• 대한본초학회지
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• 제29권6호
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• pp.55-62
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• 2014

Objectives : The objective of this study is to determine the best numbers of steaming-drying cycles of Gastrodiae Rhizoma for both efficacy and taste. We investigated various characteristics among Gastrodiae Rhizoma samples (GSD1, GSD3, GSD5 and GSD7) through the number of steaming-drying cycles increased. Methods : Gastrodiae Rhizoma were steamed and dried at different repeated numbers. They were divided into samples (GSD1; steamed and dried once, GSD3; steamed and dried three times, GSD5; steamed and dried five times, GSD7; steamed and dried seven times) for experiment. They were extracted using water, freeze dried and powdered to analyze proximate composition, free sugar amount, functional components, antioxidant activity and sensory evaluation. Results : Proximate composition and the amount of free sugars of Gastrodiae Rhizoma did not have meaningful differences among samples. Phenolic and flavonoid content of samples were increased by increasing steaming-drying numbers. Gastrodin content had different values and GSD7 was the highest in comparison with others. Increasing steaming-drying numbers led to a increasing in radical and nitrate scavenging activity in samples. Regarding to sensory evaluation, GSD5 was selected as the best sample according to its highest hedonic score mean (5.54/7) among all samples for appearance, color, taste and overall acceptability. Conclusions : The results indicated that 5th-cycling sample was effective in views of functional components, antioxidant activity and sensory characteristics. Moreover, it was suggested that steaming-drying process improved remarkably the effects of Gastrodiae Rhizoma.

• 대한한방부인과학회지
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• 제37권2호
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• pp.35-57
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• 2024

Objectives: This systematic review of animal studies was designed to examine the therapeutic mechanisms of herbal medicines of insulin resistance in Polycystic ovary syndrome and composition of them. Methods: Studies were searched from PubMed, CNKI and Medline up to February 2024. Data was extracted and organized as animal model characteristics, treatment period, experimental and control group settings, evaluation index of treatment, therapeutic mechanism of herbal medicine and Composition of prescription. Results: In the 15 studies finally selected, the herbal medicine used in the study was effective in regulating the insulin resistance index, sex hormones and blood lipid index and improving the histological morphology of the ovaries. The herbal medicine prescriptions used in each of the 15 papers were different, and Salviae Miltiorrhizae Radix (丹參), Wolfiporia cocos (茯苓) and Epimedii Herba (淫羊藿) were most frequently used herbs, 7 times. Conclusions: The results showed that herbal medicine is effective in treating insulin resistance in Polycystic ovary syndrome through several mechanisms. The herbs used in more than 4 papers had effects such as anti-inflammatory, anti-oxidant, estradiol hormone production control and glycolipid metabolism control. More diverse clinical studies on insulin resistance in Polycystic ovary syndrome are needed.

• 대한본초학회지
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• 제27권5호
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• pp.65-75
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• 2012

Objectives : Cosmeceutical activities such as anti-oxidative and anti-aging effects of the Doinseunguitang and its composition, a traditional prescription, were evaluated. Methods : We performed MTT assay, melanin synthesis inhibition assay, DPPH free radical scavenging assay, SOD-like activity, xanthine oxidase inhibition assay, astringent activity assay, tyrosinase inhibition assay, elastase and collagenase inhibition assay. Results : The results were obtained as follows : DPPH free radical scavenging of water extract Doinseunguitang (DISG) and ethanol extract DISG was 60% and 50% at 1,000 ppm. Xanthine oxidase inhibition effect of ethanol extract showed more than 80% at 500 ppm. Tyrosinase inhibition and inhibition melanin synthesis activities were measured in 40% and 50% at 1,000 ppm and 100 ppm. Elastase and collagenase inhibition rate of ethanol extracts DISG 40% and 80% at 1,000 ppm. It was concluded that compositive ingredients (Persicae Seman, Glycyrrhizae Radix, Cinnamomi Ramulus, Rhei Rhizoma) influenced the most results. Conclusions : The results indicated that, ethanol extract which is superior in its anti-oxidative and anti-aging effects is useful to be applied in herbal cosmetic industry.

• 대한한의학방제학회지
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• 제16권1호
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• pp.1-13
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• 2008

The Oriental Medical Literature Relating to Treatment of Gyogamdan in Ki Stagnation : focused on Suseunghwagang The normal drift of a current Ki can maintain a function of body. An abnormal drift of a current Ki which is called a Ki Stagnation by lots of thinking or agony gets to a various disease syndrome. A Ki Stagnation is similar to a mental stress disease. It is a common disease for us to contact easily, so, it is very valuable to study. Gyogamdan which is composed of Cyperi Rhizoma L. and Poria cum Radix pini has been used by basic prescription of a symptom related to all kinds of Ki disease, after being recorded to Hongssijibhumbang first. Gyogamdan has an ability to regulate Ki , through 'Suseunghwagang-centric'(Ascending the Water and Descending the Fire) in body. Gyogamdan compares to Gamijajoohwan which can treat eyes dizzy by ascending heat and Gongjindan which can regulate lack of basic Ki through 'Suseunghwagang-centric'. It is general for the herb and acupuncture to give medical treatment coming together in oriental medicine, so do Gyogamdan and Sagwan Acupoints. Gyogamdan in composition Cyperi Rhizoma L. and Poria cum Radix pini and Sagwan Acupoints in composition Hapkok and T'aech'ung get to synergistic effects. Therefore, a Ki Stagnation treatment through unions of Gyogamdan and Sagwan Acupoints may have more effects than when a treatment used each one alone. Be considered that we have to study Gyogamdan and Sagwan Acupoints carried out an experiment to set up the previous theory in future

• 대한한방내과학회지
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• 제38권1호
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• pp.64-71
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• 2017

In this study, we researched the effects of herbal medicine on anemia among 43 patients. Before being given prescriptions, these patients were examined for RBC count, hemoglobin, and hematocrits, which are important in evaluating improvements in anemia. After administering the herbal medicine over two weeks, we rechecked the RBC count, hemoglobin, and hematocrits on a secondary inspection. We compared the primary and secondary tests with respect to age, sex, diseases, the name of the herbal medicine, and the composition of the medicine. The results were as follows. In groups of five or more, the musculoskeletal pain disease group was more improved than the other disease groups on the secondary test. The digestive diseases group was worse than the other disease groups on the secondary test. In the composition of the prescription, herbs that enriched the blood (補血), invigorated the spleen (健脾), and nourished Eum (補陰) were used more than any other herbs for those whose status improved. Among patients who were partially normalized for the secondary test, this applied to men more than women, to patients in the pain group more than those in other disease groups, and to patients with cerebral hemorrhage more than stroke patients. Among patients who were partially normalized for the secondary test, the group taking tangyak herbal medication improved more than the other groups taking powder and pill herbal medications.

• 한국산학기술학회논문지
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• 제13권9호
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• pp.4009-4017
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• 2012

본 연구는 12주간 비만 중년여성의 복싱에어로빅 운동프로그램 참여가 신체조성, 혈액성분 및 혈관탄성에 미치는 영향을 규명하기 위해 수행되었다. 본 연구의 대상자는 40세 이상의 중년여성으로 체지방율 30%이상 병역 상심혈관질환 및 대사성 질환이 없는 신체적으로 건강한 사람을 대상으로 복싱에어로빅 운동집단 8명과 통제집단 8명으로 무선배정(random assignment)으로 나누었으며, 복싱에어로빅 운동강도는 초기 1-4주는 HRmax 50%, 5-8주는 HRmax 60%, 9-12주는 HRmax 70%로 총 60분간 실시한 후 다음과 같은 결론을 얻었다. 첫째, 복싱에어로빅 운동프로그램 참여 결과 운동집단에서 체중, 체지방률과 근육량은 측정시기, 그룹과 측정시기의 상호작용이 유의한 차이를 나타냈으며(p<.001), 그룹별 측정시기 간의 대응표본 t-test 결과에서도 운동집단에서 유의한 수준의 감소 및 증가를 나타냈다(p<.001). 둘째, 복싱에어로빅 운동프로그램 참여 결과 운동집단에서 TC, TG, HDL-C, LDL-C 모두 그룹, 측정시기, 그룹과 측정시기의 상호작용효과도 유의한 차이를 나타냈으며(p<.01, p<.001), 그룹별 측정시 기간의 대응표본 t-test 결과 운동집단에서 유의한 감소와 증가를 나타냈다(p<.01). 셋째, 복싱에어로빅 운동프로그램 참여 결과 운동집단에서 오른손, 왼손, 오른발, 왼발의 혈관탄성은 그룹, 측정시기, 그룹과 측정시기의 상호작용 효과도 유의한 차이를 나타냈으며(p<.001), 그룹별 측정시기 간의 대응표본 t-test 결과 운동집단에서 유의한 증가를 나타냈다(p<.001). 이상의 결과를 종합해 볼 때, 12주간 복싱에어로빅 운동프로그램 참여는 신체조성 및 혈액성분을 개선시키고, 혈관순환 능력을 향상시켜 심혈관질환 등의 예방 및 개선 할 수 있을 것으로 사료된다.

• 동의생리병리학회지
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• 제17권4호
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• pp.923-929
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• 2003

The purpose of this study is to examine various Oriental Medical approaches to uterine myoma treatments which have been previously proposed, and find out an appropriate method with the verification of its clinical acceptance. The treatment with GGT(Gami-gwichulikyeong-tang) and JGD (Jagungdan) has been applied to uterine myoma patients visiting Sangdang Oriental medical clinic. After the treatment, 81 cases showing significant results are selected and analyzed in terms of patients' age, social environment, previous history of treatment, condition of uterine myoma, chief complaint, and the comparison between menstrual phases before the treatment and those after it. As for the size change, no-change is dominant. For the change chief complaint take a favorable turn is better after the treatment. Color of menstruation, pathologic blood drainage, hypermenorrhea or menorrhagia. dysmentorrhea show high percentage of improvement. The results above show GGT and JGD are effective treatments for uterine myoma patients. These two are also similar to the typical prescription of Jingga, which is Gwichulpajing-tang. Thus GGT and JGD are effective to the treatment for Jingga and Jingga is one of the most valid Oriental Medical approaches to uterine myoma.

• 동의생리병리학회지
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• 제25권5호
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• pp.759-764
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• 2011

Through analyzing the frequencies of medicinal herb combinations in the prescriptions of "wenrejingwei(溫熱經緯)", we could understand the characteristics of prescription composition and author's medical thoughts. So we conducted this study that analyze combination of 187 medicinal herbs in 113 prescriptions, and found meaningful combinations of 273. Among these, the most meaningful combinations are the one of 7 herbs, Glycyrrhiza uralensis Fischer, Zingiber Rhizoma, Ziziphus jujube Mille, Pinellia ternata Breitenbach, Panax ginseng C.A.Meyer, Cyprinus carpio, Coptis chineis Franch. These are the same medicinal herbs which consist of Banhasasim-tang(banxiaxiexin-tang). It means these combinations are effective in stuffiness caused by stomach deficiency. In conclusion, prescriptions of "wenrejingwei(溫熱經緯)" involve herbs mostly used to treat stuffiness caused by stomach deficiency, and this is the author's important one of medical view points.

• 대한한의학방제학회지
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• 제15권2호
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• pp.1-8
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• 2007

The source of Gwibitang(歸脾湯) is the book of Jesaebang(濟生方), The formulae is excluded Angelicae gigantis radix(當歸) and Polygalae radis(遠志) in the Jesaebang(濟生方), Jn the Guch iryuyo(口齒類要), Jeongcheryuyo(正體類要) and Gyojubuinyangbang(校註婦人良方), has been bec ame White Pria cocos Wolf(白茯笭) instead of Hoelen cum Pini Radix(白茯神), and is followed constitution of Uihagypmun(醫學入門) in the Donguibogam(東醫寶鑑). Basic formulae of Gwibitang(歸脾湯) consist of Sanjointang(酸棗仁湯), Sagunjatang(四君子湯). Hwanggitang, Danggwibohyeoltang(當歸補血湯), a kind of Jeongjihwan(定志丸類), a kind of Chongmyeongtang(聰明湯類). To deficiency of the heart and spleen, apply Sanjointang(酸棗 仁場), a kind of Jeongjihwan(定志丸), Sagunjatang(四君子湯) and Hwanggitang. To insufficiency of the spleen-gi(脾氣), apply Sagunjatang(四君子湯), Hwanggitang and a kind of Jeonssiigongsan(定志小丸). To deficiency of blood, apply Danggwibohyeoltang(當歸補血湯). Gwibitang(歸脾湯) is used for a mnesia and severe palpitation as a result of deficiency of the heart and spleen and deficiency of both gi(氣) and blood(血).

• 동의신경정신과학회지
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• 제29권1호
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• pp.9-20
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• 2018

Objectives: The purpose of this study is to investigate the composition, origins, and utilization of Jiuwei Zhenxin Granules for anxiety disorders in Chinese medicine. Methods: Studies found in six databases were chosen, and major indicators were analyzed. Results: Jiuwei Zhenxin Granules are modified from Pyeonbojinsimdan on Taepyeonghyeminhwajegukbang. In Jiuwei Zhenxin Granule studies, there were significant effects in nine outcomes in twenty-four studies of primary anxiety disorders and seventeen outcomes were similar in effect to that in the control. Three outcomes in ten studies of secondary anxiety disorders showed significant effects, and five outcomes were similar in effect to that in the control. Conclusions: Jiuwei Zhenxin Granules is a prescription that focuses on harmony of vital energy (qi) and blood, and stability of mind. The significance of the constitution of Jiuwei Zhenxin Granules is similar to that of domestic anxiety disorder studies, so it seems to be applicable to anxiety disorders. With regard to domestic use of Jiuwei Zhenxin Granules, more research is needed on the dosage according to the formulation.