• Title/Summary/Keyword: c-jun

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Improvement of Mechanical and Interfacial Properties of Carbon Fiber/Epoxy Composites by Adding Nano SiC Fillers (나노 SiC 입자의 형상에 따른 탄소섬유 강화 에폭시 복합재료의 기계적 및 계면 물성 변화 관찰)

  • Kwon, Dong-Jun;Wang, Zuo-Jia;Kim, Je-Jun;Jang, Key-Wook;Park, Joung-Man
    • Journal of Adhesion and Interface
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    • v.14 no.2
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    • pp.75-81
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    • 2013
  • Epoxy matrix based composites were fabricated by adding SiC nano fillers. The interfacial properties of composites were varied with different shapes of SiC nano fillers. To investigate the shape effects on the interfacial properties, beta and whisker type SiC nano fillers were used for this evaluation. The dispersion states of nano SiC-epoxy nanocomposites were evaluated by capacitance measurements. FE-SEM was used to observe the fracture surface of different structures of SiC-epoxy nanocomposites and to investigate for reinforcement effect. Interfacial properties between carbon fiber and SiC-epoxy nanocomposites were also evaluated by ILSS (interlaminar shear strength) and IFSS (interfacial shear strength) tests. The interfacial adhesion of beta type nanocomposites was better than whisker type.

ESA(Electro-Static Analyzer) on the KAISTSAT-4

  • Lee, Jae-Jin;Shin, Young-Hoon;Jongho Seon;Lee, Ensang;Kim, Hee-Jun;Min, Kyoung-Wook;M.P. McCarthy;Park, G.K. s
    • Bulletin of the Korean Space Science Society
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    • 2000.04a
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    • pp.52-52
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    • 2000
  • No Abstract, See Full Text

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Antimony Surfactant Effect on p-GaN growth by Metal Organic Chemical Vapor Deposition (MOCVD)

  • Lee, Yeong-Gon;Sadasivam, Karthikeyan Giri;Baek, Gwang-Seon;Kim, Bong-Jun;Kim, Hak-Jun;Lee, Jun-Gi
    • Proceedings of the Materials Research Society of Korea Conference
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    • 2010.05a
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    • pp.56.2-56.2
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    • 2010
  • An improvement in the optical and structural properties of p-GaN was obtained by using antimony (Sb) as a surfactant during p-GaN growth. Two different growth temperatures of p-GaN such as $1030^{\circ}C$ and $900^{\circ}C$ were considered. Keeping the growth conditions for p-GaN constant, Sb was introduced during p-GaN growth while varying the [Sb]/([Ga]+[Mg]) flow ratio. [Sb]/([Ga]+[Mg]) flow ratio will be denoted as SGM ratio for convenience. SGM ratio of 0, 0.015 and 0.03% were considered for high temperature p-GaN growth. SGM ratio of 0, 0.005, 0.01 and 0.02% were considered for low temperature p-GaN growth. The analysis results suggest that using the optimum SGM ratio during p-GaN growth greatly improves the optical and structural properties of the p-GaN.

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Study of Residual Stress Control for Thickening to Hydrogen Free-DLC Films (무수소 DLC막의 후막화를 위한 잔류응력 제어 연구)

  • Kim, Jong-Guk;Gang, Yong-Jin;Kim, Gi-Taek;Kim, Dong-Sik;Ryu, Ho-Jun;Jang, Yeong-Jun
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2016.11a
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    • pp.101-101
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    • 2016
  • DLC(Diamond Like Carbon)막은 그 물성의 다양함으로 인하여 산업기계, 금형, 공구, 광학 및 수송기기의 파워셀 부품등 많은 산업분야에 활용되고 있다. 일반적으로 DLC막은 증착에 사용되는 카본의 원료에 따라 크게 두 가지로 나눌 수 있는데, 이는 탄화 수소계 가스(CxHy)를 사용하여 증착된 a-C:H(amorphous Hydro-Carbon)과 고체 카본을 사용하는 a-C(amorphous Carbon)이다. 또한 a-C 중 진공 아크 공법으로 제작된 막(ta-C : tetrahedral amorphous-Carbon)은 다이아몬드 성분인 sp3의 분률이 높아, 그 경도는 40 - 85 GPa 이상이며, 무수소화로 500도 이상의 고온에서도 그 물성의 변화가 적어 그 활용도가 높아지고 있다. 하지만 높은 경도와 더불어 막의 잔류응력이 높아 3 um 이상 후막화하는 것은 어렵다. 이는 높은 잔류응력으로 인한 막의 증착시, 막 자체가 파손되거나, 기판과 막사이의 계면 밀착력이 약하여 박리되거나, 또는 높은 밀착력으로 인하여 모재가 파손되는 등 다양한 문제를 발생한다. 본 연구에서는 이 고경도 무수소 DLC막(ta-C)의 후막화하는 방안으로 주요 코팅 변수와 잔류응력과의 관계를 에너지 관점에서 파악하고 이를 활용 잔류응력을 제어하여 할 수 있는 방법을 제시하고자 한다.

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Mechanical Alloying and Combined Process of in-situ and ex-situ to Fabricate the ex-situ C-doped $MgB_2$ Wire (기계적 합금화 및 in-situ와 ex-situ의 혼합공정을 통한 C 도핑된 ex-situ $MgB_2$ 선재 제조)

  • Hwang, Soo-Min;Lee, Chang-Min;Lim, Jun-Hyung;Choi, Jun-Hyuk;Park, Jin-Hyun;Joo, Jin-Ho;Jun, Byung-Hyuk;Kim, Chan-Joong
    • Progress in Superconductivity
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    • v.10 no.2
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    • pp.79-86
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    • 2009
  • We successfully fabricated C-doped ex-situ $MgB_2$ wires using two different methods such as mechanical alloying(MA) and combined process(CP) of in-situ and ex-situ. In the MA, the precursor powder was prepared with a mixture of $MgB_2$ and 1 at% C powders by planetary ball milling for 0-100 h. In the CP, on the other hand, C-doped $MgB_2$ powder was prepared with Mg, B, and C powders by in-situ process via compaction, sintering, and crushing. The powders prepared by two methods were loaded into Fe tube and then the assemblages were drawn by a conventional powder-in-tube technique. The MA treatment of C-added $MgB_2$ decreased the particles/grains size and resulted in C-doping into $MgB_2$ after sintering, improving the critical current density($J_c$) in high external magnetic field. For the C-doped $MgB_2$ wire by MA for 25 h, the $J_c$ was $4.1{\times}10^3A/cm^2$ at 5 K and 6.4 T, which was 5.9 times higher than that of pure and untreated $MgB_2$ wire. The CP also provided C-doping into $MgB_2$ and improved the $J_c$ in high magnetic field; the C-doped $MgB_2$ wire fabricated by CP exhibited a $J_c$ being 2.3 times higher than that of the ex-situ wire used commercial $MgB_2$ powder at 5 K and 6.0 T($2.7{\times}10^3A/cm^2\;vs.\;1.2{\times}10^3A/cm^2$).

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XRP44X Enhances the Cytotoxic Activity of Natural Killer Cells by Activating the c-JUN N-Terminal Kinase Signaling Pathway

  • Kim, Kwang-Soo;Park, Kyung-Soon
    • Development and Reproduction
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    • v.24 no.1
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    • pp.53-62
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    • 2020
  • Natural killer (NK) cells are innate lymphocytes that play an essential role in preventing cancer development by performing immune surveillance to eradicate abnormal cells. Since ex vivo expanded NK cells have cytotoxic activity against various cancers, including breast cancers, their clinical potential as immune-oncogenic therapeutics has been widely investigated. Here, we report that the pyrazole chemical XRP44X, an inhibitor of Ras/ERK activation of ELK3, stimulates NK-92MI cells to enhance cytotoxic activity against breast cancer cells. Under XRP44X stimulation, NK cells did not show notable apoptosis or impaired cell cycle progression. We demonstrated that XRP44X enhanced interferon gamma expression in NK-92MI cells. We also elucidated that potentiation of the cytotoxic activity of NK-92MI cells by XRP44X is induced by activation of the c-JUN N-terminal kinase (JNK) signaling pathway. Our data provide insight into the evaluation of XRP44X as an immune stimulant and that XRP44X is a potential candidate compound for the therapeutic development of NK cells.

Green Tea (-)EGCG Induces the Apoptotic Death of Lung Cancer Cells via Activation of c-Jun N-terminal Kinase 1 and Activating Protein-1 (녹차의 (-)EGCG에 의한 사람 폐암 세포주 A549의 c-Jun N-terminal Kinase 1과 Activating Protein-1활성화를 통한 세포고사)

  • 박지선;신미경;손희숙;박래길;김명선;정원훈
    • Journal of Nutrition and Health
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    • v.35 no.1
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    • pp.53-59
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    • 2002
  • Green tea has been recognized as a favorite beverage for centuries in Easter and Westers cultures. Recently, anti-tumor effects of green tea constituents have received increasing attention. However, the mechanism of catechin-mediated cytotoxicity against tumor cells remains to be elusive. To elucidate the mechanical insights of anti-tumor effects, (-)epigallocatechin-gallate(EGCG) of catechin was applied to human lung cancer A549 cells. (-)EGCG induced the death of A549 cells, which was revealed as apoptosis in DNA fragmentation assay. (-)EGCG induced the activation of caspase family cysteine proteases including capase-3, -8 and -9 proteases in A549 cells. Furthermore, (-)EGCG increased the phosphotransferase activity of c-Jun N-terminal kinase 1JNK 1), which further induced tole transcriptional activation of activating protein-1(AP-1) in A549 cells. We suggest that (-)EGCG-induced apotosis of A549 cells is mediated by signaling pathway involving caspase family cysteine protease, JNK1 and transcription factor, AP-1.