• Advances in Traditional Medicine
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• v.6 no.3
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• pp.167-173
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• 2006

A growing body of evidence supports lipid peroxidation as having a role in the pathogenesis of liver disease. Although the probable cause of damage to human hepatocytes may be multifactorial, free radicals have been implicated in a variety of liver diseases, particularly in the presence of iron overload and toxic substances such as ethanol. Consequently, antioxidants, particularly those of plant origin such as flavonoids, may help to reduce the risk of developing these diseases. Silybum (S.) marianum, a medicinal plant widely used in traditional European medicine for the treatment of liver disorders, was evaluated for antioxidant activity. Thin layer chromatography and High Performance Liquid Chromatography analyses of crude extract of the plant confirmed the presence of a number of flavonoids reported in the literature. The antioxidant activity of these flavonoids was measured through inhibition of lipid peroxidation and 1, 1-diphenyl-2- picrylhydrazyl radical scavenging. The crude plant extract showed marked antioxidant activity in both assays. These results suggest that S. marianum contains flavonoids with antioxidant activity, capable of inhibiting or scavenging free radicals, thus supporting its traditional use as a hepatoprotective agent.

• Journal of Biomedical Engineering Research
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• v.17 no.3
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• pp.297-304
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• 1996

Although collagen is still considered to be a poor immunogen, animals can produce antibodies to a number of different sites in the collagen molecule. In type I collagen, three classes of antigenic determinants have been described those are recogrlized as different degrees in different species. These are essentially composed of helical, conformation-dependent antigenic determinants and terminal, nonhelical antigenic determinants, and finally central antigenic determinants exposed only after denaturation of the collagen molecule. To utilize collagen as implantable biomateriall human e61bryonic collagen, ten immunological to body, was purified from human umbilical cords and found to contain [$\alpha$1(I)]$_2$. [$\alpha$2(I). Each step of purification were observed by polarized light microscope and analyzed through SDS-PAGE. The conclusious are follows; 1 . The purified collagen revealed gradual fiber indenties on each step of purification by polarized microscope. 2. The structual changes of extracted collagen as removed telopeptide were confirmed by SDS-PAGE.

• Journal of Korean Medical classics
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• v.31 no.1
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• pp.157-174
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• 2018

Objectives : The objective of this research is to look deeper into the thoughts of Sajudang in her book on fetal education, Taegyoshin-gi(TGSG), published in the early 19th century Joseon, which focused on her understanding of human development and bodily relationship the mother has with her child with comparison to Korean Medical texts. Methods : The characteristics of TGSG were laid out with comparison to previous texts on fetal education of both China and Korea. After this, they were closely cross-examined with Korean Medical thoughts on human creation, mother-child relationship, and mind-body relationship. Results : Sajudang's thoughts on fetal education as written in TGSG, show a deep understanding of human development and the father and mother's roles in it, expanding the responsibility of fetal education from just the mother to both father and mother. There is also awareness of the importance of the Heart that is at the center of the fetal education process, and of the mother-child relationship through blood. Conclusions : Fetal education as discussed in TGSG expands from previous discourses on the topic, distinguishing itself with thorough understanding of how fetal education works, when it begins, and what the roles of the parents and the community are. This attributes to Sajudang's knowledge that came from both books and her actual experiences.

• Clinical and Experimental Reproductive Medicine
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• v.49 no.2
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• pp.149-158
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• 2022

Objective: Optimizing culture media for the incubation of immature oocytes is a vital strategy to increase the oocyte maturation rate during in vitro maturation (IVM) programs. This study evaluated the IVM and fertilization rates of human germinal vesicle (GV) and metaphase I (MI) oocytes using two different maturation media (commercial and homemade) with or without growth differentiation factor 9-β (GDF9-β). supplementation. Methods: Immature oocytes from intracytoplasmic sperm injection (ICSI) cycles were collected and assigned to one of two IVM culture media (commercial or homemade; cleavage-stage base). After maturation, MII oocytes were examined under an inverted microscope for the presence of the polar body, zona pellucida (ZP) birefringence, and meiotic spindle (MS) visualization after maturation in four conditions (commercial or homemade medium, with or without GDF9-β. ICSI was done for matured oocytes, and fertilization was confirmed by the visualization of two distinct pronuclei and two polar bodies. Results: No significant differences were found between the two culture media in terms of the time and rate of oocyte maturation or the rate of fertilization (p>0.05). Growth factor supplementation increased the 24-hour maturation rate for both GV and MI oocytes only in homemade medium. The maturation rate after 24 hours was higher for MI oocytes (p<0.05). Similar results were observed for MS visualization and ZP structure in both types of media (p>0.05). Conclusion: Higher rates of oocyte maturation and fertilization were observed after application of homemade medium supplemented with GDF9-β. Therefore, this combination may be recommended as an alternative for clinical IVM programs.

• Biomolecules & Therapeutics
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• v.20 no.6
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• pp.520-525
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• 2012

Prostaglandin (PG) $E_2$, the most abundant prostaglandin in the human body, is synthesized from arachidonic acid via the actions of cyclooxygenase (COX) enzymes. $PGE_2$ exerts homeostatic, cytoprotective, inflammatory, and in some cases anti-inflammatory effects. Also, it has been reported that $PGE_2$ is involved in hair growth. Diphlorethohydroxycarmalol (DPHC) is a phlorotannin compound isolated from the brown algae Ishige okamurae, with various biological activities in vitro and in vivo. In this study, the biological effect and mechanism of action of DPHC on prostaglandin synthesis in HaCaT human keratinocytes was examined. The results showed that, in these cells, DPHC significantly and dose-dependently induced $PGE_2$ synthesis by increasing the protein and mRNA levels of COX-1 and COX-2. Interestingly, DPHC-induced COX-1 expression preceded that of COX-2. Also, while both rofecoxib and indomethacin inhibited $PGE_2$ production, the latter was seems to be the more potent. From above results, we can expect that DPHC has some beneficial effects via increasing of $PGE_2$ production.

• Journal of Magnetics
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• v.21 no.3
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• pp.442-449
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• 2016

In this paper, an effective numerical analysis method is proposed for calculating dosimetry of the wireless power transfer system operating low-frequency ranges. The finite-difference time-domain (FDTD) method is widely used to analyze bio-electromagnetic field problems, which require high resolution, such as a heterogeneous whole-body voxel human model. However, applying the standard method in the low-frequency band incurs an inordinate number of time steps. We overcome this problem by proposing a modified finite-difference time-domain method which utilizes a quasi-static approximation with the surface equivalence theorem. The analysis results of the simple model by using proposed method are in good agreement with those from a commercial electromagnetic simulator. A simulation of the induced electric fields in a human head voxel model exposed to a wireless power transmission system provides a realistic example of an application of the proposed method. The simulation results of the realistic human model with the proposed method are verified by comparing it with the conventional FDTD method.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.2
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• pp.314-321
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• 2002

An endoscope is usually inserted into the human body for the inspection of the gullet, stomach, and large intestine (colon) and this may cause discomfort to patients and damage to tissues during diagnostic or therapeutic procedures. This situation necessitates a self-propelling endoscope. There are many kinds of mechanism to move in a rigid pipe. However, these methods are difficult to apply directly to the endoscope. The main reason is that human intestine cannot be considered as a uniform, straight, and rigid pipe. This paper proposes a flexible loop wheel mechanism, which is adaptable to the human intestine. This mechanism is designed and fabricated by a simple modeling, and tested by an experiment. Finally, the actuator is inserted into the pig colon.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.05a
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• pp.196-201
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• 2003

철골조 초고층아파트 내부의 스포츠 시설 운영시 이를 사용하는 시설의 종류와 운동양상에 따라 아파트 상하부층에 소음진동의 민원문제를 유발하게 된다. 초고층 아파트 내부에 스포츠 시설의 배치는 이를 이용하는 사용자에게 편리성의 주지만 철골조의 특성상 충격성 진동원이 발생하는 스포츠 시설은 상하부층인 아파트에 소음진동의 연향으로 인해 이를 방지하는 설계가 요구된다. 일반적인 아파트의 충간 소음진동문제는 이를 발생시키는 상부거주자의 예절과 충간 소음진동 저감기술이지만 아파트 내부의 동일층을 경계로 위치한 스포츠 시설은 시설의 사용성에 반해 하부층에 미치는 영향을 기술적으로 저감하여야 한다. 입주한 초고층아파트에 발생하는 소음진동문제를 풀기 위하여 스포츠 시설 하부층 아파트의 소음진동 기준을 선정하고 스포츠 시설의 주된 진동원인 런닝머신의 하중식을 산정하고 충간 소음진동 저감을 위한 대책을 제시하였다.

• Korean Journal of Human Ecology
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• v.17 no.3
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• pp.521-532
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• 2008

The study aims to examine college students' practice characteristics related to diet and to identify factors determining their diet practice. The subjects were college students (N=387) in Youngnam region; a questionnaire survey was conducted in May, 2007. The data were analyzed by SPSS Windows. The results are as follows: first, the ratio of female students going on a diet is higher than that of male students. Second, according to the BMI, female students more regard themselves as being overweight than male students do, although they are underweight or normal weight. Third, in the interest in diet, almost half the students think of themselves as being "somewhat" or "much" concerned about diet. Fourth, the binary logistic regression analysis shows that the significant factors affecting female students' diet practice are the variables of "grade", "interest in diet", "body image evaluation in the individuals", "information/education requirement on dietary guidelines", and "necessity to go on a diet". On the other hand, the significant variables affecting male students' diet practice are the variables of "to take diet- or health-related courses", "interest in diet", "diet knowledge", and "diet practice".

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.1158-1162
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• 2005

Drug delivery systems have been developed to reduce the side toxicity of drugs by localizing them in the site of action. But it depends on the circulation of the blood and it doesn't have the function of locomotive mechanism of itself for searching for the region of disease. However, this problem could be solved by nanobot which have the locomotive function. So, we mimic the movement of cell that can move in a human body. In this paper, to polymerize the encapsulated actin within the liposome, electroporation technique is employed. In order to optimize polymerization and depolymerization of the liposome, we compare the time of polymerization and depolymerization by concentration of crown ether. we synthesis the liposome which contain azobenzene Linked crown Ether conjugated Actin protein. Azobenze linked crown ether holds the K+ ion by exposure of UV light and this disturbs the actin polymerization. In result, UV light could control the liposome growth. Finally, we could develop the liposome robot and control the growth and degeneration of the liposome by external stimuli such s UV light. The merit of the controlling by UV light doesn't need to inject proteins which induce polymerization and depolymerization of actin protein.