• Title/Summary/Keyword: changes in the value of family

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Anticancer Activity of Bispidinone Derivative by Induction of Apoptosis

  • Lee, Man Gi;Kwon, Ryong
    • Biomedical Science Letters
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    • v.26 no.4
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    • pp.336-343
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    • 2020
  • The present study was carried out to investigate the possibility that bispidinone derivative makes anticancer drug availability to human cervical carcinoma cell. The B8 has the lowest IC50 value among B8, B9 and B10 which are bispidinone analogue with bromide. According to cytotoxic test through WST-8 assay, B8 shows the most magnificent cytotoxicity effectiveness with 76 μM of IC50 value. In human cervical carcinoma cell treated with B8, it noticeably controlled cellular multiplication by increase of concentration and time. Furthermore, morphological changes like cellular shrink, disruption and nuclear condensation, feature of apoptosis, are observed. Annexin V-FITC/PI double staining assay test proved that B8 can cause apoptosis. Moreover, after treatment with 76 μM of B8, flow cytometry analysis shows that increase of active oxygen species are induced and membrane potential in mitochondria is decreased. Manifestation of Bcl-2 family and caspase cascades protein provides evidence that B8 induces apoptosis through mitochondria and caspase-related pathway. Taken together, we suggested that B8 reduced membrane potential in mitochondria and induce apoptosis through the pathway depended on mitochondria and caspase.

The Study on Wedding View in Literatures of the Customary Proprieties of a Fmaily (家禮書에 나타난 혼례관 고찰)

  • 이길표
    • Journal of Families and Better Life
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    • v.17 no.4
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    • pp.15-30
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    • 1999
  • This paper aims to accomplish the work of finding and recreating factors of evelasting wedding view through studying literatures($\ulcorner$Ka-ryae$\lrcorner$.$\ulcorner$Ka-ryae-jip-ram$\lrcorner$.$\ulcorner$Sa-ryae-pyun-ram$\lrcorner$) of customary proprieties of a family The results of this study are as follows: The norm and meanings of wedding by way of education appear self-cultivation sincerity and carefulness ancestor worship morality of husband and wife filial duty to parents and parents-in-law rank and order simplicity. From this study on wedding view the efforts to accomlish the work of finding and recreating the factors everlasting inheriting value which would not be changed by social changes have to be made from now on.

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On systematizing the Educational Programs for Consumers- With Special Attention to the Contents of Education- (소비자 교육프로그램의 체계화에 관한 연구 -교육내용을 중심으로-)

  • 박재선;문숙재
    • Journal of Families and Better Life
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    • v.3 no.1
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    • pp.51-67
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    • 1985
  • The purpose of the present paper is to review the content of the Consumer Education Programs, is to establish a hypothetical model regarding the contents of the consumer Education programs, and is also to analyze the contents of the Consumer Education Programs seen from the various angles of the value of our home life. For this, we have researched literatures and habe made the hypothetical model for the desirable contents of the consumer education programs, and also have conducted a case study together with and analysis bearing the actual evidence. Form what we have studied regarding the results of the research, conclusions that can be derived are as follows; First, the contents of the consumer education programs of Korea are not sufficient to improve the quality of the environments of our houses, family life, and decision making. Secondly, the contents of the consumer education do not meet the societal and economic changes. Third, since the contents of the consumer program of Korea emphasize the theory-oriented discussion, they are not suitable to educate the consumers who are really in need of consumer education.

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Exploration into the Determinants of Household Consumption: Liquidity Constraint and Family Characteristics (횡단면 자료를 이용한 가구소비 결정요인에 관한 연구 - 유동성 제약과 가구별 특성을 중심으로 -)

  • Hur, Seok-Kyun
    • KDI Journal of Economic Policy
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    • v.27 no.1
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    • pp.1-38
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    • 2005
  • Our paper aims to estimate a household consumption function in the presence of liquidity constraints as well as household characteristics. Empirical findings from a Korean cross-sectional data (National Survey of Household Income and Expenditure) reveal that several family characteristics, such as household size, number of working members, children in school, and educational level and age of the household head, turn out to be critical determinants of household consumption. Especially, the influence of household size on consumption decision is shown to be highly significant, not only indirectly through its impact on household income, but also directly by affecting the household's preference for consumption itself. While, the other family characteristics primarily influences household income. Our paper distinguishes itself from existing literature in that it greatly improves the explanatory power of the estimated household consumption function by measuring the degree of the liquidity constraint rather than simply identifying its presence. Based on the assumption that the present value of human capital is a function of household characteristics, the degree of the liquidity constraint is represented by the underestimated portion of the human capital. Such a method of implementing the liquidity constraint is useful in treating various types of assets according to their liquidity. Finally, our estimated household consumption function is applied to decompose cross-sectional variances of consumption inequality. The analysis confirms that the overall alleviation in liquidity constraints in Korea after the 1997 currency crisis reduced consumption inequality despite the worsening of income inequality and changes in the demographic composition of family characteristics during the same period.

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A Study on the Effects of Married Women's Intention of Childbirth (기혼여성의 출산의향에 영향을 미치는 요인에 관한 연구)

  • Un, Sun-Kyoung;Park, Hyo-Jin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.4
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    • pp.210-217
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    • 2020
  • This paper analyzes the factors influencing the childbirth intention of married women with the goal of analyzing whether times of spouses' housework, marital satisfaction, values of children and traditional gender role, and social services related to the reduction of low fertility contribute to women's intention to give birth. The respondents of the research were 1,000 married women, and the research was conducted with 482 women of childbirth intention. The findings are as follows. Age of sociodemographic factors has an influence on the childbirth intention. Related to family's character, factors influencing childbirth intention are number of children, times of spouses' housework, and marital satisfaction. In addition, emotional and instrumental values of children, number of recognized public services for reduction of low fertility. In other words, the more women share housework with spouses and satisfy their marital life, the more childbirth intention of women is increased. In order to improve childbirth intention, changes of perception of gender role and sharing housework, reinforcement of social system for work and family compatibility that convert changes of perception into action, advanced marital relationship programs, extensive support for subfertility and a huge build-up of social services related to reduction of low fertility need to be provided.

A Study on the Living Conditions of Rural Women and the Determinants of Their Life Satisfaction (농촌여성의 생활실태분석과 생활만족도에 영향을 미치는 요인)

  • Bae, Jeong In;Park, Ung Im;Lee, Hye Sang;Ahn, Geun Mee;Jeong, Woon Seon
    • The Korean Journal of Community Living Science
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    • v.24 no.4
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    • pp.485-495
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    • 2013
  • As rural life has shifted with the long term changes in the internal and external conditions of rural communities, this study aims to investigate the living conditions and life satisfaction of rural women. 70 questionnaires in health, clothing, food, shelter, economic conditions and child-rearing fields were used for a survey of 393 rural women from five rural areas in the northern region of Gyeongsangbuk-Do. Statistical techniques of frequency analysis, descriptive statistics, ANOVA, t-test and regression analysis were employed through 'SPSS Statistics 21'. Participants were divided into 3 groups, with Group A with income less than 15 million won, Group B with income of at least 15 million won and less than 30 million won, and Group C with at least 30 million won. For the life satisfaction and health conditions, Group C showed higher scores than Group A. The food security status of rural women in the research area was worse than that in the Korea National Health and Nutrition Examination Survey, and food consumption by Group C was higher than that of Group A and Group B. For the satisfaction of kitchen, bathroom facilities and heating system, the income of 15 million won seemed to be the divisive value where richer groups were more satisfied. Job satisfaction seemed more related with the income amount rather than with the job itself. The parenting efficacy and child-rearing satisfaction were higher for Group C than for Group A. Determinants of life satisfaction turned out to be health conditions, heat susceptibility, fruit consumption, kitchen unit satisfaction, job satisfaction and parenting efficacy.

Self-Care and Associating Factors in Hemodialysis Patients (혈액투석 환자의 자기관리 수행도와 이에 영향을 미치는 요인)

  • 전진호;강혜경
    • Korean Journal of Health Education and Promotion
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    • v.16 no.1
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    • pp.149-166
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    • 1999
  • Self-care and the performance of their own role might be important for the prevention of complications and improvement of quality of life in hemodialysis patients with chronic renal failure(CRF). To improve well-being and quality of life for the patients, the author estimated the level of self-care and associating factors through a questionnaire. The information was composed of the knowledge for hemodialysis and renal disease, the level of self-care, health belief, supports from the family, disease-related stresses, personal characteristics, medical history, relationships with medical personnel, etc. The data was gathered from 126 hemodialysis patients who were undergoing hemodialysis in one university hospital and five hospitals in Kyungsangnam-Do area from December 1997 to January 1998, and was analyzed by PC SAS program(version 6.12) with the level of significance($\alpha$=0.05). The mean age of subjects was 47.0$\pm$13.5years with no significant difference in gender distribution. The mean duration of hemodialysis was 39.0 months, and their frequencies of hemodialysis were more than three times per week(77.0%). Only 21.4% had the specific education on hemodialysis and CRF. In the level which was expressed as the score out of 100, the mean of knowledge was 90.7$\pm$9.1 and the mean of self-care was 73.9$\pm$12.7, that means, they only partially carried their knowledge into practice. They showed a significant correlation between knowledge and health belief($\gamma$=0.282); self-care and health belief($\gamma$=0.357), family supports and knowledge($\gamma$=0.221), self-care($\gamma$=0.402), health belief($\gamma$=0.431); and health belief and stress($\gamma$=-0.361). Age, religion, marrital status, education, and relationships with medical personnel showed positive correlations, and smoking showed negative correlation with self-care. In the multiple regression with the level of self-care as dependent variable, and each of the characeristics as independent variables, supports from the family($\beta$=6.615=0.158), the experience of disease specific education($\beta$=4.959), relationships with medical personnel($\beta$=6.615), current smoking($\beta$=-6.986), and current drinking ($\beta$=-7.095) were detected as significant factors. The value of R-square was 34%. In summary, to promote the level self-care and to improve the well beings and Quality of life for the hemodialysis patients, it would be emphasized that they terminate smoking and drinking, and it would be recommended that the education programs and supports from the family be strengthened. And, because there was a considerable difference between the level of knowledge and self-care, it would also be emphasized to propose the education programs which focused on execution. In addition to that, there is a need to improve relationships between the patients and medical personnel through positive changes in the attitudes of the medical personnel.

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A Model for Health Promoting Behaviors in Late-middle Aged Woman (중년후기 여성의 건강증진행위 모형구축)

  • Park, Chai-Soon
    • Women's Health Nursing
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    • v.2 no.2
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    • pp.298-331
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    • 1996
  • Recent improvements in living standard and development in medical care led to an increased interest in life expectancy and personal health, and also led to a more demand for higher quality of life. Thus, the problem of women's health draw a fresh interest nowadays. Since late-middle aged women experience various physical and socio-psychological changes and tend to have chronic illnesses, these women have to take initiatives for their health control by realizing their own responsibility. The basic elements for a healthy life of these women are understanding of their physical and psychological changes and acceptance of these changes. Health promoting behaviors of an individual or a group are actions toward increasing the level of well-being and self-actualization, and are affected by various variables. In Pender's health promoting model, variables are categorized into cognitive factors(individual perceptions), modifying factors, and variables affecting the likelihood for actions, and the model assumes the health promoting behaviors are affected by cognitive factors which are again affected by demographic factors. Since Pender's model was proposed based on a tool broad conceptual frame, many studies done afterwards have included only a limited number of variables of Pender's model. Furthermore, Pender's model did not precisely explain the possibilities of direct and indirect paths effects. The objectives of this study are to evaluate Pender's model and thus propose a model that explains health promoting behaviors among late-middle aged women in order to facilitate nursing intervention for this group of population. The hypothetical model was developed based on the Pender's health promoting model and the findings from past studies on women's health. Data were collected by self-reported questionnaires from 417 women living in Seoul, between July and November 1994. Questionnaires were developed based on instruments of Walker and others' health promotion lifestyle profile, Wallston and others' multidimensional health locus of control, Maoz's menopausal symptom check list and Speake and others' health self-rating scale. IN addition, items measuring self-efficacy were made by the present author based on past studies. In a pretest, the questionnaire items were reliable with Cronbach's alpha ranging from .786 to .934. The models for health promoting behaviors were tested by using structural equation modelling technique with LISREL 7.20. The results were summarized as follows : 1. The overall fit of the hypothetical model to the data was good (chi-square=4.42, df=5, p=.490, GFI=.995, AGFI=.962, RMSR=.024). 2. Paths of the model were modified by considering both its theoretical implication and statistical significance of the parameter estimates. Compared to the hypothetical model, the revised model has become parsimonious and had a better fit to the data (chi-square =4.55, df=6, p=.602, GFI=.995, AGFI=.967, RMSR=.024). 3. The results of statistical testing were as follows : 1) Family function internal health locus of control, self-efficacy, and education level exerted significant effects on health promoting behaviors(${\gamma}_{43}$=.272, T=3.714; ${\beta}_[41}$=.211, T=2.797; ${\beta}_{42}$=.199, T=2.717; ${\gamma}_{41}$=.136, T=1.986). The effect of economic status, physical menopausal symptoms, and perceived health status on health promoting behavior were insignificant(${\gamma}_{42}$=.095, T=1.456; ${\gamma}_{44}$=.101, T=1.143; ${\gamma}_{43}$=.082, T=.967). 2) Family function had a significance direct effect on internal health locus of control (${\gamma}_{13}$=.307, T=3.784). The direct effect of education level on internal health locus of control was insignificant(${\gamma}_{11}$=-.006, T=-.081). 3) The directs effects of family functions & internal health locus of control on self-efficacy were significant(${\gamma}_{23}$=.208, T=2.607; ${\beta}_{21}$=.191, T=2.2693). But education level and economic status did not exert a significant effect on self-efficacy(${\gamma}_{21}$=.137, T=1.814; ${\beta}_{22}$=.137, T=1.814; ${\gamma}_{22}$=.112, T=1.499). 4) Education level had a direct and positive effect on perceived health status, but physical menopausal symptoms had a negative effect on perceived health status and these effects were all significant(${\gamma}_{31}$=.171, T=2.496; ${\gamma}_{34}$=.524, T=-7.120). Internal health locus and self-efficacy had an insignificant direct effect on perceived health status(${\beta}_{31}$=.028, T=.363; ${\beta}_{32}$=.041, T=.557). 5) All predictive variables of health promoting behaviors explained 51.8% of the total variance in the model. The above findings show that health promoting behaviors are explained by personal, environmental and perceptual factors : family function, internal health locus of control, self-efficacy, and education level had stronger effects on health promoting behaviors than predictors in the model. A significant effect of family function on health promoting behaviors reflects an important role of the Korean late-middle aged women in family relationships. Therefore, health professionals first need to have a proper evaluation of family function in order to reflect the family function style into nursing interventions and development of strategies. These interventions and strategies will enhance internal health locus of control and self-efficacy for promoting health behaviors. Possible strategies include management of health promoting programs, use of a health information booklets, and individual health counseling, which will enhance internal health locus of control and self-efficacy of the late-middle aged women by making them aware of health responsibilities and value for oneself. In this study, an insignificant effect of physical menopausal symptoms and perceived health status on health promoting behaviors implies that they are not motive factors for health promoting behaviors. Further analytic researches are required to clarify the influence of physical menopausal symptoms and perceived health status on health promoting behaviors with-middle aged women.

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Estimation and Determinants on Residential Investment Profits in Seoul: A Focus on Housing Transaction Price from 2010 to 2018 (서울시 주택 예상투자이익 추정과 영향요인에 대한 시론적 분석 - 2010-2018년 주택 실거래가를 중심으로 -)

  • Ahn, Hye-Sung;Kang, Chang-Deok
    • Journal of the Korean Regional Science Association
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    • v.36 no.1
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    • pp.37-50
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    • 2020
  • Estimating investment profits of real estate is critical to understand real estate markets and create relevant policy as real estate market and capital market combines closely. Thus, this study applied the concept of Tobin's Q to estimate investment profits for apartments as well as row-houses and multi-family homes in Seoul from 2010 to 2018. Investment profits were estimated by two approaches: subtracting the replacement cost from the transaction price and calculating ratio of the transaction price to the replacement cost, respectively. The spatio-temporal changes in investment profits were apparent in apartments compared with row-houses and multi-family homes. As a result of analyzing the spatial econometrics models, the investment profit was higher in the area with high density and new developments regardless of the housing types. The framework and key findings would be the effective reference to understand residential investment behavior, create relevant housing policy, introduce value capture of windfall, measure regional competitiveness, and estimate housing bubble.

The Effects of Peroxiredoxin III on Human HeLa Cell Proliferation

  • Choi, Soonyoung;Kang, Sangwon
    • IMMUNE NETWORK
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    • v.3 no.4
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    • pp.276-280
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    • 2003
  • Background: Peroxidases (Prx) of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol respectively. Hydrogen peroxide is implicated as an intracellular messenger in various cellular responses such as proliferation and differentiation. And Prx I activity is regulated by Cdc-2 mediated phosphorylation. This work was undertaken to investigate the proliferation role of peroxiredoxin III as a member of Prx family in Prx III overexpressed HeLa cell line. Methods: To provide further evidence of proliferation, we selected Prx III stably expressed HeLa Tet-off cell lines. Cell proliferation was examined by using proliferation reagent WST-1 in the presence or absence of doxycycline. Prx III, 2-cys Prx enzymes exist as homodimer. The activation of Prx III heterodimer with induced and endogenous Prx III was examined by immunoprecipitation. Results: Immunoprecipitation analysis of the induced and endogenous Prx III with anti-myc showed that the induced wild type (WT) and dominant negative (DN) Prx III from HeLa Prx III Tet-off stable cell heterodimerized with endogenous Prx III each other. And the expression level of induced Prx III was examined after addition of doxycycline. By 72 hr, the expression level of induced Prx III was diminished gradually and the half-life of the induced wild type Prx III was approximately 17 hr. The proliferation experiment demonstrated that the relative proliferation value of induced and endogenous WT Prx III stable cell has no changes but the DN Prx III induced HeLa Tet-off stable cells were lower than endogenous Prx III. Conclusion: In conclusion, the HeLa dominant negative Prx III Tet-off stable cells were decreased the proliferation.