• Bulletin of the Korean Chemical Society
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• 제33권12호
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• pp.4023-4027
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• 2012

Cytotoxicity assessment of silver nanoparticles (AgNPs) was performed using MTT-based microfluidic image cytometry (${\mu}FIC$). The $LC_{50}$ value of HeLa cells exposed to AgNPs in the microfluidic device was estimated as 46.7 mg/L, which is similar to that estimated by MTT-based IC for cells cultured in a 96 well plate (49.9 mg/L). These results confirm that the ${\mu}FIC$ approach can produce cytotoxicity data that is reasonably well-matched with that of the conventional 96 well plate system with much higher efficiency. This ${\mu}FIC$ method provides many benefits including ease of use and low cost, and is a more rapid in vitro cell based assay for AgNPs. This may aid in speeding up data acquisition in the field of nanosafety and make a significant contribution to the quantitative understanding of nanoproperty-toxicity relationships.

• 한국방사선학회논문지
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• 제10권7호
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• pp.531-537
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• 2016

물과 지방에서 발생하는 화학적 이동의 인공물을 확인하기 위해 다양한 MRI parameter를 적용하여 실험하였다. MRI의 1.5T와 3.0T에서 parameter와 bandwidth 및 부호화 변화에 따른 영상을 스캔하여 SNR, CNR을 비교하였다. MRI 영상에서 물과 기름의 화학적 이동의 인공물의 발생을 확인할 수 있었고, 3.0T보다 1.5T에서의 영상이 인공물이 비교적 줄어드는 것을 확인할 수 있었다. Bandwidth의 폭이 넓어짐에 따라 인공물이 줄어드는 것을 확인할 수 있었다. 따라서 MRI검사에서 화학적 이동의 인공물을 감소하기 위해서는 주 자장의 세기가 약하고, bandwidth의 폭을 넓히는 것이 적절할 것으로 생각된다.

• 한국인쇄학회지
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• 제22권2호
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• pp.111-122
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• 2004

The purpose of this study was to investigate the possibility of application of microwave energy for the fabrication of polymer/clay nanocomposite. APES/Clay nanocomposites were prepared at $130^{\circ}C$ for 30min with various amount of MMT or OMMT used the melt-intercalation method applied the classical and microwave heating source. APES/Clay samples were characterized by the means of X-ray diffractometry (XRD), transmitted electron microscopy (TEM) differential scanning calorimetry (DSC), and rheometric dynamic analysis (RDA). It was found that intercalated or exfoliated state of the samples could be controlled by the clay type, clay content, and heating type.

• 한국정밀공학회지
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• 제23권5호
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• pp.59-67
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• 2006

Chemical Mechanical Polishing(CMP) in semiconductor production is characterized its output property by Removal Rate(RR) and Non-Uniformity(NU). Some previous works show that RR is determined by production of pressure and velocity and NU is also largely affected by velocity of flowfield during CMP. This study is about the direct measurement of velocity of slurry during CMP and whole flowfield upon the non-groove pad by Particle Image Velocimetry(PIV). Typical PIV system is modified adequately for inspecting CMP and slurry flowfield is measured by changing both pad rpm and carrier rpm. We performed measurement with giving some variation in the kinds of pad. The results show that the flowfield is majorly determined not by Carrier but by Pad in the case of non-groove pad.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2006년도 6th International Meeting on Information Display
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• pp.1100-1102
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• 2006

A three-band white LED was fabricated by combining a blue LED with SrGa2S4:Eu (green) and CaS:Eu (red) phosphors for improving the color gamut, which is favorable to full color image.

• Korea-Australia Rheology Journal
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• 제14권1호
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• pp.11-16
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• 2002

Cephalosporium acremonium is a filamentous microorganism producing cephalosporin C. The morphological differentiation of C. acremonium in submerged culture is closely related with the rheological properties of culture broth and production of cephalosporin C. In this study, the rheological and morphological properties of culture broth of C. acremonium were investigated. In the seed broths of shake-flask and fermenter culture, the Herschel-Berkley equation was in excellent agreement with experimental results in the whole range of shear rate. In the seed broths of shake-flask culture, morphological differentiation into arthrospores affected to changes of apparent viscosity. But results in the fermenter culture, morphological factors such as mean hyphal thickness and the number of tips gave more effect on changes of apparent vitacosity than differentiation into arthrospores. Overall, it suggested that the morphological parameters measured by image analysis can be used as a good parameter to indicate the rheological properties of culture broth of C. acremonium M25.

• 상하수도학회지
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• 제38권2호
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• pp.109-117
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• 2024

In this study, various pre-treatment methods were evaluated for microalgae separation. These methods aimed to facilitate safe, rapid, and cost-effective online imaging for real-time observation and cell counting. As pre-treatment techniques, heating, chemical hydrolysis, heating combined with chemical hydrolysis, and sonication were employed. The effectiveness of these methods was evaluated in the context of online imaging quality through experimentation on cultivated microalgae (Chlorella vulgaris and Scenedesmus quadricauda). The chemical treatment method was found to be inappropriate for improving image acquisition. The heating pre-treatment method exhibited a drawback of prolonged cell dispersion time. Additionally, the heating combined with chemical hydrolysis method was confirmed to have the lowest dispersion effect for Chlorella vulgaris. Conversely, ultrasonication emerged as a promising technique for microalgae separation in terms of repeatability and reproducibility. This study suggests the potential for selecting optimal pre-treatment methods to effectively operate real-time online monitoring devices, paving the way for future research and applications in microalgae cultivation and imaging.

• ETRI Journal
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• 제46권2호
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• pp.290-306
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• 2024

To treat the novel COronaVIrus Disease (COVID), comparatively fewer medicines have been approved. Due to the global pandemic status of COVID, several medicines are being developed to treat patients. The modern COVID medicines development process has various challenges, including predicting and detecting hazardous COVID medicine responses. Moreover, correctly predicting harmful COVID medicine reactions is essential for health safety. Significant developments in computational models in medicine development can make it possible to identify adverse COVID medicine reactions. Since the beginning of the COVID pandemic, there has been significant demand for developing COVID medicines. Therefore, this paper presents the transferlearning methodology and a multilabel convolutional neural network for COVID (MLCNN-COV) medicines development model to identify negative responses of COVID medicines. For analysis, a framework is proposed with five multilabel transfer-learning models, namely, MobileNetv2, ResNet50, VGG19, DenseNet201, and Inceptionv3, and an MLCNN-COV model is designed with an image augmentation (IA) technique and validated through experiments on the image of three-dimensional chemical conformer of 17 number of COVID medicines. The RGB color channel is utilized to represent the feature of the image, and image features are extracted by employing the Convolution2D and MaxPooling2D layer. The findings of the current MLCNN-COV are promising, and it can identify individual adverse reactions of medicines, with the accuracy ranging from 88.24% to 100%, which outperformed the transfer-learning model's performance. It shows that three-dimensional conformers adequately identify negative COVID medicine responses.

• 대한화장품학회지
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• 제40권3호
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• pp.259-268
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• 2014

최근 여러 가지 비침습적인 방법으로 피부조직의 생검 또는 조직학적 처리과정 없이 피부의 실시간 이미지를 이용한 연구가 가능해졌다. Confocal scanning laser microscope (CSLM) 이미지는 830 nm의 근적외선 파장을 사용하는 비침습적 방법으로 피부의 내부 구조를 이미지화할 수 있으며, CSLM을 이용한 연구를 통해 비침습적인 피부 측정법으로 색소 침착 부위의 기저층과 진피 유두 사이에서 melanin cap, papillary ring과 같은 지표가 뚜렷하게 관찰된다고 보고되었다. 본 연구에서는 scanning probe image processor (SPIP)소프트웨어를 사용하여 CSLM 디지털 이미지 정량 분석을 처음 시도하였으며 본 연구결과는 정성적 피부조직 이미지 데이터를 정량화함으로써 향후 CSLM 활용범위를 높이게 될 것으로 기대하고 있다.

• 한국정보통신학회논문지
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• 제10권1호
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• pp.111-116
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• 2006

본 연구에서는 비정질 실리콘 박막 트랜지스터를 스위칭소자로 포토센서를 구동 하는 방식의 이미지 센서를 구현하고자 한다. 먼저 PECVD(Plasma Enhanced Chemical Vapor Deposition) 진공 증착장비로 최적의 비정질실리콘 박막을 형성하고, 이 박막을 이용하여 스위칭소자인 박막트랜지스터와 광전변환소자인 광다이오드를 제조한다. 또한 이들을 결합하여 이미지 센서를 형성하고 그 특성 및 동작을 분석하고 최적의 동작특성을 이끌 수 있는 밀착이미지 센서를 제조한다. 제작한 이미지 센서를 측정한 결과 광전변환소자인 photodiode는 암전류의 경우 $\~10^{-l2}A$정도였으며, 광전류 $\~10^{-9}A$정도로서 Iphoto/Idark ${\ge}10^3$ 이상을 이루어 좋은 광전변환 특성을 갖고 있었다. 또한 a-Si:H TFT의 경우 Ioff ${\le}10^{-l2}A$, Ion ${\le}10^{-6}A$ 으로서 Ion/Ioff ${le}10^6$ 이상을 나타냈으며 Vth는 $2\~4$ volts였고, Id는 수 ${\mu}A$ 정도로 photodiode를 스위치하기에 충분한 전류-전압특성을 나타내고 있다. 이미지 센서 전체 동작 특성을 측정하기 위하여 photodiode의 ITO쪽에 -5volts의 역 bias를 가한 상태에서 TFT의 gate에 $70\;{\mu}sec$의 pulse를 가하여 photodiode에서 생성된 광전류 와 암전류를 측정하였다. 이렇게 하여 측정된 전압은 암상태에서 수십 mvolts이고, 광상태에서는 수백 mvolts로 나타나 우수한 이미지센서 특성을 갖고 있음을 확인하였다.