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Process Optimization of Biphenile Chloromethylation  

Pak, V.V. (Institute of Plant Substance Chemistry, Uzbekistan Academy of Sciences)
Karimov, R.K. (Institute of Plant Substance Chemistry, Uzbekistan Academy of Sciences)
Shakhidoyatov, Kh.M. (Institute of Plant Substance Chemistry, Uzbekistan Academy of Sciences)
Soh, D.W. (Myongji University)
Publication Information
Journal of the Speleological Society of Korea / v., no.73, 2006 , pp. 1-8 More about this Journal
Abstract
Optimization of the biphenile chloromethylation process with paraphormaldegide has been done in the presence of $ZnCl_2$ with HCl gas by the Box-Wilson method of mathematical planning of experiment. The 4,4'-(dichloromethyl)-biphenile yield dependence on the piphenile -paraphormaldegide ratio, temperature and reaction duration has been studied. A mathematical model of the process has been developed and optimal conditions for the biphenile chloromethylation procedure has been determined.
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