• Biomolecules & Therapeutics
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• v.21 no.5
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• pp.381-390
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• 2013

The purpose of this study was to examine whether ginsenoside Rg3 (GRg3) could improve learning and memory impairments and inflammatory reactions induced by injecting lipopolysaccharide (LPS) into the brains of rats. The effects of GRg3 on proinflammatory mediators in the hippocampus and the underlying mechanisms of these effects were also investigated. Injection of LPS into the lateral ventricle caused chronic inflammation and produced deficits in learning in a memory-impairment animal model. Daily administration of GRg3 (10, 20, and 50 mg/kg, i.p.) for 21 consecutive days markedly improved the LPS-induced learning and memory disabilities demonstrated on the step-through passive avoidance test and Morris water maze test. GRg3 administration significantly decreased expression of pro-inflammatory mediators such as tumor necrosis factor-${\alpha}$, interleukin-1${\beta}$, and cyclooxygenase-2 in the hippocampus, as assessed by reverse transcription-polymerase chain reaction analysis and immunohistochemistry. Together, these findings suggest that GRg3 significantly attenuated LPS-induced cognitive impairment by inhibiting the expression of pro-inflammatory mediators in the rat brain. These results suggest that GRg3 may be effective for preventing or slowing the development of neurological disorders, including Alzheimer's disease, by improving cognitive and memory functions due to its anti-inflammatory activity in the brain.

• The Journal of the Korea Contents Association
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• v.14 no.7
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• pp.324-333
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• 2014

This study was conducted to investigate the factors affecting the social anxiety in nursing students. A total of 227 nursing students participated in the study. Data were analyzed by frequencies, t-test, ANOVA, Pearson correlation coefficient, and multiple stepwise regression with SPSS WIN 18.0. The mean scores for problem solving ability and social anxiety were at the intermediate level. Problem solving ability negatively correlated with social anxiety. The significant predictors of social anxiety included cognitive reaction within the seven problem solving ability subscales and perceived interpersonal relationship. The regression model explained 22.6% of social anxiety. As a result, to decrease social anxiety in nursing students, nursing educators should develop educational intervention programs to change cognitive distortions presented in unfamiliar social situations and improve interpersonal relationships ability.

• Korean Journal of Cognitive Science
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• v.22 no.1
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• pp.39-55
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• 2011

People tend to overestimate their emotional reactions to events such as physical handicap and buying a new car in the future. Students overestimate their reactions to a future grade as compared to their reactions after receiving the grade. Impact bias refers to people's tendency to overestimate the intensity and the duration of emotional reactions to a future event. The present study explored whether impact bias occurs to risky objects such as nuclear energy, genetically engineered food, and mobile phone. Participants were asked to predict their emotional reactions at three time points, that is, at the present, a week after, and a year after. They predicted their reactions before and after two debiasing tasks. The present study demonstrated a different pattern of impact bias at three time points: A largest bias was observed a week after the present. A defocalism manipulation has eliminated the impact bias whereas an adaptation manipulation has not. Several points were discussed regarding the difference between the previous and the present work.

• Journal of the Korean Society of Clothing and Textiles
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• v.28 no.910
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• pp.1329-1340
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• 2004

The purpose of this study is to survey about the images of the sexy clothes that young women sympathize in modern society, that is, to make a research into the cognitive dimensions of 'Sexy image' and the constructive peculiarity of clothing. The researches into dimension of image by sexy clothing make that female mainly consist of in their twenties during May to October in 2003. The independent variables were: 1) The physical beauty dimension, 2) The negative estimate dimension, 3) The characteristic devaluation dimension,4) The elegance/ high grade dimension,5) The freshness/ beauty dimension,6) The sex appeal/ exposure dimension. Judging from each characteristic of costume in classified by articles, that is, colors, texture, shapes, details, and others-phenomenon of outerization of under clothing, print. We can know the clothes showing up our nice figures are the sleeveless design tied with strap, soft texture as silk chiffon and the colors that are not strong. And there were no embarrassed, ugly and pitiful clothing. Expressing sexy beauty by clothing is the result that the wearer produces intentionally by compounding design factors, it's the ideal when the observer's reaction and the wearer's intention correspond. Therefore, it will be helpful in expressing ideally if the subject, what kinds of sexy beauty the compounding design factors express, is studied carefully. Also it is expected to be used in grasping modem consumers' desires that want to look sexy, finding out how to express, dealing with the consumers' desires correctly, and the reference materials of the planning goods, sales promotion, and selecting of a medium of advertisement according to the consumers' desires.

• The Journal of the Korea Contents Association
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• v.21 no.6
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• pp.318-326
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• 2021

This study aims to the effectiveness of physical examination using VR contents to solve problems such as the increase in chronic diseases and shortage of professional manpower in the health care field according to the aging and low birth rate, and to provide efficient healthcare. Therefore, this study implemented a one-stop VR content physical examination system by wearing HTC VIVE Pro VR and a stick controller. The system is from step 1 to step 5, and the final body age is determined and a simple solution is provided through five steps sequentially: color blind test, memory test, audiogram test, reaction speed test, and instantaneous cognitive ability test. In addition, for the one-stop VR content physical examination system developed by this study, as a result of verifying the user satisfaction for normal people who visited the health examination center and VR/AR clinical trial center of certified tertiary hospital in Daejeon, the overall satisfaction and the intention to reuse Was high, and according to gender, there was a significant difference in the 5-step test, and according to the age, there were significant differences in the 4-step test and the 5-step test.

• Science of Emotion and Sensibility
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• v.14 no.4
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• pp.627-636
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• 2011

The purpose of this study is to develop the multi-modal interaction system. This system provides realistic and an immersive experience through multi-modal interaction. The system recognizes user behavior, intention, and attention, which overcomes the limitations of uni-modal interaction. The multi-modal interaction system is based upon gesture interaction methods, intuitive gesture interaction and attention evaluation technology. The gesture interaction methods were based on the sensors that were selected to analyze the accuracy of the 3-D gesture recognition technology using meta-analysis. The elements of intuitive gesture interaction were reflected through the results of experiments. The attention evaluation technology was developed by the physiological signal analysis. This system is divided into 3 modules; a motion cognitive system, an eye gaze detecting system, and a bio-reaction sensing system. The first module is the motion cognitive system which uses the accelerator sensor and flexible sensors to recognize hand and finger movements of the user. The second module is an eye gaze detecting system that detects pupil movements and reactions. The final module consists of a bio-reaction sensing system or attention evaluating system which tracks cardiovascular and skin temperature reactions. This study will be used for the development of realistic digital entertainment technology.

• Science of Emotion and Sensibility
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• v.12 no.4
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• pp.373-380
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• 2009

This study tried to investigate how three levels of arousal affect performance of a 3-back task. Ten university male (age $25.7{\pm}1.5$) and ten female (age $24.5{\pm}1.8$) students participated in this experiment. Using pictures selected from a group test, three levels of arousal, i.e. tensed, neutral, and relaxed emotions, were induced. Each subject was run through the procedure three times, once for each arousal level. The procedure consisted of six phases for each arousal condition Rest 1(2 min), Picture 1(presenting emotion arousing photos for 2 min), 3-back task 1(2 min), Picture 2(presenting emotion arousing photos for 2 min), 3-back task 2(2 min), and Rest 2(2 min). Skin conductance level(SCL) of electrothermal activity was also measured during all phases of the experiment. The accuracy rate of 3-back task performance was the highest at a neutral emotional state, followed by relaxed and then tensed emotional state. There was no difference in reaction time(RT) among the three levels of arousal. SCL was the highest at a tensed emotional state, followed by neutral emotional state and then relaxed emotional state. Based on the results, it could be inferred that tension, induced by stimuli unrelated to cognitive tasks, decreases the ability to perform cognitive tasks.

• Korean Journal of Cognitive Science
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• v.26 no.1
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• pp.1-26
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• 2015

The purpose of this study was to examine whether the phonological information or the orthographic information plays a major role in visual word recognition. To do so, we used a non-word lexical decision task(LDT) in Experiment 1 and masked priming tasks in Experiement 2 and 3. The results of Experiment 1 showed that reaction times and the error rates were affected by the orthographic characteristics of the non-word stimuli such that orthographically similar non-words condition showed prolonged reaction times and higher error rates than control condition. In Experiment 2 and Experiment 3, the participants performed masked priming lexical decision tasks in two SOA conditions(60ms, 150ms). The results of the both experiments showed that the orthographically identical first syllable priming facilitated lexical decision of the target words while both of the pseudo-homophone priming and the phonologically identical first syllable priming did not. The dual route hypothesis(Coltheart et al, 2001), assuming that orthographic information rather than phonological information is the major source for the visual word recognition processes, fits well with the results of the current study.

• Journal of Korean Medicine Rehabilitation
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• v.18 no.3
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• pp.1-17
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• 2008

Objectives : Ohyaksungi-san(Wuyaoshunqi-san) has been used for many years as a treatment for cerebrovascular diseases in Oriental medicine. This study was designed to evaluate the effects of Ohyaksungi-san(Wuyaoshunqi-san) on cognition and motor function recovery after ischemic brain injury, and also the expression of BDNF in hippocampus. Methods : This study was designed with 4 subgroups to evaluate the effects of Ohyaksungi-san(Wuyaoshunqi-san). As control groups, group I has no treatment during 1 week after ischemic brain injury and group II has no treatment during 2 weeks after ischemic brain injury. As experimental groups, group III has been treated with Ohyaksungi-san(Wuyaoshunqi-san) during 1 week after ischemic brain injury and group IV have treated with Ohyaksungi-san(Wuyaoshunqi-san) during 2 week after ischemic brain injury. Each group has been examined by tests as follows, neurological motor behavioral tests, cognitive motor behavior test and histological test. Neurological motor behavior tests consisted of limb placement test, beam-walking test and horizontal wire test. Cognitive motor behavior test was performed by using Morris water maze. In the histological test, TTC(2,3,5-triphenylteterazolium chloride) staining, hematoxylin & eosin staining, and immunohistochemical staining were used. Results : 1. The tests for motor function recovery change had significantly good result in the experimental groups as compared with control groups(p<.05). 2. The Morris water maze test on cognition also had significantly good result in the experimental groups as compared with control groups(p<.05). 3. In the immunohistochemical staining for the expression of BDNF in hippocampus, more immune reaction was investigated in the experimental groups as compared with control groups. Especially group IV has the greatest immune reaction. Conclusions : Ohyaksungi-san(Wuyaoshunqi-san) has good effects on cognition and motor function recovery after ischemic brain injury, and also the expression of BDNF in hippocampus.

• Journal of Korean Medicine Rehabilitation
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• v.18 no.2
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• pp.45-60
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• 2008

Objectives : Sopung-tang(Shufeng-tang) is a famous herbal prescription that treated ischemic brain injury. This study was designed to evaluate the effects of Sopung-tang(Shufeng-tang) on congnition and motor function recovery after ischemic brain injury in rats. Methods : Male rats were divided into 4 groups. Those rats caused ischemic brain injury by occlusion of MCA as Longa method. Control group I was per os normal saline for 7 days after ischemic brain injury. Control group II was per os normal saline for 14 days after ischemic brain injury. Experimental group I(Ex I) was taken with Sopung-tang(Shufeng-tang) for 7 days after ischemic brain injury. Experimental group II(Ex II) was taken with Sopung-tang(Shufeng-tang) for 14 days after ischemic brain injury. The author carried out neurological, cognitive motor behavior tests and histological assessment. Neurological motor behavior tests consist of limb placement test, beam-walking test and horizontal wire test. Morris water maze test was used for cognitive motor behavior test. In the histological assessment test, TTC(2,3,5-triphenylteterazolium chloride) staining, Hematoxylin & Eosin staining and immunohistochemical staining were experimented. Results : 1. In neurological motor behavior tests, motor function recovery was significantly increased in the experimental groups as compared with control groups(p<0.05). Especially Ex II was significantly increased as compared with Ex I(p<0.05). 2. In Morris water maze test, congnitive motor function recovery was significantly increased in the experimental groups as compared with control group(p<0.05). Especially Ex II was significantly increased as compared with Ex I(p<0.05). 3. In the immunohistochemical staining for the expression of BDNF in hippocampus, more immune reaction was investigated in the experimental groups as compared with control groups. Especially most immune reaction was experimented in the EX II. Conclusions : According to the above results, Sopung-tang(Shufeng-tang) can treat on the congnition and motor function recovery after ischemic brain injury in rats. And it is effective method in expression of BDNF in hippocampus.