• Nuclear Engineering and Technology
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• 제49권8호
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• pp.1575-1588
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• 2017

In order to develop a domestic research roadmap for severe accidents, a special committee was established by the Korean Nuclear Society. One of the subcommittees discussed the characteristics and the relevant technical issues in the stages of fission product release and physical forms of radionuclide release and transport. The group members developed a tree to identify fission product release phenomena by tracing failures of individual defense-in-depth barriers and added possible countermeasures against failure. For each elemental issue, they searched for technical problems by examining the phenomena, accident management actions, and regulatory aspects relevant to the mitigation features for containment, including mitigation strategies against containment bypass accidents. Regulatory concerns, including the source term and the acceptance criteria for radionuclide release, were also considered. They identified further research needs regarding important technical issues based on the degree of the current knowledge level in Korea and in foreign countries, looking at the significance and urgency of issues and the expected research period required to reach an advanced level of knowledge. As a result, the group identified the 12 most important and urgent issues, most of which were expected to require mid-term and long-term research periods.

• Journal of Ginseng Research
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• 제32권1호
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• pp.39-47
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• 2008

본 실험은 홍삼 혼합물 (KTNG0345)을 이용한 주름 예방 및 개선효과가 있는 건강기능 식품을 개발하기 위한 기초자료로 활용하기 위하여 시료를 경구투여한 무모생쥐의 피부조직 으로부터 MMP-3의 발현양상과 작용 메커니즘을 연구하였다. MMP-3의 발현정도는 농도 의존적으로 현저한 감소를 나타내었으며, 유전자와 단백질 모두에서 동일한 양상을 보였다. PAK는 변화가 없었지만, p38, p-p38 그리고 c-Jun, p-c-Jun 을 통계적으로 유의하게 감소시킴으로써 MMPs의 발현 감소를 가져온 것으로 보인다. 뿐만 아니라 자외선에 의한 $TNF-{\alpha}$의 생성 또는 유입을 억제함으로써 $TNF-{\alpha}$ receptor에 의해 매개되는 신호전달 경로를 둔화시켜 MMPs의 발현을 감소시킨 것으로 보인다. 이렇게 KTNG0345는 복합적인 활성으로 작용하여 주름생성 억제 활성을 보이는 것으로 판단된다.

• 대한수학회보
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• 제53권1호
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• pp.91-102
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• 2016

A chief factor H/K of G is called F-central in G provided $(H/K){\rtimes}(G/C_G(H/K)){\in}{\mathfrak{F}}$. A normal subgroup N of G is said to be ${\pi}{\mathfrak{F}}$-hypercentral in G if either N = 1 or $N{\neq}1$ and every chief factor of G below N of order divisible by at least one prime in ${\pi}$ is $\mathfrak{F}$-central in G. The symbol $Z_{{\pi}{\mathfrak{F}}}(G)$ denotes the ${\pi}{\mathfrak{F}}$-hypercentre of G, that is, the product of all the normal ${\pi}{\mathfrak{F}}$-hypercentral subgroups of G. We say that a subgroup H of G is ${\pi}{\mathfrak{F}}$-embedded in G if there exists a normal subgroup T of G such that HT is s-quasinormal in G and $(H{\cap}T)H_G/H_G{\leq}Z_{{\pi}{\mathfrak{F}}}(G/H_G)$, where $H_G$ is the maximal normal subgroup of G contained in H. In this paper, we use the ${\pi}{\mathfrak{F}}$-embedded subgroups to determine the structures of finite groups. In particular, we give some new characterizations of p-nilpotency and supersolvability of a group.

• Parasites, Hosts and Diseases
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• 제45권1호
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• pp.59-63
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• 2007

Merozoite surface protein-1(MSP-1) and merozoite surface protein-2(MSP-2) were used to develop vaccines and to investigate the genetic diversity in Plasmodium falciparum malaria in Iran. Nested polymerase chain reaction amplification was used to determine polymorph isms of block 2 of the MSP-1 and the central domain of MSP-2 genes. A total of 67 microscopically positive P. falciparum infected individuals from a major endemic region, southeast Iran, were included in this trial. Nine alleles of MSP-1 and 11 alleles of MSP-2 were identified. The results showed that amplified product from these surface antigen genes varied in size and there was specific pattern for each isolate. Besides, regarding this pattern, 23 multiple infections with at least 2 alleles were observed. While the endemic regions of malaria in Iran is classified in low to moderate group, but extensive polymorphism was observed for each marker and the MSP-2 central repeat was the most diverse that could be considered in designing malaria vaccine.

• Natural Product Sciences
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• 제20권4호
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• pp.301-305
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• 2014

The aim of our study is to investigate the anti-nociceptive and anti-inflammatory properties of an ethanol extract of the leaf and stem of Aralia cordata. Writhing responses induced by acetic acid, tail immersion test, and formalin-induced paw pain response for nociception and formalin-induced paw edema for inflammation were evaluated in mice. A. cordata (50 - 200 mg/kg, p.o.) and ibuprofen (100 mg/kg, p.o.), a positive non-steroidal anti-inflammatory drugs (NSAIDs), inhibited the acetic acid-induced writhing response, but they did not protect the thermal nociception in tail immersion test. However, morphine (5 mg/kg, s.c.) used as positive opioid control alleviated both the acetic acid-induced writhing response and thermal nociception in tail immersion test. In the formalin test, A. cordata (50 - 200mg/kg) and ibuprofen (200mg/kg) inhibited the second phase response (peripheral inflammatory response), but not the first phase response (central response), whereas morphine inhibited both phase pain responses. Both A. cordata (100 mg/kg) and ibuprofen (200 mg/kg) significantly alleviated the formalin-induced increase of paw thickness, the index of inflammation. These results show for the first time that the leaf and stem of A. cordata has a significant anti-nociceptive effect that seems to be peripheral, but not central. A. cordata also displays an anti-inflammatory activity in an acute inflammation model. The present study supports a possible use of the leaf and stem of A. cordata to treat pain and inflammation.

• 도시과학
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• 제9권1호
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• pp.41-49
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• 2020

This study analyzed the factors affecting economic growth using multiple regression model and Geographically Weighted Regression in consideration of population, industry and employment, housing and political characteristics on economic growth by region. The analysis results are summarized as follows. First, the total employment growth rate, manufacturing employment growth rate, local election turnout and the level of party consensus between the central and local governments are having a positive impact on regional economic growth. Second, according to the GWR analysis, the population has a positive impact on economic growth in the southern region of Korea, and the increase in the total number of employees has a positive impact on the southern region of Gyeonggi Province, Gangwon Province, North Chungcheong Province and North Gyeongsang Province. Finally, the voter turnout of urbanites is positively affecting economic growth in South Chungcheong Province, Gangwon Province and the southern coast, while North Jeolla and South Jeolla provinces have a positive impact on economic growth as the parties of the central and local governments are equal. The results of this study may suggest the role of local government for regional economic development.

• 한국생산제조학회지
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• 제21권6호
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• pp.954-960
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• 2012

Nowadays, rapidly changing and unstable global economic environments request a lot of roles to engineers. In this situation, product should be designed to make more profit by cost down and to satisfy distinguished performance comparing to other competitive ones. In this research, the optimization design of the industrial robot casting will be done. The weight and deflection have to be reduced as objective functions and stress has to be constrained under some constant value. To reduce time cost, CCD (Central Composite Design) will be used to make experimental design. And RSM (Response Surface Methodology) will be taken to make regression model for objective functions and constraint function. Finally, optimization will be done with Genetic Algorithm. In this problem, the objective functions are multiple, so NSGA-II which is brilliant and efficient for such a problem will be used. For the solution quality check, the diversity between Pareto solutions will be also checked.

• Journal of Applied Biological Chemistry
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• 제43권3호
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• pp.136-140
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• 2000

A novel 6-deoxyhexose biosynthetic gene cluster different from the one for the biosynthesis of streptomycin was isolated from Streptomyces griseus using specifically designed PCR primers to compare the sequence of known dTDP-glucose synthase genes. We cloned a 5.8-kb DNA from Streptomyces griseus ATCC10137, which contained the 4-ketoreductase homologue (grsB), dTDP-glucose synthase (grsD), and dTDP-glucose 4, 6-dehydratase (grsE) genes. Escherichia coli cultures containing plasmid of the PCR product which encoded the grsE region under the controUed T7 promoter were able to catalyze the formation of dTDP-4-keto-6-deoxy-D-glucose from TDP-glucose. The enzyme showed high substrate specificity, being specific to only dTDP-glucose that is known to be incorporated into secondary metabolites such as antibiotics.

• The Journal of Asian Finance, Economics and Business
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• 제7권10호
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• pp.369-376
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• 2020

Credit capital from customers' savings deposit (CSD) of banks has an important meaning in the business activities of the banking industry. There are many factors that influence the CSD satisfaction with banks. Certain changes have been made when there are fluctuations due to COVID-19. The article is based on an analysis assessing the factors that influence the CSD satisfaction of Vietnamese commercial banks in the context of COVID-19. The authors use a sample of 1,639 CSD. The results show that there are three variables that positively affect CSD satisfaction, including legal provisions of the Central bank (Legal), policies and mechanisms of commercial banks (Policy), and products of commercial banks (Product). Accordingly, in order to contribute to strengthening this capital mobilization of savings deposit, the Central bank of Vietnam needs to play a pivotal role in the regulations of the banking system to ensure its stability; control well monetary policy, interest rates, and inflation to keep a stable position in the economy; and provide timely financial support packages to enhance the confidence of CSD. Moreover, Vietnamese commercial banks need flexible policies and mechanisms to stimulate CSD; strengthen support on deposit rates for CSD; and diversify products to easily adapt to each CSD's situation.

• Journal of Magnetics
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• 제3권1호
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• pp.4-8
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• 1998

Two different compositions of melt spun magnetic alloys, $ Nd_4Fe_{80}B_{16} and Nd_4Fe_{76}Co}\_3Hf_{0.5}Ga_{0.5}B_{16},$ were characterized in terms of magnetic properties and thermal behaviors. It was found that the addition of Hf and Ga effectively slow down the crystallization rate of the nanocomposite $ Nd_2Fe_{14}B/Fe_3B$ magnet. Coercivity(iHc) changes only slightly with varying the post annealing conditions confirming that iHc is not a sensitive magnetic quantity as a function of grain size and exchange coupled interaction. The experimentally observed behaviors of Mr and Hc do not vary monotonously with in-creasing grain size which is not in agreement with the numerically calculated result near the critical grain size (dc). The plot of the grain size dependence for the remanence and coercivity in isotrop!c nanocomposite magnets has been revised in this study. The maxium energy product, $(B, H)_{max}$ =15.34 MGOe, and a reduced remanence, Mr/Ms=0.84 were obtained, respectively.