• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.1B
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• pp.64-70
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• 2003

In order to provide seamless wireless Internet service, the basic mobile IP protocol should be enhanced to solve packet loss problem from large registration latency because frequent handoffs occur in cellular networks. In this paper, we suggest a new micro-mobility management protocol based on MPLS while supporting Qos, and evaluate its performance using simulation. We use MPLS label switching techniuqe in cellular access networks to simplify location management and speed up packet transmission. We adopt context transfer procedure to minimize the delay needed to attain prior level of service after handoff Packet loss can be minimized during handoff by transmitting received packets from old BSLER to new BSLER using a spliced LSP between them. Simulation results show that the proposed MPLS-based micro-mobility management protocol provides a seamless handoff and supports QoS of user traffic.

• Journal of Microbiology and Biotechnology
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• v.23 no.1
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• pp.131-135
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• 2013

A DOTAP analog labeled by NBD on the head group (DTNBD) was designed and synthesized to label DOTAP liposome. The structure was confirmed by $^1H$ NMR and FAB-MS, and the fluorescence of the newly synthesized DT-NBD was observed by fluorescent microscopy. The transfection efficiency of DOTAP liposome containing DT-NBD was comparable to commonly used NBD PE in COS7 and MCF7 cells. Furthermore, the level of cellular uptake and fluorescent intensity of fluorescent liposome containing DT-NBD was higher than NBD PE. Therefore, the novel NBD-labeled DOTAP analog seems to be effectively used for investigation of the cellular interaction and transfection mechanism of DOTAP liposome.

• Molecules and Cells
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• v.38 no.8
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• pp.677-684
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• 2015

Osteoarthritis (OA) is one of the most prevalent forms of joint disorder, associated with a tremendous socioeconomic burden worldwide. Various non-genetic and lifestyle-related factors such as aging and obesity have been recognized as major risk factors for OA, underscoring the potential role for epigenetic regulation in the pathogenesis of the disease. OA-associated epigenetic aberrations have been noted at the level of DNA methylation and histone modification in chondrocytes. These epigenetic regulations are implicated in driving an imbalance between the expression of catabolic and anabolic factors, leading eventually to osteoarthritic cartilage destruction. Cellular senescence and metabolic abnormalities driven by OA-associated risk factors appear to accompany epigenetic drifts in chondrocytes. Notably, molecular events associated with metabolic disorders influence epigenetic regulation in chondrocytes, supporting the notion that OA is a metabolic disease. Here, we review accumulating evidence supporting a role for epigenetics in the regulation of cartilage homeostasis and OA pathogenesis.

• Archives of Pharmacal Research
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• v.22 no.3
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• pp.255-261
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• 1999

The effect of biphenyl dimethyl dicarboxylate (PMC) on the cellular and nonspecific immunosuppressions by ketoconazole (KCZ) was investigated in ICR mice. PMC at a dose of 6 mg/kg was administered orally to mice daily for 14 consecutive days. KCZ was suspended in RPMI 1640 medium and orally administered at 160 mg/kg/day 2 hrs after the administration of PMC. Immune responses of the delayed-type hypersensitively (DTH) reaction to sheep red blood cells (SRBC), phagocytic activity and natural killer (NK) cell activity were evaluated. DTH reaction to SRBC was enhanced to normal level by the combination of PMC and KCZ, as compared with treatment of KCZ alone. In the combination of PMC and KCZ, as compared with treatment of KCZ alone, there were also significant increases in activities of natural killer (NK) cells and phagocytes along with circulating leukocytes. These findings indicate that PMC shows a significant restoration from the immunotoixc status induced by KCZ.

• Molecules and Cells
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• v.41 no.12
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• pp.1000-1007
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• 2018

Mitochondria and endoplasmic reticulum (ER) are essential organelles in eukaryotic cells, which play key roles in various biological pathways. Mitochondria are responsible for ATP production, maintenance of $Ca^{2+}$ homeostasis and regulation of apoptosis, while ER is involved in protein folding, lipid metabolism as well as $Ca^{2+}$ homeostasis. These organelles have their own functions, but they also communicate via mitochondrial-associated ER membrane (MAM) to provide another level of regulations in energy production, lipid process, $Ca^{2+}$ buffering, and apoptosis. Hence, defects in MAM alter cell survival and death. Here, we review components forming the molecular junctions of MAM and how MAM regulates cellular functions. Furthermore, we discuss the effects of impaired ER-mitochondrial communication in various neurodegenerative diseases.

• Journal of Advanced Information Technology and Convergence
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• v.8 no.2
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• pp.13-25
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• 2018

The paper analyzes the sum spectral efficiency (SE) for a heterogeneous cellular network (HetNet) which has the backhaul, provided with wireless full-duplex massive multiple-input multiple-out (MIMO) with hardware distortions. We derive approximate expressions to obtain the uplink/downlink sum SE of the backhaul. The analytic results have been shown to be exact when compared to Monte Carlo simulations. From the analysis, it is shown that the desired signal and the hardware distortion noise have the same order. The sum SE generally improves when the number of receive antennas increases but degrades when the hardware quality reduces. A sum SE performance ceiling is introduced by the hardware quality level.

• Journal of Advanced Information Technology and Convergence
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• v.10 no.1
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• pp.25-36
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• 2020

Motivation: Fibers as the extracellular filamentous structures determine the shape of the cytoskeletal structures. Their characterization and reconstruction from a 3D cellular image represent very useful quantitative information at the cellular level. In this paper, we presented a novel automatic method to extract fiber diameter distribution through a pipeline to reconstruct fibers from 3D fluorescence confocal images. The pipeline is composed of four steps: segmentation, skeletonization, template fitting and fiber tracking. Segmentation of fiber is achieved by defining an energy based on tensor voting framework. After skeletonizing segmented fibers, we fit a template for each seed point. Then, the fiber tracking step reconstructs fibers by finding the best match of the next fiber segment from the previous template. Thus, we define a fiber as a set of templates, based on which we calculate a diameter distribution of fibers.

• CELLMED
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• v.13 no.13
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• pp.49.1-49.6
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• 2023

Objective: A Case report on the improvement of dermatitis through implementation of OCNT. Methods: OCNT was implemented for 3 months for a Korean man in his 70's with dermatitis with unknown cause since 2015. Results: Following the implementation of OCNT, fever that accompanied dermatitis subsided, occurrence of itchiness and abscess decreased, and the stratum corneum of the palm although displayed improvement of being thinned. As the result of visual follow-up observation upon discontinuation of OCNT, damaged skin due to inflammation was restored to the level of normal skin. Conclusion: OCNT can provide assistance to those experiencing inconvenience due to dermatitis.

• CELLMED
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• v.14 no.3
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• pp.67.1-67.3
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• 2024

Objective: A Case study on improvement of ICE syndrome through the use of OCNT. Methods: OCNT was performed on a 45-year-old Korean female who had difficulty in opening the eyes widely due to painful and xerophthalmias, and suffered inconvenience in daily life due to myodesopsia. Results: After the implementation of OCNT, the intraocular pressure (IOP) level was restored to normal, and the pain, dryness and myodesopsia symptoms were alleviated. This resulted in improvement in depressive symptoms and quality of life. Conclusion: For patients suffering from problems such as elevated intraocular pressure, myodesopsia, and xerophthalmia, OCNT can be helpful in improvement and treatment of symptoms.

• Proceedings of the IEEK Conference
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• 2000.06b
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• pp.226-229
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• 2000

In this paper, we describe implementation of 32-Bit RISC Core for portable communication/information equipment, such as cellular telephones and personal digital assistants, notebook, etc. The RISC core implements the ARM$\^$R/V4 instruction set on the basis of low power techniques in architecture level and logic level. It operates with 5-stage pipeline, and has harvard architecture to increase execution speed. The processor is modeled and simulated in RTL level using VHDL. Behavioral Cache and MMU are added to the VHDL model for instruction level verification of the processor. The core is implemented using Mentor P'||'&'||'R tools with IDEC C-631 Cell library of 0.6$\mu\textrm{m}$ CMOS 1-poly 3-metal CMOS technology.