• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.6
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• pp.1622-1628
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• 2005

This study was undertaken to define the effect of SoPung-Tang extract on hypertension in spontaneous hypertensive rat and norepinephrine- induced arterial contraction in rabbit. In order to investigate the effect of SoPung-Tang extract on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of SoPung-Tang extract-induced relaxation, SoPung-Tang extract infused into contracted arterial strips induced by norepinephrine after treatment of indomethacin, Nu-nitro-L-arginine, methylene blue or tetraethylammonium chloride. Blood pressure was significantly decreased five days after administration of SoPung-Tang extract. SoPung-Tang extract relax arterial strip with endothelium contracted by norepinephrine, but in the strips without endothelium, SoPung-Tang extract- induced relaxation was significantly inhibited. SoPung-Tang relax arterial strip contracted by norepinephrine, but in the strips contracted by high $K^+$, SoPung-Tang extract-induced relaxation was significantly inhibited. The endothelium-dependent relaxation induced by SoPung-Tang extract was decreased by the pre-treatment of $N{\omega}$-nitro-L-arginine or methylene blue, but it was not observed in the strips pre-treated with indomethacin or tetraethylammonium chloride. When $Ca^{2+}$ was applied, the strips which were contracted by norepinephrine in a $Ca^{2+}$-free solution, arterial contraction was increased. But pre-treatment of SoPung-Tang extract inhibited contractile response to $Ca^{2+}$. We suggest that SoPung-Tang could be applied effectively for hypertension and may suppress influx of extra-cellular $Ca^{2+}$ through the formation of nitric oxide in the vascular endothelial cells.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.1
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• pp.131-136
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• 2008

This study was undertaken to define the effect of Polygoni cuspidatae Radix on contracted rabbit common carotid artery and its mechanism. In order to investigate the effect of Polygoni cuspidatae Radix on rabbit's contracted vascular ring detached from common carotid artery, vascular ring with intact or damaged endothelium was used for the experiment using organ bath. To analyze the mechanism of Polygoni cuspidatae Radix-induced relaxation, Polygoni cuspidatae Radix extract was infused into contracted vascular ring which had been pretreated by $N{\omega}-nitro-L-arginine(L-NNA)$, Methylene blue(MB), and $Ca^{2+}$ was infused into contracted vascular ring induced by NE or KCl after treatment of Polygoni cuspidatae Radix extract in $Ca^{2+}-free$ solution. The results were as follows : Polygini cuspidatae Radix had an effective relaxation to the contracted vascular ring by NE in 0.1 mg/ml and 0.3 mg/ml level. Polygini cuspidatae Radix had an effective relaxation to the intact endothelium vascular ring, but when endothelium was removed, vascular ring did not relax. Polygini cuspidatae Radix-induced relaxation was inhibited by the pretreatment of L-NNA and MB. Pretreatment of Polygini cuspidatae Radix extract inhibit the contraction by influx of $extra-Ca^{2+}$ in contracted vascular ring induced by NE or KCl in $Ca^{2+}-free$ solution. As mentioned above, we suggest that Polygini cuspidatae Radix relaxes vascular ring through suppress influx of extra-cellular $Ca^{2+}$ by the action of nitric oxide from endothelium.

• The Journal of Dong Guk Oriental Medicine
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• v.4
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• pp.267-311
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• 1995

This study was performed to analyze the effects of WhoaDam-JiHae PyeongChunYak on contracted tracheal smooth muscle in rat. Transverse strips were used for the experiment using organ bath. The test strip was perfused with modified Krebs-Ringer Bicarbonate solution which was aerated with 95% $O_2$-5% $CO_2$ mixed gas and kept at $37^{\circ}C$. WhoaDam-JiHae PyeongChunYak extract and acetylcholine infused tracheal strip that was contracted with acetylcholine. The results were as follows : 1. The contractile force of tracheal strip by acetylcholine was significantly increased by Pinelliae Rhizoma, Arisaematis Rhizoma, Sinapis Semen. Typhonii Rhizoma, Peucedani Radix, Eriobotryae Folium, Platycodi Radix, Bambusae Caulis Taeniam, Benincasae Semen, Armeniacae Amarum Semen, Asteris Radix, Periliae Fructus, Mori cortex and Lepidii Semen. 2. Arisaematis Rhizoma($1{\mu}{\ell}/m{\ell}$, $3{\mu}{\ell}/m{\ell}$, $10{\mu}{\ell}/m{\ell}$) and Asteris Radix($1{\mu}{\ell}/m{\ell}$, $3{\mu}{\ell}/m{\ell}$) slightly relaxed the contracted tracheal strip by acetylcholine. 3. Farfarae Flos significantly relaxed the contracted tracheal strip by acetylcholine. 4. The contractile force of tracheal strip by acetylcholine was significantly increased by Stemonae Radix at $30{\mu}{\ell}/m{\ell}$, on the other hand Stemonae Radix at $100{\mu}{\ell}/m{\ell}$ significantly relaxed the contracted tracheal strip by acetylcholine.

• Journal of Practical Engineering Education
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• v.8 no.1
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• pp.63-68
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• 2016

As job mismatch intensifies in the employment market, the work based learning has emerged as a solution to this social problem. The so called Korean dual education system is expected to raise jobseekers equipped with knowledge and skills demanded by industry. This study intends to recommend an effective operational model for contracted education programs at higher institutions in order to support soft landing of Korean dual education system. Students of contracted education programs are adults graduated from vocational high schools and working for companies during weekdays. In consideration of the difficulties experienced by employee students, more flexible operation of academic affairs is required. To address these challenges, the recommended contracted education model includes such beneficial features as S-OJT courses, standard curriculum based on National Competency Standard, recognition of prior learning, flipped classroom, and tutoring system. In the last part, several directions for implementing the new contracted education model are discussed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.2
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• pp.465-471
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• 2017

This study examined the effects of neoliberal educational policy on the appointment system of teachers to assess the impacts of this neoliberal education policy. Neoliberal education policy has led to increased private education cost, and strengthened the function of social stratum reproduction in the education system despite increasing the efficiency and flexibility. Since contracted employment was applied to the educational field, the number of regular teachers began to decrease, while that of contracted teachers increased. For example, the number of contracted teachers was 300 in the 1990, which increased to 42,042 in 2015. Neoliberal education policy contributed to teacher's quantitative demand; however, the increase in the number of contracted teachers is ultimately degrading the education quality. In an education market, the issues of balancing between supply and demand often occur. Therefore, it is necessary to strongly control the number of contracted teachers by limiting their contract period. Furthermore, an institutional device that can convert a contracted teacher to a regular one must be established.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.4
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• pp.198-206
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• 2019

This study was conducted to evaluate the vasorelaxant effect of DangGuiSu-San and SamHwangSaSim-Tang extract on contracted rabbit carotid artery. To study the effect of DangGuiSu-San and SamHwangSaSim-Tang extract on contracted rabbit carotid arterial strips, arterial strips with intact or damaged endothelium were used for experiment using organ bath. The pre-contracted arterial strips with Phenylephrine(PE) was treated with various concentrations of DangGuiSu-San and SamHwangSaSim-Tang extract(0.01, 0.03, 0.1, 0.3 and $1.0mg/m{\ell}$). To determine the mechanisms of DangGuiSu-San and SamHwangSaSim-Tang-induced vasorelaxant, DangGuiSu-San and SamHwangSaSim-Tang extract were infused into contracted arterial rings which had been pretreated by indomethacin(IM), tetraethylammonium chloride(TEA), $N{\omega}$-nitro-L-arginine ($_L-NNA$), methylene blue(MB). And calcium chloride(Ca) 1 mM was infused into precontracted arterial ring induced by PE after treatment of DangGuiSu-San and SamHwangSaSim-Tang extract in $Ca^{2+}$-free krebs solution. DangGuiSu-San and SamHwangSaSim-Tang extract revealed significant relaxation on PE-induced arterial contraction. DangGuiSu-San and SamHwangSaSim-Tang extract also had an effective relaxation to the intact endothelium arterial ring. SamHwangSaSim-Tang extract on contracted rabbit carotid artery is related with NO-cGMP pathway. Pretreatment of DangGuiSu-San and SamHwangSaSim-Tang extract inhibited the contraction by influx of extracellular $Ca^{2+}$ in contracted arterial ring induced by NE. This study indicated that the relaxation effect of SamHwangSaSim-Tang extract on contracted rabbit carotid artery is related with NO-cGMP pathway. Pretreatment of DangGuiSu-San and SamHwangSaSim-Tang extract inhibited the contraction by influx of extracellular $Ca^{2+}$ in contracted arterial ring induced by NE.

• Communications of the Korean Mathematical Society
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• v.17 no.4
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• pp.593-606
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• 2002

We prove local existence and global uniqueness in one dimensional nonlinear hyperbolic inverse problems. The basic key for showing the local existence of inverse solution is the principle of contracted mapping. As an application, we consider a hyperbolic inverse problem with damping term.

• The Transactions of the Korea Information Processing Society
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• v.5 no.4
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• pp.1048-1056
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• 1998

In this paper, a fractal image coding based on discrete wavelet transform is proposed to improve PSNR at low bit rates and reduce computational complexity of encoding process. The proposed method takes the absolute value of discrete wavelet transform coefficients, and then constructs significant coefficients trees, which indicate the positions and signs of the significant coefficients. This method improves PSNR and reduces computational complexity of mapping contracted domain pool onto range block, by matching only the significant coefficients of range block to coefficients of contracted domain block. Also, this paper proposes a classification scheme which minimizes the number of contracted domain blocks compared with range block. This scheme significantly reduces the number of range and contracted domain block comparison.

• Journal of Veterinary Clinics
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• v.30 no.1
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• pp.27-31
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• 2013

We investigated the effects of Ponciri Fructus (PF) and Aurantii Fructus Immaturus (AI) on the cicular and longitudinal smooth muscle of rat gastric fundus. Methanol extracts of PF (PFM) and AI (AIM), water-fractions (PFW, AIW) and chloroform-fractions (PFC, AIC) of the extracts induced relaxation in the rat fundic circular muscle pre-contracted by U46619. All extracts showed relaxation without significant differences among the extracts. In the longitudinal smooth muscle, PFM and its water fraction, PFW, showed multiphasic effects, fast relaxation and rebound contraction followed by lasting relaxation. AIM and AIW showed diphasic effects, transient contraction followed by lasting relaxation. However, PFC and AIC induced only relaxation in the rat fundic longitudinal muscle contracted by U46619. PFM showed significantly more effective relaxation compared with PFW, AIM and AIW. Hesperidin, flavonoids known as common constituent of PF and AI and it's an aglycon, hesperetin, induced relaxation in both fundic circular and longitudinal smooth muscle pre-contracted by U46619. Poncirin, known as flavonoid content of PF showed also induced relaxation in the both circular and longitudinal smooth muscle pre-contracted by U46619. These results suggest that both PF and AI has relaxing effects on the gastric fundus smooth muscle and its effects might be caused by their flavonoids constituents.

• International Journal of Fluid Machinery and Systems
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• v.3 no.2
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• pp.113-121
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• 2010

LES(Large Eddy Simulation) with a cavitation model was performed to calculate an unsteady flow for a mixed flow pump with a closed type impeller. First, the comparison between the numerical and experimental results was done to evaluate a computational accuracy. Second, the torque acting on the blade was calculated by simulation to investigate how the cavitation caused the fluctuation of torque. The absolute pressure around the leading edge on the suction side of blade surface had positive impulsive peaks in both the numerical and experimental results. The simulation showed that those peaks were caused by the cavitaion which contracted and vanished around the leading edge. The absolute pressure was predicted by simulation with -10% error. The absolute pressure around the trailing edge on the suction side of blade surface had no impulsive peaks in both the numerical and experimental results, because the absolute pressure was 100 times higher than the saturated vapor pressure. The simulation results showed that the cavitation was generated around the throat, then contracted and finally vanished. The simulated pump had five throats and cavitation behaviors such as contraction and vanishing around five throats were different from each other. For instance, the cavitations around those five throats were not vanished at the same time. When the cavitation was contracted and finally vanished, the absolute pressure on the blade surface was increased. When the cavitation was contracted around the throat located on the pressure side of blade surface, the pressure became high on the pressure side of blade surface. It caused the 1.4 times higher impulsive peak in the torque than the averaged value. On the other hand, when the cavitation was contracted around the throat located on the suction side of blade surface, the pressure became high on the suction side of blade surface. It caused the 0.4 times lower impulsive peak in the torque than the averaged value. The cavitation around the throat caused the large fluctuation in torque acting on the blade.