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The Korean Association of Immunobiologists (대한면역학회)
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Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing

  • Park, Sun-Im (College of Pharmacy, Chungbuk National University) ;
  • Im, Sun-A (College of Pharmacy, Chungbuk National University) ;
  • Kim, Ki-Hyang (College of Pharmacy, Chungbuk National University) ;
  • Lee, Chong-Kil (College of Pharmacy, Chungbuk National University)
  • Received : 2011.10.11
  • Accepted : 2011.11.01
  • Published : 2011.12.31
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Abstract

Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the $H-2K^b$-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.

Keywords

References

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