• Title/Summary/Keyword: clearing method

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Development of an Optical Tissue Clearing Laser Probe System

  • Yeo, Changmin;Kang, Heesung;Bae, Yunjin;Park, Jihoon;Nelson, J. Stuart;Lee, Kyoung-Joung;Jung, Byungjo
    • Journal of the Optical Society of Korea
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    • v.17 no.4
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    • pp.289-295
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    • 2013
  • Although low-level laser therapy (LLLT) has been a valuable therapeutic technology in the clinic, its efficacy may be reduced in deep tissue layers due to strong light scattering which limits the photon density. In order to enhance the photon density in deep tissue layers, this study developed an optical tissue clearing (OTC) laser probe (OTCLP) system which can utilize four different OTC methods: 1) tissue temperature control from 40 to $10^{\circ}C$; 2) laser pulse frequency from 5 to 30 Hz; 3) glycerol injection at a local region; and 4) a combination of the aforementioned three methods. The efficacy of the OTC methods was evaluated and compared by investigating laser beam profiles in ex-vivo porcine skin samples. Results demonstrated that total (peak) intensity at full width at half maximum of laser beam profile when compared to control data was increased: 1) 1.21(1.39)-fold at $10^{\circ}C$; 2) 1.22 (1.49)-fold at a laser pulse frequency of 5 Hz; 3) 1.64 (2.41)-fold with 95% glycerol injection; 4) 1.86 (3.4)-fold with the combination method. In conclusion, the OTCLP system successfully improved the laser photon density in deep tissue layers and may be utilized as a useful tool in LLLT by increasing laser photon density.

Review of the domestic research trends in the study of Korean herbal medicine with anti-inflammation effects (국내에서 연구된 항염 효능이 있는 한약재의 본초학적 분석)

  • Ha, Hee-Jung;Kim, Yun-Jung;Kweon, Kee-Tae;Kim, Jin-Ju
    • The Korea Journal of Herbology
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    • v.26 no.4
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    • pp.15-22
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    • 2011
  • Objective : This paper analyzed the research trend of the experiment papers where inflammation was treated based on the oriental herbs among the issued papers of many areas such as oriental medicine and pharmacy, etc. Method : All experiment papers on the oriental herbs have been searched with the keyword of 'inflammation' in the internet sites like KISTI, OASIS, etc., and then they are analyzed on the basis of the effective classification of Korean herbal medicine, the frequency of research on Korean herbal medicine, and so forth. Result & Conclusion : It is presumed that anti-inflammation, the concept of Western Medicine, is related to clearing away heat, the concept of Korean herbal medicine, because it is ascertained that the highest cases is kinds of Korean herbal medicine effectively classified as clearing away heat medicine in the research of anti-inflammation. Also, it is checked that a ginseng is the most researched among the 138 Korean herbal medicine.

Contrast Enhancement of Laser Speckle Contrast Image in Deep Vasculature by Reduction of Tissue Scattering

  • Son, Taeyoon;Lee, Jonghwan;Jung, Byungjo
    • Journal of the Optical Society of Korea
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    • v.17 no.1
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    • pp.86-90
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    • 2013
  • Various methods have been proposed for enhancing the contrast of laser speckle contrast image (LSCI) in subcutaneous blood flow measurements. However, the LSCI still suffers from low image contrast due to tissue turbidity. Herein, a physicochemical tissue optical clearing (PCTOC) method was employed to enhance the contrast of LSCI. Ex vivo and in vivo experiments were performed with porcine skin samples and male ICR mice, respectively. The ex vivo LSCIs were obtained before and 90 min after the application of the PCTOC and in vivo LSCIs were obtained for 60 min after the application of the PCTOC. In order to obtain the skin recovery images, saline was applied for 30 min after the application of the PCTOC was completed. The visible appearance of the tubing under ex vivo samples and the in vivo vasculature gradually enhanced over time. The LSCI increased as a function of time after the application of the PCTOC in both ex vivo and in vivo experiments, and properly recovered to initial conditions after the application of saline in the in vivo experiment. The LSCI combined with the PCTOC was greatly enhanced even in deep vasculature. It is expected that similar results will be obtained in in vivo human studies.

Predictive of Osteoporosis by Tree-based Machine Learning Model in Post-menopause Woman (폐경 여성에서 트리기반 머신러닝 모델로부터 골다공증 예측)

  • Lee, In-Ja;Lee, Junho
    • Journal of radiological science and technology
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    • v.43 no.6
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    • pp.495-502
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    • 2020
  • In this study, the prevalence of osteoporosis was predicted based on 10 independent variables such as age, weight, and alcohol consumption and 4 tree-based machine-learning models, and the performance of each model was compared. Also the model with the highest performance was used to check the performance by clearing the independent variable, and Area Under Curve(ACU) was utilized to evaluate the performance of the model. The ACU for each model was Decision tree 0.663, Random forest 0.704, GBM 0.702, and XGBoost 0.710 and the importance of the variable was shown in the order of age, weight, and family history. As a result of using XGBoost, the highest performance model and clearing independent variables, the ACU shows the best performance of 0.750 with 7 independent variables. This data suggests that this method be applied to predict osteoporosis, but also other various diseases. In addition, it is expected to be used as basic data for big data research in the health care field.

Real-time Stability Assessment and Energy Margin Estimation using Fuzzy (퍼지를 이용한 실시간 안정도 판별과 에너지 마진의 추정)

  • Choi, Won-Chan;Kim, Soo-Nam;You, Seok-Ku
    • Proceedings of the KIEE Conference
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    • 1999.07c
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    • pp.1239-1241
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    • 1999
  • In this paper, we propose real time transient stability assessment and energy margin estimation using fuzzy approximate reasoning. The proposed method used rotor angle, kinetic energy and acceleration power of generators at clearing time as fuzzy input. In order to calculate energy margin in transient energy function (TEF), we obtained controlling unstable equilibrium point (UEP) using mode of disturbance procedure (MOD). The proposed algorithm is tested on 4-machine, 6-bus, 7-line power system to prove of effectiveness.

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Countermeasure of Voltage Sag in Radial Power Distribution System using Load Transfer Switching (부하 절환 스위칭을 이용한 방사상 배전계통에서의 순간전압강하 대책)

  • Yun, Sang-Yun;Oh, Jung-Hwan;Kim, Jae-Chul
    • The Transactions of the Korean Institute of Electrical Engineers A
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    • v.49 no.11
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    • pp.558-565
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    • 2000
  • In this paper, we propose a method for mitigating for mitigating the effect of voltage of voltage sag in radial power distribution systems using load transfer switching (LTS). The term of LTS is defined that the weakness load points for voltage sag transfer to the alternative source during the fault clearing practices. The sequenced of proposed LTS method is divided into the search of weakness points for voltage sag using the risk assessment model and transfer behavior of weakness points. The search of weakness point is carried out using the risk assessment model of voltage sag and Monte Carlo simulation method and the historical reliability data in Korea Electric Power Corporation (KEPCO) are also used. Through the case studies, we verify the effectiveness of proposed LTS method and present the searching method of effective application points of LTS method using the risk assessment model.

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A literature study on the nasal stuffiness (鼻塞의 病因.病機.治療에 對한 文獻的 考察)

  • Yun, Chan-ho;Roh, Sek-seon
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.12 no.1
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    • pp.295-312
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    • 1999
  • A literature study on the nasal stuffiness, the results are as follows. 1. The pathogenic factors nasal stuffiness are wind-cold, cold, fire-heat, heart & lung disease, deficiency of lung-energy and spleen & stomach disease caused by internal damage. 2. The method on the external treatment of nasal stuffiness are obstructive method, blowing method and pouring method, obstructive method used many. 3. The method on the internal treatment of nasal stuffiness are diaphoretic therapy, clearing away heat & toxic materials and warming the lung & invigorating the spleen. 4. You-taek-tong-gue-tang is used in nasal stuffness. 5. Herba Asari, Radix Angelicae Dahuricae, Flos Magnaliae, Fructus Xanthii, Rhizama Acori Graminei, Herba Menthae, Zanthoxyli Fructus and Spina Gleditsiae are used in nasal stuffness.

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Load Transfer Switching for Reducing the Voltage Sag's Effect in Radial Power Distribution System (순간전압강하 저감을 위한 방사상 배전계통에서의 부하 절환 스위칭)

  • Yun, Sang-Yun;Kim, Jae-Chul
    • Proceedings of the KIEE Conference
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    • 2000.11a
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    • pp.208-210
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    • 2000
  • In this paper, we present a method for mitigating the effect of voltage sag in radial power distribution systems using load transfer switching (LTS). The term of LTS is defined that the weakness load points for voltage sag transfer to the alternative source during the fault clearing practices. The sequences of proposed LTS method is divided into the search of weakness points for voltage sag using the risk assessment model and transfer behavior of weakness points. Through the case studies, we verify the effectiveness of proposed LTS method and present the searching method of effective application points of LTS method using the risk assessment model.

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A Literertual study of Gastric Cancer-(focus on the journal of oriental medicine since 1990)- (위암(胃癌)에 대(對)한 문헌고찰(文獻考察)-(근래(近來) 잡지(雜誌)를 중심(中心)으로)-)

  • Kong, Hyeon-Sig;Rhu, Bong-Ha;Park, Dong-Won;Ryu, Ki-Won
    • The Journal of Internal Korean Medicine
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    • v.15 no.1
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    • pp.210-226
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    • 1994
  • This study was performed to investigate the gastric cancer through the journal of oriental medicine since 1990. The following results have been obtaied. 1. The Herb-medication in Gastric Cancer was composed to the oral-method and the injection-method. but, the oral-method was major and the injection-method rarely used. 2. In the treatment of Gastric Cancer, the Herb-medication that copperated with the operation and chemotherahpy was much more used 3. In the oriental medical therapy, the therapy for invigoration(補法) was common used. and the therapy for regulating vital energy(理氣), removing blood stasis(祛瘀), relieving pain(止痛), clearing away the heat evil (淸熱), removing toxic material(解毒) was used. 4. The following Herb was much more used to threat the Gastric Cancer.

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A Method for Transient Stability Assessment using Maximum Generator Angle (발전기 최대 위상각을 이용한 전력계통 과도안정도 평가)

  • Lee, Duck-Jae;Jang, Gil-Soo;Kwon, Sae-Hyuk;Kim, Tae-Kyun;Choo, Jin-Boo
    • Proceedings of the KIEE Conference
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    • 2003.11a
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    • pp.239-241
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    • 2003
  • The time domain simulation method of transient stability presents accuracy and reliability, but it demands much computational time. Therefore it is necessary to filter out very stable and very unstable cases from a large set of contingencies. Following a disturbance, the shape and magnitude of representative generator angle which is most increased after fault clearing are the measure of transient stability. This paper propose a method that is not a calculation of the exact CCT of contingency, but a fast assessment of transient stability. Also it can help operators identify transient stability immediately without analyzing the graphical results. The proposed method is applied to the KEPCO system. The PSS/E is used as a time domain simulation engine by IPLAN.

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