• 한국한의학연구원논문집
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• 제14권3호
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• pp.173-182
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• 2008

"EuiBangShinGam" is a classic on oriental medicines written by Han Byung Lyun with the pen name Shin Oh in 1913. It was written under the base of the writer's own experience as well as in the light of 36 other classics on oriental medicines such as "DongEuiBoGam", Introduction to Medicine, and Complete Works of Jingyue. In an attempt to avoid difficult theories and list only the essential informations and formulas for clinical purposes, it attained its own characteristics of not only reorganizing DongEuiBoGam in a pragmatic way but also explaining diseases classified in western medicines in oriental medicines' point of view as well as suggesting medicine formulas regarding such explanations. As a result, it is a complete and efficient medical classic through which one can gain knowledge in both classic oriental medicines and combination of western and oriental medicines. Its special features are making a separate chapter for cholera and phthisis, which is also a contagious disease, and trying in the chapter to explain the disease s in words of oriental medicines; listing details of nine major epidemic and matching them with the diseases known in oriental medicines: and recording a case of enforcing sterilization and preventive injection against contagious diseases. Han Byung Lyun, the writ er of the book, was born in northern province of Ham Gyoung, Woong Bu, and the date of death is unknown. He is one of the eight members who conceived and started the idea of organizing the Organization of Practioners of Oriental Medicines, which was a nationwide organization under the motive of restoring Oriental Medicines against the policy under the colonial government of Japan. Living a era of Japanese Imperialism, he stressed the need to accept western medicines if its beneficial to oriental medicines in order to develop oriental medicines for progressive causes. This reflects that he was a person who tried in various ways to extend oriental medicines to another level by facing up to the reality and coming up with a measure to cope up with it. In fact, he was a oriental medicine doctor who tried to protect oriental medicines by founding academic organizations, publishing academic magazines, and writing himself many papers related to oriental medicines. EuiBangShinGam can he summarized as a classic on traditional korean medicine through which one can find out about realities of Japan Imperialism and the attempts of oriental medicine practitioners under the colonial policies of Japan to make oriental medicines more developed by adding one's own thoughts as well as keeping the old, and adjusting to such situations.

• 한방재활의학과학회지
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• 제27권3호
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• pp.61-70
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• 2017

Objectives The purpose of this review is to analyse the trend in papers related with Korean Medicine Treatment after musculoskeletal disorder surgery. Methods We reviewed Korean Medicine papers by searching Korean web databases 'Korea Traditional Knowledge Portal', 'Scientific and Technological Information Integration Service (NDSL)', 'Academic Research Information Service (RISS)', 'Korea Medical Informati on Portal (OASIS)'. We classified the papers by the year of publishment, the title of journals, the type of study, surgery region, chief complain after surgery, main treatment, periods after surgery, assessment for outcomes. Results 1. Korean Medicine treatment after musculoskeletal disorder surgery has received more attention than in the past and there are attempts to do various studies besides the case reports. 2. 41 research papers were divided in to 3 original articles, 3 review articles, 35 case reports. But almost presented a low level of evidence. 3. Pain was the most common symptom after the musculoskeletal disorder surgery. Pain should be the primary goal of Korean rehabilitation treatment after musculoskeletal disorder surgery. 4. Assessment tools for outcome were concentrated in questionnaries, VAS and NRS. In order to evaluate better, it is necessary to evaluate the overall condition of the patient such as the quality of life evaluation and patient satisfaction. Conclusions In this study, we expect that the development and clinical application of Korean rehabilitation treatment program after musculoskeletal disorder surgery will be actively pursued.

• Tuberculosis and Respiratory Diseases
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• 제41권5호
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• pp.568-573
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• 1994

저자들은 급성 기관지 천식환자에서 치료제로 사용하는 hydrocortisone을 투여 후 유발된 기관지 수축이 발생한 예를 경험 하였기에 문헌고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제46권5호
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• pp.729-734
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• 1999

저자들은 객혈을 주소로 내원한 35세의 남자 환자에서 기관지경, 식도내시경 및 식도조영술로 기관지확장증에 의한 식도기관지루를 진단하고, 수술적 치료를 시행한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 인간행동과 음악연구
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• 제17권1호
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• pp.1-24
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• 2020

본 연구의 목적은 음악치료 인턴들의 치료적 노래만들기 경험을 심층 탐구하는 것이다. 이를 위해 음악치료 인턴 다섯 명을 대상으로 경험적 음악치료 집단의 일환으로 치료적 노래만들기 워크샵을 240분씩 총 2회 진행한 후, 포커스 그룹 인터뷰를 실시하고 그들의 경험에 대한 자료를 수집하였다. 본 자료를 Braun & Clarke(2006)의 방법으로 주제분석하여, 총 6개의 주제와 18개의 하위 주제를 도출하였다. 6개의 주제는 '치료적 노래만들기에 대한 선입견', '의미있는 작사 과정', '작곡에서의 도전적 경험', '치료적 노래만들기 기법의 구조성 경험', '음악을 통한 자기인식의 발전', '집단작업을 통한 관계적 경험'으로 나타났다. 음악치료 인턴들은 치료적 노래만들기의 단계적 구조를 통해 집단의 다양한 의견을 조율하고 소통하면서 자신들의 이야기를 하나의 노래로 완성하였다. 이를 통해 자신들의 약점이라 느꼈던 작곡에 대한 부담감을 극복하고, 스스로의 욕구와 필요성을 인식하며 개인적 성장을 경험할 수 있었다. 결과적으로, 본 연구에 참여한 음악치료 인턴은 치료적 노래만들기 과정에 참여하면서 인턴훈련 과정에서 직면하는 도전을 규명할 수 있었고 더 나아가 개인적 성장과 전문가로서의 성장을 도모할 수 있었다는 점에서 본 연구의 의의가 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7351-7355
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• 2014

Background: Laryngeal carcinogenesis is a multifactorial process that has not been fully elucidated. Despite extensive research, reliable markers with diagnostic and prognostic value are still lacking. It was recently reported that an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) may correlate with an increased risk of recurrence, tumor aggressiveness and poorer prognosis in various malignancies. The aim of this study was to examine whether NLR could be used as an inflammatory marker to differentiate laryngeal squamous cell carcinoma (LSCC) patients from benign laryngeal lesion (BLL) and precancerous laryngeal lesion (PLL) patients. Materials and Methods: This retrospective study was performed on 209 patients admitted to a tertiary referral center with laryngeal lesions and undergoing biopsies to establish their histopathological diagnosis. We reviewed the patient files for their clinical, histopathological and laboratory data. The patients were divided into three groups according to their histopathological findings, as BLL, PLL and LSCC groups. The patients in the PLL group were also divided into three subgroups as mild, moderate and severe dysplasia/carcinoma in situ (CIS) subgroups. The groups were compared for NLR and the other laboratory data. Results: The mean NLRs of the BLL, PLL and the LSCC groups were $2.12{\pm}0.86$, $2.32{\pm}0.68$ and $3.46{\pm}1.51$, respectively, and the difference was statistically significant (p=0.001). The mean NLRs of the patients with PLL and LSCC were significantly higher than the patients with BLL (p=0.031 and p=0.001, respectively). The mean NLRs were similar among mild dysplasia, moderate dysplasia and severe dysplasia / CIS groups (p>0.05). Conclusions: To our knowledge, this is the first study investigating NLR in BLL, PLL and LSCC. NLR is an inexpensive, reproducible and widely available blood test, and could be a useful inflammatory marker to differentiate LSCC from BLL and PLL.

• Journal of Ginseng Research
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• 제40권2호
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• pp.160-168
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• 2016

Background: Ginseng (Panax ginseng Meyer) is a well-characterized medicinal herb listed in the classic oriental herbal dictionary as "Shin-nong-bon-cho-kyung." Ginseng has diverse pharmacologic and therapeutic properties. Black ginseng (BG, Ginseng Radix nigra) is produced by repeatedly steaming fresh ginseng nine times. Studies of BG have shown that prolonged heat treatment enhances the antioxidant activity with increased radical scavenging activity. Several recent studies have showed the effects of BG on increased lipid profiles in mice. In this study report the effects of water and ethanol extracts of BG on hypercholesterolemia in rats. To our knowledge, this is the first time such an effect has been reported. Methods: Experiments were conducted on male Sprague Dawley rats fed with a high-cholesterol diet supplemented with the water and ethanol extracts of BG (200 mg/kg). Their blood cholesterol levels, serum white blood cell levels, and cholesterol-metabolizing marker genes messenger RNA (mRNA) expression were determined. Liver and adipose tissues were histologically analyzed. Results: We found that BG extracts efficiently reduced the total serum cholesterol levels, low-density lipoprotein (LDL) levels with increased food efficiency ratio and increased number of neutrophil cells. It also attenuated the key genes responsible for lipogenesis, that is, acetyl-coenzyme A (CoA) acetyltransferase 2, 3-hydroxy-3-methyl-glutaryl-CoA reductase, and sterol regulatory element-binding protein 2, at the mRNA level inside liver cells. Furthermore, the BG extract also reduced the accumulation of fat in adipose tissues, and inhibited the neutral fat content in liver cells stained with hematoxylin and eosin and oil red O. Conclusion: Administration of BG extracts to Sprague Dawley rats fed with high-cholesterol diet ameliorated hypercholesterolemia, which was mediated via modulation of cholesterol-metabolizing marker genes. This data throw a light on BG's cardioprotective effects.

• 한국임상수의학회지
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• 제30권5호
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• pp.333-338
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• 2013

우리는 한국의 서울에 있는 다른 지역에 사는 길 고양이와 집 고양이의 범백혈구감소증 바이러스의 유병률을 조사하였다. 혈액 샘플은 200마리 고양이 (길 고양이 100마리와 집 고양이)에서 수집하였으며 모든 샘플은 중합효소 반응검사를 실시하였다. 전체적인 고양이 범백혈구감소증 바이러스의 유병률은 2%이다. 검사를 통해 양성 고양이 중 3% (100 분의 3)은 길 고양이이며 1% (100분의 1)은 집 고양이였다. 고양이 백혈구감소증 바이러스의 발생은 성묘 (1살이상, 0.5%) 보다 자묘 (1살이내, 1.5%)에서 더 높았다. 건강한 고양이의 양성률은 1.8% (3/166)이며 아픈 고양이의 양성률은 2.2% (1/44)이다. 예방 접종한 고양이의 양성률은 1.3% (1/77)이었고 예방 접종하지 않은 고양이의 양성률은 2.3% (3/133)이다. 항체검사와 비교시 고양이 범백혈구 바이러스 항원의 검출은 길 고양이와 집 고양이의 현재 질병 감염 상태를 암시할 수 있다. 따라서 항원검사는 질병의 진단과 치료에 도움을 줄 수 있다. 결론적으로 우리의 연구는 현재까지 서울에서 고양이 범백혈구감소증 바이러스의 유병률을 평가한 적이 없었기 때문에 비교적 중요하다. 고양이 범백혈구감소증 바이러스의 유병률은 길 고양이와 어린 고양이에서 높았다. 따라서 고양이 범백혈구감소증 바이러스 발생을 예방하기 위해서는 적절한 예방접종과 감시가 중요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5775-5781
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• 2013

Background: The gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is the most common type of neuroendocrine neoplasm. We summarized data in our centre to investigate the clinicopathological features, diagnostic methods, therapeutic approaches and prognosis for this neoplasm to increase knowledge of this disease in Asian populations. Method: A total of 122 patients treated at Sun Yet-san Memorial Hospital of Sun Yat-sen University between January 2000 and December 2011 were analyzed retrospectively. Results: Pancreas was the most common site of involvement (65/122, 53.3%); this disease has no special symptoms; positive rates of chromogranin A (CgA) and synaptophysin (Syn) were 81.1% and 87.7%, respectively. The positive rate of Syn had statistical difference among the three grades, but not CgA. Some 68 patients had G1 tumors, 32 G2 tumors and 22 G3 tumors, and Chi-square test showed that higher grading was correlated with worse prognosis (${\chi}^2=32.825$, P=0.0001). A total of 32 patients presented with distant metastasis, and 8 cases emerged during following up. Cox proportional hazards regression modeling showed that the tumor grade (P=0.01), lymphatic metastasis (P=0.025) and distant metastasis (P=0.031) were predictors of unfavorable prognosis. The overall 5-year survival rate was 39.6%, the 5-year survival rate of G1 was 55.7%, and the G2 and G3 were 34.2% and 0%, respectively. Conclusions: The incidence of gastroenteropancreatic neuroendocrine tumors has risen over the last 12 years. All grades of these diseases metastasize readily, and further research regarding the treatment of patients after radical surgery is needed to prolong disease-free survival.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3437-3445
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• 2016

Background: There is an increasing concern in the role of microRNA (miRNA) in the pathogenesis of bone metastasis (BM) secondary to prostate cancer (CaP). In this exploratory study, we hypothesized that the expression of vinculin (VCL) and chemokine X3C ligand 1 (CX3CL1) might be down-regulated in clinical samples, most likely due to the post-transcriptional modification by microRNAs. Targeted genes would be up-regulated upon transfection of the bone metastatic prostate cancer cell line, PC3, with specific microRNA inhibitors. Materials and Methods: MicroRNA software predicted that miR-21 targets VCL while miR-29a targets CX3CL1. Twenty benign prostatic hyperplasia (BPH) and 16 high grade CaP formalin-fixed paraffin embedded (FFPE) specimens were analysed. From the bone scan results, high grade CaP samples were further classified into CaP with no BM and CaP with BM. Transient transfection with respective microRNA inhibitors was done in both RWPE-1 (normal) and PC3 cell lines. QPCR was performed in all FFPE samples and transfected cell lines to measure VCL and CX3CL1 levels. Results: QPCR confirmed that VCL messenger RNA (mRNA) was significantly down-regulated while CX3CL1 was up-regulated in all FFPE specimens. Transient transfection with microRNA inhibitors in PC3 cells followed by qPCR of the targeted genes showed that VCL mRNA was significantly upregulated while CX3CL1 mRNA was significantly down-regulated compared to the RWPE-1 case. Conclusions: The down-regulation of VCL in FFPE specimens is most likely regulated by miR-21 based on the in vitro evidence but the exact mechanism of how miR-21 can regulate VCL is unclear. Up-regulated in CaP, CX3CL1 was found not regulated by miR-29a. More microRNA screening is required to understand the regulation of this chemokine in CaP with bone metastasis. Understanding miRNA-mRNA interactions may provide additional knowledge for individualized study of cancers.