• 동의생리병리학회지
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• 제26권6호
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• pp.818-822
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• 2012

We in this paper propose a prognosis graph, analyzing prognoses of each pattern described in the Korean medicine literatures. This graph is represented as the integrated graphs about knowledge of patterns and their transitions in the prognoses, where a node becomes a pattern name and a edge becomes a transition between patterns, along with a condition with respect to cause or mechanism of the pattern. The knowledge of prognoses which a pattern is transit into another pattern can be identified at a glance by using this model. We also construct a upper-level prognosis graph, excluding five viscera and six entrails from the model. This upper-level prognosis graph contains the conceptual knowledge than clinical one so that it may be helpful to students and researchers in the Korean medicine fields.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2003년도 가을 학술발표논문집 Vol.30 No.2 (2)
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• pp.835-837
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• 2003

본 논문에서는 병원간의 정보를 교환하기 위한 목적으로 정의된 의료 분야의 표준기관인 HL7에서 제안하는 Clinical Document Architecture(CDA)문서를 관리하기 위한 시스템을 제안한다. CDA Manager라는 이 시스템은 각 병원의 관계형 데이터베이스인 CDA local repository에서 CDA문서를 저장, 검색, 수정의 기능을 제공한다. 본 논문에서는 XML로 기술된 CDA문서의 특성을 살려 테이블을 설계하고 검색속도를 향상시켰다.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2005년도 공동추계학술대회
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• pp.258-263
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• 2005

Haplotype-based analysis using high-density SNP markers have gained a great attention in evaluating genes in gene analysis and various clinical situations. However, there has been no research on disease diagnostic modeling based on SNPs analysis to our knowledge. The purpose of this study is to explore how knowledge discovery techniques are applied in medical informatics area and proposes a Case Based Reasoning (CBR) technique for diagnosis of gastric caner using Single Nucleotide Polymorphism(SNP).

• 대한한의정보학회지
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• 제11권2호
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• pp.40-48
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• 2005

Objective It is difficult medicine pass by prostatic barrier. so prostatis is charaterized as relatively incurable illness. Neverthless in chronic prostatis, there is improvement of symptom and blood test numberical index by hominis placenta herbal-acupunture. The purpose of this report is evaluate of improvement of symptom and blood test numberical index by hominis placenta herbal-acupunture Method We observed 2 chronic proststis patient for 6 months. It is evaluate of treatment effect by NIH-chronic prostatis symptom index(CPSI) and expressed prostatic secretion(EPS) per 1month. Result The hominis placenta herbal-acupunture therapy is effective to treat chronic proststis. NIH-CPSI and EPS WBC were decreased considrably.

• Journal of Ginseng Research
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• 제35권2호
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• pp.209-218
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• 2011

Ginseng has been used as a general tonic agent to invigorate the human body as an adaptogenic agent. In a previous report, we have shown that ginseng contains a novel glycolipoprotein called gintonin. The main function of gintonin is to transiently enhance intracellular free $Ca^{2+}$ $[Ca^{2+}]_i$ levels in animal cells. The previous method for gintonin isolation included multiple steps using organic solvents. In the present report, we developed a simple method for the preparation of crude gintonin from ginseng root as well as stem and leaf, which produced a higher yield of gintonin than the previous one. The yield of gintonin was 0.20%, 0.29%, and 0.81% from ginseng root, stem, and leaf, respectively. The apparent molecular weight of gintonin isolated from stem and leaf through sodium dodecyl sulfate polyacrylamide gel electrophoresis was almost same as that from root but the compositions of amino acids, carbohydrates or lipids differed slightly between them. We also examined the effects of crude gintonin from ginseng root, stem, and leaf on endogenous $Ca^{2+}$-activated $Cl^-$ channel (CaCC) activity of Xenopus oocytes through mobilization of $[Ca^{2+}]_i$. We found that the order of potency for the activation of CaCC was ginseng root > stem > leaf. The $ED_{50}$ was $1.4{\pm}1.4$, $4.5{\pm}5.9$, and $3.9{\pm}1.1$ mg/mL for root, stem and leaf, respectively. In the present study, we demonstrated for the first time that in addition to ginseng root, ginseng stem and leaf also contain gintonin. Gintonin can be prepared from a simple method with higher yield of gintonin from ginseng root, stem, and leaf. Finally, these results demonstrate the possibility that ginseng stem and leaf could also be utilized for ginstonin preparation after a simple procedure, rather than being discarded.

• Journal of Ginseng Research
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• 제35권2호
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• pp.191-199
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• 2011

The human ether-a-go-go-related gene (HERG) cardiac $K^+$ channels are one of the representative pharmacological targets for development of drugs against cardiovascular diseases such as arrhythmia. Panax ginseng has been known to exhibit cardioprotective effects. In a previous report we demonstrated that ginsenoside $Rg_3$ regulates HERG $K^+$ channels by decelerating deactivation. However, little is known about how ginsenoside metabolites regulate HERG $K^+$ channel activity. In the present study, we examined the effects of ginsenoside metabolites such as compound K (CK), protopanaxadiol (PPD), and protopanaxatriol (PPT) on HERG $K^+$ channel activity by expressing human a subunits in Xenopus oocytes. CK induced a large persistent deactivatingtail current ($I_{deactivating-tail}$) and significantly decelerated deactivating current decay in a concentration-dependent manner. The $EC_{50}$ for persistent $I_{deactivating-tail}$ was $16.6{\pm}1.3$ ${\mu}M$. In contrast to CK, PPT accelerated deactivating-tail current deactivation. PPD itself had no effects on deactivating-tail currents, whereas PPD inhibited ginsenoside $Rg_3$-induced persistent $I_{deactivating-tail}$ and accelerated HERG $K^+$ channel deactivation in a concentration-dependent manner. These results indicate that ginsenoside metabolites exhibit differential regulation on Ideactivating-tail of HERG $K^+$ channel.

• 인터넷정보학회논문지
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• 제18권5호
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• pp.55-60
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• 2017

The pulmonary function test (PFT) is an essential data source for evaluating the effect of drugs on the lungs or the status of lung function. However, the numeric values of PFT cannot be easily used for clinical studies without labor-intensive manual efforts, because PFTs are usually recorded as image files. This study was aimed at constructing a de-identified, open-access PFT database with various clinical information. For constructing the PFT database, optical character recognition (OCR), regular expression, and the parsing technique were used to extract alphanumeric data from the PFT images in a Korean tertiary teaching hospital. This longitudinal observational database contains 413,000 measurements of PFT from 183,000 patients.

• The Journal of Korean Physical Therapy
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• 제22권2호
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• pp.55-60
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• 2010

Purpose: The purpose of this study was to use the theory of planned behavior, past habit and moral obligation to better understand the behavior of physical therapists (PTs) and occupational therapists (OTs) in protecting the medical information of patients. Methods: We conducted a survey using self-writting questionnaires structured within the framework of the theory of planned behavior to understand to analyze information from 103 clinical PTs and OTs in their efforts to protect patient medical information. Results: The PTs and OTs' medical information protecting behavior was 2.85 mean points. That point failed to reach 1.0 points. Behavior intention was 3.83 mean points. That was judged to be improved. Behavioral intention was closely correlated with behavior, behavioral attitude, subjective norms, behavior control, and past habit. Variables related to the theory of planned behavior, attitude, subjective norms, and perceived behavior control all explained 50% of the behavioral intention of PTs and OTs regarding future divulgence of patient information. The past habits of PTs and OTs were also a significant predictor in explaining the behavioral intention to protect a patient's medical information (p<0.01). Conclusion: Revising the behavioral attitudes, subjective norms, perceived behavior control, and past habits of PTs and OTs helped improve their behavior regarding protection of the medical information of patents.

• Journal of Acupuncture Research
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• 제30권5호
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• pp.1-9
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• 2013

Objectives : The purpose of this study was to present clinical utility of therapeutic exercise on the neck and shoulder parts based on the movement system impairment syndrome(MSIS) as Dong-Qi therapy of the Dong-Si Acupuncture and was to examine which Dong-Si acupoints were most effective and non-invasive when performing therapeutic exercise of the MSIS. Methods : Totally eight therapeutic exercises correspondent to eight neck and shoulder MSIS were summarized and tabulated from the Diagnosis and Treatment of Movement Impairment Syndrome and Movement System Impairment Syndromes Of The Extremities, Cervical and Thoracic Spines by Sahrmann SA. Together with the MSIS summaries, acupuncture points and Dong-Qi therapy were summarized and tabulated from Yangweijiequanji 1 and Yangweijiequanji 2 by Yangweijie. According to the posture and movement of the MSIS exercise, effective and non-invasive acupoints were selected. Thereafter, clinical pilot study which five normal volunteers participated in were performed to examine whether these acupoints resulted in any side effects of acupuncture therapy such as pain and distortion of the needle during the MSIS exercises. Results : Through clinical pilot study, ZhongZi, ZhongXian, ZhengJin, ZhengZong and MuLiu in a sitting position, and HuaGuYi, ZhongZi and ZhongXian in a supine position were finally determined as safe and non-invasive Dong-Si acupoints to treat cervical pain. In terms of shoulder pain, ZuQianJin, ZuWuJin, HuaGuEr and JianZhong in a supine position, SiHuaZhong, ZuQianJin, ZuWuJin, QuLing, JianZhong, ShenGuan and JiuLi in a standing position, and ZuQianJin, ZuWuJin, HuaGuEr, QuLing and JianZhong in a prone position were finally accepted as safe and non-invasive Dong-Si acupoints. Conclusion : It is concluded that Dong-Si acupoints can be safely and non-invasively used together with therapeutic exercises of the MSIS to treat cervical and shoulder pains.

• 보건의료생명과학 논문지
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• 제11권2호
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• pp.191-196
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• 2023

본 연구는 COVID-19 시기에 보건계열 학생들의 임상실습 교육의 비대면 방향으로 전향하는 시기에 백신접종과 임상실습의 관련성을 살펴보고자 진행되었다. 임상실습은 보건계열 학생의 면허 필수 과목이다. 또한, 학생들이 졸업 후 임상실습의 경험이 그들의 전문직종에 중요한 부분을 차지한다. 연구결과 보건직에 취업하길 희망하는 학생의 대면 임상실습 정도가 희망하지 않은 학생보다 높게 나타났다(OR: 3.421, 95%CI: 1.333-8.775). 백신접종을 완료한 학생의 대면 임상실습이 높게 나타났다OR: 2.522, 95%CI: 1.017-6.254). 코로나19 상화에서 진행된 비대면 임상실습은 학생들에게 전염병의 감염우려로 전만적이 임상실습의 만족도가 낮게 나타났다. 또한, 취업 후 현장 업무에서도 불안하게 생각하였다. 이에 전염병 감염에 대한 불안을 해소할 수 있는 백신접종을 적극 지지하여 대면 임상실습을 실행하여 학생들의 전문직군의 역할을 향상 시킬 수 있을 것이다.