Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.306.2-306.2
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- 2002
Tacrolimus and cyclosporine A inhibit both class I-restricted presentation pathway and class II- restricted presentation pathway of exogenous antigen.
- Yang, In-Ho (College of Pharmacy, Chungbuk National University) ;
- Lee, Young-Ran (College of Pharmacy, Chungbuk National University) ;
- Kim, Hyeon-Seon (College of Pharmacy, Chungbuk National University) ;
- Lee, Jae-Kwon (College of Pharmacy, Chungbuk National University) ;
- Im, Sun-A (College of Pharmacy, Chungbuk National University) ;
- Li, Hong (College of Pharmacy, Chungbuk National University) ;
- Han , Kun (College of Pharmacy, Chungbuk National University) ;
- Song, Suk-Gil (College of Pharmacy, Chungbuk National University) ;
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Lee, Chong-Kil
(College of Pharmacy, Chungbuk National University)
- Published : 2002.10.01
Abstract
The main targets for the immunosuppressive calcineurin inhibitors. tacrolimus (FK-506) and cyclosporine A (CsA). have been considered to be activated T cells. but not antigen presenting cells (APCs). In the present study. we examined the effects of these drugs on the MHC-restricted presentation of exogenously added antigen. ovalbumin (OVA). in dendritic cells (DCs). Particulate form of OVA was efficiently captured. processed and presented on class I MHC molecules (cross-presentation) as well as on class II MHC molecules. (omitted)
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