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http://dx.doi.org/10.4110/in.2011.11.6.412

Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing  

Park, Sun-Im (College of Pharmacy, Chungbuk National University)
Im, Sun-A (College of Pharmacy, Chungbuk National University)
Kim, Ki-Hyang (College of Pharmacy, Chungbuk National University)
Lee, Chong-Kil (College of Pharmacy, Chungbuk National University)
Publication Information
IMMUNE NETWORK / v.11, no.6, 2011 , pp. 412-415 More about this Journal
Abstract
Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the $H-2K^b$-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.
Keywords
Hypocrellin A; MHC-restricted antigen presentation; Immunomodulator;
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