• 센서학회지
• /
• 제32권6호
• /
• pp.378-385
• /
• 2023

Human biosignals provide essential information for diagnosing diseases such as dementia and Parkinson's disease. Owing to the shortcomings of current clinical assessments, noninvasive solutions are required. Machine learning (ML) on wearable sensor data is a promising method for the real-time monitoring and early detection of abnormalities. ML facilitates disease identification, severity measurement, and remote rehabilitation by providing continuous feedback. In the context of wearable sensor technology, ML involves training on observed data for tasks such as classification and regression with applications in clinical metrics. Although supervised ML presents challenges in clinical settings, unsupervised learning, which focuses on tasks such as cluster identification and anomaly detection, has emerged as a useful alternative. This review examines and discusses a variety of ML algorithms such as Support Vector Machines (SVM), Random Forests (RF), Decision Trees (DT), Neural Networks (NN), and Deep Learning for the analysis of complex clinical data.

• 대한한방체열의학회지
• /
• 제3권1호
• /
• pp.6-14
• /
• 2004

Purpose: We intended to research the relations between abdominal temperature and primary dysmenorrhea severity. Methods: We selected the 95 primary dysmenorrhea patients by means of screening test (first screening test-inquiry, second screening test-clinical test, additionally Waist-to-Hip ratio (WHR) by Inbody 2.0). We measured 4 points abdominal temperature (Chon-jung(CV17), Chung-wan(CV12), Kwan-won(CV4), Chung-guk(CV3)) by DITI (DOREX Inc., USA). And then we checked the difference of temperature $({\Delta}T)$ between CV17 and CV4 / CV17 and CV3 / CV12 and CV4 / CV12 and CV3. After that, we compared ${\Delta}T$ with primary dysmenorrhea severity evaluated by multidimensional scales (verbal rating scale modified from the one devised by Bibe roglu & Berhrman(VRS; B&B), multidimensional verbal rating scale by Andersch & Milsom(MVRS)). In dysmenorrhea severity, we standardized scale score and 3-group-severity by score (mild, moderate, severe). For statistics, we used Pearson correlations and Spearman's rho correlations, SPSS 11.0 for windows. Results: In case of MVRS, MVRS score and 3-group-severity were not correlated to ${\Delta}T$. In case of VRS; B&B, VRS; B&B score was correlated to ${\Delta}T$ (CV12 and CV4 / CV12 and CV3) and 3-group-severity was correlated to ${\Delta}T$ (CV12 and CV3). Statistically they showed significant result (p<0.05). So we can consider that ${\Delta}T$ (CV12 and CV3) and the primary dysmenorrhea severity by VRS; B&B are most correlated. Conclusion: The primary dysmenorrhea patients showed that severity by VRS; B&B was connected with ${\Delta}T$ (CV12 and CV3). So we can consider DITI as primary dysmenorrhea evaluation instrument and must further research measurement points for the exact primary dysmenorrhea evaluation by DITI.

• Clinical and Experimental Reproductive Medicine
• /
• 제47권3호
• /
• pp.233-234
• /
• 2020

• 한국미생물·생명공학회지
• /
• 제42권1호
• /
• pp.82-88
• /
• 2014

본 연구는 DNCB 도포를 통해 아토피 피부염을 유발시킨 BALB/c mice에 SMEE를 2주 동안 지속적으로 처리하여 SMEE의 아토피 피부염 완화 효과에 대해 연구하였다. 따라서 IFN-${\gamma}$ 및 IL-4 cytokine의 분비량, 비장세포 증식능, 혈청 중 총 IgE 함량, 육안 평가 및 skin clinical severity score를 실시하였다. 그 결과 SMEE를 지속적으로 도포함으로써 IL-4 cytokine과 총 IgE 함량이 현저히 감소하는 것을 확인할 수 있었으며 IFN-${\gamma}$ cytokine은 유의적으로 증가하는 것을 확인하였다. 세포증식능 측정결과, SMEE 처리구의 경우 negative control군과 유사한 수준까지 억제됨을 나타냈으며, 비장세포의 비이상적인 증식에 SMEE 도포처리가 큰 영향을 미치지 않는 것으로 나타났다. 육안평가 및 skin clinical severity score 결과, SMEE를 2주간 지속적으로 도포 처리하였을 때, 그 증상이 눈에 띄게 완화되는 것을 확인할 수 있었으며 score 또한 positive control과 비교 시 유의적으로 감소하였다. 결과적으로 SMEE는 Th1 cytokine 생성은 증가시키고 Th2 cytokine 생성은 억제하여 IgE의 과다발현을 억제함으로써 아토피 피부염의 개선에 뛰어난 효능을 가지고 있는 것으로 사료된다.

• 대한임상독성학회지
• /
• 제12권1호
• /
• pp.14-21
• /
• 2014

Purpose: The objective of this study was to develop a new scoring tool that is comprehensively applicable and predicts fatality within 24 h of intoxication. Methods: This was a cohort study conducted in two emergency medical centers from 2011 to 2012. We identified factors associated with severe/fatality. Through a discriminant analysis, we devised the aBIG (age, Base deficit, Infection, and Glasgow coma scale) score. To compare the ability of aBIG to predict intoxication severity with that of previous scoring systems such as APACHE II, MODS, SAPS IIe, and SOFA, we determined the receiver operating characteristic curves of each variable in predicting severe-to-fatal toxicity. Results: Compared with the mild/moderate toxicity group (n=211), the severe/fatal group (n=143) had higher incidences of metabolic acidosis, infection, serious mental change, QTc prolongation and hepato-renal failure. Age, base deficit, infection-WBC count, and Glasgow Coma Scale were independently associated with severe/fatal poisoning. These variables were combined into the poisoning "aBIG" score [$0.28{\times}$Age group+$0.38{\times}WBC$ count/$10^3+0.52{\times}$Base deficit+$0.64{\times}$(15-GCS)], which were each calculated to have an area under the curve of 0.904 (95% confidence interval: 0.868-0.933). The aBIG poisoning score had an equivalent level of severity predictability as APACHE II and a superior than MODS, SOFA, and SAPS IIe. Conclusion: We developed a simplified scoring system using the four variables of age, base deficit, infected leukocytosis, and GCS. The poisoning aBIG score was a simple method that could be performed rapidly on admission to evaluate severity of illness and predict fatal severity in patients with acute intoxications.

• Journal of Trauma and Injury
• /
• 제18권2호
• /
• pp.141-147
• /
• 2005

Purpose: Recently, The new Injury Severity Score (NISS) has become a more accurate predictor of mortality than the traditional Injury Severity Score (ISS) in the trauma population. Trauma Score Injury Severity Score (TRISS) method, regarded as the gold standard for mortality prediction in trauma patients, still contains the ISS as an essential factor within its formula. The purpose of this study was to determine whether a simple modification of the TRISS by replacing the ISS with the NISS would improve the prediction of in-hospital mortality in a trauma population with blunt head and neck trauma. Objects and Methods: The study population consisted of 641 patients from a regional emergency medical center in Kyoungsangnam-do. Demographic data, clinical information, the final diagnosis, and the outcome for each patient were collected in a retrospective manner. the ISS, NISS, TRISS, and modified TRISS were calculated for each patients. The discrimination and the calibration of the ISS, NISS, modified TRISS and conventional TRISS models were compared using receiver operator characteristic (ROC) curves, areas under the ROC curve (AUC) and Hosmer-Lemeshow statistics. Results: The AUC of the ISS, NISS, modified TRISS, and conventional TRISS were 0.885, 0.941, 0.971, and 0.918 respectively. Statistical differences were found between the ISS and the NISS (p=0.008) and between the modified TRISS and the conventional TRISS (p=0.009). Hosmer-Lemeshow chi square values were 13.2, 2.3, 50.1, and 13.8, respectively; only the conventional TRISS failed to achieve the level of and an excellent calibration model (p<0.001). Conclusion: The modified TRISS is a more accurate predictor of in-hospital mortality than the conventional TRISS in a trauma population of blunt head and neck trauma.

• Korean Journal of Acupuncture
• /
• 제29권4호
• /
• pp.623-633
• /
• 2012

Objectives : Fatigue is a common and distressing symptom that is a concern for cancer patients. It has a decisive effect on quality of life. The purpose of this study was to examine the feasibility of clinical trial to evaluate of efficacy and safety of acupuncture on cancer related fatigue of lung cancer patients. Methods : Total lung cancer 9 patients complained of fatigue were treated by acupuncture twice a week for four weeks(8 times in total). Evaluation of the severity of fatigue was measured by FSS(Fatigue Severity Score). In visit 1, 10, we checked FSS. For check safety of acupuncture treatment, we did blood test. Results : After 4 weeks of acupuncture treatment, the FSS was significantly decreased from $4.92{\pm}1.06$ to $3.74{\pm}1.37$(p=0.008). And the level of hemoglobin was significantly increased from 10.87 g/dl to 12.01 g/dl(p=0.014). No other lab measures indicated any significant differences between before and after acupuncture treatment. Conclusions : This study suggests that acupuncture treatment will be beneficial for lung cancer patients to improve the fatigue severity. And acupuncture treatment is safe method for lung cancer patients. A large-scale study to confirm efficacy and safety of acupuncture is needed.

• 응용통계연구
• /
• 제24권6호
• /
• pp.1045-1054
• /
• 2011

임상 연구자는 일정기간의 치료에 의해 환자에게 증상 발현 또는 증상 비발현을 관측할 뿐만 아니라 증상이 발현된 환자의 경우에는 증상 심각성 점수가 측정됨을 자주 본다. 예를 들어서 대조군을 비롯하여 치료의 정도에 차이가 있는 여러 치료군이 있을 때 발현율의 감소를 검정하는 전통적인 방법은 Cochran-Armitage 추세검정이며, 한편 비정규분포하는 연속자료의 감소를 검정하는 전통적인 방법은 Jonckheere-Terpstra 추세검정이다. 전자의 추세검정은 증상 발현의 이항자료만을 사용한 검정이 되며 한편 후자의 추세검정은 증상의 심각성 점수만을 사용한 검정이 된다. 본 논문에서는 증상 발현율과 증상의 심각성 점수로 나타나는 정보의 특성을 모두 감안한 추세검정법을 제안한다. 새로운 추세검정법을 항정신병 약제를 복용하는 정신분열증 입원환자로부터 수집된 자료에 적용하며 본 논문에서 취급하는 여러 다른 검정법과 비교한 효율성을 모의실험으로 알아본다.

• 대한불안의학회지
• /
• 제11권2호
• /
• pp.136-142
• /
• 2015

Objective : Subjective tinnitus is defined as an acoustic sensation perceived without any external source. Patients with tinnitus have often experienced psychological distress and low quality of life. However, the connection between psychiatric characteristics and tinnitus has not yet been established. The purpose of this study was to investigate the relationship of psychiatric characteristics with tinnitus severity. Method : A total of 124 patients with tinnitus were included in the study. Demographic and clinical characteristics were retrospectively collected in the otolaryngology clinic. The self-reported scales including the Tinnitus Handicap Inventory, the Hospital Anxiety and Depression Scale and the Anxiety Sensitivity Index were used in this study. Results : The Pearson product moment correlation revealed significant correlations between tinnitus severity and psychiatric characteristics including depression (r=0.26, p<0.01), anxiety (r=0.38, p<0.01), anxiety sensitivity (r=0.27, p<0.01). After controlling for age, sex and awareness of tinnitus, tinnitus severity was positively correlated with anxiety (partial r=0.39, p<0.01) and anxiety sensitivity (partial r=0.28, p<0.01). These correlations remained significant in male but not in female patients. Conclusion : Results of the present study indicated that not only anxiety symptoms but also anxiety sensitivity could relate to tinnitus severity. Our findings have implications for the understanding of the psychiatric characteristics in patients with tinnitus.

• 한국콘텐츠학회논문지
• /
• 제17권5호
• /
• pp.200-208
• /
• 2017

본 연구의 목적은 하지불안증후군 환자를 대상으로 중증도 및 우울이 수면의 질에 미치는 영향요인을 규명하기 위함이다. 총 303명의 하지불안증후군 환자들이 참여하여 자가설문지를 완성하였고 대상자의 의무기록을 통해서 임상적 정보를 수집하였다. 자료 분석은 기술통계, t-test, ANOVA, Pearson's correlation, 다중회귀분석을 시행하였다. 대상자의 수면의 질은 중증도(r=. 21, p<.001 ), 우울(r=. 37, p<.001)과 정적 상관관계를 보였다. 다중회귀분석을 통해 수면의 질에 미치는 영향요인을 파악한 결과, 우울(${\beta}=.35$, p<.001), 연령(${\beta}=.21$, p<.001), 중증도(${\beta}=.15$, p=.005)가 유의한 변인으로 나타났고, 모형의 설명력은 21.0%였다. 하지불안증후군 환자의 수면의 질을 향상하기 위해서는 우울, 연령, 중증도를 고려한 간호중재가 필요하다.