Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Phytochemical analysis of the antioxidant properties of Silybum marianum L

  • Pendry Barbara (Human and Exercise Science Academic Group, School of Health and Social Sciences, Middlesex University) ;
  • Busia Kofi (Department of Chemistry, University of Ghana) ;
  • Bell Celia M (Human and Exercise Science Academic Group, School of Health and Social Sciences, Middlesex University)
  • Published : 2006.09.01
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Abstract

A growing body of evidence supports lipid peroxidation as having a role in the pathogenesis of liver disease. Although the probable cause of damage to human hepatocytes may be multifactorial, free radicals have been implicated in a variety of liver diseases, particularly in the presence of iron overload and toxic substances such as ethanol. Consequently, antioxidants, particularly those of plant origin such as flavonoids, may help to reduce the risk of developing these diseases. Silybum (S.) marianum, a medicinal plant widely used in traditional European medicine for the treatment of liver disorders, was evaluated for antioxidant activity. Thin layer chromatography and High Performance Liquid Chromatography analyses of crude extract of the plant confirmed the presence of a number of flavonoids reported in the literature. The antioxidant activity of these flavonoids was measured through inhibition of lipid peroxidation and 1, 1-diphenyl-2- picrylhydrazyl radical scavenging. The crude plant extract showed marked antioxidant activity in both assays. These results suggest that S. marianum contains flavonoids with antioxidant activity, capable of inhibiting or scavenging free radicals, thus supporting its traditional use as a hepatoprotective agent.

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References

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