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Green Tea (-)EGCG Induces the Apoptotic Death of Lung Cancer Cells via Activation of c-Jun N-terminal Kinase 1 and Activating Protein-1  

박지선 (전북대학교 식품영양학과)
신미경 (원광대학교 식품영양학과)
손희숙 (전북대학교 식품영양학과)
박래길 (원광대학교 의과대학 미생물학교실)
김명선 (원광대학교 의과대학 미생물학교실)
정원훈 (원광보건대학)
Publication Information
Journal of Nutrition and Health / v.35, no.1, 2002 , pp. 53-59 More about this Journal
Abstract
Green tea has been recognized as a favorite beverage for centuries in Easter and Westers cultures. Recently, anti-tumor effects of green tea constituents have received increasing attention. However, the mechanism of catechin-mediated cytotoxicity against tumor cells remains to be elusive. To elucidate the mechanical insights of anti-tumor effects, (-)epigallocatechin-gallate(EGCG) of catechin was applied to human lung cancer A549 cells. (-)EGCG induced the death of A549 cells, which was revealed as apoptosis in DNA fragmentation assay. (-)EGCG induced the activation of caspase family cysteine proteases including capase-3, -8 and -9 proteases in A549 cells. Furthermore, (-)EGCG increased the phosphotransferase activity of c-Jun N-terminal kinase 1JNK 1), which further induced tole transcriptional activation of activating protein-1(AP-1) in A549 cells. We suggest that (-)EGCG-induced apotosis of A549 cells is mediated by signaling pathway involving caspase family cysteine protease, JNK1 and transcription factor, AP-1.
Keywords
(-)EGCG; catechin; apoptosis; lung cancer; caspase; JNK1; AP-1;
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