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http://dx.doi.org/10.4014/kjmb.1401.01002

Anti-atopic Activity of Sargassum micracanthum Ethanol Extracts  

Jeong, Da-Hyun (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Kim, Koth-Bong-Woo-Ri (Institute of Fisheries Sciences/Pukyong National University)
Kim, Min-Ji (Institute of Fisheries Sciences/Pukyong National University)
Kang, Bo-Kyeong (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Bark, Si-Woo (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Pak, Won-Min (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Kim, Bo-Ram (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Park, Hong-Min (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Im, Moo-Hyeog (Division of Hazardous Substances Analysis, Daegu Food & Drug Administration)
Ahn, Dong-Hyun (Department of Food Science & Technology/Institute of Food Science, Pukyong National University)
Publication Information
Microbiology and Biotechnology Letters / v.42, no.1, 2014 , pp. 82-88 More about this Journal
Abstract
Atopic dermatitis (AD) is a common chronic inflammatory disease preceding the development of allergic disorders. The aim of this study was to evaluate the effect of Sargassum micracanthum ethanol extract (SMEE) on AD. AD was induced by spreading 2,4-dinitrochlorobenzen (DNCB) on the back sides of BALB/c mice. The efficacy of SMEE was tested by observing the skin clinical severity score, proliferations of Raw 264.7 cells and the secretion of cytokines and IgE. The secretion of IL-4, and IgE was significantly decreased by SMEE in a dose dependent manner, while IFN-${\gamma}$ was increased. In addition, SMEE alleviated the AD symptoms better when compared to the positive controls. In conclusion, these results suggest that SMEE has an inhibitory effect on AD, and may serve as a useful biomaterial for the development of cosmeceuticals.
Keywords
Sargassum micracanthum; atopic dermatitis; IgE; skin severity score;
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