• Journal of Physiology & Pathology in Korean Medicine
• /
• v.18 no.2
• /
• pp.311-343
• /
• 2004

Various aspect of epidemics broke out continually from the middle of Joseon Dynasty due to the famine and drought caused by abnormal climate of the sixteenth century and the war. Thus the Dynasty performed sacrificial rites, isolated the patients and published plenty of medical books related epidemics in order to cure of the patients, and Heojun edited 『Byeokyeoksinbang』 as 'Dangdokyeok' broke out at Gwanbuk(關北) districts in 1613, Heojun explained the cause of Dangdokyeok as meteorology under the feudal conditions, and concluded Simhwa(心火) by fever toxin, Therefore he selected the method of puting out Simhwa by attack of fever toxin. In addition he presented emergency treatment that can maintain the airway by bleeding. To treat Dangdokyeok, Heojun presented lots of prescriptions so as Seungmagalgeuntang(升麻葛根湯), Cheongyeolhaedoksan(淸熱解毒散), Yeongyopaedok-san(連翹敗毒散), Bangpungtongsaongsan(防風通聖散), Jowiseunggitang(調胃升氣湯) and Hwangryeonhaedoktang(黃連解毒湯) etc. And he proposed Samdueum (三豆飮), Realgar(石雄黃) and so on to prevent infection from that. They presume from 120 to 150 years as the period of human adaptation to the first epidemics. Dangdokyeok put a large number of people to death at first, but it wasn't referred at the history any more after Byeokyeoksinbang. So we can say that the treatment of Heojun may be effective. Common cold and dyspeptic cold broke out in our country differently from 'Shanghan(傷寒)' in the China, so we had settled 'pestilence infectious epidemic disease(瘟疫)' while 'epidemic febrile disease(溫病)' of the China. Dangdokyeok of Heojun is similar to 'Scalet fever' belonging to 'virulent heat pathogen(溫毒)', 'newly epidemic febrile disease(新感溫病)'. As a cure of Dangdokyeok, the Korean medicine uses the treatment of removing fever state whereas the western medicine uses the antibiotics to kill the streptococcus. The symptoms of Dangdokyeok are remarkably similar to those of the Scarlatina, so this occupies a high position on the world history of medicine in aspects of the period and details of symptoms. These days we have the problems that the tolerance of antibiotics increases and disease of unknown cause is prevalent. It means the western medicine get to limits. So if we progress epidemiography based on Heojun's medicine, we may contribute to the world history of medicine.

• Horticultural Science & Technology
• /
• v.18 no.1
• /
• pp.22-27
• /
• 2000

National plant quarantine inspector of exporting country should inspect agricultural products according to the quarantine requisites of counterpart country when the commodities are shipped. Export of pear fruits was held because quarantine pests including Conogethes punctiferalis were found at the point of entry in Canada. In order to examine the problems in detail, the inspected pear fruits were stored at a low temperature for 43 days, almost the same period necessary for fruit sorting, quarantine procedures, and transportation by ship. Dead larvae of fruit moths, C. punctiferalis and Grapholita molesta were found during cold storage. Quarantine pathogens were not found, but non-quarantine ones such as Penicillium sp. was infected through wounds by bruises and stabs resulted from sorting procedures. Because of the wounding problem during export procedures, pear fruits with thin exocarp, such as fruits of P. pyrifolia Nakai cv. Whangkeumbae, are required more careful handling during fruit sorting and conveyance.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.29 no.2
• /
• pp.127-132
• /
• 2015

In order to grasp the clear concepts and variables to treat Shanghan diseases which has complex meaning by each medical literature, several concepts and analytic method of structuralism from early to late stage encompassing Saussure and Derrida were used. Main concepts are langue and parole, signifiant and signifie, syntagme and paradigme, denotation and connotation, synchronie and diachronie, identity of structure and differance etc. and methods are substituting these concepts to historical Shanghan theories from Zhongjing to Ming-Qing dynasty and comparisons of synchronie about their era. Essential qualities of Shanghan diseases are pathologic phenomena under the order of unification of nature and man formed through concrescence between individual human body and geo-climatico-socio-cultural environmental conditions, neither injuries by cold pathogen nor five types of exopathogenic febrile diseases. The former environmental elements can be inferred from general traits of desires and public pathological aspects of social members, and the latter personal factors from corresponding features to those pathogenic variables. In addition, the concepts of Shanghan disease are added successively up to now via Jin-Yuan's four great masters and Wenbing masters, and thus the new concepts of denotation became another connotation obtaining new signifiant. In this way, for the treatment of Shanghan diseases, new theories should be made for ranging prescription over the wenbing field; reflecting not only climatical variables but also each patient's physio-pathological features and sociocultural variables. Thereby an appropriate and reasonable therapeutical systems can be designed and can guide research direction hereafter.

• The Plant Pathology Journal
• /
• v.24 no.2
• /
• pp.131-142
• /
• 2008

Magnaporthe oryzae, the causal agent of the rice blast disease, poses a worldwide threat to stable rice production. The large-scale functional characterization of genes controlling the pathogenicity of M. oryzae is currently under way, but little is known about heat shock protein 40 (Hsp40) function in the rice blast fungus or any other filamentous plant pathogen. We identified 25 genes encoding putative Hsp40s in the genome of M. oryzae using a bioinformatic approach, which we designated M. oryzae heat shock protein forty (MHF 1-25). To elucidate the roles of these genes, we characterized the functions of MHF16 and MHF21, which encode type ill and type n Hsp40 proteins, respectively. MHF16 and MHF21 expression was not significantly induced by heat shock, but it was down-regulated by cold shock. Knockout mutants of these genes $({\Delta}$mhf16 and ${\Delta}$mhf21) were viable, but conidiation was severely reduced. Moreover, sectoring was observed in the ${\Delta}mhf16$ mutant when it was grown on oatmeal agar medium. Conidial germination, appressorium formation, and pathogenicity in rice were not significantly affected in the mutants. The defects in conidiation and colony morphology were fully complemented by reintroduction of wild type MHF16 and MHF21 alleles, respectively. These data indicate that MHF16 and MHF21 play important roles in conidiation in the rice blast fungus.

• Herbal Formula Science
• /
• v.15 no.2
• /
• pp.47-64
• /
• 2007

This report describes 94 prescriptions related to the use of Radix Angelicae Dahuricae main bl ended from Donguibogam. The following conclusions were reached through investigations on the prescriptions that use Radix Angelicae Dahuricae as a key component. 11.7% of wind. 10.6% of carbuncle and deep-rooted carbuncle. recorded the largest number of clinical frequency of the prescriptions in therapeutic use when Radix Angelicae Dahuricae was ta ken as a monarch drug in prescriptions, Prescriptions that utilize Radix Angelicae Dahuricae as t he main component are used in the treatment of apoplexy and carbuncle and deep-rooted carbuncle. headache. wound and they are also used for treating 26 different types of diseases. The prescriptions are compounded with Radix Angelicae Dahuricae as a monarch drug can ap ply to apoplexy, exogenous febrile disease, invasion by wind. wind-cold pathogen, wind-heat path ogen. epidemic disease, pestilence. bruise, bites, deficiency of liver and kidney, deficiency, phlegm-fire, phlegm-heat. The dosage of Radix Angelicae Dahuricae is 0.37g to 7.5g, however 3.75g has be en taken the most for clinical application. The function of Radix Angelicae Dahuricae is to expelling Wind and relieving pain, to expelling wound and forming muscle. to astrict and neutralizing poison. to expelling wind and to getting through body hole. to emit and relieving pain from the combination of drugs and prescriptions.

• Journal of Korean Medical classics
• /
• v.25 no.3
• /
• pp.127-147
• /
• 2012

Objective : Methods of Jang Cong-zheng's treatment related to his theories include of promoting the sweating-vomiting-purgation(汗吐下三法), prickling-bleeding method(瀉血療法), and emotional therapy(情志療法). He succeeded Liu wan-su(劉完素) as promoter of fire-heat pattern theory(火熱論), thereby emphasizing six qi(六氣), especially fire(火) and dampness(濕), as pathogens. He suggested that physician should treat patients whose diseases occurred due to fire(火) and dampness(濕) with promoting the sweating(汗)-vomiting(吐)-purgation(下) methods, which would remove pathogen qi(邪氣) and help circulation of qi and blood, therefore getting them back healthy qi(正氣). Method : I will try to describe the Jang Cong-zheng's treatment in "Ru-Men-Shi-Qin", and I would like to explain the sweating-vomiting-purgation(汗吐下三法), prickling-bleeding method(瀉血療法), and emotional therapy(情志療法). Result : For emotional diseases, he suggested that most should be caused by heart fire(心火) so they should be treated with methods of suppressing heart fire and medication would be using cool and cold herbal drugs which lead to clear heart fire. Conclusion : Theories of Zhang zi-he(張子和) can be applied to nurturing for modern world maintaining and improving health by his care methods. People these days suffer usually from excess intake or unbalanced diet problem, so wastes matter and pathogenic qi can be driven out of the human body by applying the sweating-vomiting-purgation methods. His medical theories could contribute to modernization of traditional medicine this way.

• The Journal of Korean Medical History
• /
• v.31 no.1
• /
• pp.71-87
• /
• 2018

This study investigated Hua Tuo's Shang-han theory, which precedes the period of Zhang Zhong Jing's Shang-han theory, and considers the relationship between the two approaches. Researchers compared terminology and language of Hua Tuo's Shang-han theory as published in Theory in Qian Jin Yao Fang and Wai Tai Mi Yao, with Zhang Zhong Jing's Shang-han theory. In Hua Tuo's theory, Shang-han involves pathogenic invasion of the body surface, where the pathogen transforms to 6 different stages, Pi (皮), Fu (膚), Ji (肌), Xiong (胸), Fu (腹), Wei (胃). Among these, the stage sof Pi (皮), Fu (膚), Ji (肌) can be considered as exterior syndrome (表證). Those that invade the lower chest can be considered as lower chest disease, and those that violate the abdomen or stomach can be considered as Interior heat excess syndrome (裏熱實證). Stomach heat excess syndrome (胃中實熱證) is the most severe and is similar to septicaemia or bubonic plague. Hua Tuo's treatment used three methods which are 汗 (perspiration), 吐 (emesis), 下 (purgation). In the case of Phlegm syndrome (痰?證), HuoTuo's theory was similar to Zhang Zhong Jing's Shang-han exterior syndrome (傷寒表證) and therefore used Zhuling-powder (猪?散). In the case of deficiency hot flush Syndrome (虛煩證) in Shang-han disease, HuoTuo uses ZhuYe-decoction (竹葉湯), of which the drug contents is the same as Zhang Zhong Jing's ZhuYeShiGao-decoction (竹葉石膏湯), which was used for the same condition.

• BMB Reports
• /
• v.40 no.3
• /
• pp.325-332
• /
• 2007

The mitogen-activated protein kinase (MAPK) cascade is one of the major and evolutionally conserved signaling pathways and plays pivotal role in the regulation of stress and developmental signals in plants. Here, a novel gene, termed Gossypium hirsutum MAPK (GhMAPK), was isolated from cotton. The full-length cDNA of GhMAPK encodes for a 372 amino acid protein that contains all 11 of the MAPK conserved subdomains and the phosphorylationactivation motif, TEY. Amino acid sequence alignment revealed that GhMAPK shared high identity with group-C MAPK in plants and showed 83~89% similarities with MAPKs from Arabidopsis, apricot, pea, petunia, and tobacco. Southern blot analysis indicated that the GhMAPK belonged to a multygene family in cotton. Two introns were found within the region of genomic sequence. Northern blot analysis revealed that the transcripts of GhMAPK accumulated markedly when the cotton seedlings were subjected to various abiotic stimuli such as wounding, cold (4$^{\circ}C$), or salinity stress; Furthermore, GhMAPK was upregulated by the exogenous signaling molecules, such as salicylic acid (SA) and hydrogen peroxide ($H_2O_2C$), as well as pathogen attacks. These results indicate that the GhMAPK, which has a high degree of identity with group-C plant MAPKs, may also play an important role in response to environmental stresses.

• Journal of Korean Medical classics
• /
• v.31 no.2
• /
• pp.155-172
• /
• 2018

Objectives : The first object is to reveal the mechanism of diarrhea based on exterior heat syndrome for Taeumin as explained in Donguisusebowon's Taeeumingansuyeoliyeolbyeonglon. The second objective is to review the treatment for Taeumin as explained in Leejema's Galgeunnabogjatang because the drug composition of Galgeunnabogjatang, the drug that treats this syndrome, is not written. Methods : As the first step, the paper will review the disease pathology for Taeumin written, and check the existence of disease path that can be viewed as exterior heat syndrome. As the second step, the paper will review the probability of exterior heat syndrome deriving from Taeumin disease path and morph into the exterior heat syndrome. Results : Using the first step to discover the direct correlation between exterior heat syndrome and the theory of disease for Taeumin led to a failure, but through the second step, the paper was able to confirm the probability that exterior heat syndrome could derive from Wiwansuhanpyohanbyeong's Wiwanhanjeung. Based on this, the paper was able to determine the Galgeunnabogjatang suitable for the treatment of exterior heat syndrome. Conclusions : Exterior heat syndrome is created when healthy qi is stimulated to quickly build up the pathogen of Taeumin exterior heat syndrome, but only exterior heat is generated and the cold remains. Its main symptoms are fever, excessive sweating, and difficult painful red-urination. Exterior heat syndrome diarrhea refers to the diarrhea which is generated from the Taeumin's disease pathology. The paper determined that Galgeunnabogjatang, which is listed in Donguisusebowon the seventh edition Boyubang.

• Korean Journal of Microbiology
• /
• v.45 no.1
• /
• pp.10-16
• /
• 2009

A diverse range of stresses such as heat, cold, salt, ethanol, oxygen starvation or nutrient starvation induces same stress-responsive proteins. This general stress response enhances bacterial survival significantly. In Bacillus subtilis and closely related Gram-positive bacteria Listeria monocytogenes, the general stress response is controlled by the alternative transcription factor ${\sigma}^B$. The activity of ${\sigma}^B$ is regulated post-translationally by a signal transduction network that has been extensively studied in B. subtilis, and serve as a model for L. monocytogenes. The proposed model of L. monocytogenes signal transduction network is similar to that of B. subtilis, but the energy stress pathway is missing. More than 150 general stress proteins belong to ${\sigma}^B$ regulon of B. subtilis and L. monocytogenes. In both bacteria, ${\sigma}^B$ function is primarily important for resistance to diverse stresses. In addition, ${\sigma}^B$ function contributes to the control of important virulence genes in food-borne pathogen L. monocytogenes. Therefore, understanding of the general stress response is important not only for bacterial physiology, but also for pathogenicity.