• 생약학회지
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• 제41권1호
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• pp.1-5
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• 2010

Korean folk medicine 'DulGugWha' has been used to cure common cold, cough and chronic and acute gastiritis in Korea. The botanical origin of the crude drug has never been studied pharmacognostically. To clarify the botanical origin of 'DulGugWha', the morphological and anatomical characteristics of Chrysanthemum species growing in Korea, i.e. C. boreale, C. indicum, C. zawadskii and C. zawadskii var. latilobum were studied. As a result, 'DulGugWha' was proved to be the whole plant body of Chrysanthemum boreale of Compositae.

• 생약학회지
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• 제27권1호
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• pp.15-19
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• 1996

In the course of phytochemical studies of Chrysanthermi Flos(Chrysanthemum indicum L., Compositae), two compounds were isolated by repeated column chromatography. Compound 1 is identified as adenosine on the basis of spectroscopic means and comparison with an authentic standard. Compound 2 is determined to be a new alkyl alcohol glycoside, 1-octen-3-ol $3-O-{\beta}-D-xylopyranosyl(1{\rightarrow} 6)-{\beta}-D-glucopyranoside$ on the spectroscopic evidence. Compounds 1 and 2 are reported for the first time from this plant.

• 생약학회지
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• 제19권4호
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• pp.228-232
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• 1988

From the rhizome of Atractylodes japonica Koidzumi (Compositae) which is the original plant of oriental medicine 'Cang-Zhu', four essential oil compounds were isolated. Three of them were identified as atractylon, hydroxyatractylon and $5{\alpha}H,\;10{\beta}-selina-4(14),\;7(11)-diene-8-one$, which were already known as the constitutents of Atractylodes Rhizoma. The fourth is a novel polyacetylene type compound, and the structure is postulated as 1, 4-diacetoxytetradeca-6, 12-diene-8, 10-diyne by the spectral data.

• 생약학회지
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• 제34권4호통권135호
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• pp.324-326
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• 2003

The methanol (MeOH) extract and ist fractions of Taraxacum mongolicum (Compositae) were examined for their scavenging effects on 1,1-diphenyl-2- phenylhydrazyl (DPPH) and superoxide radicals, and hepatoprotective effects on tacrine-induced cytotoxicity in human hepatoma cell line, Hep G2 cells. Both methylene chloride $(CH_2Cl_2)$ and butanol (n-BuOH) soluble fractions of the MeOH extract showed the free radicals scavenging and hepatoprotective effects. From these results, it is suggested that hepatoprotective effect of these fractions partly relies on their free radical scavenging activity.

• 생약학회지
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• 제40권3호
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• pp.161-164
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• 2009

'NuRo (漏蘆)' is one of the crude drugs which has been used for removal of fever and skin disease. With regard to the botanical origin of 'NuRo', it has been considered to be Echinops species of Compositae, but there has no pharmacognostical confirmation on it. To clarify the botanical origin of 'NuRo', the anatomical characteristics of the root of Echinops latifolius and E. setifer were studied. As a result, it was clarified that 'NuRo' from Korea was the root of Echinops setifer.

• Archives of Pharmacal Research
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• 제29권3호
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• pp.203-208
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• 2006

The chromatographic separation of the MeOH extract of the roots of Ainsliaea acerifolia (Compositae) led to the isolation of six known terpenes and two known lignans. Their structures were identified by spectroscopic methods as mokko lactone (1), betulonic acid (2), betulinic acid (3), zaluzanin C (4), $1{\beta}-hydroperoxygermacra-4(15)$, 5, 10(14)-triene (5), pluviatilol (6), (+)-syringaresinol (7), and glucozaluzanin C (8). Compounds $1{\sim}4$ and 8 showed non-specific significant cytotoxicity against five human tumor cell lines with $ED_{50}$ values ranging from $0.36{\sim}5.54{\mu}g/mL$.

• 생약학회지
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• 제30권1호
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• pp.48-53
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• 1999

Isolation and quantitative determination of costunolide from Saussurea lappa Clarke (Compositae) has been conducted by using HPLC method. Costunolide in an acetone extract from the crude drug was separated on a RP-18 column using a $MeOH-H_20$ mixture (65:35) as an eluent and the average content is about $1.32{\sim1.42%.$ The content of costunolide in dried extract was decreased by about 24% in seven days. However it showed a slight decrease in solution. It is highly recommended that quantitative determination of costunolide from Saussureae Radix should be conducted as early as possible after solvent extraction.

• Natural Product Sciences
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• 제3권1호
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• pp.14-18
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• 1997

Two new diterpenoids, orientalin A (1), and B (2), have been isolated together with six known compounds, kirenol (3), $ent-16{\beta},17-dihydroxykauran-19-oic$ acid (4), $ent-16{\beta},17-dihydroxykauran-19-oic$ $acid-16{\beta},l7-acetonide$ (5), $3,7-dimethylquercetin$ (6), ${\beta}-sitosterol$ (7), and daucosterol (8) from the ethanol extract of Siegesbeckia orientalis (Compositae). Their chemical structures have been elucidated as $ent-15-acetoxy-2{\alpha},16,19-trihydroxypimar-8(14)-ene$ (1), $ent-16-acetoxy-2{\alpha},15,19-trihydroxypimar-8(14)-ene$ (2), respectively, on the basis of chemical and spectral evidence.

• 생약학회지
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• 제47권2호
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• pp.110-116
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• 2016

As a part of an ongoing search for natural plants with antioxidant compounds by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH), a total extract of the aerial parts of Bidens frondosa L. (Compositae) was found to show potent antioxidant activity. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of five compounds, quercetin-3-O-${\beta}$-D-glucopyranoside (1), luteolin-7-O-${\beta}$-D-glucopyranoside (2), 7,8,3',4'-tertrahydroxy-flavanone (3), okanin-4-O-${\beta}$-D-glucopyranoside (4), and okanin (5). Their structures were elucidated by spectroscopic studies. Compounds 3-5 were isolated for the first time from this plant. Among them, compounds 3 and 5 showed the significant radical scavenging effects on DPPH, and compounds 3 and 5 also showed the potent riboflavin and xanthine originated superoxide quenching activities.

• 생약학회지
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• 제42권1호
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• pp.54-60
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• 2011

In an attempt to find the activity of Aster glehni (Compositae) leaves on the obesity in vivo, 30% ethanolic extract rich in caffeoylquinic acids was orally treated with 100 and 200 mg/kg for consecutive four weeks during feeding high-fat diet in rats for 6 weeks. This extract prevented the increase of atherogenic index and body weight and oxidative stress from dietinduced obese rats probably due to the pharmacological mechanism of the CQ complex.