• IMMUNE NETWORK
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• v.11 no.6
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• pp.412-415
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• 2011

Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the $H-2K^b$-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.306.2-306.2
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• 2002

The main targets for the immunosuppressive calcineurin inhibitors. tacrolimus (FK-506) and cyclosporine A (CsA). have been considered to be activated T cells. but not antigen presenting cells (APCs). In the present study. we examined the effects of these drugs on the MHC-restricted presentation of exogenously added antigen. ovalbumin (OVA). in dendritic cells (DCs). Particulate form of OVA was efficiently captured. processed and presented on class I MHC molecules (cross-presentation) as well as on class II MHC molecules. (omitted)

• The korean journal of orthodontics
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• v.26 no.1 s.54
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• pp.95-104
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• 1996

This study was undertaken to investigate the correlations bite force and the electromyographic activities of masticatory muscle in deepbite, using the T-Scan system and electromyograph. The subjects of this study consisted of two groups ; one of 20 individuals with normal occlusion, the other group of 30 with deepbite. The deepbite was composed of Class I deepbite(male 9, female 7) and Clas II div. 1 deepbite(male 8, female 6). The obtained results of this study were as follows : 1. The maximum bite force was 155.93 N in normal occlusion, 165.11 N in Class I deepbite group, 111.55 N in Class II div. 1 deepbite group. 2. The greater !he number of tooth contacts, the more the bite force increased in all groups. 3. During maximum clenching, masseter and ant. temporailsmuscle activity of normal and Class I deepbite group were significantly higher than that of Class II div. 1 deepbite group, and the activity of masseter muscle was higher than that of ant. temporalis muscle in all groups. 4. The greater the maximum bite force, the more the muscle activities increased in all groups.

• The korean journal of orthodontics
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• v.10 no.1
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• pp.71-79
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• 1980

The purpose of this study was (1) to determine the prevalence of some causes by which dental occlusion might be affected , (2) to determine the prevalence of malocclusion, and types of molar, vertical incisor and horizontal incisor relationships, and (3) to examine the sex difference in the prevalence ratios, and (4) to determine the between-examiner differences in assessing types of dental occlusion. The material consisted of 1281 males and 811 females, total 2091 persons, aged 17 to 21 years. Two examiners who were graduate students in the orthodontic course, examined independently dental occlusion of the material. Before calculating the statistics, the subjects consisted of 156 mates and 164 females, total 320 persons, haying any one or more causes suspected to affect dental occlusion, was eliminated. Then the remained subjects, 1124 males and 647 females, total 1771 persons, were assessed. The results were as follows 1. The prevalence of some causes by which dental occlusion might be affected was 15.32 per cent. The missing rate of any one or more first molars was 8.85 percent, that of any one or more teeth positioned anterior to the first molar was 3.83 per cent. The prevalence of crossbite of the first molar was 0.48 per cent, that of retained primary teeth was 0.77 percent, and that of orthodontic treatment was 0.43 per cent. 8. The rate of between-examiner difference was 12.53 per cent in assessing the types of molar relationship, 18.86 percent in assessing the types of horizontal incisor relationship, and 26.37 percent in assessing the types of horizontal incisor relationship. 3. There was no sex difference in the prevalence ratios of the types of molar relationship. The prevalence of Class I molar relationship was 80.91 percent, that of Class II was 5,03, that of Class II subdivision was 4.01, Percent, that of Class III was 5.99 percent and that of Class III subdivision was 4.07 percent. 4. In the prevalence of the types of horizontal incisor relationship, there were no sex differences except that of Class II division 2. The prevalence of Class I horizontal incisor relationship was 73.12 percent, that of Class II division t was 12.03 percent, that of Class II division 2 was 6.58 percent in male and 4.33 percent in female, and that of Class III was 9.09 percent. 5. In the prevalence of the types of vertical incisor relationship, there were no sex differences except that of deep bite, The prevalence of open bite was 2.20 per cent, that of edge-to-edge bite was 9.15 percent, that of normal bite was 76,34 percent, and that of deep bite was 14.15 percent in male and 9.12 percent in female. 6. There was no sex difference in the prevalence of malocclusion the prevalence of malocclusion was 82.67 percent and that of normal occlusion was 17.33 percent. 7. There was a tendency that when Class I molar relationship changed to Class II, incisor relationships were to be larger overjet or upright upper incisors and deep bite, but when that changed to Class III molar relationship, these were to be cross bite and openbite.

• Childhood Kidney Diseases
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• v.7 no.2
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• pp.150-156
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• 2003

Purpose : Efforts to predict the clinicopathological outcome of IgA nephropathy have been made but have yielded conflicting results and have not helped in deciding the appropriate timing of the renal biopsy. In this study, we reviewed the predictive factors of clinicopathological outcome for finding out the criteria of renal biopsy timing of IgA nephropathy. Methods : Forty children diagnosed with biopsy proven IgA nephropathy at Wonju Christian Hospital were studied retrospectively, based on medical records. Results : Among 39 patients, 2 children progressed to higher serum creatinine level. One of them reached to the end stage renal disease within 2 year 7 months. According to WHO histopathological classification, there were 15 cases of class I, 14 cases of class II, 7 cases of class III, and 3 cases of class IV. In the mild histological classes(class I, II), gross hematuria was shown in 23 out of 29 children(P=0.02). In the severe histological classes(class III, IV), gross hematuria was noted in 4 out of 10(P>0.05). The tubulointerstitial changes were grade 1 in 24 cases, grade 2 in 4 cases, grade 3 in 8 cases, and grade 4 in 3 cases. With an increase in the tubulointerstitial grade, the 24 hour urine protein/albumin ratio increased. Serum creatinine less than 0.79 mg/dL could predict the lower grade(grade 1 and 2) of tubulointerstitial changes. But serum creatinine greater than 1.13 mg/dL could predict the higher grade(grade 3 and 4) of tubulointerstitial changes. In children with gross hematuria(n=27), serum creatinine was lower(0.78 vs 1.09 mg/dL, P=0.027), serum IgA was higher(316.3 vs 198.8 mg/dL), and the cases of lower WHO classification(I and II) were more common(23 vs 4, P=0.029) than the children with microscopic hematuria. Conclusion : Serum creatinine less than 0.79 mg/dL, macroscopic hematuria, and higher 24 hour urine protein/albumin ratio would predict the lower grade glomerulo tubulointerstitial lesion in IgA nephropathy and could be used as the criteria delaying the renal biopsy.

• The korean journal of orthodontics
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• v.22 no.3 s.38
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• pp.691-701
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• 1992

Over recent 20 years, with socioeconomic development and change of recognition of the population, more people are concerned about their health and appearance. To obtain the change of frequency of malocclusion and the demand for orthodontic treatment, with this trend, 2460 freshmen and students of Yonsei Univ. in 1991, aged from 18 to 21 were examined excluding 187 students who have history of orthodontic treatment, 86 students who are undergoing treatment, 39 students who have too much missing teeth to classify. After analize the frequency of malocclusion and the demand for orthodontic treatment, following results was obtained. 1. Sex ratio in the prevalence of malocclusion was $91.7\%/90.8\%$, male to female, so there was no sex predilection. 2. With regard to Angle's Classification, each percentage of Class I, Class II div. 1, Class II div. 2 and Class III was $61.6\%,\;11.3\%,\;1.9\%\;and\;16.7\%$. 3. Of Class I malocclusion, percentage of crowding was 53.2, this occupied the largest part of single findings and prevalent findings in combinations were also crowding - crossbite and crowding - Protrusion. 4. Of Class I malocclusion, over the portion of$95\%$, Bialveolar Protrusion have arised alone. 5. The distribution of Demands for orthodontic treatment of malocclusion were $41.3\%$ in males, and $51.3\%$ in females.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.9 no.6
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• pp.52-62
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• 2006

The flora of vascular plants around Chunji and Sochunji in Mt. Baekdu was listed 120 taxa; 31 families, 81 genera, 97 species, 1 subspecies, 21 varieties and 1 form. About endangered wild plants, 2 taxa (Paeonia obovata, Rhododendron aureum) are in class II. 12 taxa were listed as rare and endangered plants; Disporum ovale, Lilium davuricum, Saxifraga punctata, Rosa marretii, Cnidium tachiroei, Bupleurum euphorbioides, Halenia corniculata, Gentiana jamesii, Pedicularis verticillata, etc. 10 taxa were listed as Korean endemic plants; Lilium amabile, Aconitum pseudolaeve var. erectum, Oxytropis anertii for. alba, Valeriana officinalis var. latifolia, Cardamine resedifolia var. morii, Homopteryx nakaiana, Saussurea alpicola, Ligularia jamesii, etc. Specific plants by floral region were total 47 taxa; 3 taxa (Paeonia obovata, Rhododendron aureum, Pedicularis verticillata) in class V, 15 taxa (Lycopodium annotinum, Alnus maximowiczii, Saxifraga punctata, Petasites saxatile, etc.) in class IV, 5 taxa (Spiraea salicifolia, Sanguisorba hakusanensis, Acer ukurunduense, Campanula glomerata var. dahurica, Cacalia adenostyloides) in class III, 18 taxa (Lycopodium chinense, Disporum ovale, Ceologlossum viride var. bracteatum, Betula ermani, Aruncus dioicus var. kamtschaticus, Filipendula multijuga, Geranium eriostemon, Cnidium tachiroei, Ligularia stenocephala, etc.) in class II, 6 taxa (Pinus koraiensis, Cimicifuga simplex, Sanguisorba tenuifolia var. alba, Senecio nemorensis, Cacalia hastata subsp. orientalis, Cirsium pendulum) in class I. Peculiar flora around Chunji is thought to be made by the environmental factors such as wind, temperature and rainfall that influence the plants' growth.

• The korean journal of orthodontics
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• v.17 no.1
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• pp.107-117
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• 1987

The study was designed to examinate the discrimination rate of 4 antero-posterior cephalometric measurements from Angle's malocclusion groups. The material was 246 cephalometric radiographs taken from 42 Normal occlusions, 83 Class I malocclusions, 64Class II Division I malocclusions, 57Class III malocclusions. ANB angle, APDI, AB/OP angle, and Wits appraisal as measurements of antero-posterior skeletal relationship were measured on the cephalometric radiographs and statistically analyzed by the Canonical Discriminant Function. The results of this study were as follows: 1. ANB angle, APDI, AB/OP angle, and Wits appraisal were clinically useful measurements for the evaluation of the antero-posterior skeletal relationship. 2. The rates that discriminate actual malocclusion groups were $77.45\%$ in Wits appraisal, $74.02\%$ in AB/OP angle, $71.08\%$ in ANB angle, and $70.59\%$ in APDI. 3. The discrimination rate of actual Class III malocclusion show above $93\%$, but actual Class I and Class II division I malocclusions were relatively low.

• The korean journal of orthodontics
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• v.42 no.1
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• pp.23-31
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• 2012

Objective: The purpose of this study was to determine the soft tissue thickness of male and female orthodontic patients with different skeletal malocclusions. Methods: Soft tissue thickness measurements were made on lateral cephalometric radiographs of 180 healthy orthodontic patients with different skeletal malocclusions (Class I: 60 subjects, Class II: 60 subjects, Class III: 60 subjects). Ten measurements were analyzed. For statistical evaluation, one-way ANOVA and Kruskal-Wallis tests were performed. Least significant difference (LSD) and Dunnet T3 post hoc tests were used to determine the individual differences. Results: Soft tissue thicknesses were found to be greater for men than for women. Statistically significant differences among the skeletal groups were found in both men and women at the following sites: labrale superius, stomion, and labrale inferius. The thickness at the labrale superius and stomion points in each skeletal type was the greatest in Class III for both men and women. On the other hand, at the labrale inferius point, for both men and women, soft tissue depth was the least in Class III and the greatest in Class II. Conclusions: Soft tissue thickness differences among skeletal malocclusions were observed at the labrale superius, stomion, and labrale inferius sites for both men and women.

• Journal of environmental and Sanitary engineering
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• v.9 no.2
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• pp.41-49
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• 1994

Water- borne infectious diseases can be acquired by contact with contaminated water or by ingestion of contaminated water. There are many water- borne infectious agents such as bacteria, virus, and parasite. Among many of water- borne infectious diseases, health authorities of Korean government has particularly intensified to prevent and control typhoid fever(class I ), shigellosis(class I ), cholera(class I ), paratyphoid fever(class I), amebiasis(class II ) and leptospirosis(euivalent to class II ) under the communicable disease control law. Water- borne disease Prevention and control guideline itself has been also well provided by the health authorities. However, in practical public health point of view, there are still many problems remained to be solved out; no prospective investigation project to survey water borne infectious diseases under the national disease prevention and control programmes, incredible statistic data of annual notifiable disease report frequent appearance and varieties of drug resistance water- borne infectious agents, little cooperation and information- exchange system in between the related government authorities( the health authorities, the environment sanitation authorities and the food hygiene authorities) which should be closely collaborated, lack of health consciousness of the people, necessity of evaluation and Hndification on to the outcomes of performed health activities and programmes, neglect activities for water quality investigation, shortage of expertise and human resources in the related field, and poor investment of the government budget to develope and improve public health and sanitation field. In order to prevent and control water- borne infectious diseases effectively, it is emphasized that all the above indicated should be considered and performed to improve under the national health and sanitation development programmes.