• Environmental Analysis Health and Toxicology
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• v.3 no.1_2
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• pp.9-19
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• 1988

The effect of rancid perilla oil on the immune response in mice was studied. ICR male mice were divided into 5 groups and were fed on the experimental diets for 4 weeks. Mice were sensitized and challenged with sheep red blood cell. Immune responses were evaluated by antibody production, Arthus reaction, delayed type hypersensitivity (DTH), Rosette forming cell and macrophage activity. Biochemical items were measured by serum protein and serum albumin. The weight of spleen, thymus and liver were measured. The rancid perilla oil diets decreased humoral and cellular immune responses, the number of peripheral circulating white blood cells and total protein and serum albumin. These results showed that the high rancid perilla oil diet decreased more humoral and cellular immune response, the number of peripheral circulating white blood cells, and total protein and serum albumin than the low rancid perilla oil diet did.

• 한국생물공학회:학술대회논문집
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• 2000.04a
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• pp.355-356
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• 2000

Three 'stress probe' plasmids were constructed and characterized which utilize a green fluorescent protein (CFP) as a non-invasive reporter to elucidate Escherichia coli cellular stress responses in quiescent or 'resting' cells. Facile detection of cellular stress levels was achieved by fusion of three heat shock stress protein promoter elements, those of the heat shock transcription factor ${\sigma}^{32}$, pretense subunit ClpB, and chaperone DnaK, to the reporter gene $gfp_{uv}$. When perturbed by chemical or physical stress (such as heat shock, nutrient (amino acid) limitation, addition of IPTG, acetic acid, ethanol, phenol, antifoam, and salt (osmotic shock), the E. coli cells produced GFPuv which was easily detected from within the cells as emitted green fluorescence. A temporal and amplitudinal mapping of these responses was performed, demonstrating regions where quantitative delineation of cell stress was afforded.

• Molecules and Cells
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• v.19 no.2
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• pp.167-179
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• 2005

The cells of metazoans respond to DNA damage by either arresting their cell cycle in order to repair the DNA, or by undergoing apoptosis. This response is highly conserved across species, and many of the genes involved in this DNA damage response have been shown to be inactivated in human cancers. This suggests the importance of DNA damage response with regard to the prevention of cancer. The DNA damage checkpoint responses vary greatly depending on the developmental context, cell type, gene expression profile, and the degree and nature of the DNA lesions. More valuable information can be obtained from studies utilizing whole organisms in which the molecular basis of development has been well established, such as Drosophila. Since the discovery of the Drosophila p53 orthologue, various aspects of DNA damage responses have been studied in Drosophila. In this review, I will summarize the current knowledge on the DNA damage checkpoint response in Drosophila. With the ease of genetic, cellular, and cytological approaches, Drosophila will become an increasingly valuable model organism for the study of mechanisms inherent to cancer formation associated with defects in the DNA damage pathway.

• The Plant Pathology Journal
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• v.26 no.2
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• pp.101-109
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• 2010

Protein phosphorylation is one of the major mechanisms for controlling many cellular processes in all living organisms. Mitogen-activated protein kinase (MAPK) cascades are known to transducer extracellular stimuli to several cellular processes, including cell division, differentiation as well as responses to various stresses. In plants, several studies have revealed that MAPK cascade pathways play an important role in responses against biotic and abiotic stresses, including wounding, pathogen infection, temperature, drought, salinity and plant hormones. It is also known that MAPK cascades-mediated signaling is an essential process in the resistance step to pathogens by regulating the activity of transcription factors. Here, the insights into the functions of MAPK cascade pathways in plant defense response signaling from Arabidopsis, tobacco and rice are described.

• Journal of the Korean Institute of Telematics and Electronics D
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• v.35D no.4
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• pp.32-39
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• 1998

Remez exchange algorithm was applied to realize an IF SAW filter for CDMA cellular phone systems. A SAW filter with withdrawal weighted transducers was simulated and then fabricated on 42.75.deg. ST-cut Quaritz wafer. Excellent agreement wasobtained between calculated andmeasured responses. Fabricated SAWfilterswere mounted on ceramic SMD package for reducing their size and volume. SAW filters were measured under matched circuit. As a result, 5 dB bandwidth of 1.32 MHz, 33dB bandwidth of 1.76 MHz, insertion loss of 13.8 dB and peak to peak ripple at passband of 0.26 dB were obtained. Linear group delay responses at passband were also obtained. These characteristics were good for practical use of IF SAW filter for CDMA system.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2000.09a
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• pp.19-19
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• 2000

Most renal diseases progress by consecutive cell responses such as hypertrophy, hyperplsia, proliferation, defferentiation, sclerosis, fibrosis and other cellular degenerative process. These cellular responses are mediated by the activation of various mitogens such as vasoconstrictors, growth factors, hormone, genotoxins and cytokines through mechanical, hemodynamic, immunological injury as well as metabolic abnormality. (omitted)

• IMMUNE NETWORK
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• v.13 no.1
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• pp.1-9
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• 2013

Autophagy is a fundamental cellular process in eukaryotic cells for maintaining homeostasis by degrading cellular proteins and organelles. Recently, the roles of autophagy have been expanded to immune systems, which in turn modulate innate immune responses. More specifically, autophagy acts as a direct effector for protection against pathogens, as well as a modulator of pathogen recognition and downstream signaling in innate immune responses. In addition, autophagy controls autoimmunity and inflammatory disorders by negative regulation of immune signaling. In this review, we focus on recent advances in the role of autophagy in innate immune systems.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.3
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• pp.199-204
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• 2001

In order to understand the phenomenon in a living cell correctly, it has been required to obtain intact responses from the cell membrane without disrupting the cytoplasmic circumstances. Gramicidin perforated patch configuration allows the electrical access to the whole cell with a minimal dialysis of cytoplasm and preventing the loss of native intracellular constituents, such as $Cl^-.$ Here, we would like to show the background of this method and the actual application of the gramicidin perforated patch recording mode on the dissociated neurons.

• Mycobiology
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• v.47 no.3
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• pp.346-349
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• 2019

AMP-activated protein kinase sucrose non-fermenting 1 (Snf1) is a representative regulator of energy status that maintains cellular energy homeostasis. In addition, Snf1 is involved in the mediation of environmental stress such as salt stress. Snf1 regulates metabolic enzymes such as acetyl-CoA carboxylase, indicating a possible role for Snf1 in metabolic regulation. In this article, we performed nuclear magnetic resonance (NMR) spectroscopy to profile the metabolic changes induced by Snf1 under environmental stress. According to our NMR data, we suggest that Snf1 plays a role in regulating cellular concentrations of a variety of metabolites during environmental stress responses.

• Korean Journal of Child Studies
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• v.35 no.1
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• pp.119-133
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• 2014

The purpose of this study is to examine the effects of time perspective, self-control and cellular phone addiction on academic procrastination, and to cellular phone addiction has any mediating effects in relation to the effects of adolescents' time perspective and self-control on academic procrastination. For this study, a survey was conducted with total 651 students in middle and high schools. Those who omitted responses or answered in ways which were otherwise invalid were excluded and finally, questionnaires responded to by 558 students were analyzed. Employing SPSS Win 12.0, average value, standard deviation, frequency analysis, Pearson's correlation analysis, stepwise multiple regression analysis, and simple linear regression analysis were used for the purposes of statistical analysis. In conclusion, first, explanations were made in order of future-oriented time perspective which is subordinate domain of view of time perspective, self-control, and cellular phone addiction. Second, it was found that cellular phone addiction has partially mediating effect on the relationships between future-oriented time perspective which is a subordinate area of adolescents' time perspective, and academic procrastination. Third, it was found that cellular phone addiction has partially mediating effect on the relationships between adolescents' self-control and academic procrastination.