Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effects of Ponciri Fructus and Aurantii Fructus Immaturus on the Gastric Fundus Motility

위저부 평활근 운동에 대한 국산과 중국산 지실의 효능

  • Kim, Tae-Wan (College of Veterinary Medicine, Kyungpook National University)
  • 김태완 (경북대학교 수의과대학.산업동물의학연구소)
  • Accepted : 2013.02.14
  • Published : 2013.02.28
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Abstract

We investigated the effects of Ponciri Fructus (PF) and Aurantii Fructus Immaturus (AI) on the cicular and longitudinal smooth muscle of rat gastric fundus. Methanol extracts of PF (PFM) and AI (AIM), water-fractions (PFW, AIW) and chloroform-fractions (PFC, AIC) of the extracts induced relaxation in the rat fundic circular muscle pre-contracted by U46619. All extracts showed relaxation without significant differences among the extracts. In the longitudinal smooth muscle, PFM and its water fraction, PFW, showed multiphasic effects, fast relaxation and rebound contraction followed by lasting relaxation. AIM and AIW showed diphasic effects, transient contraction followed by lasting relaxation. However, PFC and AIC induced only relaxation in the rat fundic longitudinal muscle contracted by U46619. PFM showed significantly more effective relaxation compared with PFW, AIM and AIW. Hesperidin, flavonoids known as common constituent of PF and AI and it's an aglycon, hesperetin, induced relaxation in both fundic circular and longitudinal smooth muscle pre-contracted by U46619. Poncirin, known as flavonoid content of PF showed also induced relaxation in the both circular and longitudinal smooth muscle pre-contracted by U46619. These results suggest that both PF and AI has relaxing effects on the gastric fundus smooth muscle and its effects might be caused by their flavonoids constituents.

Keywords

References

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