• Molecules and Cells
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• v.37 no.6
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• pp.441-448
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• 2014

Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 can form inflammasome complexes. These multiprotein complexes activate inflammatory caspases (i.e., caspase-1) which in turn catalyze the maturation of select pro-inflammatory cytokines, including interleukin (IL)-$1{\beta}$ and IL-18. Activation of the NLRP3 inflammasome typically requires two initiating signals. Toll-like receptor (TLR) and NOD-like receptor (NLR) agonists activate the transcription of pro-inflammatory cytokine genes through an NF-${\kappa}B$-dependent priming signal. Following exposure to extracellular ATP, stimulation of the P2X purinoreceptor-7 ($P2X_7R$), which results in $K^+$ efflux, is required as a second signal for NLRP3 inflammasome formation. Alternative models for NLRP3 activation involve lysosomal destabilization and phagocytic NADPH oxidase and /or mitochondria-dependent reactive oxygen species (ROS) production. In this review we examine regulatory mechanisms that activate the NLRP3 inflammasome pathway. Furthermore, we discuss the potential roles of NLRP3 in metabolic and cognitive diseases, including obesity, type 2 diabetes mellitus, Alzheimer's disease, and major depressive disorder. Novel therapeutics involving inflammasome activation may result in possible clinical applications in the near future.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.179-193
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• 2020

Ginseng products on the market show high variability in their composition and overall quality. This becomes a challenge for both consumers and health-care professionals who are in search of high-quality, reliable ginseng products that have a proven safety and efficacy profile. The botanical extract standardization is of crucial importance in this context as it determines the reproducibility of the quality of the product that is essential for the evaluation of effectiveness and safety. This review focuses on the well-characterized and standardized ginseng extract, G115, which represents an excellent example of an herbal drug preparation with constant safety and efficacy within the herbal medicinal products. Over the many decades, extensive preclinical and clinical research has been conducted to evaluate the efficacy and safety of G115. In vitro and in vivo studies of G115 have shown pharmacological effects on physical performance, cognitive function, metabolism, and the immune system. Furthermore, a significant number of G115 clinical studies, most of them double-blind placebo-controlled, have reinforced the findings of preclinical evidence and proved the efficacy of this extract on blood glucose and lipid regulation, chronic obstructive pulmonary disease, energy, physical performance, and immune and cognitive functions. Clinical trials and 50 years of presence on the market are proof of a good safety profile of G115.

• International Commerce and Information Review
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• v.10 no.4
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• pp.47-62
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• 2008

The purpose of this study is to explore the antecedent factors to the piracy of the digital copyrights in order to provide basic data for piracy prevention policy. The findings of study revealed that most respondents had experiences to copy MP3 files illegally. And many respondents answered they didn't copy pirated material by themselves but others did piracy a lot. The feeling of quilt and anxiety against piracy is shown very low level. Low copy cost and regulation level significantly impact upon the cognitive level of other's piracy. Updated contents, the higher price of authenticated materal, piracy regulation are the significant antecedent factors to the level of piracy. The level of piracy activity and anxiety against piracy are significantly different by age. The cognitive level of other's piracy, piracy activity and anxiety are significantly different by gender.

• Journal of Korean Medicine for Obesity Research
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• v.4 no.1
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• pp.161-183
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• 2004

Context : Oriental medicine deals with mind cardinally and effectiveness of CBT on weight control is well-known. but there is no well-structured psychotherapy for weight control like CBT in Oriental medicine so far. Therefore It is necessary to develop new cognitive program based on the theory of Oriental medical. Objective: This study examined whether Yangsung program based on new cognitive weight regulation model is effective on weight loss, self esteem and self control. Design and setting: 44 women were assigned randomly to 2 groups; experimental group(n=24) and control group(n=10). experimental group had 11 sessions consisted of cognitive therapy, meditation, general diet and exercise education. Control group had personal interview with general diet and exercise education and ear acupuncture once a week for two months. All subjects were weighed and evaluated with Rosenberg self esteem scale, and three factor eating questionnaires at the beginning of the program and at the end of the program. Result: Experimental group reported significant changes of weight, self esteem, restraint eating, disinhibition and hunger(p<0.01). Compared with control group, more significant(p<0.05) Weight reduction and self-esteem enhancement were reported in experimental group than control group. There is no significant difference between two groups in changes of restraint eating, disinhibition and hunger.

• Safety and Health at Work
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• v.5 no.1
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• pp.1-6
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• 2014

Background: Workflow interruptions during surgery may cause a threat to patient's safety. Workflow interruptions were tested to predict failure in action regulation that in turn predicts near-accidents in surgery and related health care. Methods: One-hundred-and-thirty-three theater nurses and physicians from eight Swiss hospitals participated in a cross-sectional questionnaire survey. The study participation rate was 43%. Results: Structural equation modeling confirmed an indirect path from workflow interruptions through cognitive failure in action regulation on near-accidents (p < 0.05). The indirect path was stronger for workflow interruptions by malfunctions and task organizational blockages compared with workflow interruptions that were caused by persons. The indirect path remained meaningful when individual differences in conscientiousness and compliance with safety regulations were controlled. Conclusion: Task interruptions caused by malfunction and organizational constraints are likely to trigger errors in surgery. Work redesign is recommended to reduce workflow interruptions by malfunction and regulatory constraints.

• Journal of the Korea Convergence Society
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• v.10 no.12
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• pp.525-534
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• 2019

The purpose of this convergence study was to evaluate the influence of interpersonal problems on sleep quality in college students and to analyze the mediating role of mental health and the moderated mediating role of emotional regulation. This was a cross-sectional study of 307 students at a college in Seoul. The results of hierarchical linear regression showed that interpersonal problems and mental health were statistically significant predictors of sleep quality in college students. A mediation analysis further revealed that students' mental health mediates the relationship between interpersonal problems and sleep quality. Additionally, there was a moderated mediating role of dysfunctional emotional regulation in this process. Our findings suggest that supportive and adaptive cognitive emotional regulation educational programs should be designed based on college students' maladaptive emotional regulation experiences and individual characteristics.

• Korean Journal of Child Studies
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• v.27 no.6
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• pp.1-11
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• 2006

Analysis of the data concerning 525 middle and high school students showed that positive affect correlated positively with cognitive reappraisal strategy and with self-control but correlated negatively with expressive suppression strategy. Negative affect correlated positively with expressive suppression strategy and negatively with self-control. The group of higher positive and higher negative affect was higher than the group of lower positive and lower negative affect in cognitive reappraisal strategy. The group of higher positive and higher negative affect was higher than the group of higher positive and lower negative affect in expressive suppression strategy. The group of higher positive and lower negative affect was higher than the group of higher positive and higher negative affect in self-control.

• Journal of Gifted/Talented Education
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• v.13 no.1
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• pp.97-116
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• 2003

The purpose of this study was to examine the relationship between children's cognitive intelligence and emotional intelligence and to examine the relationship of each subordinate factors. Also, this study investigated whether there is a difference in emotional intelligence according to level of intelligence and gender. The subjects consisted of 104 children enrolled in a kindergarten in the Kangnam area. These children were given two tests, Multimensional Cognitive Abilities Tests for Children(MCAT-C) and Emotional Intelligence Test(EIT). The results of this study are as follows. First, there was a significant relationship between cognitive intelligence(IQ) and emotional intelligence. And there were some correlation between intelligence(IQ) and regulation of emotion(the subordinate factor of emotional intelligence). Second, there was a statistically significant difference in the total score of emotional intelligence, empathy, regulation of emotion(the subordinate factor of emotional intelligence) according to intelligence level. Third, there was a statistically significant difference in emotional intelligence according to gender. Girls received relatively higher scores than boys in the total score of emotional intelligence, empathy, regulation of emotion(subordinate factors of emotional intelligence).

• Journal of Korean Elementary Science Education
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• v.35 no.4
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• pp.406-415
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• 2016

The purpose of this study was to compare self-regulation and sociality between elementary scientific gifted students and general students. The subjective students are composed of fifth and sixth grade elementary school students. A survey on self-regulation and sociality had been conducted to 106 general students, 38 gifted class students and 43 students in science educational institute for the gifted. The results of this study were as follows: First, the results of ANOVA test showed that the scientific gifted students were significantly better than general students on all subscales of self-regulation and sociality. Second, the results of correlation analysis indicated that self-regulation and sociality and their subscales were all highly positive relationship on students in science educational institute for the gifted, gifted class students and general students. Third, the results of multiple regression analysis showed that the motivational factor of self-regulation gave the greatest effect to the sociality of students in science educational institute for the gifted, whereas, the cognitive factor of self-regulation gave the greatest effect to the sociality of the general students and gifted class students.

• Korean Journal of Culture and Social Issue
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• v.18 no.2
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• pp.169-190
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• 2012

This research explored cognitive emotion regulation strategy, behavioral emotion regulation strategy, and experiential emotion regulation strategy, each moderating effect in the relationship between maladjustment schema and marital satisfaction. The data was analyzed through hierarchical multiple regression analysis. The results of the study are as follows: the regression analysis showed the moderating effects for adaptive emotion regulation strategy on the relationship between the maladjustment schema and marital satisfaction. The result showed the selection of 'Disconnection and Rejection', 'Impaired autonomy and Performance', 'Other-Directedness', 'Overvigilance and Inhibition' as maladjustment schema variables affecting marital satisfaction via cognitive emotion regulation strategy, that of 'Disconnection and Rejection', 'Impaired autonomy and Performance', 'Other-Directedness' as maladjustment schema variables affecting marital satisfaction via behavioral emotion regulation strategy, and that of 'Impaired limits', 'Impaired autonomy and Performance', 'Other-Directedness', 'Overvigilance and Inhibition' as maladjustment schema variables affecting marital satisfaction via experiential regulation strategy. Finally, the clinical implication and limitation of this study and suggestion for future studies were also discussed.