Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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THE IMMUNE SUPPRESSIVE EFFECT FROM THE STRESS OF MAXILLOFACIAL OPERATIONS

구강악안면 영역의 수술이 인체내 세포면역성 억제에 미치는 영향

  • Kim, Soung-Min (Department of Oral & Maxillofacial Surgery, Research Institute of Oral Science, College of Dentistry, Kangnung National University) ;
  • Lee, Suk-Keun (Department of Oral Pathology, College of Dentistry, Kangnung National University)
  • 김성민 (강릉대학교 치과대학 구강악안면외과학교실 및 구강과학연구소) ;
  • 이석근 (강릉대학교 치과대학 구강병리학교실)
  • Published : 2003.04.30
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Abstract

Suppression of cellular immunity is the host responses to surgical stress. When the body is exposed to surgical stress, decreased immunocyte function is one of the surgical stress-induced biologic responses. In all patients exposed to the surgical stress, peripheral blood lymphocyte numbers and function were suppressed until at least 2 weeks postoperatively. This immunosuppression was mainly due to a decrease of helper-inducer T cells, cytotoxic T cells, natural killer cells, and an increase of suppressor T cells. The blood levels of interleukin-6(IL-6) cytokine increase in response to surgical stress and cause an increase of so-called acute phase reactants, including C-reactive protein(CRP). In the previously damaged patients group, expected to early stress expose, immunosuppression was more developed than other normal groups. Cellular immunosuppression by surgical stress was mainly due to an increase of lymphocyte subsets that depress cellular immunity coupled with a decrease of the subsets that promote it. Overproduction of CRP in response to surgical stress may play an important role in the development of immunosuppression.

Keywords

References

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