• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.33 no.5
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• pp.445-454
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• 2007

Background: Phosphatidic acid(PA), an important second messenger, is involved in inflammation. Notably, cell-cell interactions via adhesion molecules playa central role in inflammation. This thesis show that PA induces expression of intercellular adhesion molecule-1(ICAM-1) on macrophages and describe the signaling pathways. Materials and methods: Macrophages were cultured in the presence of 10% FBS and assayed cell to cell adhesion using HUVEC. For the gene and protein analysis, RT-PCR, Western blot and flow cytometry were performed. In addition, overexpressed cell lines for dominant negative PKC-${\delta}$ mutant established and tested their effect on the promoter activity and expression of ICAM-1 protein by PA. Results: PA-activated macrophages significantly increased adhering to human umbilical vein endothelial cell and this adhesion was mediated by ICAM-1. Pretreatment with rottlerin(PKC-${\delta}$ inhibitor) or expression of a dominant negative PKC-${\delta}$ mutant, but not Go6976(classical PKC-${\alpha}$ inhibitor) and myristoylated PKC-${\xi}$ inhibitor, attenuated PA-induced ICAM-1 expression. The p38 mitogen-activated protein kinase(MAPK) inhibitor blocked PA-induced ICAM-1 expression in contrast, ERK upstream inhibitor didn't block ICAM-1. Conclusion: These data suggest that PA-induced ICAM-1 expression and cell-cell adhesion in macrophages requires PKC-${\delta}$ activation and that PKC-${\delta}$ activation is triggers to sequential activation of p38 MAPK.

• Korean Journal of Agricultural Science
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• v.37 no.2
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• pp.223-229
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• 2010

This study is to analyze location conditions for erosion control dams to be constructed in Chungcheongnam-do, Daejeon Metropolitan City, Chungcheongbuk-do and Gyeongsangbuk-do in order to establish proper conditions for erosion control dams in the future. 199 sites where erosion control dams are expected to be built in 2010 were chosen and investigated in terms of 12 factors including basin area, basin slope, and landslide risk. The results showed that erosion control dams for Chungcheongnam-do and Daejeon Metropolitan City are mostly impermeable gravity dams mainly composed of concrete. In contrast, Chungcheongbuk-do and Gyeongsangbuk-do are increasing the number of permeable or compound erosion control dams. Basin analysis at planned erosion control dam sites showed that at least 44.5% of the total area has high landslide risk. Gyeongsangbuk-do had the largest basin area for erosion control dam sites at 157.3ha, followed by Chungcheongbuk-do at 64.4ha and Chungcheongnam-do at 54.8ha. Analysis of sand deposits in the Chungcheongnam-do erosion control dam built in 2010 confirmed an average deposit of 971.8m3. The sand deposit capacity and amount of sediment control for erosion control dams have a very low correlation with basin area or flow path slope, and this needs to be addressed in future sand deposit capacity designs.

• Journal of Korea Water Resources Association
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• v.32 no.4
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• pp.417-426
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• 1999

A series of numerical experiments is performed to compare the characteristics of outflow hydrograph using linear and nonlinear Muskingum-Cunge methods for two cases: (a) sinusoidal inflow hydrographs and (b) rainfall inputs. The nonlinear method shows the steepening of the rising limb, coupled with a corresponding flattening of the receding limb. The linear method conserves mass exactly. In contrast, the nonlinear method is subject to a gain and a loss of mass. The loss of mass and the subsidence of peak outflow increases with a mild slope, a small baseflow $q_b$ and a large peak inflow to baseflow ratio $q_p/q_b$. A shock wave and associated numerical instability results in the increase of mass for a steep slope and a large $q_p/q_b$ ratio. While the linear method depends on the reference flow per unit-width, the nonlinear method depends on a baseflow and the $q_p/q_b$ ratio. It is found that, unlike for the sinusoidal inflow, the outflow for the rainfall inputs conserves mass fairly exactly in the nonlinear method.

• The Journal of Engineering Geology
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• v.24 no.1
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• pp.137-146
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• 2014

The geology of the study area which is located in Samkoe-dong, Dong-gu, Daejeon city comprises black slate, limestone, and pebble-bearing phyllitic rock as meta-sedimentary rocks; and biotite granite and quartz porphyry intrusions. Face mapping revealed sliding in three or four sites of contained coaly slate, where the dip of the foliation and other discontinuities is parallel to the surface slope. The cause of the slope sliding is this parallelism as well as the swelling of the coaly slate when wet. In contrast, the slop on the opposite side of the road is relatively stable because the dip of the foliation and other discontinuities are oblique or normal to the surface slope. To ensure slope stability, a cut-and-cover tunnel was designed and constructed for the new road.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.149-149
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• 2010

The double-layer antireflection (DLAR) coatings have significant advantages over single-layer antireflection (SLAR) coatings. This is because they will be able to cover a broad range of the solar spectrum which would enhance the overall performance of solar cells. Moreover films deposited at high frequency are expected to show excellent and UV-stable passivation in the refractive index that we adopted. In this work, we present a novel DLAR coating using SiNx:H thin films with refractive indices 1.9 and 2.3 as the top and bottom layers. This approach is cost effective when compared to earlier DLAR coatings with two different materials. SiNx:H films were deposited by Plasma enhanced chemical vapor deposition (PECVD) technique using $SiH_4$, $NH_3$ and $N_2$ gases with flow rates 20~80sccm, 200sccm and 85 sccm respectively. The RF power, plasma frequency and substrate temperature for the deposition were 300W, 13.56 MHz and $450^{\circ}C$, respectively. The optimum thickness and refractive indices values for DLAR coatings were estimated theoretically using Macleod simulation software as 82.24 nm for 1.9 and 68.58 nm for 2.3 respectively. Solar cells were fabricated with SLAR and DLAR coatings of SiNx:H films and compared the cell efficacy. SiNx:H> films deposited at a substrate temperature of $450^{\circ}C$ and that at 300 W power showed best effective minority carrier lifetime around $50.8\;{\mu}s$. Average reflectance values of SLAR coatings with refractive indices 1.9, 2.05 and 2.3 were 10.1%, 9.66% and 9.33% respectively. In contrast, optimized DLAR coating showed a reflectance value as low as 8.98% in the wavelength range 300nm - 1100nm.

• Journal of Veterinary Clinics
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• v.32 no.4
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• pp.343-346
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• 2015

A 4-year-old castrated male Dachshund was presented with a chronic history of dyspnea and cyanosis. Complete blood count revealed marked polycythemia with a hematocrit of 79.7%. Thoracic radiographs showed mild right-sided cardiac enlargement. Echocardiography showed a large ventricular septal defect in the left ventricular outflow tract region just proximal to the aortic valve. On Doppler echocardiography, right-to-left shunt flow through the defect was found and confirmed by contrast echocardiography. Based on these diagnostic findings and clinical signs, the dog was diagnosed as right-to-left shunting ventricular septal defect. Phlebotomy and oxygen supplement were performed, but the dog died the day after presentation.

• The Korean journal of internal medicine
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• v.34 no.1
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• pp.146-155
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• 2019

Background/Aims: Indoxyl sulfate (IS) is a uremic toxin and an important causative factor in the progression of chronic kidney disease. Recently, paricalcitol (19-nor-1,25-dihydroxyvitamin D2) was shown to exhibit protective effects in kidney injury. Here, we investigated the effects of paricalcitol treatment on IS-induced renal tubular injury. Methods: The fluorescent dye 2',7'-dichlorofluorescein diacetate was used to measure intracellular reactive oxygen species (ROS) following IS administration in human renal proximal tubular epithelial (HK-2) cells. The effects of IS on cell viability were determined using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays and levels of apoptosis-related proteins (Bcl-2-associated protein X [Bax] and B-cell lymphoma 2 [Bcl-2]), nuclear $factor-{\kappa}B$ ($NF-{\kappa}B$) p65, and phosphorylation of mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) were determined by semiquantitative immunoblotting. The promoter activity of $NF-{\kappa}B$ was measured by luciferase assays and apoptosis was determined by f low cytometry of cells stained with f luorescein isothiocyanate-conjugated Annexin V protein. Results: IS treatment increased ROS production, decreased cell viability and induced apoptosis in HK-2 cells. IS treatment increased the expression of apoptosis-related protein Bax, decreased Bcl-2 expression, and activated phosphorylation of MAPK, $NF-{\kappa}B$ p65, and Akt. In contrast, paricalcitol treatment decreased Bax expression, increased Bcl-2 expression, and inhibited phosphorylation of MAPK, $NF-{\kappa}B$ p65, and Akt in HK-2 cells. $NF-{\kappa}B$ promoter activity was increased following IS, administration and was counteracted by pretreatment with paricalcitol. Additionally, flow cytometry analysis revealed that IS-induced apoptosis was attenuated by paricalcitol treatment, which resulted in decreased numbers of fluorescein isothiocyanate-conjugated Annexin V positive cells. Conclusions: Treatment with paricalcitol inhibited IS-induced apoptosis by regulating MAPK, $NF-{\kappa}B$, and Akt signaling pathway in HK-2 cells.

• Journal of The Korean Society of Agricultural Engineers
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• v.61 no.6
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• pp.67-72
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• 2019

This study compared the theory of a culvert spacing and analytical results of the seepage flow for the subsurface drainage. i) If culvert spacing (Sc) is within 5 m, the unit drainage (q) is very larger; in contrast, if Sc is 5 m or more, there is very little drainage in the middle between drains. Therefore, the drain spacing should be within 5 m to ensure high drainage efficiency. ii) Since the planned culvert drainage increases linearly with the soil's permeability coefficient (k), k must be taken into account when determining the drain diameter by the planned culvert drainage. iii) As a result of analyzing the drainage performance of the absorbing culvert, the drainage performance is sufficient with the diameter of the corrugated drain pipe Dc = 50 mm at the length of the drain Lc = 100 m. iv) Therefore, if the drain spacing (Sc) is less than 5 m using the low-cost non-excavated drainage pipe method (${\Phi}50mm$ the corrugated drain pipe and fiber mat) rather than the conventional trench drain method (Sc > 10 m, Dc > 100 mm), uniform and high drainage efficiency can be ensured as well as low construction cost. v) The sub-irrigation+drainage culvert requires narrower drain spacing (Sc < 2-3 m) for irrigation. As a result of examining the condition of 35 mm in diameter (Dc) and 2~3 m in drain spacing, it is possible to apply the non-excavated drainage pipe method to the sub-irrigation+drainage culvert because drainage performance is sufficient at the drain length Lc = 50 m.

• Journal of the Korean Society of Propulsion Engineers
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• v.17 no.2
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• pp.9-15
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• 2013

An effect of a spiral turbulent ring, so-called Shchelkin spiral, on a detonation performance was studied experimentally for acetylene and oxygen mixture. A couple of dynamic pressure transducers were used to calculate a detonation wave velocity by a time difference between two pressure peaks. In addition, impulse was measured by a load cell and the impulse was used to analyze the spiral effect on the detonation performance. A CFD analysis was adopted to calculate mass flow rates of the propellants and the minimum filling time. The maximum velocity and pressure were measured at the equivalence ratio of 2.4, and the measured values showed similar trend to C-J conditions calculated from CEA. For the shorter chamber with the short spiral, the maximum detonation velocity was appeared. In contrast, the longer chamber without the spiral showed the maximum thrust performance.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.1
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• pp.371-384
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• 2019

Motion perception has been tremendously improved in neuroscience and computer vision. The baseline motion perception model is mediated by the dorsal visual pathway involving the cortex areas the primary visual cortex (V1) and the middle temporal (V5 or MT) visual area. However, few works have been done on the extension of neural models to improve the efficacy and robustness of motion perception of real sequences. To overcome shortcomings in situations, such as varying illumination and large displacement, an adaptive V1-MT motion perception (Ad-V1MTMP) algorithm enriched to deal with real sequences is proposed and analyzed. First, the total variation semi-norm model based on Gabor functions (TV-Gabor) for structure-texture decomposition is performed to manage the illumination and color changes. And then, we study the impact of image local context, which is processed in extra-striate visual areas II (V2), on spatial motion integration by MT neurons, and propose a V1-V2 method to extract the image contrast information at a given location. Furthermore, we take feedback inputs from V2 into account during the polling stage. To use the algorithm on natural scenes, finally, multi-scale approach has been used to handle the frequency range, and adaptive pyramidal decomposition and decomposed spatio-temporal filters have been used to diminish computational cost. Theoretical analysis and experimental results suggest the new Ad-V1MTMP algorithm which mimics human primary motion pathway has universal, effective and robust performance.