• Molecules and Cells
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• v.43 no.3
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• pp.276-285
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• 2020

Circadian rhythm is an endogenous oscillation of about 24-h period in many physiological processes and behaviors. This daily oscillation is maintained by the molecular clock machinery with transcriptional-translational feedback loops mediated by clock genes including Period2 (Per2) and Bmal1. Recently, it was revealed that gut microbiome exerts a significant impact on the circadian physiology and behavior of its host; however, the mechanism through which it regulates the molecular clock has remained elusive. 3-(4-hydroxyphenyl)propionic acid (4-OH-PPA) and 3-phenylpropionic acid (PPA) are major metabolites exclusively produced by Clostridium sporogenes and may function as unique chemical messengers communicating with its host. In the present study, we examined if two C. sporogenes-derived metabolites can modulate the oscillation of mammalian molecular clock. Interestingly, 4-OH-PPA and PPA increased the amplitude of both PER2 and Bmal1 oscillation in a dose-dependent manner following their administration immediately after the nadir or the peak of their rhythm. The phase of PER2 oscillation responded differently depending on the mode of administration of the metabolites. In addition, using an organotypic slice culture ex vivo, treatment with 4-OH-PPA increased the amplitude and lengthened the period of PER2 oscillation in the suprachiasmatic nucleus and other tissues. In summary, two C. sporogenes-derived metabolites are involved in the regulation of circadian oscillation of Per2 and Bmal1 clock genes in the host's peripheral and central clock machineries.

• Proceedings of the Korean Information Science Society Conference
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• 2004.10c
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• pp.319-321
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• 2004

최근 이더넷(Ethernet) 보급과 사용자의 증가 그리고 다양한 응용 서비스들의 등장으로 인하여 점차 네트워크 트래픽이 폭증하고 있다. 이에 따라서 SLA(Service Level Agreement)를 위한 대역폭 조절(Bandwidth의 Regulation)의 중요성은 더욱 높아지고 있다. 그러나 기존에 제시된 대역폭 조절 방식들은 이더넷에 적합하지 않거나 또는 너무 복잡하여, EFM(Ethernet for First Mile)에 적용하기 어려웠다. 그래서 본 논문에서는 이더넷에 적용하기 적합한 간단하면서도 효과적인 대역폭 조절(Bandwidth Regulation) 방법인 속도 계산(Rate Calculation)방식을 제안하며, 제안한 메커니즘에 대한 시뮬레이션을 통한 성능 분석을 수행하였다.

• Journal of KIISE:Computer Systems and Theory
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• v.31 no.1_2
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• pp.67-77
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• 2004

Value prediction is a technique to obtain performance gains by supplying earlier source values of its data dependent instructions using predicted value of a instruction. To fully exploit the potential of value speculation, however, the efficient recovery mechanism is necessary in case of value misprediction. In this paper, we propose a sequential and selective recovery mechanism for value misprediction. It searches data dependency chain of the mispredicted instruction sequentially without pipeline stalls and adverse impact on clock cycle time. In our scheme, only the dependent instructions on the predicted instruction is selectively squashed and reissued in case of value misprediction.

• Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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• 2006.06a
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• pp.390-393
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• 2006

IEEE 802.11e 과 IEEE 802.11n에서 data의 높은 전송률을 구현하기 위해 Block Ack와 frame agegation 과 같은 새로운 mechanism이 논의 되고 있다. 이러한 mechanism은 각각의 MPDU processing 마다 짧은 응답시간을 요구한다. 본 논문에서는 위의 새로운 MAC을 지원하는 IEEE 802.11i를 위한 효율적인 CCMP 설계를 제안한다. 제안된 설계에서는 한 AES-CCM core에서 MIC calculation 과 정보 암호화가 128bit씩 순차적으로 수행되어지는 mode toggling 접근을 채택했다. 본 설계에서는 응답시간이 44 clock cycle의 짧은 짧은 시간으로 줄었다. 또한 하나의 AES-CCM core를 사용하고 낮은 주파수에서 수용할만한 data throughput과 응답시간을 얻었기 때문에 하드웨어적인 복잡성과 전력 소모를 줄일수 있었다.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.133.3-133
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• 2001

This paper analyses the real-time performance of Ethernet based intranet whether it is applicable to the real-time network. Unpredictability of transmission delay by collision-delay-retransmission mechanism in CAMA/CD(Carrier Sense Multiple Access with Collision Detect) of Ethernet is the major reason making hard to apply to real-time system. Both retransmission mechanism of TCP(Transmission Control Protocol) for reliability and sliding windows algorithm for high utilization make hard to predict transmission delay. Because real-time control network require fast responsibility and bustle of short-periodic messages, global-clock for collision avoidance and UDP(User Datagram Protocol) for high utilization of network are used. The mathematical models for time-delay that can be occured between ...

• Journal of Communications and Networks
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• v.8 no.3
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• pp.351-359
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• 2006

In this article, we present a new slow-start variant, which improves the throughput of transmission control protocol (TCP) Vegas. We call this new mechanism Gallop-Vegas because it quickly ramps up to the available bandwidth and reduces the burstiness during the slow-start phase. TCP is known to send bursts of packets during its slow-start phase due to the fast window increase and the ACK-clock based transmission. This phenomenon causes TCP Vegas to change from slow-start phase to congestion-avoidance phase too early in the large bandwidth-delay product (BDP) links. Therefore, in Gallop-Vegas, we increase the congestion window size with a rate between exponential growth and linear growth during slow-start phase. Our analysis, simulation results, and measurements on the Internet show that Gallop-Vegas significantly improves the performance of a connection, especially during the slow-start phase. Furthermore, it is implementation feasible because only sending part needs to be modified.

• Molecules and Cells
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• v.40 no.7
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• pp.450-456
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• 2017

Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm. Specifically, genetic deletion of the circadian nuclear receptor Rev-$erb{\alpha}$ induces mania-like behavior caused by increased midbrain dopaminergic (DAergic) tone at dusk. The association between circadian rhythm and emotion-related behaviors can be applied to pathological conditions, including neurodegenerative diseases. In Parkinson's disease (PD), DAergic neurons in the substantia nigra pars compacta progressively degenerate leading to motor dysfunction. Patients with PD also exhibit non-motor symptoms, including sleep disorder and neuropsychiatric disorders. Thus, it is important to understand the mechanisms that link the molecular circadian clock and brain machinery in the regulation of emotional behaviors and related midbrain DAergic neuronal circuits in healthy and pathological states. This review summarizes the current literature regarding the association between circadian rhythm and mood regulation from a chronobiological perspective, and may provide insight into therapeutic approaches to target psychiatric symptoms in neurodegenerative diseases involving circadian rhythm dysfunction.

• Convergence Security Journal
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• v.15 no.2
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• pp.81-89
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• 2015

HIGHT is an 64-bit block cipher, which is suitable for low power and ultra-light implementation that are used in the network that needs the consideration of security aspects. This paper presents a key scheduler that employs the presented LFSR and reverse LFSR that can generate four outputs simultaneously. In addition, we construct new key scheduler that generates 4 subkey bytes at a clock since each round block requires 4 subkey bytes at a time. Thus, the entire HIGHT processor can be controlled by single system clock with regular control mechanism. We synthesize the HIGHT processor using the VHDL. From the synthesis results, the logic size of the presented key scheduler can be reduced as 9% compared to the counterpart that is employed in the conventional HIGHT processor.

• Animal cells and systems
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• v.16 no.1
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• pp.27-33
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• 2012

The suprachiasmatic nucleus (SCN) of the teleost hypothalamus contains a central circadian pacemaker, which adjusts circadian rhythms within the body to environmental light-dark cycles. It has been shown that exposure to darkness during the day causes phase shifts in circadian rhythms. In this study, we examined the effect of exposure to darkness on the mRNA expression levels of two circadian clock genes, namely, $Period2$ ($Per2$) and $Cryptochrome1$ ($Cry1$), and the rate-limiting enzyme in melatonin synthesis, arylalkylamine $N$-acetyltransferase-2 (Aanat2), in the pineal gland of olive flounder, $Paralichthys$ $olivaceus$. The expression of these genes showed circadian variations and was significantly higher during the dark phase. These changes may be involved in the mechanism of dark-induced phase shifts. Furthermore, this study suggests that olive flounder may be a teleost model to investigate the localization and function of circadian oscillators.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.12
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• pp.2263-2268
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• 2008

We investigated the malfunction and destruction characteristics of microcontroller devices under high power electromagnetic(HPEM) wave by magnetron. HPEM was rated at a microwave output of 0 to 1,000 W, at a frequency of 2,450${\pm}$50 MHz and was radiated from the open-ended standard rectangular waveguide(WR-340) to free space. The influence of different reset-, clock-, data-, and power supply-line lengths has been tested. The variation of the line length was done with flat cables. The susceptibility of the tested microcontroller devices was in general much influenced by clock-, reset-, and power supply-line length, little influenced by data-line length. Further the line length was increased, the malfunction threshold was decreased as expected, because more energy couples to the devices. The surfaces of the destroyed microcontroller devices were removed and the chip conditions were investigated with microscope. The microscopic analysis of the damaged devices showed component and bondwire destructions such as breakthroughs and melting due to thermal effects. The obtained results are expected to provide fundamental data for interpreting the combined mechanism of microcontroller devices in an intentional microwave environment.