• Biomedical Science Letters
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• v.11 no.3
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• pp.355-363
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• 2005

This study aimed to investigate the cerebroprotective effect of vascular endothelial growth factor (VEGF) on permanent focal cerebral ischemia in Sprague-Dawley rats. Right middle cerebral artery (MCA) was occluded for 6 and 24 hours by an intraluminal monofilament technique. An open cranial window was made on the right parietal bone for determination of continuous changes in regional cerebral blood flow (rCBF) by laser-Doppler flowmetry. The infarct size was morphometrically determined using the 2,3,5-triphenyltetrazolium chloride technique. Brain edema was determined by measuring brain water content. In normal rats, rCBF was significantly increased by intravenous infusion of VEGF for 10 minutes. The VEGF-induced increase in rCBF was significantly inhibited by pretreatment with suramin, a heparin-binding growth factor inhibitor as well as $N^{\omega}-nitro-L-arginine$, a nitric oxide synthase inhibitor. In focal cerebral ischemic rats, the amplitude of decrease in rCBF during ischemic period was significantly less in VEGF-treated group, compared with that in vehicle-treated group. The cerebral infarct size was reduced by VEGF in a dose-dependent manner. The brain edema formation was dose-dependently reduced by VEGF in 24-hour MCA occlusion group but not in 6-hour MCA occlusion group. It is suggested that VEGF not only improves the rCBF during cerebral ischemic period but also reduces the brain edema formation, and thereby exert a protective effect on focal cerebral ischemia in rats.

• Journal of Korean Medicine Rehabilitation
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• v.30 no.1
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• pp.47-61
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• 2020

Objectives This study is carried out to investigate the effects of Lonicera japonica in wound-induced rats. Methods Rats were divided into 5 groups; normal (Nor), control (Veh), positive comparison (PC), Lonicera japonica 100 mg/kg (LL), Lonicera japonica 200 mg/kg (LH), each n=8. Total polyphenol and flavonoid were quantified. 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3 ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging activation were measured. Reactive oxygen species (ROS) was measured in serum. Antioxidant factors and inflammatory factors were measured in skin tissue, and also hydroxyproline content. Skin tissue was analyzed by Hematoxylin & Eosin and Masson's trichrome staining method. Results Total polyphenol and flavonoid were 32.86±0.14 mg/g and 67.17±0.57 mg/g. The IC₅₀ values of DPPH and ABTS free radical scavenging activation were 26.69±1.50 ㎍/mL and 49.33±4.52 ㎍/mL. ROS was significantly lower in LL and LH groups. Nuclear factor-erythroid 2-related factor 2 (Nrf2) was significantly higher in LH group and higher in LL group but not significant. Superoxide dismutase 1 (SOD-1), catalase, and heme oxygenase 1 (HO-1) were significantly higher in LL and LH groups. Nuclear factor kappa-B p65 (NF-κBp65), phosphorylated iκBα (p-iκBα), cyclooxygenase 2 (COX-2), and tumor necrosis factor alpha (TNF-α) were significantly lower in LL and LH groups. Hydroxyproline was significantly higher in LL and LH groups. The histopathologic analysis showed that skin tissue had recovered further more in LL and LH groups than in Veh group. Conclusions These results suggest that Lonicera japonica has the anti-oxidant, anti-inflammatory and healing effects in wound-induced rats.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.19 no.9
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• pp.838-842
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• 2006

0.03Pb$(Sb_{0.5}Nb_{0.5})O_{3}-0.03Pb(Mn{1/3}Nb{2/3)O_{3}-(0.94-x)PbTiO_{3}-xPbZrO_{3}$ ceramics doped with $CeO_{2}$ were synthesized by conventional bulk ceramic processing technique. Phases analysis, microstructures and piezoelectric properties were investigated as a function of $CeO_{2}$ content (0.03, 0.05, 0.1 0.3, 0.5 and 0.7 wt%). Microstructures and phases information were characterized using a scanning electron microscope (SEM) and an X-ray diffractometer (XRD). Mechanical quality factor ($Q_{m}$) and coupling factor(kp) were obtained from the resonance measurement method. Both $Q_{m}$ and $k_{p}$ were shown to reach to the maximum at 0.1 wt% $CeO_{2}$. In order to evaluate the stability of resonance frequency and effective electromechanical coupling factor ($K_{eff}$) as a function of $CeO_{2}$, the variation of resonance and anti-resonance frequency were also measured using a high voltage frequency response analyzer under various alternating electric fields from 10 V/mm to 80 V/mm. It was shown that the stability of resonance frequency and effective electromechanical coupling factor were increased with increasing the $CeO_{2}$ contents.

• Transactions on Electrical and Electronic Materials
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• v.13 no.6
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• pp.283-286
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• 2012

(1-X)$(Na_{0.5}K_{0.5})NbO_3-XK_{5.4}Cu_{1.3}Ta_{10}O_{29}$ (NKN-KCT) lead-free piezoelectric ceramics have been synthesized by the conventional solid state sintering method, and their sinterability and piezoelectric properties were investigated. Typically, this material is sintered between 1,025 and $1,100^{\circ}C$ for 2 hours to achieve the required densification. Crystalline structures and Microstructures were analyzed by X-ray diffraction and scanning electron microscope. The density, dielectric constant (${\varepsilon}_r$), piezoelectric constant $d_{33}$, electromechanical coupling factor $k_p$ and mechanical quality factor $Q_m$ value of the NKN ceramics depended upon the KCT content and the sintering temperature. In particular, the KCT addition to NKN greatly improved the mechanical quality factor $Q_m$ value. The ceramic with X = 1.0 mol% sintered at $1,050^{\circ}C$ exhibited optimum properties (${\varepsilon}_r$=246, $d_{33}$=95, $k_p$=0.38 and $Q_m$=1,826). These results indicate that the ceramic is a promising candidate material for applications in lead free piezoelectric transformer and filter materials.

• The Korean Journal of Pharmacology
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• v.29 no.1
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• pp.1-8
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• 1993

To elucidate involvement of platelet-activating factor (PAF) in cerebral ischemia-reperfusion injury, male Sprague-Dawley rats and albino mice of either sex were subjected to a 10-min bilateral carotid artery occlusion and 6-hr recirculation. The McGraw stroke index in mice was markedly inhibited by PAF antagonists, BN 52021 and CV 6209 (1 mg/kg, i.p., each) When they were administered 10 min before bilateral carotid artery occlusion or 1 hr after reperfusion. The increases in brain water content were significantly attenuated by treatment with BN 52021 or CV 6209 in both animals. BN 52021 exhibited a significant improvement in the postischemic blood pressure change in association with a beneficial effect on the delayed dilatation of pial arterioles after 10 min of ischemia. Thus it is suggested that PAF plays an important role as an endogenous mediator in development of cerebral ischemia-reperfusion injury, and further, specific antagonists to PAF will be able to prevent or reverse the pathological sequelae of cerebral ischemia.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.6A
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• pp.449-456
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• 2011

Spacing factor proposed by Power is a concept of averaging air void spacing composed of geometric models. Thus, there's a limitation on simulating actual air void characteristics in concrete. This study presents SDI(spacing distribution index) to overcome the limitation of spacing factor. SDI is also evaluated through comparing SDI with SF(spacing factor). In this study, it was confirmed that SF decreased due to increasing air-entrainer content but SDI increased. This occurs because SDI is the area of spacing distribution curve and SDI increases with increasing the frequency of spacing. SDI is evaluated to have better coverage below $300{\mu}m$ of SF so that determination of critical point of SDI above 80% of durability index can be easily obtained with more reliability. SDI is the area of spacing distribution curve and reflects actual air void characteristics in concrete. A comparative study of SDI and results of freeze-thaw test will be performed later.

• Child Health Nursing Research
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• v.8 no.3
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• pp.291-301
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• 2002

This study was performed to develop a scale of maternal conflict based on already established scales and the literature review. The major purpose of this study was to develop a scale of which contains difficulties which mother can feel to rearing her child and can be applied to mothers at home or employed mothers. 68 items were developed. For content validity test, the items were examined by 7 experts panel with Likert 4 scale. The 39 items were selected as high validity from 86% of the experts. The item number of each area and the misunderstanding words were corrected by advices of experts. 10 mothers again examined 39 items in order to correct the misunderstanding words and the long sentences. For reliability and factor analysis of 39 items, 496 mothers participated. 34 items were chosen because 5 items that corrected item-total correlation coefficient were lower than 0.2 were excluded by the result of reliability analysis. Factor analysis was done with 34items. 6 factors were classified higher than eigen value 1.0, 28 items were chosen because 6 items that factor loadings were lower than 0.4 were excluded. These factors were named as employment and caring for child(6 items), child education(5 items), support system for caring for child(4 items), interaction with mother and child(4 items), view of maternal role(5 items) and me as human being(4 items). Reliability analysis was done with 28 items. 1 item(36 number of factor 1) was excluded because corrected item-total correlation coefficient were lower than 0.2. Therefore, 27 items were chosen. Maternal Conflict Scale was contained 27 items. The corrected item-total correlation coefficient of 27 items were ranged from .2345 to .5240 and Cronbach alpha coefficient of those was .8207 by the results of reliability analysis. It can be evaluated that this scale had a high validity and reliability because of passing through an objective process of test.

• The Journal of the Korea Contents Association
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• v.21 no.9
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• pp.164-175
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• 2021

The purpose of this study is to develop the 'Kkondae Scale' and verify its validity. For this purpose, three constructive concepts (attribution error, cognitive rigidity, and one-way communication) were derived through expert interviews, prior research and literature analysis, and 15 preliminary questions were selected. In addition, a preliminary scale was developed by modifying or adding items to conform to each constructive concept through expert content validity evaluation. Next, as a result of the exploratory factor analysis of about 250 adults, a three-factor structure model was derived. As a result of the confirmatory factor analysis on the preliminary scale for about 401 adults, it was confirmed that the fit of the three-factor structure was good. As a result of convergence and discriminatory validity analysis, it was confirmed that the developed scale was a valid tool to measure Kkondae by showing appropriate correlations with listening attitude, empathy, acceptance of others, and intellectual humility. Finally, based on the results of this study, the significance, limitations, and future research direction of the study were discussed.

• Journal of Climate Change Research
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• v.7 no.4
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• pp.513-520
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• 2016

Korea's energy consumption has been constantly increasing. Final energy consumption was increased by an annual average of 2.9% compared to 2010. The consumption of all energy sources except for its oil was increased during the same time. While electric demand has increased coal consumption increased rapidly. Therefore, calorfic value and carbon emission factor development can improve the quality of Korea's greenhouse gas inventory. Calorific value is the amount of heat generated while burning coal. Caloric value is one of the most important factors in the development of carbon emission factors. Calorific value is used as the basis for the analysis of the various energy statistics. This study has calculated the other bituminous coal and coking coal's calorfic value by the data received from domestic coal-fired power plants and steel manufacturer. Calorofic value's trend analysis period is the year of 2010~2014. Through analyzing the carbon content it was calculated the carbon emission factor. The bituminous coal and coking coal's uncertainty analysis was performed using a Monte Carlo simulation.

• Journal of Climate Change Research
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• v.8 no.2
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• pp.145-151
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• 2017

Korea's energy consumption has been constantly increasing. Final energy consumption was increased by anannual average of 2.9% compared to 2010. The consumption of all energy sources except for its oil was increased during the same time. While electric demand has increased coal consumption increased rapidly. Therefore, calorfic value and carbon emission factor development can improve the quality of Korea's greenhouse gas inventory. Calorific value is the amount of heat generated while burning coal. Caloric value is one of the most important factors in the development of carbon emission factors. Calorific value is used as the basis for the analysis of the various energy statistics. This study has calculated the sub-bituminous coal's calorfic value by the data received from domestic coal-fired power plants. Calorofic value's trend analysis period is the year of 2011~2015. Through analyzing the carbon content it was calculated the carbon emission factor. The sub-bituminous coal's uncertainty analysis was performed using a Monte Carlo simulation.