• Pediatric Infection and Vaccine
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• 제25권2호
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• pp.107-112
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• 2018

포도알균은 피부 및 연조직 감염과 관련된 병원체로 재발 감염의 위험이 높다. 저자들은 국내에서 Panton-Valentine leukocidin (PVL) 양성 메티실린 감수성 포도알균 ST1에 의한 가족 내 재발성 종기를 경험하였으며, 16개월의 남자 환아와 아버지, 어머니의 종기에서 획득한 검체는 모두 동일한 항생제 감수성을 보였다. 세 환자의 균주 모두 agr 그룹으로 확인되었고, polymerase chain reaction (PCR) 검사에서 sec, seh가 확인되었으며 PVL 유전자를 포함하고 있었다. 가족 내 신체 접촉으로 인한 포도알균의 전파 가능성 및 예방에 대한 고려를 해 볼 필요가 있다.

• 한국수소및신에너지학회논문집
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• 제13권3호
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• pp.224-232
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• 2002

CdS-$TiO_2$ nano-composite sol was prepared by the sol-gel method in organic solvents at room temperature and further hydrothermal treatment at various temperatures to control the physical properties of the primary particles. Again, CdS-$TiO_2$ composite particulate films were made by casting CdS-$TiO_2$ sols onto $F:SnO_2$ conducting glass and then heat-treatment at $400^{\circ}C$. Physical properties of these 61ms were further controlled by the surface treatment with $TiCl_4$, aqueous solution. The photo currents and hydrogen production rates measured under the experimental conditions varied according to the $CdS/[CdS+TiO_2]$ mole ratio and the mixed-sol preparation method. For $CdS-TiO_2$ composite sols prepared in IPA, CdS particles were homogeneously surrounded by $TiO_2$ particles. Also, the surface treatment with $TiCl_4$ aqueous solution caused a considerable improvement in the photocatalytic activity, probably as a result of close contacts between the primary particles by the etching effect of $TiCl_4$. It was found that the photoelectrochemical performance of these particulate films could be effectively enhanced by this approach.

• Tuberculosis and Respiratory Diseases
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• 제81권1호
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• pp.6-12
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• 2018

The role of the treatment for latent tuberculosis infection (LTBI) has been underscored in the intermediate tuberculosis (TB) burden countries like South Korea. LTBI treatment is recommended only for patients at risk for progression to active TB-those with frequent exposure to active TB cases, and those with clinical risk factors (e.g., immunocompromised patients). Recently revised National Institute for Health and Care Excellence (NICE) guideline recommended that close contacts of individuals with active pulmonary or laryngeal TB, aged between 18 and 65 years, should undergo LTBI treatment. Various regimens for LTBI treatment were recommended in NICE, World Health Organization (WHO), and Centers for Disease Control and Prevention guidelines, and superiority of one recommended regimen over another was not yet established. Traditional 6 to 9 months of isoniazid (6H or 9H) regimen has an advantage of the most abundant evidence for clinical efficacy-60%-90% of estimated protective effect. However, 6H or 9H regimen is related with hepatotoxicity and low compliance. Four months of rifampin regimen is characterized by less hepatotoxicity and better compliance than 9H, but has few evidence of clinical efficacy. Three months of isoniazid plus rifampin was proved equivalence with 6H or 9H regimen in terms of efficacy and safety, which was recommended in NICE and WHO guidelines. The clinical efficacy of isoniazid plus rifapentine once-weekly regimen for 3 months was demonstrated recently, which is not yet introduced into South Korea.

• Acta Via Serica
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• 제3권1호
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• pp.103-117
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• 2018

This article aims to examine European reactions against the Ottoman mission headed by Enver Pasha, who was dispatched to China during the 'Boxer Uprising' in 1901. Based on Western archival documents, we can find reliable and informative correspondence about the attitude of the European countries toward the sultan's mission and its pan-Islamic plans in China. The coming of the Ottoman mission caused great reaction in such European countries as Britain, France, Germany and Russia, who were engaged in a competitive power struggle for an influential political and economic position in China. They kept a close watch on the sultan's envoy to find out his secret mission on the one hand and tried to persuade Enver Pasha not to work against their advantage in China on the other. From time to time, Abdul Hamid II (r. 1876-1909), the sultan of the Ottoman Empire, sent China an official mission and secret agents, through whom he tried to subjugate Chinese Muslims for his own advantage. The significance for the Ottoman Empire of any success in penetrating China by way of a pan-Islamic approach cannot be overrated, not only for political advantage but also for commercial and cultural benefit. Like other European countries, Ottomans could retain or gain rights which might bring them opportunities for free trade in opium and in other commodities. The sultan believed that they would constitute a great political factor to his advantage, because most of the tens of millions of Chinese Muslims recognized the Ottoman sultan as their caliph and praised him in their Friday sermon (Khutuba). Taking these factors into consideration, he decided to dispatch the Enver Pasha mission during the Boxer Uprising (1898-1901), responding to the suggestion of German Kaiser Wilhelm II. However, when the Ottoman mission arrived in China, the uprising had already been suppressed. This unexpected situation made the envoy initiate meaningful contacts with Chinese Muslims during its stay in China.

• 한국가족관계학회지
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• 제21권1호
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• pp.123-141
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• 2016

Objective: This study examined correlates of residential proximity between parents and non-coresident married children. A majority of existing studies on intergenerational living arrangement has focused on exploring factors that are associated with intergenerational coresidence only, despite an increasing number of parents and children who do not live together but close by. Because residential proximity facilitates frequent contacts and support exchanges between the two generations, it is important to understand its correlates. Method: The data were drawn from first wave of the Korean Longitudinal Study of Ageing (KLoSA, 2006), a nationally representative sample of adults 45 years or older and their spouses. The analytic sample consisted of 3,950 parents with 10,946 non-coresident married children. Both regression with robust standard errors and sibling fixed effects regression models were estimated using the reg and xtreg procedures in STATA. Results: Younger, less depressed, and more physically impaired parents lived closer to at least one of their married children (within a 30-minute distance by public transportation). Fathers (compared to mothers), parents living in cities (compared to those living in rural areas), parents with at least one co-resident child or fewer numbers of married children tended to have at least one married child living nearby. With regard to child characteristics, married children who were less educated, homeowners, and had more children lived closer to their parents. Also, sons (compared to daughters) lived in closer distance to their parents. Conclusion: Overall, findings suggest that intergenerational residential proximity may primarily be motivated by the childcare needs of married children or parents' needs for assistance with functional impairment. Also, the traditional patrilineal norms of intergenerational support may still be a critical factor in residential decisions as observed in the difference between married sons and daughters in proximity to their parents.

• International Journal of Computer Science & Network Security
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• 제21권1호
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• pp.12-18
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• 2021

This paper proposes a framework for the development of the health recommender system, designed to cater COVID-19 symptoms' self-assessment and monitoring as well as to provide recommendations for self-care and medical treatments. The aim is to provide an online platform for Patient Under Investigation (PUI) and close contacts with positive COVID-19 cases in Malaysia who are under home quarantine to perform daily self-assessment in order to monitor their own symptoms' development. To achieve this, three main phases of research methods have been conducted where interviews have been done to thirty former COVID-19 patients in order to investigate the symptoms and practices conducted by the Malaysia Ministry of Health (MOH) in assessing and monitoring COVID-19 patients who were under home quarantine. From the interviews, an algorithm using user-based collaborative filtering technique with Pearson correlation coefficient similarity measure is designed to cater the self-assessment and symptoms monitoring as well as providing recommendations for self-care treatments as well as medical interventions if the symptoms worsen during the 14-days quarantine. The proposed framework will involve the development of the health recommender system for COVID-19 self-assessment and treatments using the progressive web application method with cloud database and PHP codes.

• 한국인터넷방송통신학회논문지
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• 제22권1호
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• pp.171-179
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• 2022

본 논문은 캠퍼스 내 건물별 출입구에 출입명부를 관리할 수 있는 장치를 설치하고, 수집된 데이터를 근거로 코로나19 확진자에 대한 감시 및 추적 시스템을 소개한다. 기존 QR 기반의 전자출입명부는 스마트폰으로 QR 코드를 인식해야 하는 불편함과 건물 내 출입자의 온도를 측정할 수 없다는 단점이 있다. 또한, 국가가 캠퍼스 내의 확진자와 접촉자 정보를 관리함에 있어, 구성원들에게 신속한 정보 공유와 추적이 쉽지 않다. 이는 확진자와 밀접 접촉한 이가 또 다른 확진자를 만드는 경우를 초래할 수 있다. 따라서, 본 논문에서는 이에 대응하기 위해 얼굴 인식 기능과 온도센서를 포함한 장치를 캠퍼스 내 건물 출입구에 설치하고, 관리자가 실시간으로 건물별 구성원들의 출입현황을 모니터링하여 신속하게 추적할 수 있는 기능을 소개한다.

• 대한예방한의학회지
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• 제27권1호
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• pp.69-87
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• 2023

Objectives : This study collected and analyzed information related to preventive formulas from continuously published and revised COVID-19 treatment guidelines in various regions of China. Methods : We collected treatment guidelines published in different regions of China and categorized formulas for prevention and medical observation period listed in them according to the editions. The categorized preventive formulas were compared by type and target group. Results : Herbal medicines used for prevention included formulas derived from Korean medical classics, such as Okbyeongpungsan(玉屏風散) and Eunkyosan(銀翹散). The newly composed formulas, totaling over 100, were created by adding, subtracting, and combining formulas such as Sang-gukeum(桑菊飮), Eunkyosan(銀翹散), Sasammaekmundongtang(沙參麥門冬湯), Okbyeongpungsan(玉屏風散), Gwakhyangjeong-gisan(藿香正氣散), and Soshihotang(小柴胡湯). Patent medicines including Huoxiangzhengqi capsule(藿香正氣膠囊), Lianhuaqingwen capsule(連花淸瘟膠囊), Shufengjiedu capsule(疏風解毒膠囊), and Jinhuaqinggan granule(金花淸感顆粒) were frequently used, mainly targeting close contacts. These medicines were used differently depending on the specific population group, such as the general population, the elderly, children, pregnant women, and patients with underlying diseases, and were also applied differently according to the individual's constitution. Conclusion : We were able to identify various background factors contained in the guidelines for the use of preventive formulas presented by TCM group, and understand the social conditions that enabled the group to provide such guidelines. Through this, thorough preparation should be made so that the Korean Medicine can actively respond to another future pandemic.

• 대한약리학회지
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• 제23권2호
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• pp.57-75
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• 1987

Two modalities of gonadotropin secretion, pulsatile gonadotropin and preovulatory gonadotropin surge, have been identified in the mammals. Pulsatile gonadotropin secretion is modulated by the pulsatile pattern of GnRH release and complex ovarian steroid feedback actions. The neural mechansim that regulates the pulsatile release of GnRH in the hypothalamus is called "GnRH pulse generator". Ovarian steroids, estradiol and progesterone, appear to exert thier feedback effects both directly on the pituitary to modulate gonadotropin release and on a hypothalamic site to modulate GnRH release; estradiol primarily affects the amplitude while progesterone decreases the frequency of the pulsatile GnRH. Steroid hormones are known to affect catecholamine transmission in brain. MBH-POA is richly innervated by NE systems and close apposition of NE terminals and GnRH cell bodies occurs in the MBH as well as in the POA. NE normally facilitates pulsatile LH release by acting through ${\alpha}-receptor$ mechanism. However, precise nature of facilitative role of NE transmission in maintaining pulsatile LH has not been clearly understood. Close apposition of DA and GnRH terminals in ME might permit DA to influence GnRH release. Action of DA transmission probably is mediated by axo-axonic contacts between GnRH and DA fibers in the ME. Dopamine transmission does not normally regulate pulsatile LH release, but under certain conditions, increased DA transmission inhibit LH pulse. Endogenous opioid acts to suppress the secretion of GnRH into hypophysial portal circulation, thereby inhibiting gonadotropin secretion. However, an interaction between endogenenous opioid peptides and gonadotropin release is a complex one which involves ovarian hormones as well. LH secretion appears to be most suppressed by endogenenous opioids during the luteal phase, at a time of elevated progesterone secretion. The arcuate nucleus contains not only cell bodies for GnRH and ${\beta}-endorphin$ but also a dense aborization of fibers suggesting that GnRH release is changed by the interactions between GnRH and ${\beta}-endorphin$ cell bodies within the arcuate nucleus. The frequency and amplitude of pulsatile LH release seem to be increased during the preovulatory gonadotropin surge. Estradiol exerts positive feedback action on the hypothalamo-pituitary axis to trigger preovulatory LH surge. GnRH is also crucial hormonal stimulus for preovulatory LH surge. It is unlikely, however, that increased secretion of GnRH during the preovulatory gonadotropin surge represents an obligatory neural signal for generation of the LH discharge in primates including human. Modulation of preovulatory LH surge by catecholamines has been studied almost exclusively in rats. NE and E may be involved in distinct way to accumulate GnRH in the MBH and its release into the hypophysial portal system during the critical period for LH surge on proestrus in rats. However, the mechanisms whereby augmented adrenergic transmission may facilitate the formation and accumulation of GnRH in the ME-ARC nerve terminals before the LH surge have not been clearly understood.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제43회 하계 정기 학술대회 초록집
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• pp.308-309
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• 2012

One of the critical issues in the growth of multijunction solar cell is the formation of a highly doped Esaki interband tunnel diode which interconnects unit cells of different energy band gap. Small electrical and optical losses are the requirements of such tunnel diodes [1]. To satisfy these requirements, tens of nanometer thick gallium arsenide (GaAs) can be a proper candidate due to its high carrier concentration in low energy band gap. To obtain highly doped GaAs in molecular beam epitaxy, the temperatures of Si Knudsen cell (K-cell) for n-type GaAs and Be K-cell for p-type GaAs were controlled during GaAs epitaxial growth, and the growth rate is set to 1.75 A/s. As a result, the doping concentration of p-type and n-type GaAs increased up to $4.7{\times}10^{19}cm^{-3}$ and $6.2{\times}10^{18}cm^{-3}$, respectively. However, the obtained n-type doping concentration is not sufficient to form a properly operating tunnel diode which requires a doping concentration close to $1.0{\times}10^{19}cm^{-3}$ [2]. To enhance the n-type doping concentration, n-doped GaAs samples were grown with a lower growth rate ranging from 0.318 to 1.123 A/s at a Si K-cell temperature of $1,180^{\circ}C$. As shown in Fig. 1, the n-type doping concentration was increased to $7.7{\times}10^{18}cm^{-3}$ when the growth rate was decreased to 0.318 A/s. The p-type doping concentration also increased to $4.1{\times}10^{19}cm^{-3}$ with the decrease of growth rate to 0.318 A/s. Additionally, bulk resistance was also decreased in both the grown samples. However, a transmission line measurement performed on the n-type GaAs sample grown at the rate of 0.318 A/s showed an increased specific contact resistance of $6.62{\times}10^{-4}{\Omega}{\cdot}cm^{-2}$. This high value of contact resistance is not suitable for forming contacts and interfaces. The increased resistance is attributed to the excessively incorporated dopant during low growth rate. Further studies need to be carried out to evaluate the effect of excess dopants on the operation of tunnel diode.