• Animal cells and systems
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• v.10 no.1
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• pp.1-6
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• 2006

Previous studies showed that Cdc7 kinase of Schizosaccharomyces pombe phosphorylated the minichromosome maintenance (Mcm) complex efficiently in the presence of spMcm10 protein. The biochemical properties of the phosphorylated Mcm complexes were examined to understand the activation mechanism of the Mcm complex by Cdc7 kinase. The phosphorylation of Mcm complex in the presence of spMcm10 by Cdc7 kinase did not affect the stability of the Mcm complex containing all six subunits, and the changes in the sedimentation properties were not observed after the phosphorylation. The reconstitution of the Mcm complex using the purified proteins showed that the phosphorylation of Mcm2 proteins did not affect the interactions between Mcm proteins. The phosphorylation of the Mcm2-7 complex at the same condition also did not activate the other biochemical activities such as DNA helicase and single stranded (ss) DNA binding activities. On the other hand, spMcm10 protein that was used for the stimulation of Mcm phosphorylation showed single stranded DNA binding activity, and inhibited the DNA helicase activity of the Mcm4/6/7 complex. These inhibitory effects were reduced by the addition of Cdc7 kinase, suggesting that the phosphorylation by Cdc7 kinase decreased the interactions between spMcm10 and the Mcm complex. Taken together, these results suggested that the phosphorylation by Cdc7 kinase alone is not sufficient for the remodeling and the activation of the Mcm complex, and the additional factors or the phosphorylations might be required for the activation of the Mcm complex.

• Korean Journal of Veterinary Research
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• v.40 no.1
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• pp.63-71
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• 2000

An immunogenic, high molecular weight lipopolysaccharide (LPS)-protein complex isolated from a potassium thioncyanate extract of a Pasteurella multocida (P multocida ; strain P-2383, capsular type A and somatic type 3) was characterized. Chemical analysis of the complex by gas chromatography on a capillary column demonstrated that this complex contained most of the chemical constituents characteristic of LPS extracted by the phenol-water methed from the whole bacterium. However, there was proportionately more carbohydrate than fatty acid in the complex in contrast to LPS in which fatty acid seemed to be in excess. When toxicity of the complex was evaluated in 10-day-old chicken embryos, the complex was less toxic ($LD_{50}=12.72{\mu}g$) than the purified LPS ($LD_{50}=0.44{\mu}g$). The $LD_{50}$, of the LPS moiety extracted from the complex was $5.24{\mu}g$. Composition of the complex was analyzed by SDS-PAGE with silver staining and Western immunoblotting. The complex did not migrate through the polyacrylamide gel unless dissociated with SDS. The complex dissociated with SDS contained at least 32 different protein and polysaccharide components: 18 components reacted with an antiserum against the complex. There was no significant compositional variation between the complexes from different strains, but quantitative differences in individual components were noted. When cross-protectivity of the complex was evaluated in mice, this complex provided substantial protection not only against the homologous bacteriun but also against different P multocida strains of the same serotype. LPS-protein complexes isolated by the same method from other strains also induced protection against an challenge with P-2383.

• Journal of the Korean Mathematical Society
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• v.46 no.3
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• pp.513-521
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• 2009

We first introduce a complex hyperbolic space and a complex hyperbolic manifold. After defining the canonical horoball and the canonical cusp on the complex hyperbolic manifold, we estimate the volumes of canonical cusps of complex hyperbolic manifolds. Finally, we deal with cusped, complex hyperbolic 2-manifolds, and in particular, the ones with only one cusp.

• Communications of the Korean Mathematical Society
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• v.9 no.2
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• pp.369-383
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• 1994

A complex n-dimensional Kahler manifold of constant holomorphic sectional curvature c is called a complex space form, which is denoted by $M_{n}$ (c). A complete and simply connected complex space form consists of a complex projective space $P_{n}$ C, a complex Euclidean space $C^{n}$ or a complex hyperbolic space $H_{n}$ C, according as c > 0, c = 0 or c < 0.(omitted)

• Journal of the Korean Mathematical Society
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• v.32 no.2
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• pp.161-170
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• 1995

A complex $n(\geq 2)$-dimensional Kaehlerian manifold of constant holomorphic sectional curvature c is called a complex space form, which is denoted by $M_n(c)$. A complete and simply connected complex space form is a complex projective space $P_nC$, a complex Euclidean space $C^n$ or a complex hyperbolic space $H_nC$, according as c > 0, c = 0 or c < 0. Takagi [12] and Berndt [2] classified all homogeneous real hypersufaces of $P_nC$ and $H_nC$.

• Journal of the Korean Mathematical Society
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• v.59 no.2
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• pp.379-405
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• 2022

We introduce the notions of Koszul N-complex, Čech N-complex and telescope N-complex, explicit derived torsion and derived completion functors in the derived category D_N (R) of N-complexes using the Čech N-complex and the telescope N-complex. Moreover, we give an equivalence between the categories of cohomologically 𝖆-torsion N-complexes and cohomologically 𝖆-adic complete N-complexes, and prove that over a commutative Noetherian ring, via Koszul cohomology, via RHom cohomology (resp. ⊗ cohomology) and via local cohomology (resp. derived completion), all yield the same invariant.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.05a
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• pp.135-135
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• 2001

Mating behavior and reproductivity of male fish were studied as an in vivo screening method of endocrine disruptors. Male medaka (Oryzias latipes) were exposed to 17$\beta$-estradiol at nominal concentrations of 2 and 20 $\mu\textrm{g}$/L for 14 days.(omitted)

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.4045-4049
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• 2015

Objective: To investigate the effect of coenzyme complex on decreasing cardiotoxicity in elderly patients with gastrointestinal cancer who were treated by chemotherapy. Methods: From September 2011 to February 2015, we recruited 54 elderly (with more than 70 years of age) patients with gastrointestinal cancer, with advanced disease. Then treated with chemotherapy combined with or without coenzyme complex. After two cycles of treatment, the effect of coenzyme complex on decreasing cardiotoxicity were evaluated. Results: Chemotherapy was combined with coenzyme complex in 32 patients (22man, 10 woman; median age: 74 years, range: 70-87 years) without coenzyme complex in 22 patients (15man, 7 woman; median age: 73 years, range: 70-80 years) with gastrointestinal cancer. Cardiac event was significantly lower in patients treated with chemotherapy combined with coenzyme complex (p<0.01). Conclusions: Coenzyme Complex decreased cardiotoxicity when combined with chemotherapy in treating elderly patients with gastrointestinal cancer.

• Journal of the Korean Society of Systems Engineering
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• v.2 no.1
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• pp.37-41
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• 2006

The KSLV-I satellite launch vehicle will be launched in a space center currently under construction. The Space Center which is an advance post base of space development of Korea is located on Oenaro island in Kohung, South Cholla Province. A Ground Complex of the Space Center consists of an AC(Assembly Complex), a LC(Launch Complex), and a MCC(Mission Control Center). Assembly and test facilities are located in the AC in which stage assembly, integrated assembly, check-up, certification test, and pre-launch test are made effectively. A launch pad, fuel supply facilities, a launch control center and associated supporting facilities are located in the LC, and the MCC has control over the space center. These ground complex facilities have diverse forms of an interface with mechanical device, electric device, and etc. These should also provide optimum condition and performance during launch operation processes of the launch vehicle. This paper introduces the result of R&D for the AC of the ground complex performed during system design period.

• YAKHAK HOEJI
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• v.27 no.1
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• pp.11-19
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• 1983

Rifampicin-arginine complex was prepared to increase the solubility and dissolution rate of rifampicin. Solvation method was applied to make the complex and its formation was identified by the solubility method, powder x-ray diffractometry, differential thermal analysis and spectroscopic determination. The complex was formed in the molar ratio of 1 : 1 which was proved by the slope ratio method and continuous variation method. The complex was a non-crystalline form determined by the x-ray powder diffractometric analysis. The solubility of complex in water was significantly higher than that of rifampicin itself. The stability constant and thermodynamical properties of the complex were determined to investigate the solubilization phenomena. The thermodynamic data showed that the complexation between rifampicin and arginine was an exothermic and spontaneous reaction. Simulated absorption studies carried out through the artificial lipid barrier in artificial gastric and intestinal juices. The results showed that the complex had an enhanced absorption rate of rifampicin nearly twice compared with that of rifampicin itself.