• The Korean Journal of Physiology and Pharmacology
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• v.19 no.3
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• pp.257-262
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• 2015

It is well known that cigarette smoke can cause erectile dysfunction by affecting the penile vascular system. However, the exact effects of nicotine on the corpus cavernosum remains poorly understood. Nicotine has been reported to cause relaxation of the corpus cavernosum; it has also been reported to cause both contraction and relaxation. Therefore, high concentrations of nicotine were studied in strips from the rabbit corpus cavernosum to better understand its effects. The proximal penile corpus cavernosal strips from male rabbits weighing approximately 4 kg were used in organ bath studies. Nicotine in high concentrations ($10^{-5}{\sim}10^{-4}M$) produced dose-dependent contractions of the corpus cavernosal strips. The incubation with $10^{-5}M$ hexamethonium (nicotinic receptor antagonist) significantly inhibited the magnitude of the nicotine associated contractions. The nicotine-induced contractions were not only significantly inhibited by pretreatment with $10^{-5}M$ indomethacin (nonspecific cyclooxygenase inhibitor) and with $10^{-6}M$ NS-398 (selective cyclooxygenase inhibitor), but also with $10^{-6}M$ Y-27632 (Rho kinase inhibitor). Ozagrel (thromboxane $A_2$ synthase inhibitor) and SQ-29548 (highly selective TP receptor antagonist) pretreatments significantly reduced the nicotine-induced contractile amplitude of the strips. High concentrations of nicotine caused contraction of isolated rabbit corpus cavernosal strips. This contraction appeared to be mediated by activation of nicotinic receptors. Rho-kinase and cyclooxygenase pathways, especially cyclooxygenase-2 and thromboxane $A_2$, might play a pivotal role in the mechanism associated with nicotine-induced contraction of the rabbit corpus cavernosum.

• Journal of Digital Convergence
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• v.18 no.8
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• pp.169-177
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• 2020

The purpose of this study is to forecast the sales of convenience store flagship products with nonlinear characteristics and time series characteristics. According to the results, the sales of 'Ice Cup' began to increase from March, reached the highest value in summer, especially July and August, and then decreased, revealing a seasonal pattern. Cigarettes showed a seasonal pattern of higher sales in summer and lower sales in winter and was predicted to decrease in sales in the future. This study provides an academic implication in that it focused on the top-selling products that affected an increase in financial performance in a specific convenience store, a method that has been hardly adopted by the existing studies.

• Korean Journal of Community Nutrition
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• v.9 no.6
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• pp.695-705
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• 2004

The risks of the metabolic syndrome (MS) is known to be related to the dietary behavior. The objective of this study is to evaluate the association between the relative risks of MS and the dietary habit and to provide the ideal dietary habits for prevention of chronic disease of the middle-aged. Healthy subjects aged 40-64 years (male n=122, female n=173) were recruited throughout Seoul area. MS was defined according to NCEP-ATP III criteria except central obesity, and Asia-Pacific Area criteria for central obesity (2000) was adapted. Subjects were stratified into 3 groups according to the number of total risk factors:'MS group' was defined as the subjects who have three or more risk factors, 'Risk group' was defined as ones to have one or two risk factors, and 'Healthy group' defined as ones with no risk factor. In this study, 'Health group' comprised of $40.7\%$, the percentage of 'Risk group' was $49.0\%$, and the 'MS group' was $9.5\%$ of the total subjects. The MS incidence was associated with low education (p<0.001), low economic status (p<0.05), and low self-assessed health recognition (p<0.05). The risk of MS increased with adverse life styles such as cigarette smoking (p<0.05), irregular meal time (p<0.05), skipping lunch (p<0.05), low interests in balanced diet (p<0.05), and higher salt intake (p<0.01). Healthy group self-evaluated nutritional knowledge more highly (p<0.05) and scored higher nutritional knowledge (p<0.001). However, there was no difference in overall nutritional behavior among the three groups, which implies that nutritional education method should be developed for the subjects to practice their teaming efficiently.

• Research in Community and Public Health Nursing
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• v.13 no.3
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• pp.456-470
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• 2002

Objectives: The purpose of this study was to test the Theory of Planned Behavior (TPB) in the prediction of smoking cessation intention and smoking cessation behavior among adolescent smokers, in order to provide basic data to develop a future smoking cessation program as a nursing intervention. Method: The study subjects were 80 adolescent smokers who had smoked one cigarette and attended a five-day school smoking cessation program. The data were collected from October 24 to December 21, 1999. The instruments used in this study were the tools developed by Jee (1994) to measure TPB variables such as attitude toward smoking cessation behavior, subjective norm, perceived behavioral control, smoking cessation intention, and smoking cessation behavior. The data were analyzed with the SAS/PC program using descriptive statistics, hierarchical multiple regression, and logistic multiple regression. Results: 1. Attitude toward smoking cessation behavior, subjective norm, and perceived behavioral control were partially significant in predicting smoking cessation intention. 2. Smoking cessation intention and perceived behavioral control toward smoking cessation behavior did not significantly predict smoking cessation behavior. 3. There were partial interaction effects among the attitude toward smoking cessation behavior, subjective norm, and perceived behavioral control in the prediction of smoking cessation intention. 4. There were partial interaction effects between smoking cessation intention and perceiver behavioral control toward smoking cessation behavior in the prediction of smoking cessation behavior. Conclusion: This study partially demonstrated support for the TPB model that was partially useful in predicting smoking cessation intention and smoking cessation behavior among adolescent smokers. Therefore, it is recommended that attitude toward smoking cessation behavior and perceived behavioral control should be considered in developing smoking cessation programs and implementing nursing interventions to change the smoking behavior of adolescent smokers.

• Journal of Korean Academy of Nursing
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• v.23 no.3
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• pp.487-503
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• 1993

This study was designed to investigate the situation of adolescent drug use in Seoul, and to com-pare this with the 1991 survey in order to better understand the present situation. The subject for this study were 1000 students in High School and Middle School. The data were collected during the period from september 1, 1992 to December 30, 1992. The guestionnaire developed by Kim So Ya Ja (1991) to survey adolescent drug use was used. The data was analyzed using descriptive statistics, 1-test and ANOVA with the SPSS program. The results of this study can be summarized as follows 1. Prevalence of Substance use : Antihistamines were used by 0.3% of adolescent, Sedatives 0.6%, Stimulants 8.1%, Hallucinogens 0.9%, Inhalants 3.2%, Narcotics 1.7%, and Analgetics 154.3%. 2. Trend in substance use compared to the 1991 surbey : Alcohol use increased from 52.8% to 63.7% and narcotics from 0.6% to 1.7%, while Smeking, Analgetics, Antihistamines, Sedatives, and Inhalants showed a decrease. 3. Smoking and Alcohol use : Twenty five percent of school adolescent had experienced cigarette smoking and 63.7% of school adolescent had experienced alcohol use. 4. Motives for drug use : The highest was avoidence of sleep at 49.4% and the next highest was adventure seeking at 27.7%. As to feeling after drug use, 34.3％ felt apathy, 22.8% had feelings of sleepiness and unconsciousness. 5. Places were dreg were purchased : The most frequent was the drug store (78.3%) and 84.4% of the respondents answered that drug purchase was easy and 86.7% that drug use was mainly at home. 6. Related Variables : There was a statistically significent high score for drug and alcohol use by adolescents whose fathers used drugs. (PC.05) In conclusion, adolescents in Seoul showed in decrease in the tendency to use drugs compared to the 1991 survey, however drugs which are habit-forming and lead to dependency are still being abused. Therefore, counter-plans and preventive stratiges are important.

• Korean Journal of Occupational Health Nursing
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• v.18 no.1
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• pp.44-54
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• 2009

Purpose: The aim of this study was to examine the effects of obesity on the physiological levels of adiponectin, leptin and components of metabolic syndrome (MS) in male workers, aged 30-40 years. Methods: Body mass index (BMI) was measured with Anthropometric equipment. Blood pressure and serum parameters were measured with an automatic digital sphygmomanometer and autochemical analyzer, respectively. Adiponectin and leptin were analysed by ELISA kits and MS was defined based on the NCEP-ATP III. Results: Body fat mass of waist and hip, systolic and diastolic blood pressure were significantly higher, as expected, in the BMI>25kg/$m^2$ in comparison with the $BMI{\leq}25kg/m^2$. While fasting glucose, insulin, HOMA-IR and leptin in the BMI>25kg/$m^2$ were also significantly higher compared with $BMI{\leq}25kg/m^2$, HDL-cholesterol and adiponectin were significantly higher in $BMI{\leq}25kg/m^2$. On multiple logistic regression analysis for the components of MS, exercise, adiponectin and leptin were an only independent factor for MS in non-obese male workers($BMI{\leq}25kg/m^2$) after adjustment for age, cigarette smoking and drinking habits. Conclusion: These results suggested that the obesity in men was associated with physiological levels of adiponectin and leptin contributing to feedback control of MS and that dysfunction and/or declination in feedback control system associated with changes in physiological levels of neurptrophics: adiponectin and leptin might ultimately induce MS.

• Korean Journal of Health Education and Promotion
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• v.17 no.2
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• pp.229-237
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• 2000

The purpose of this study was to be useful in working out plans for improving national health by identifying public workers' knowledge of and attitude to smoking, actual conditions of smoking within nonsmoking areas, and related factors. For the purpose, the questionnaire was carried out with 761 public officials of the division manager-level and lower working in Taegu Metropolitan City Hall in september, 1998. The results are summarized as follows; Smokers of the subject group accounted for 55.1％, and the smoking rate had a significant relation with age and religion. In view of the time when smokers started smoking, smokers who started smoking after graduation from a high school accounted for 70.6％. Smokers who smoke one pack of cigarettes per day and a cigarette to its two-thirds length was the most. In the smoking place of smokers at home, 54.9％ of the smokers responded that they smoke in an outdoor space The rate of smoking in an office was 68.3％ and the rate of smoking within the nonsmoking areas of other public institutions was 43.0％. The results of multiple regression analysis with the actual state of smoking within the nonsmoking area of other public institutions as an independent variable revealed that smokers who check for a nonsmoking area before smoking in the public institutions and who do not smoke in an office do not smoke within the nonsmoking areas of other public institutions. In conclusion, more smoking and health education for public workers is needed to reduce the rate of national smoking and allow people to have a good smoking attitude, and it is required to arrange an institutional system who can strictly control public workers' smoking in their offices or public places and to stress a function of surveillance and monitoring by nonsmokers.

• Journal of East-West Nursing Research
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• v.14 no.1
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• pp.14-23
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• 2008

Purpose: The purpose of this study was to identify the relationship between health promoting lifestyle and general characteristics of the person undergoing health checkups in cancer prevention center. Method: A cross-sectional survey was used. This study has been done from February 1 to March 31, 2005 and the subjects of the study were 199 persons who had undergone health checkups in Cancer Prevention Center located in Seoul. Data were collected by using self reporting questionnaire on the health promoting lifestyle. The collected data were analyzed by using t-test, ANOVA, and Pearson's correlation coefficient. Result: The average score of performance in the health promoting lifestyle was 162.99(range of score is 60-240). There were significant differences in scores of health promoting lifestyle according of marital status, age, education and smoking. The score of health promoting lifestyle of the married group was higher than that of the single group. The score of health promoting lifestyle was higher in those aged 60-69 years than in those aged 20-29 years. As compared to college graduates the score of health promoting lifestyle was higher among those whose schooling is less than middle school and higher than a master`s program. The score of health promoting lifestyle was higher among non-smokers than among those who used a cigarette in their life time. There were no differences in scores of health promoting lifestyle according to sex, cancer family history, disease family history and drinking.There was positive relationship between age and health promoting lifestyle. Conclusion: Marital status, age, education and smoking affected Health Promoting Lifestyle of the person undergoing health checkups in Cancer Prevention Center.

• Journal of Ginseng Research
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• v.19 no.3
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• pp.225-230
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• 1995

The effect of long-term ginseng (Panax ginseng C.A. Meyer) administration on the clearance of carboxyhemoglobin (CO-Hb) and the property of blood gases was investigated in rats. Rats were received ginseng water extract (0.025% in drinking water) for 42 weeks starting at the age of 6 weeks. They were exposed to the diluted mainstream smoke generated from 15 filter cigarettes for 20 min in a round polycarbonate chamber (D37 cmXH13 cm). Under this condition, the mean CO-Hb content of control and the ginseng-treated rats immediately after the exposure was nearly the same as 13.8$\pm$2.9 f) and 13.9$\pm$1.6%, respectively. However, CO-Hb was more rapidly removed from blood in the ginseng treated rats than in untreatEd control with the laps of time, namely, its biological half life In the former was 36.9$\pm$1.5 min and in the latter was 56.9$\pm$13.2 min. Although long-term ginseng treatment did not affect the content of hemoglobin and blood pH of rats, it slightly increased blood oxygen content and its partial pressure value, and decreased levels of carbon dioxide and bicarbonate. These results suggest that long-term administration of rats with ginseng extract accelerate the elimination of CO from the blood. This effect seems to be related to the enhancement of oxygen consumption of the rat by a certain action of ginseng components as previously reported.

• Journal of Community Nutrition
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• v.2 no.2
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• pp.119-128
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• 2000

Lifestyle and dietary behavior intervention as the primary prevention of lipid disorder seems safe and compatible with other treatments of cardiovascular diseases. Cross-sectional associations between lifestyle factors and dietary behavioral factors with plasma lipid and lipoprotein levels were analyzed in 189 middle-aged men in Suwon, Korea. Overnight fasting plasma levels of total cholesterol, high-density lipoprotein(HDL)-cholesterol, triacylglycerol and glucose were analyzed. Blood pressure and anthropometric data were also measured. Lifestyle factors such as smoking status, alcohol consumption and frequency of physical exercise were evaluated by a self-administered questionnaire. Questions regarding dietary behavior were also asked. The subjects were 43.8%${\pm}$7.9 years old, and 23.8%${\pm}$2.6kg/m$^2$. From stepwise regression analyses, significant correlates with total cholesterol level were body mass index(BMI), alcohol intake(negative), age and coffee drinking(model R$^2$=14.3%). BMI, breakfast-skipping, age, and sleeping hours were significant for triacylglycerol level(model R$^2$=15.8%). BMI, alcohol drinking(negative), age, and coffee drinking were significant for low-density lipoprotein(LDL)(model R$^2$=11.7%). Age(negative), BMI(negative), alcohol drinking, stress level(negative), physical exercise, and cigarette smoking(negative) were significant for high-density lipoprotein(HDL)(model R$^2$=12.1%). From stepwise regression analyses, excluding BMI and age as factors in the model, alcohol intake(negative) and coffee drinking were significantly correlated with total cholesterol level(model R$^2$=4.4%) : breakfast-skipping with triacylglycerol(model R$^2$=3.2%) : alcohol intake (negative) with LDL level(model R$^2$=3.4%) : alcohol intake, physical exercise and stress level(negative) with HDL level(model R$^2$=6.3%). The findings suggest that a healthy daily lifestyle and dietary behavior may have an anti-atherogenic effect by altering plasma lipid and lipoprotein levels in middle-aged Korean men. (J Community Nutrition 2(2) : 119∼128, 2000)