Process Optimization of Biphenile Chloromethylation

  • Pak, V.V. (Institute of Plant Substance Chemistry, Uzbekistan Academy of Sciences) ;
  • Karimov, R.K. (Institute of Plant Substance Chemistry, Uzbekistan Academy of Sciences) ;
  • Shakhidoyatov, Kh.M. (Institute of Plant Substance Chemistry, Uzbekistan Academy of Sciences) ;
  • Soh, D.W. (Myongji University)
  • Published : 2006.08.31

Abstract

Optimization of the biphenile chloromethylation process with paraphormaldegide has been done in the presence of $ZnCl_2$ with HCl gas by the Box-Wilson method of mathematical planning of experiment. The 4,4'-(dichloromethyl)-biphenile yield dependence on the piphenile -paraphormaldegide ratio, temperature and reaction duration has been studied. A mathematical model of the process has been developed and optimal conditions for the biphenile chloromethylation procedure has been determined.

Keywords

References

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