이변화율을 고려하였을 때 SRS 혼입률 2%가 적정한 혼입률이라고 판단된다. 또한 대량치환과 노출콘크리트용 혼화제 적용에 관한 연구를 진행할 예정이다.

• 한국응용과학기술학회지
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• 제29권4호
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• pp.552-560
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• 2012

약물 전달 시스템은 약물의 방출 프로파일, 흡수, 분배 및 제품의 효율성과 안전성, 환자의 편의성과 협조를 향상시키기 위한 제거를 개선하는 명백하게 보호화된 공식화 기술이다. 가장 일반적으로 쓰이는 transdermal 시스템은 다양한 종류의 기술을 사용하는 skin patch다. 다른 투약 방법과 달리, transdermal 시스템은 장기간 사용이 가능하다. 또한, 부작용이 생길 경우, 약물 투약의 중단이 가능하다. karaya gum and locust bean gum(LBG)/water-soluble chitosan oligomer(WSCO)과 같은 Polysaccharide를 TDS의 기본 물질로 선택하였다. 또한, 이 polymers들은 tacrine 물질, 강화제로 규정되어진다. 이러한 polysaccharide 중에서, karaya gum matrix의 침투율은 lipophilic drug in vitro 와 같은 tacrine 내에서 가장 빠르다. 우리는 glycerin, PEG 400, and PEG 800를 강화제로 사용하였다. 그러므로, transdermal의 tacrine 흡수율은 vehicle 구성을 바꿈으로써, 혹은 침투 강화제를 사용함으로써 향상되었을 것이다. 특히, vehicle이 스스로의 효과를 강화하는 것과 더불어, vehicle에 강화제를 첨가함으로써 높은 침투 효율이 얻어질 것으로 기대된다.