Journal of Pharmaceutical Investigation
- Volume 18 Issue 2
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- Pages.83-88
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- 1988
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Development of Optically Active Chelate Resin for Direct Resolution of Enantiomers (II) -Effect of Methylmethacrylate Content on Chloromethylation of Crosslinked Styrene-Methylmethacrylate Copolymer-
Enantiomer의 분리에 이용될 수 있는 Chelate Resin의 개발 (제2보) -Methylmethacrylate의 함유율이 Styrene-Methylmethacrylate 공중합체의 염화메칠화에 미치는 영향-
- Kim, Kil-Soo (College of Pharmacy, Ewha Womans University) ;
- Jeon, Dong-Won (College of Home Economics, Ewha Womans University) ;
- Park, Kyoung-Hae (College of Home Economics, Ewha Womans University)
- Published : 1988.06.20
Abstract
We examined effects of crosslinking agents, i.e., ethyleneglycol dimethacrylate (EGD) and butanediol dimethacrylate (BDD) containing ester groups on chloromethylation of crosslinked polystyrene resin matrices. It was proved that the ester group in methylmethacrylate (MMA) accelerates the chloromethylation of the divinylbenzene (DVB)-crosslinked styrene-MMA copolymer. As the MMA content increased in the styrene-MMA copolymers, the chloromethylation was enhanced. Complete chloromethylation was obtained at about 25% MMA content.
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