• Journal of Chest Surgery
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• 제41권3호
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• pp.386-389
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• 2008

폐장은 신장세포암의 흔한 전이 장기 중 하나이지만 기관지내 전이는 매우 드물다. 저자들은 신장세포암이 기관지내로 전이한 환자를 수술하였기에 보고한다. 8년전 신장세포암으로 좌측 신장 적출술을 받은 63세 남자가 반복적인 기침을 주소로 내원하였다. 흉부 컴퓨터 단층촬영과 기관지 내시경 검사에서 좌하엽 기관지로부터 이차 기관 분기부까지 자라는 폴립모양의 기관지내 종양이 발견되었고 생검 결과는 만성 염증 소견과 함께 괴사성 조직으로 진단되었다. 수술 중 종괴의 냉동 절편 조직검사에서 전이성 신장세포암으로 확인되었고 상부의 좌하엽 기관지의 점막 침윤이 없어서 좌하엽 절제술과 림프절 청소술을 시행하였다. 치종 병리학적 검사에서도 전이성 신장세포암으로 확진되었고 림프절 전이는 없었다. 환자는 수술 후 10일째 특별한 합병증이 없이 퇴원하였다.

• Tuberculosis and Respiratory Diseases
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• 제44권1호
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• pp.191-196
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• 1997

저자들은 객담과 기침을 주소로 내원한 62세의 흡연력이 있는 남자환자에서 우중엽 증후군을 유발한 기관지 내 종물을 발견하고, 폐엽절제술을 시행하여 기관지 지방종으로 진단한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• International Journal of Industrial Entomology and Biomaterials
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• 제18권1호
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• pp.13-17
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• 2009

The caterpillar-shaped Chinese medicinal mushroom (DongChongXiaCao) looks like a worm in the winter and like a grass in the summer. The fruiting body has been regarded as popular folk or effective medicines used to treat human diseases such as asthma, bronchial and lung inflammation, and kidney disease. The fruiting bodies of Cordyceps militaris, C. pruinosa and Paecilomyces tenuipes that formed on the living silkworm (Bombyx mori) host were used in this examination. This study was carried out to investigate the soluble sugar, amino acid and fatty acid profiles in the fruiting-bodies. Soluble sugars such as glycerol, glucose, mannitol and sucrose were mainly found in the fruiting bodies of C. militaris, C. pruinosa and P. tenuipes. Total soluble sugar content was 29.23 mg/g in C. militaris, 8.61 mg/g in C. pruinosa and 24.00 mg/g 1in P. tenuipes on dry weight basis. Total free amino acid content was 14.09 mg/g 1in C. militaris, 34.60 mg/g in C. pruinosa and 17.09 mg/g in P. tenuipes. The content of oleic acid in fatty acids was above high more than 30% regardless of species.

• Tuberculosis and Respiratory Diseases
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• 제52권6호
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• pp.645-650
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• 2002

저자들은 54세 여자 환자에서 좌상엽의 종괴에 대한 경피적 경흉 침생검을 통해 연골성 과오종으로 진단하고 방사선 소견상 폐결핵이 같이 의심되었으나 활동성 여부가 불분명하여 3개월 간격으로 외래 추적관찰 도중, 15개월째 객담 항산균 도말검사상 양성으로 판명되어 항결핵제를 투여하였으나, 21개월째 증상의 호전이 없고 종괴의 크기가 증가되는 소견을 보여 악성변화를 배제할 수 없어 수술을 시행하였으며, 조직검사상 만성 육아종성 병변과 함께 탈분화형 연골육종으로 과오종에서 악성화된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Mycobiology
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• 제35권4호
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• pp.215-218
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• 2007

The caterpillar-shaped Chinese medicinal mushroom (DongChongXiaCao) looks like a worm in the winter and like a grass in the summer. The fruiting body has been regarded as popular folk or effective medicines used to treat human diseases such as asthma, bronchial and lung inflammation, and kidney disease. The fruiting bodies of Paecilomyces tenuipes that formed on the living silkworm (Bombyx mon) host were used in this examination. This study was carried out to investigate the proximate composition, soluble sugar, amino acid and fatty acid profiles, and contents of the bioactive ingredient including adenosine and D-mannitol in the fruiting-bodies. The moisture content was 57.56%. Soluble sugars found were glycerol, glucose, mannitol and sucrose, and the contents exceeded $24\;mgg^{-1}dry$ weight. Total free amino acid content was $17.09\;mgg^{-1}dry$ weight. Arginine, glycine, proline and tyrosine were main amino acids. The content of oleic acid in fatty acids was high. Adenosine was more abundant in fruiting bodies than corpus.

• Journal of Chest Surgery
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• 제29권6호
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• pp.621-625
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• 1996

"중엽증후군"의 용어는 Grahaml)등에,의해 처음 기술되어졌으며 대개 비후된 림프절에 의해 기관지 가 외부적으로 압박되 어 발생된다고 하였다. 환자들은 거의 증상이 없을 수 있으나 가장 흔한 발현 증상 은 기침, 호흡 곤란, 반복되는 발열, 객혈, 그리고 흥통 등이다. 진단방법은 흉부 X선, 기관지경검사, 기 관지조영술, 흉부컴퓨터단층될영 등이며 대개 공기가 없이 압축된 중엽이 중요한 소견이다. 본 저자들은 1990년 3월에서 1995년 5월까지 15례의 중엽증후군을 경 험하였으며 그 중 11례에서 수술 적 치료를 시행하였다. 중엽 증후군의 환자에서 수술적용은 악성 종양이 의심되거나,비가역적 기관지 확장증,기관지협착증,약물 치료에 호전이 없는 경우, 치료후 반복되는 감염 등의 경우에 시행하였다. 수술은 중엽절제술 8례,중엽 및 하엽절제술2례,상엽 및 중엽절제술 1례를시술하였다. 수술후 병리조 직소견상 결핵 6례, 만성감염 3례, 악성 종양 1례, 국소적 출혈 1례의 소견을 보였다 술후 합병증은 2례에서 발생하였으며,그 중 1례에서 술후 폐허탈, 1례에서 간장장애를 경험하였으며 치유되었다.였으며 치유되었다.

• Genomics & Informatics
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• 제3권4호
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• pp.149-153
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• 2005

Asthma is an inflammatory airways disease characterized by bronchial hyperresponsiveness and airways obstruction, which results from a complex interaction of genetic and environmental factors. Interleukin (IL)-13 and IL-4 are important in IgE synthesis and allergic inflammation, therefore genes encoding IL-13 and IL-4 are candidates for predisposition to asthma. In the present study, we screened single-nucleotide polymorphisms (SNPs) in IL-13 and IL-4 and examined whether they are risk factors for asthma. We resequenced all exons and the promoter region in 12 asthma patients and 12 normal controls, and identified 18 SNPs including 2 novel SNPs. The linkage disequilibrium(LD) pattern was evaluated with 16 common SNPs, and haplotypes were also estimated within the block. Although IL-13 and IL-4 are localized within 27 kb on chromosome 5q31 and share many biological profiles, this region was partitioned into 2 blocks. One SNP and three SNPs were determined as haplotype-taggingSNPs (htSNPs) within IL-13 and IL-4 haplotype-block, respectively. No significant associations were observed between any of the SNPs or haplotypes and development of asthma in small number of Korean subjects. However, the genetic variants of IL-13 and IL-4 would provide valuable strategies for the genotyping studies in large population.

• Tuberculosis and Respiratory Diseases
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• 제43권2호
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• pp.285-290
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• 1996

저자들은 특징적인 임상 증상과 함께 전형적인 흉부 x-선 및 고해상 흉부 전산화 단층 촬영을 보이는 미만성 법세기관지염 환자에서 흉강경을 이용한 폐생검으로 확진하여 erythromycin 소량 투여로 임상적 효과를 얻은 1예를 문헌 고찰과 함께 보고는 바이다.

• 대한본초학회지
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• 제28권2호
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• pp.9-15
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• 2013

Objectives : The root of Codonopsis pilosula (Fr.) Nannf. (Codonopsis Pilosulae Radix) has been traditionally used as a oriental medicine with an anti-thrombotic, antidiabetic, anticancer, and anti-gastric ulcer effects and immunological adjuvant. In this study, we investigated the effect of 70% ethanol extract of Codonopsis Pilosulae Radix (CPR-E) on ovalbumin (OVA)-induced allergic responses in mice. Methods : Mice were sensitized (1, 8, and 15 days) with OVA and airway challenged(22, 24, 26, 28, and 30 days) to induced allergic responses. CPR-E extract at doses of 50 and 100 mg/kg/body weight was orally administered from days 21 to 30 consecutively. The levels of allergic mediators such as histamine, OVA-specific immunoglobulin (Ig) E, and Th1/Th2 cytokines such as IFN-${\gamma}$ and IL-4 were measured in the sera of mice by ELISA. The histological change of lung tissue was observed by hematoxylin and eosin (H&E) staining. Results : CPR-E extract significantly decreased the serum levels of histamine, OVA-specific IgE, and IL-4 compared with those of OVA control group, but significantly increased the serum level of IFN-${\gamma}$. Based on H&E staining, CPR-E extract inhibited the infiltration of inflammatory cells into lung tissues with histological changes. Conclusions : These results indicate that CPR-E extract has anti-inflammatory and anti-allergic responses through regulating the cytokine balance, suggesting that the extract may be useful for the treatment of allergic inflammatory diseases such as bronchial asthma and allergic rhinitis.

• The Korean Journal of Physiology and Pharmacology
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• 제26권2호
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• pp.95-111
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• 2022

Chronic obstructive pulmonary disease (COPD) is an important healthcare problem worldwide. Often, glucocorticoid (GC) resistance develops during COPD treatment. As a classic hypoglycemic drug, metformin (MET) can be used as a treatment strategy for COPD due to its anti-inflammatory and antioxidant effects, but its specific mechanism of action is not known. We aimed to clarify the role of MET on COPD and cigarette smoke extract (CSE)-induced GC resistance. Through establishment of a COPD model in rats, we found that MET could improve lung function, reduce pathological injury, as well as reduce the level of inflammation and oxidative stress in COPD, and upregulate expression of nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), multidrug resistance protein 1 (MRP1), and histone deacetylase 2 (HDAC2). By establishing a model of GC resistance in human bronchial epithelial cells stimulated by CSE, we found that MET reduced secretion of interleukin-8, and could upregulate expression of Nrf2, HO-1, MRP1, and HDAC2. MET could also increase the inhibition of MRP1 efflux by MK571 significantly, and increase expression of HDAC2 mRNA and protein. In conclusion, MET may upregulate MRP1 expression by activating the Nrf2/HO-1 signaling pathway, and then regulate expression of HDAC2 protein to reduce GC resistance.