Journal of Pharmaceutical Investigation
- Volume 18 Issue 2
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- Pages.69-81
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- 1988
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Development of Optically Active Chelate Resin for Direct Resolution of Enantiomers (I) -Solvent Effects in Chloromethylation of Crosslinked Polystyrene Resin Matrix-
Enantiomer의 분리에 이용될 수 있는 Chelate Resin의 개발 (제1보) -가교 폴리스티렌 Resin Matrix의 염화메칠화에 있어서의 용매효과-
- Kim, Kil-Soo (College of Pharmacy, Ewha Womans University) ;
- Jeon, Dong-Won (College of Home Economics, Ewha Womans University) ;
- Park, Kyoung-Hae (College of Home Economics, Ewha Womans University)
- Published : 1988.06.20
Abstract
We studied on the synthesis of chloromethylated polystyrene as a precursor of optically active polymers for direct resolution of optical isomers. Changing the degree of crosslinking and the kind of crosslinking agents, several polystyrene resin matrices were synthesized. The matrices were chloromethylated with methylal and chlorosulfonic acid as chloromethylating agents. The effects of solvents of various dielectric constants on the chloromethylation were quantitavely examined. We also synthesized chloromethylated polystyrene of macroreticular type that retained large surface area and good physical stability. The differences between the macroreticular type and macroporous type were investigated.
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