• Title/Summary/Keyword: case-controlled study

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The Systematic Review on Clinical Studies of Traditional Korean Medicine Treatment for Obesity in Menopausal Women (폐경 여성의 비만에 응용되는 한방치료에 대한 문헌 고찰)

  • Nam, Eun Young
    • Journal of Korean Medicine for Obesity Research
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    • v.19 no.1
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    • pp.56-67
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    • 2019
  • Objectives: The purpose of this study is to review clinical studies of herb medicine and acupuncture treatment on obesity in menopausal women. Methods: Key words "Obesity", "Menopause", "Herb medicine", "Acupuncture", "Moxibustion", "Catgut embedding" were searched on 9 database systems (PubMed Central, Cochrane Controlled Register of Trials, Embase, China Academic Journals, Korean Traditional Knowledge Portal, Oriental Medicine Advanced Searching Integrated System, Korean Studies Information Service System, National Digital Science Library, DBpia) on April 30th 2019. Results: 1 case report and 17 clinical trials were collected in accordance with the selection and exclusion criteria. Among the 17 trials, 6 were randomized controlled trials, 1 was controlled clinical trial, and 10 were single-arm trials. The types of intervention were herb medicine, electroacupuncture, acupuncture, auricular acupuncture, warm needle acupuncture, moxibustion, laser acupuncture, and catgut embedding. The study design, study results and method of intervention were analyzed. Conclusions: 1 case report described the effectiveness of pharmacopuncture, 4 trials described the effectiveness of herbal medicine, 2 of electroacupuncture, 1 of laser acupuncture, and 2 of catgut embedding. Among the 17 trials, 2 studies showed that herbal medicine treatment was more effective than no treatment or selective serotonin reuptake inhibitors, and 1 study showed that electroacupuncture was more effective than hormone therapy. All of 18 selected studies reported the effectiveness of weight reduction and abdominal obesity reduction after the traditional Korean medicine treatment for obesity in menopausal women.

Usage of Korean Herbal Medicine for Climacteric Symptoms - Analysis of Korean Clinical Studies (갱년기 증상에 대한 한약 사용 - 국내 한의 임상연구 분석)

  • Minjung Bae;Jaewoon Ha;Youngju Yun
    • Journal of Society of Preventive Korean Medicine
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    • v.27 no.2
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    • pp.85-107
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    • 2023
  • Objective : To investigate the usage of Korean herbal medicine (KHM) for climacteric symptoms, this study reviewed clinical studies conducted in Korea. Method : Literature search was performed on three Korean database; OASIS, RISS and NDSL. Studies published before July 2023 were categorized and analyzed according to the study type and herbal prescriptions. Results : Fifty-eight studies including 7 controlled trial, 27 case series and 24 single case reports were included in our review and the total number of case patients was 420. 52 prescriptions based on syndrome identifications and 11 prescriptions of Sasang constitutions were used and the most frequently used prescriptions were Soyosan(逍遙散) and Guibitang(歸脾湯). Thirty-two prescriptions were also mentioned in previous delphi research or clinical practice guideline, and the rest were not. Thirty-five studies used acupuncture combined with KHM and 10 studies used pharmacopuncture and 5 studies used herbal hipbath. Conclusion : To increase the therapeutic effect of KHM and establish KHM as an alternative to hormone treatment, various prescriptions should be used according to syndrome identifications in the clinical field. High-quality RCTs on frequently used prescriptions and the development of various type of KHM are also necessary.

A Review on Clinical Studies of the Acupuncture and Moxibustion Therapy for Gastroesophageal Reflux Disease in China by Searching CAJ (CAJ 검색을 통해 살펴 본 중국에서의 역류성 식도질환 침구치료 임상연구 동향에 대한 고찰)

  • Kang, Sei-Young
    • Korean Journal of Acupuncture
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    • v.32 no.1
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    • pp.1-12
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    • 2015
  • Objectives : The purpose of this study was to review the acupuncture and moxibustion therapy for gastroesophageal reflux disease(GERD) in China. Methods : The literatures were searched using the database-China Academic Journals(CAJ)(~2015.1.). Clinical studies of acupuncture and moxibustion therapy for GERD such as randomized controlled trial(RCT), non-randomized controlled trial(NRCT), case series, or case report were included. Results : Thirty studies met our inclusion criteria: 24 RCTs, 4 NRCTs, 1 case series, 1 case report. Various kinds of treatment such as body acupuncture, abdominal acupuncture, acupuncture therapy with finger on back-shu point, electroacupuncture, acupoint injection, auricular acupuncture, and moxibustion were used in the clinical studies. The treatment groups take herbal medicines at the same time in 16 studies, and proton pump inhibitor(PPI) and histamine 2 receptor antagonist were used as a comparative treatment in the most of studies. Acupuncture or moxibustion treatments were done daily or 2~3 times a week for 5 days~18 weeks. All of studies reported higher effective rate in the acupuncture or moxibustion treatment group compared to the western medication control group. Conclusions : The results of this study could be used for the future practice and the clinical research about the acupuncture and moxibustion therapy for GERD.

Study of Diffusion-controlled Processes. Solution of the Smoluchowski Equation with a Step Potential

  • Kim, Dae-Young;Shin, Seok-Min;Shin, Kook-Joe
    • Bulletin of the Korean Chemical Society
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    • v.7 no.4
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    • pp.271-275
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    • 1986
  • The Smoluchowski equation with a step potential is solved in one-dimensional case and three-dimensional case with spherical symmetry. Exact analytic expressions for the solution and the remaining probability are obtained in one-dimensional case for the reflecting boundary condition and the long time behavior of the remaining probability is compared with the earlier work. In three-dimensional case, only the long time behavior is evaluated. More general case with the radiation boundary condition is also investigated and the results are shown to approach correct limits of the reflecting boundary condition.

Descriptor Profiling for Research Domain Analysis (연구영역분석을 위한 디스크립터 프로파일링에 관한 연구)

  • Kim, Pan-Jun;Lee, Jae-Yun
    • Journal of the Korean Society for information Management
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    • v.24 no.4
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    • pp.285-303
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    • 2007
  • This study aims to explore a new technique making complementary linkage between controlled vocabularies and uncontrolled vocabularies for analyzing a research domain. Co-word analysis can be largely divided into two based on the types of vocabulary used: controlled and uncontrolled. In the case of using controlled vocabulary, data sparseness and indexer effect are inherent drawbacks. On the other case, word selection by the author's perspective and word ambiguity. To complement each other, we suggest a descriptor profiling that represents descriptors(controlled vocabulary) as the co-occurrence with words from the text(uncontrolled vocabulary). Applying the profiling to the domain of information science implies that this method can complement each other by reducing the inherent shortcoming of the controlled and uncontrolled vocabulary.

A new proposal for controlled recycling of decommissioning concrete waste as part of engineered barriers of a radioactive waste repository and related comprehensive safety assessment

  • In Gyu Chang;Jae Hak Cheong
    • Nuclear Engineering and Technology
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    • v.55 no.2
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    • pp.530-545
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    • 2023
  • As an alternative to conventional management options for a lot of concrete waste from decommissioning of nuclear power plants, a set of scenarios for controlled recycling of decommissioning concrete waste as engineered barriers of a radioactive waste repository was proposed, and a comprehensive safety assessment model and framework covering both pre-and post-closure phases was newly developed. The new methodology was applied to a reference vault-type repository, and the ratios of derived concentration limits to unconditional clearance levels of eighteen radionuclides for controlled recycling were provided for three sets of dose criteria (0.01, 1, and 20 mSv/y for the pre-closure and 0.01 mSv/y for the post-closure phases). It turns out that decommissioning concrete waste whose concentration is much higher than the unconditional clearance level can be recycled even when the dose criterion 0.01 mSv/y is applied. Moreover, a case study on ABWR bio-shield shows that the fraction of recyclable concrete waste increases significantly by increasing the dose criterion for the radiation worker in the pre-closure phase or the duration of storage prior to recycling. The results of this study are expected to contribute to demonstrating the feasibility of controlled recycling of a lot of decommissioning concrete waste within nuclear sectors.

Recent Clinical Research on Effect of Acupuncture for Strabismus (사시의 침치료에 대한 최근 임상 연구 동향)

  • Lee, Ji Na;Lee, Sun Haeng;Lee, Jin Yong
    • The Journal of Pediatrics of Korean Medicine
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    • v.30 no.2
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    • pp.23-30
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    • 2016
  • Objectives The purpose of this study is to investigate recent clinical studies on effect of acupuncture for strabismus in Korea and other countries. We have analyzed 10 years (from 2006 to 2015) of case studies and randomized controlled trials (RCT) on effect of acupuncture for strabismus. Methods The search database includes Oasis, KTKP (Korean Traditional Knowledge Portal), Medline, Embase, and Cochrane library. To narrow the search, the following key search terms were used: 'strabismus, acupuncture'. The search was limited to the publication date from 2006 to 2015. 7 case studies and 5 control studies were selected for analysis. Results and Conclusions 1. The acupuncture treatment is effective for paralytic strabismus 2. The studies used BL1, GB1, ST2, TE23, GB15, EX-HN5, ST1, and LI4 acupoints and also an electroacupuncture treatment, which is 15 minutes of extraocular muscle stimulation, was used. 3. Degree of strasbismus was tested by Ocular motor range test, Corneal light reflex test, Ocular abducent scale test (Scott and Kraft, Diploptic range test).

A Clinical Study on 1 Case of Pregnancy in Ovulation Disorder Patient Resistant to Controlled Ovarian Hyperstimulation (배란 유도에 실패한 배란장애 환자의 한방치료 후 자연 임신 및 출산 1례에 대한 증례 보고)

  • Hwangbo, Su-Min;Hwang, Deok-Sang;Lee, Jin-Moo;Lee, Chang-Hoon;Jang, Jun-Bock
    • The Journal of Korean Obstetrics and Gynecology
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    • v.31 no.3
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    • pp.121-130
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    • 2018
  • Objectives: The purpose of this study is to report the effects of Korean medical treatment in ovarian disorder patients resistant to controlled ovarian hyperstimulation. There are some case-reports about effectiveness of the Korean medical treatment to treat ovulation disorder and become pregnant, but cases are still deficient. Methods: The patient was diagnosed possibility of premature ovarian failure by serum hormone assay and underwent hyperstimulation to freeze oocyte. But ovary had no response to hyperstimulation. She was treated by Korean medical treatment, such as herbal medicine, acupuncture and moxibustion. Results: After the treatment, the patient recovered from irregular ovulation & menstrual cycle and became pregnant and gave birth. Conclusions: This case shows the Korean medical treatment might be effective in ovarian disorder patients resistant to hyperstimulation.

A Study on Frequency Controlled Bandwidth adjustable Bandpass Filter (주파수제어 대역폭조정 대역통과 여파기에 관한 연구)

  • 최갑석
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.12 no.1
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    • pp.18-26
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    • 1975
  • In this paper, a frequency controlled bandwidth adjustable bandpass filter consisting of 4-path system is precented. It is shown that this system has characteristics similar to ihose of the magneticuly coupled double tuned amplifier and the center frequency of the passband is able to be shifted contineolisly. The adjustable range of the bartdwidth of the filter system is anslyzed for she case of the double and single tuned characteristics. The experiment has been conducted to verify the theory of this system and the experimental resulis are in good agreement with the theoretically calculated values.

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A Study of Clinical Efficacy of GnRH Antagonist (Cetrorelix) Single and Multiple Dose Protocol for Controlled Ovarian Hyperstimulation (과배란유도에서 GnRH Antagonist (Cetrorelix) Single 및 Multiple Dose Protocol의 임상적 효용성에 관한 연구)

  • Ko, Sang-Hyeon;Kim, Dong-Ho;Bae, Do-Hwan;Lee, Sang-Hoon
    • Clinical and Experimental Reproductive Medicine
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    • v.29 no.4
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    • pp.259-267
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    • 2002
  • Objective: This study was performed to compare the clinical outcomes of GnRH antagonist (Cetrorelix) single dose and multiple dose protocols for controlled ovarian hyperstimulation with GnRH agonist long protocol. Materials and Method: From September 2001 to March 2002, 48 patients (55 cycles) were performed controlled ovarian hyperstimulation for ART using by either GnRH antagonist and GnRH agonist. Single dose of 3 mg GnRH antagonist was administered in 15 patients (17 cycles, single dose group) at MCD #8 and multiple dose of 0.25 mg of GnRH antagonist was administered in 15 patients (18 cycles, multiple dose group) from MCD #7 to hCG injection day. GnRH agonist was administered in 18 patients (20 cycles, control group) by conventional GnRH agonist long protocol. We compared the implantation rate, number of embryos, and clinical pregnancy rate among three groups. Student-t test and Chi-square were used to determine statistical significance. Statistical significance was defined as p<0.05. Results: There were no significant differences in ampules of used gonadotropins, number of mature oocytes, obtained embryos between single and multiple dose group, but compared with control group, ampules of used gonadotropins, number of mature oocytes, obtained embryos were decreased significantly in both groups. Clinical pregnancy rate and implantation rate were not different in three groups. There were no premature LH surge and ovarian hyperstimulation syndrome in three groups. Multiple pregnancy were occurred 1 case in multiple dose group and 2 case in control group. Conclusions: GnRH antagonist is a safe, effective, and alternative method in the controlled ovarian hyperstimulation compared with GnRH agonist. Clinical outcomes and efficacy of both single and multiple dose protocol are similar between two groups.