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A Case of Dedifferentiated Chondrosarcoma : It was Changed From a Hamartoma  

Kim, Hak-Ryul (Department of Internal Medicine, College of Medicine Wonkwang University)
Yang, Sei-Hoon (Department of Internal Medicine, College of Medicine Wonkwang University)
Jung, Eun-Taek (Department of Internal Medicine, College of Medicine Wonkwang University)
Publication Information
Tuberculosis and Respiratory Diseases / v.52, no.6, 2002 , pp. 645-650 More about this Journal
Abstract
Extraosseous pulmonary chondrosarcoma is rare neoplasm, which is characterized into two groups. One is termed a primary chondrosarcoma, and arise de novo (bronchial cartilage), the other is termed a secondary chondrosarcoma, and is superimposed on preexisting benign cartilagenous neoplasms, such as a chondroma or hamartoma. The preferred treatment is surgical resection. We recently experienced a secondary chondrosarcoma changed from a hamartoma. A 54-year-old woman was referred to our hospital because of an abnormal chest X-ray with mild dyspnea. We performed a percutaneous transthoracic needle biopsy and sputum examination. The abnormal mass had been diagnosed as a chondromatous hamartoma with active pulmonary tuberculosis, which had been treated with anti-tuberculosis regimens. Despite her medication, an abnormal mass had grown. Therefore, we undertook a pneumonectomy with chest wall reconstruction. Histopathologically, the mass was a grade II, dedifferenciated chondrosarcoma, with chronic granulomatous inflammation and necrosis. We suggest this case had changed from a chondromatous hamartoma to a dedifferentiated chondrosarcoma, with associated pulmonary tuberculosis. We report this case with a brief literature review.
Keywords
Dedifferentiated chondrosarcoma; Hamartoma;
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