• Journal of Pharmaceutical Investigation
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• v.18 no.2
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• pp.83-88
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• 1988

We examined effects of crosslinking agents, i.e., ethyleneglycol dimethacrylate (EGD) and butanediol dimethacrylate (BDD) containing ester groups on chloromethylation of crosslinked polystyrene resin matrices. It was proved that the ester group in methylmethacrylate (MMA) accelerates the chloromethylation of the divinylbenzene (DVB)-crosslinked styrene-MMA copolymer. As the MMA content increased in the styrene-MMA copolymers, the chloromethylation was enhanced. Complete chloromethylation was obtained at about 25% MMA content.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.07a
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• pp.707-710
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• 2000

Optimization of the biphenyl chloromethylation process with para-formaldehyde has been investigated in the presence of ZnCl$_2$with HCI gas by the Box-Wilson method of mathematical planning of experiment. The 4,4'- (dichloromethyl)-biphenyl yield dependence on the biphenyl para-formaldehyde ratio, temperature and reaction duration has been studied. A mathematical model of the process has been developed and optimal conditions for the biphenyl chloromethylation procedure has been determined.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2004.05a
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• pp.77-79
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• 2004

Optimization of the biphenile chloromethylation process with paraphormaldegide has been done in the presence of ZnCl$_2$ with HCI gas by the Box-Wilson method of mathematical planning of experiment. The 4, 4'-( dichloromethyl)-biphenile yield dependence on the biphenile - paraphormaldegide ratio, temperature and reaction duration has been studied. A mathematical model of the process has been developed and optimal conditions for the biphenile chloromethylation procedure has been determined

• Journal of the Speleological Society of Korea
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• no.73
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• pp.1-8
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• 2006

Optimization of the biphenile chloromethylation process with paraphormaldegide has been done in the presence of $ZnCl_2$ with HCl gas by the Box-Wilson method of mathematical planning of experiment. The 4,4'-(dichloromethyl)-biphenile yield dependence on the piphenile -paraphormaldegide ratio, temperature and reaction duration has been studied. A mathematical model of the process has been developed and optimal conditions for the biphenile chloromethylation procedure has been determined.

• Journal of the Korean Chemical Society
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• v.8 no.4
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• pp.153-157
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• 1964

The syntheses of substituted tert.-butyl ${\beta}$-(o-tolyl)- perpropionates via intermediates obtained by chloromethylation, malonic syntheses and decarboxylation is described. The intermediates substituted with a group possessing moderate substituent effect such as bromo, chloro, and methyl group were obtained in good yields. The nitro-substituted intermediat was obtained in poor yield. The chloromethylation of toluenes containing electron donating groups resulted in polymerization.

• Journal of Pharmaceutical Investigation
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• v.18 no.2
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• pp.69-81
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• 1988

We studied on the synthesis of chloromethylated polystyrene as a precursor of optically active polymers for direct resolution of optical isomers. Changing the degree of crosslinking and the kind of crosslinking agents, several polystyrene resin matrices were synthesized. The matrices were chloromethylated with methylal and chlorosulfonic acid as chloromethylating agents. The effects of solvents of various dielectric constants on the chloromethylation were quantitavely examined. We also synthesized chloromethylated polystyrene of macroreticular type that retained large surface area and good physical stability. The differences between the macroreticular type and macroporous type were investigated.

• Membrane Journal
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• v.6 no.2
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• pp.72-78
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• 1996

This paper was to investigate the preparation of quaternary ammonium polysulfone. The aminated polysullone (AMPS) as quaternary ammonium polysulfone was synthesized by two-step process. The first step involves the preparation of chloromethylated polysulfone (CMPS) which was produced by the introducion of chloromethyl group into polysulfone using chloromethyl methyl ether as a chloromethylation agent and zinc oxide as a catalyst. The second step, amination of CMPS was to give rise to AMPS using triethylamine.

• Journal of the Speleological Society of Korea
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• no.71
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• pp.1-4
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• 2006

Chloromethylnaphthalene is a valuable compound for obtaining of the plant growing stimulator - -napthylacetic acid. Chloromethylation of naphthalene by paraformaldehyde in the presence of glacial acetic acid, phosphoric and hydrochloric acids at temperature 80 - 85C and duration - 6 hours the -chloromethylnaphthalene yield was 55-57%. Using Box-Wilson method for mathematical planning of experiment carried out optimization of its synthesis for purpose increasing -chloromethylnaphthalene yield. Preliminary, one - factor experiments were carried out for selecting independence main parameters influencing on the synthesis. A full factor experiment of 23 with extended matrix of planning was used for optimization. Aiming to increase the -chloromethylnaphthalene yield, the obtained mathematical model was used for program of sharp raising on the reply surface. The received optimal conditions for the -chloromethylnaphthalene synthesis were selected as following: molar ratio of naphthalene parapfsormaldehyde of 1 : 2 temperature - 105C duration of the reaction - 3 hours. The yield of -chloromethylnaphthalene under these optimal conditions was 75%.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2004.05a
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• pp.36-37
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• 2004

$\alpha$-Chloromethylnaphthalene is a valuable compound for obtaining of the plant growing stimulator - $\alpha$-napthylacetic acid. Chloromethylation of naphthalene by paraformaldehyde in the presence of glacial acetic acid, phosphoric and hydrochloric acids at temperature 80-85$^{\circ}C$ and duration - 6 hours the $\alpha$-chloromethyl-naphthalene yield was 55-57%. Using Box-Wilson method for mathematical planning of experiment carried out optimization of its synthesis for purpose increasing $\alpha$-chloromethylnaphthalene yield. Preliminary, one - factor experiments were carried out for selecting independence main parameters influencing on the synthesis. A full factor experiment of 2$^3$with extended matrix of planning was used for optimization. Aiming to increase the $\alpha$-chloromethylnaphthalene yield, the obtained mathematical model was used for program of sharp raising on the reply surface. The received optimal conditions for the $\alpha$-chloromethylnaphthalene synthesis were selected as following: molar ratio of naphthalene - parapfsormaldehyde of 1 : 2; temperature -105$^{\circ}C$; duration of the reaction -3 hours. The yield of $\alpha$-chloromethylnaphthalene under these optimal conditions was 75 %.

• Bulletin of the Korean Chemical Society
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• v.30 no.9
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• pp.2161-2164
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• 2009