• 한국동물학회:학술대회논문집
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• 한국동물학회 1999년도 한국생물과학협회 학술발표대회
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• pp.297.1-297
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• 1999

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• Animal cells and systems
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• 제12권4호
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• pp.193-201
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• 2008

The eventual goal of tumor immunotherapy is to develop a vaccine inducing a specific anti-tumor immunity. Cytokine gene therapy is an effective way at least in animal models, but limited efficacy and various side effects obstruct clinical applications. In this study, we developed a tumor vaccine expressing a membrane-bound form of IL-2(mbIL-2) and SDF-1 in B16F10 melanoma cells. The tumor clones expressing mbIL-2 showed reduced tumorigenicity, and additional expression of SDF-1 to mbIL-2 expressing tumor cells caused more severe reduction in tumorigenicity. However, expression of the SDF-1 alone did not affect on the tumorigenicity, probably because of limited production of SDF-1 in the SDF-1 transfected clones. When the mice once rejected mbIL-2/SDF-1 expressing tumor clone were re-challenged with wild type B16F10 tumor cells, all of the mice survived. This result suggests that mbIL-2/SDF-1 tumor clone is effective in inducing systemic anti-tumor immunity against wild type B16 melanoma. Furthermore, culture supernatant of tumor clones expressing SDF-1 induced lymphocyte migration in vitro. These results, all together, suggest that expression of mbIL-2 and SDF-1 in tumor cells enhances anti-tumor immune responses through different roles; the secreted SDF-1 may function as a chemoattractant to recruit immune cells to tumor vaccine injection site, and the mbIL-2 on tumor cells may provide costimulatory signal for CTL activation in physical contacts.

• International Journal of Control, Automation, and Systems
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• 제6권6호
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• pp.960-967
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• 2008

This paper shows that design of a robustly stable repetitive control system is equivalent to that of a feedback control system for an uncertain linear time-invariant system satisfying the well-known robust performance condition. Once a feedback controller is designed to satisfy the robust performance condition, the feedback controller and the repetitive controller using the performance weighting function robustly stabilizes the repetitive control system. It is also shown that we can obtain a steady-state tracking error described in a simple form without time-delay element if the robust stability condition is satisfied for the repetitive control system. Moreover, using this result, a sufficient condition is provided, which ensures that the least upper bound of the steady-state tracking error generated by the repetitive control system is less than or equal to the least upper bound of the steady-state tracking error only by the feedback system.

• 대한수학회지
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• 제54권2호
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• pp.479-491
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• 2017

We investigate the zeros of Epstein zeta functions associated with positive definite quadratic forms with rational coefficients in the vertical strip ${\sigma}_1$ < ${\Re}s$ < ${\sigma}_2$, where 1/2 < ${\sigma}_1$ < ${\sigma}_2$ < 1. When the class number h of the quadratic form is bigger than 1, Voronin gave a lower bound and Lee gave an asymptotic formula for the number of zeros. Recently Gonek and Lee improved their results by providing a new upper bound for the error term when h > 3. In this paper, we consider the cases h = 2, 3 and provide an upper bound for the error term, smaller than the one for the case h > 3.

• Communications for Statistical Applications and Methods
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• 제6권2호
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• pp.443-456
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• 1999

The estimation of mean lifetimes in presence of interval censoring with mixed replacement procedure are examined when the distribution s of lifetimes are exponential. it is assumed that due to physical restrictions and/or economic constraints the number of failures is investigated only at several inspection times during the lifetime test; thus there is interval censoring. Comparisons of mixed replacement designs are made with those with and without replacement The maximum likelihood estimator is found in an implicit form. The Cramer-Rao lower bound which is the asymptotic variance of the estimator is derived. The test conditions for minimizing the Cramer-Rao lower bound and minimizing the test costs within a desired width of the Cramer-Rao bound have been studied.

• Journal of Microbiology and Biotechnology
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• 제11권1호
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• pp.72-78
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• 2001

It is possible ot prepare protoplasts of the zygomycete fungus, Phycomyces blakesleeanus, by digesting the cell wall of spore germlings with commercially available chitinase and chitosanase. However, the cells without any cell walls immediately form large aggregates, and thus, it is difficult to isolate the individually separated protoplasts. Inherent problem with the formation of aggregates in preparing protoplasts could be solved by the use of bovine serum albumin (BSA). As a result, we were able to prepare a large number of single protoplsts quickly and easily. We took time-lapse photomicrographs of the formation of protoplasts, and found that there were certain regions of the cell wall of spore germlings that were sensitive to chitinase and chitosanase, although the cell wall of the original spores is known to be insensitive to these enzymes. There are two kinds of cell walls on a spore germling; one with a bound wheat germ agglutinin (WGA), and the other a bound concanavalin A (ConA). Furthermore, only cells with walls which had bound WGA were able to regenerate, while those with walls with bound ConA were not able to regenerate.

• 한국식품영양과학회지
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• 제46권8호
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• pp.937-943
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• 2017

본 연구에서는 발아에 의한 팥의 기능성분 변화를 살펴보기 위하여 6일 동안 발아시키면서 유리형 및 결합형 폴리페놀, 플라보노이드, 페놀산 및 안토시아닌의 변화를 분석하였다. 유리형 폴리페놀 및 플라보노이드 함량은 발아기간이 증가함에 따라 각각 약 2.6배 및 5배 정도 증가하였으며, 결합형 폴리페놀 및 플라보노이드 함량은 발아 초기 감소하였다가 발아 3일 및 2일 이후 각각 증가하였다. 발아기간에 따른 구성 페놀산의 변화의 경우 ferulic acid, veratric acid, hesperidin, salicylic acid, naringenin 및 hesperidin과 총 페놀산은 유리형 및 결합형 페놀산 함량이 모두 증가하였지만, 안토시아닌 및 안토시아니딘은 침지 및 발아과정에서 손실되어 감소하였다. 본 연구 결과 팥을 발아시킬 경우 폴리페놀, 플라보노이드 및 페놀산 함량이 증가함에 따라 팥에 함유된 기능성분의 이용성을 증대시키기 위해서는 발아공정의 적용이 효과적이라고 판단된다.

• 한국지반공학회논문집
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• 제22권9호
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• pp.23-36
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• 2006

본 연구는 사질토 지반에 근입되어 있는 벽체의 극한지지력을 구하기 위해 새로운 근사적인 해석법의 전개과정에 대해 설명한다. 이러한 근사적인 형태의 해석기법은 상계 및 하계법으로 구성되어 있다. 상 하계법으로 계산된 값은 소성영역에서 구해진 2차원 실내벽체모형의 하중재하시험 및 유한요소해석 결과와 비교하였다. 비교 결과, 모형실험과 유한요소해석으로부터 구한 극한하중 값은 상계와 하계 사이에 모두 분포하는 것으로 나타났다. 이러한 비교에서 특이 할 사항은 하계법으로 구한 벽체의 극한하중이 모형실험 및 유한요소해석에서 구한 극한하중과 잘 일치되는 것을 보여 주었다. 그러나, 평면변형률 조건에서 기존의 경험적인 식에 의한 계산에서 얻어진 극한하중은 하계법의 극한하중에 훨씬 못 미치는 것으로 나타났다.

• 복식
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• 제27권
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• pp.17-26
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• 1996

This thesis is to study the original form of Buckles of our country in ancient times On the upper garment bound the leather belts that was hanged a hook that shaped of animal form at the end. The background of Buckles was originated from those northern mounted normadic groups which was Scythe style costume culture. In Korea through the antique records and tombs bequests the styles of Buckles was divided into three groups horse-shaped tiger-shaped bar-shaped Buckle. These styles were influened by scythe style and developed greatly and trasmitted to Japan.

• Journal of Ginseng Research
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• 제8권2호
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• pp.75-81
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• 1984

The effect of the saponin fraction extracted from Panax ginseng C.A. Meyer on the absorption of ${\alpha}$-tocopherol in rat has been investigated and realized that the saponin fraction stimulated not only the absorption of ${\alpha}$-tocopherol (1.5-2 times that of control) but also its transport and excretion. ${\alpha}$-tocopherol is known to be transported mainly in the form of ${\beta}$-lipoprotein but the present study showed that the ${\alpha}$-tocopherol was transported in the form of albumin bound or micellar structure as well.