• 대한한방소아과학회지
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• 제23권2호
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• pp.179-195
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• 2009

Objectives : Paeonia lactiflora Pall(芍藥) is known for curing caking muscular contraction(結實而拘攣) according to Yakucho(藥徵) published by Yoshimasu Todo(吉益東洞), but the descriptions of caking muscular contraction(結實而拘攣) are not fully provided. Methods : In order to further investigate and review the exact meaning of caking muscular contraction(結實而拘攣), present study has been conducted on the basis of researches of Yoshimasu Todo's literatures, focusing on Yakucho. Results : As a result of wide range of investigation, it is concluded that caking muscular contraction(結實而拘攣) indicates an abnormal muscular contraction of rectus abdominis. Conclusions : This study will provide helpful clinic information to doctors who will apply medical treatment specified in Yoshimasu Todo's Yakucho(藥徵) to patients in the future.

• 약학회지
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• 제56권3호
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• pp.180-185
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• 2012

The aim of present study was to investigate the possible influence and related mechanism of alcohol on the arterial contraction. Vascular contraction involves the activation of thick or thin filament pathway. However, there are no reports addressing the question whether this pathway is involved in alcohol-induced regulation. We hypothesized that alcohol plays a role in vascular contraction evoked by a vasoconstrictor in rat aortae regardless of endothelial function. Denuded arterial rings from male rats were used and isometric contractions were recorded using a computerized data acquisition system. Interestingly, alcohol at a low concentration (3% v/v) inhibited thromboxane $A_2$ or phorbol ester-induced contraction with endothelial function but at a high concentration (10%) didn't inhibit and rather increased the contraction in the denuded muscle. Therefore, alcohol at a low concentration decreases the contraction and alcohol at a high concentration increases the contraction suggesting that additional pathways different from endothelial nitric oxide synthesis might be involved in the regulation of contractility. In conclusion, alcohol has some effect on the regulation of contractility regardless of endothelial function.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.77.3-78
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• 2003

We previously shown that sphingosylphosphorylcholine, a lysophosphatidic acid, produced contraction in isolated single cells of cat ilium. We investigated the mechanism of sphingosine-1-phosphate (S1P)-induced contraction of circular smooth muscle cells in cat esophagus. S1P produced esophageal contraction in a dose dependent manner. The maximal contraction (l0$\^$-7/ M) induced at 1min. Pertusis toxin (PTX) inhibited contraction induced by S1P, suggesting that the contraction is mediated to a PTX-sensitive G-protein. (omitted)

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2003년도 The Fifth Asian Computational Fluid Dynamics Conference
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• pp.17-18
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• 2003

Drop deformation in a cylindrical contraction geometry, characterized here by the formation of a thread of drop fluid in the contraction, is predicted using a Volume-of-Fluid numerical technique. The predicted drop shape is found to closely follow the observed deformation. A capillary instability in the developing drop thread in the contraction was predicted, in agreement with experimental observation.

• Nonlinear Functional Analysis and Applications
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• 제28권2호
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• pp.311-335
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• 2023

Fixed point theory is the center of focus for many mathematicians from last few decades. A lot of generalizations of the Banach contraction principle have been established. In this paper, we introduce the concepts of 𝜃-contraction and 𝜃-𝜑-contraction in quasi-metric spaces to study the existence of the fixed point for them.

• 한국수학교육학회지시리즈B:순수및응용수학
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• 제14권4호
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• pp.283-287
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• 2007

An extension of the contraction mapping theorem is provided in a Banach space setting to approximate fixed points of operator equations. Our approach is justified by numerical examples where our results apply whereas the classical contraction mapping principle cannot.

• 대한수학회논문집
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• 제34권4호
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• pp.1157-1162
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• 2019

In this paper, we extend the study of general convergence theorems for the Picard iteration of Proinov contraction from the class of continuous mappings to the class of discontinuous mappings. As a by product we provide a new affirmative answer to the open problem posed in [20].

• Nonlinear Functional Analysis and Applications
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• 제27권2호
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• pp.261-269
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• 2022

The purpose of this paper is to introduce a new generalization class of cyclic mappings, called cyclic generalized 𝜑-weak contraction and obtain a corresponding best proximity point theorem for this cyclic mapping under certain conditions.

• 약학회지
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• 제34권3호
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• pp.180-191
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• 1990

A comparison was made of the effects of selective ${\alpha_1}-adrenoceptor$ agonist phenylephrine and selective ${\alpha_2}-adrenoceptor$ agonist clonidine on endothelium-containing and endothelium-denuded rings of the rat aorta. In the case of phenylephrine, removal of endothelium increased sensitivity 2.5 fold at $EC_{50}$ level and maximum contractive response 1.4 fold. In the case of clonidine, which gave only 15% of maximum contractive response given to phenylephrine on endothelium-containing rings, removal of the endothelium increased sensitivity 5.6 fold at $EC_{50}$ level and maximum contractive response 5 fold, which was about 55% of that given by phenylephrine. In endothelium-denuded ring, phenylephrine-induced contraction tended to be more increased in tonic contraction than in phasic contraction as compared to that in endothelium-containing ring, while clonidine-induced contraction was monophasic and was increased only in tonic contraction. In the calcium-free solution or in the presence, of verapamil, contraction stimulated by clonidine was almost abolished while that stimulated by phenylephrine produced only phasic contraction. The depression of sensitivity to these agonists in rings with endothelium appeared to be due to the vasodepressor action of endothelium derived relaxing factor (EDRF), because hemoglobin, a specific blocking agent of EDRF, abolished this depression. It is unlikely that the endothelium-dependent relaxation was due to stimulation of release of EDRF, because clonidine did not produce endothelium-dependent relaxation in 5-hydroxytryptamine-precontracted ring even when its contractile action was blocked by the ${\alpha_1}-adrenoceptor$ antagonist, prazosin. When the efficacy of phenylephrine was reduced to about the initial efficacy of clonidine by pretreatment with dibenamine, the contraction-response curves for phenylephrine became very similar to the corresponding curves obtained for clonidine before receptor inactivation. In the dibenamine-treated rings, contraction of phenylephrine was abolished in calcium-free solution or in the presence of verapamil like that obtained for clonidine before receptor inactivation. These results suggest that EDRF spontaneously released from endothelium depress contraction more profoundly in a case of an agonist with low efficacy and the phenylephrine-induced contraction was totally dependent on extracellular calcium as was that obtained for clonidine when the efficacy of phenylephrine was reduced to that of clonidine by irreversible inactivation of ${\alpha_1}-adrenoceptor$ with dibenamine.

• 한국잠사곤충학회지
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• 제39권1호
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• pp.44-55
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• 1997

This study was carried out to find out the relationship between qualities and contraction phenomenon of silk fibers by treatment of concentrated neutral salts. The contraction effects of silk fibers showed the critical point on the treatment conditions of concentration, temperature and time, among three kinds of neutral salts such as calcium nitrate, calcium chloride and lithium bromide. But, The silk fibers, pretreated with bromide and/or formaldehyde, did not show the contraction upon treating with calcium nitrate. This indicates that tyrosine and serine can be correlated with the contraction reaction because of coupling these amino acids with bromide and formaldehyde. In conclusion, a mechanism for the contraction of silk fiber with highly concentrated calcium nitrate solution is supposed as follows. At the initial stage of ration, the water was penetrated into the amorphous regions and fibers swollen, therefore, the contraction took place mainly in amorphous regions, which have plenty of functional groups with hydroxyl residues. Then, as the calcium nitrate is penetrated into the microfibril, the gydrogen bonds of tyrosine and serine residues and broken and crystalline regions are more and more influenced by increasing concentration of calcium nitrate solution. Microgibrils of crystalline regions become entangled, contracted to linear direction and rearranged to form new stable hydrogen bonds.