• Genomics & Informatics
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• 제8권2호
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• pp.90-93
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• 2010

A-kinase-anchoring proteins (AKAPs) are scaffold proteins which compartmentalize protein kinase A (PKA, cAMP-dependent protein kinase) and other enzymes to specific subcellular sites. The spatiotemporal control of these enzymes by AKAPs is important for cellular function like cell growth and development etc. Hence, it is important to understand the basic function of AKAPs and their functional domains. However, diverse names, function, cellular localizations and many members of AKAPs increase difficulties when researchers search appropriate AKAPs for their experimental purpose. Nevertheless, there was no previous AKAPs-related database regardless of their important cellular functions and difficulty of finding appropriate AKAPs. So, we developed AKAPs database (AKAPDB), which contains their sequence information, functions and other information derived from prediction programs and other databases. Therefore, we propose that AKAPDB can be an important tool to researchers in the related fields. AKAPDB is available via the internet at http://plaza3.snu.ac.kr/akapdb/.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제29권2호
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• pp.108-115
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• 2003

Suppression of cellular immunity is the host responses to surgical stress. When the body is exposed to surgical stress, decreased immunocyte function is one of the surgical stress-induced biologic responses. In all patients exposed to the surgical stress, peripheral blood lymphocyte numbers and function were suppressed until at least 2 weeks postoperatively. This immunosuppression was mainly due to a decrease of helper-inducer T cells, cytotoxic T cells, natural killer cells, and an increase of suppressor T cells. The blood levels of interleukin-6(IL-6) cytokine increase in response to surgical stress and cause an increase of so-called acute phase reactants, including C-reactive protein(CRP). In the previously damaged patients group, expected to early stress expose, immunosuppression was more developed than other normal groups. Cellular immunosuppression by surgical stress was mainly due to an increase of lymphocyte subsets that depress cellular immunity coupled with a decrease of the subsets that promote it. Overproduction of CRP in response to surgical stress may play an important role in the development of immunosuppression.

• Structural Engineering and Mechanics
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• 제23권1호
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• pp.29-42
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• 2006

This paper describes the design scheme of the three-dimensional structures based on the concept of the cellular automata simulation. The cellular automata simulation is performed according to the local rule. In this paper, the local rule is derived in the mathematical formulation from the optimization problem. The cell density is taken as the design variable. Two objective functions are defined for reducing the total weight of the structure and obtaining the fully stressed structure. The constraint condition is defined for defining the local rule. The penalty function is defined from the objective functions and the constraint condition. Minimization of the penalty function with respect to the design parameter leads to the local rule. The derived rule is applied to the design of the three-dimensional structure first. The final structure can be obtained successfully. However, the computational cost is expensive. So, in order to reduce the computational cost, the material parameters $c_1$ and $c_2$ and the value of the cell rejection criterion (CRC) are changed. The results show that the computational cost depends on the parameters and the CRC value.

• Molecular & Cellular Toxicology
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• 제3권4호
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• pp.222-230
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• 2007

Some drugs may be limited in their clinical application due to their propensity towards their adverse effects. Toxicogenomic technology represents a useful approach for evaluating the toxic properties of new drug candidates early in the drug discovery process. Nitrofurantoin (NF) is clinical chemotherapeutic agent and antimicrobial and used to treatment of urinary tract infections. However, NF has been shown to result in pulmonary toxic effects. In this research, we revealed the changing expression gene profiles in BEAS-2B, human bronchial epithelial cell line, exposed to NF by using human oligonucleotide chip. Through the clustering analysis of gene expression profiles, we identified 136 up-regulated genes and 379 down-regulated genes changed by more than 2-fold by NF. This study identifies several interesting targets and functions in relation to NF-induced toxicity through a gene ontology analysis method including biological process, cellular components, molecular function and KEGG pathway.

• 대한전자공학회논문지TC
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• 제48권1호
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• pp.55-61
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• 2011

본 논문에서는 device-to-device (D2D) 시스템이 M 개의 셀룰러 단말기들과 상향 링크의 주파수 자원을 공유할 때 셀룰러 단말기들에 의한 간섭과 D2D 통신 단말기 쌍의 신호의 파워 비에 따른 outage 확률을 분석한다. 이 때, D2D 통신 전송기의 최대 전송 파워는 셀룰러 네트워크에 어떠한 해로운 간섭도 발생하지 않게 하기 위해서 엄격하게 제한된다. 수학적 모델에 의해 D2D 통신 수신기의 outage 확률은 셀룰러 사용자 단말기들에 의해 발생하는 간섭 대 선호 비 및 셀룰러 사용자 단말기의 개수, M에 의한 함수로 표현된다. 또한, 셀룰러 사용자 단말기들에 의해 발생하는 간섭 대 신호 비는 D2D 통신 단말기 쌍, 셀룰러 사용자 단말기들, 및 기지국과의 거리의 함수로 표현된다. 얻어진 outage 확률을 이용해서, D2D 통신 시스템의 신뢰성을 쉽게 평가할 수 있다. 또한, 분석의 타당성을 입증하기 위해 모의실험들을 제공한다.

• 한국통신학회논문지
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• 제36권6C호
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• pp.361-367
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• 2011

본 논문에서는 효율적인 영상 암호화를 위해 NBCA(Null Boundary CA)에 기초한 여원 MLCA(Maximum Length Cellular Automata)와 2D CAT(Two-Dimensional Cellular Automata Transform)를 이용한 암호화 방법을 제안한다. 암호화 방법은 먼저, Wolfram Rule 행렬에 의해 전이행렬 T를 생성한다. 그 후, 암호화하려는 원영상에 생성된 전이 행렬 T를 곱하여 원 영상의 픽셀 값을 변환한다. 또한 변환된 원 영상을 여원 벡터 F와 XOR 연산하여 여원 MLCA가 적용된 영상으로 변환한다. 다음, 게이트웨이 값을 설정하여 2D CAT 기저함수를 생성한다. 그리고, 여원 MLCA가 적용된 영상에 생성된 기저함수를 곱하여 2D CAT 암호화를 한다. 마지막으로 안정성 분석을 통하여 제안한 방법이 높은 암호화 수준의 성질을 가졌음을 검증한다.

• 한국정보통신학회논문지
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• 제13권2호
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• pp.299-308
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• 2009

본 논문에서는 온라인 게임 상의 사용자 인증에 적용 가능한 이차원 셀룰라 오토마타 기반 해쉬함수에 대한 충돌쌍 공격을 제안한다. 이것은 라운드 함수에서 사용되는 비선형 함수의 비선형 성질을 이용하여 입력된 베시지 차분을 확률 $2^{-28}$으로 상쇄시키는 공격이다. 또한, 최근 발표된 Wang의 분석 기법을 이용하여 확률 1로 만족하는 충돌쌍 공격을 제시한다.

• Integrative Medicine Research
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• 제6권3호
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• pp.254-259
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• 2017

Background: Those classified as Tae-Eum (TE)-type people in Sasang constitutional medicine (SCM) are prone to obesity. Although extensive clinical observations have confirmed this tendency, the underlying physiological mechanisms are unknown. Here, we propose a novel hypothesis using integrative physiology to explain this phenomenon. Methods: Hypoactive lung function in the TE type indicates that respiration is attenuated at the cellular level - specifically, mitochondrial oxygen consumption. Because a functional reduction in cellular energy metabolism is suggestive of intrinsic hypoactivity in the consumption (or production) of metabolic energy, we reasoned that this tendency can readily cause weight gain via an increase in anabolism. Thus, this relationship can be derived from the graph of cellular metabolic power plotted against body weight. We analyzed the clinical data of 548 individuals to test this hypothesis. Results: The statistical analysis revealed that the cellular metabolic rate was lower in TEtype individuals and that their percentage of obesity (body mass index >25) was significantly higher compared to other constitutional groups. Conclusion: Lower cellular metabolic power can be an explanation for the obesity trend in TE type people.

• The Korean Journal of Physiology and Pharmacology
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• 제25권4호
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• pp.297-305
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• 2021

Luteolin, a sort of flavonoid, has been reported to be involved in neuroprotective function via suppression of neuroinflammation. In this study, we investigated the protective effect of luteolin against oxidative stress-induced cellular senescence and its molecular mechanism using hydrogen peroxide (H₂O₂)-induced cellular senescence model in House Ear Institute-Organ of Corti 1 cells (HEI-OC1). Our results showed that luteolin attenuated senescent phenotypes including alterations of morphology, cell proliferation, senescence-associated 𝛽-galactosidase expression, DNA damage, as well as related molecules expression such as p53 and p21 in the oxidant challenged model. Interestingly, we found that luteolin induces expression of sirtuin 1 in dose- and time-dependent manners and it has protective role against H₂O₂-induced cellular senescence by upregulation of sirtuin 1 (SIRT1). In contrast, the inhibitory effect of luteolin on cellular senescence under oxidative stress was abolished by silencing of SIRT1. This study indicates that luteolin effectively protects against oxidative stress-induced cellular senescence through p53 and SIRT1. These results suggest that luteolin possesses therapeutic potentials against age-related hearing loss that are induced by oxidative stress.

• 디지털융복합연구
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• 제17권12호
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• pp.117-127
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• 2019

본 연구의 목적은 중국 소비자의 휴대폰 선택 시 고려하는 주요 평가영역에 대한 세부 특성요인의 만족도가 해당 평가영역 만족도에 어떠한 영향을 미치며, 각 평가영역에 대한 만족도가 고객의 재구매의도와 타인추천의도에 어떠한 영향을 미치는가를 사용 휴대폰 유형에 따른 집단별로 분석하는데 있다. 설문조사 시 평가요인으로 가격, 디자인, 품질, 편리성, 기능 그리고 개인적 요인을 설정하였으며, 재구매의도와 타인추천의도로 구분 실시하였다. 연구결과, 가격을 제외한 모든 특성요인이 해당 평가영역의 만족에 유의한 것으로 나타났으며 유의한 경로가 집단별로 차이가 존재함을 알 수 있었다. 또한 모든 집단에서 평가영역에 대한 만족이 재구매의도와 타인추천의도에 유의한 것으로 평가되었다. 연구 결과 우리 기업의 경우 디자인, 기능, 개인적 요인에 관한 특성요인은 평가영역 만족에 유의한 영향을 미치나 해당 특성요인의 만족도는 상대적으로 낮은 것으로 나타난다. 따라서 이들 특성요인에 대한 만족도를 높일 수 있는 품질 개선방안을 강구하여야 할 것으로 사료된다.