• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제39권2호
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• pp.77-84
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• 2013

Objectives: This study evaluated implant success rate, survival rate, marginal bone resorption of implants, and material resorption of sinus bone graft in cases wherein tapered body implants were installed. Materials and Methods: From September 2003 to January 2006, 20 patients from Seoul National University Bundong Hospital, with a mean age of 54.7 years, were considered. The mean follow-up period was 19 months. This study covered 50 implants; 14 implants were placed in the maxillary premolar area, and 36 in the maxillary molar area; 24 sinuses were included. Results: The success rate was 92%, and the survival rate was 96.0%. The mean amount of sinus augmentation was $12.35{\pm}3.27$ mm. The bone graft resorption rate one year after surgery was $0.97{\pm}0.84$ mm; that for the immediate implantation group was $0.91{\pm}0.86$ mm, and that for the delayed implantation group was $1.16{\pm}0.77$ mm. However, the difference was not statistically significant. The mean marginal bone resorption one year after restoration was $0.17{\pm}0.27$ mm (immediate group: $0.12{\pm}0.23$ mm; delayed group $0.40{\pm}0.33$ mm); statistically significant difference was observed between the two groups. Conclusion: Tapered body implant can be available in the maxillary posterior edentulous ridge which sinus bone graft is necessary.

• Journal of Korean Dental Science
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• 제2권2호
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• pp.31-34
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• 2009

The survival rate of the OSSTEM GS II Implant 1 year after serving the prosthetic function in 2 domestic and foreign medical institutes was 97.57%; the success rate was 95.7%, and the average alveolar bone resorption was 0.24mm(n=389). In particular, the alveolar bone resorption occurred differently according to the placement location as well as whether or not the patient underwent bone grafting operation, but the implant s length and diameter did not have significant impact on alveolar bone resorption.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.133.1-133.1
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• 2003

Cathepsin K (CK) is a cysteine protease that plays a major and essential role in osteoclast-mediated degradation of collagen matrix of bone. Its tissue-limited distribution and pivotal contribution to bone resorption meet the requirements as the potential therapeutic target of the disease with excessive bone loss such as osteoporosis. In a search for potent CK inhibitors. we found OST-5440 that effectively inhibited bone resorption in vivo as well as in vitro. (omitted)

• 한국동물학회지
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• 제39권3호
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• pp.317-324
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• 1996

파골세포는 골조직을 분해하는 세포로 알려져 있다. 따라서, 파골세포 활성조절은 골조직의 성장과 재조합의 조절에 있어 매우 중요한 의미를 갖는다. 기관배양을 통해 파골세포의 활성을 조절하는 여러가지 인자들이 알려져 있다. 그 중에서 transforming growth factor-$\beta$ (TGF-$\beta$)는 골조직 대사에 중요한 영향을 미치는 것이 알려져 있고, 또한 골조직내에 다량 존재하고 있기 때문에, TGF-$\beta$의 파골세포에 대한 효과를 알아보는 것은 전체 파골작용의 조절기작을 알아보는데 있어 중요한 의미를 갖는다. 본 연구인들은 계배를 이용한 파골세포의 배양법을 개발하였고, 이를 파골세포 활성을 측정하는데 사용하였다. 이 방법을 통해, TGF-$\beta$1이 파골세포의 골분해 활성을 증가시킨다는 것을 알수 있었다. 또한, 이러한 활성작용은 TGF-$\beta$의 파골세포에 대한 직접적인 효과라기 보다는 다른 세포를 통한 간접적인 효과일 가능성이 높다는 사실을 알 수 있었다. TGF-$\beta$에 의한 파골세포의 활성화는 nordihydroguaiaretic acid에 의해 현저하게 저해된 반면, idomethacin에 의해서는 저해되지 않았다. 이러한 실험결과들은 TGF-$\beta$가 arachidonic acid의 lipoxygenase 유도체를 통해 파골세포의 영향을 미칠 가능성을 제시하고 있다.

• Journal of Korean Neurosurgical Society
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• 제60권6호
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• pp.749-754
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• 2017

Objective : To quantitatively measure the degree of bone flap resorption (BFR) following autologous bone cranioplasty and to investigate factors associated with BFR. Methods : We retrospectively reviewed 29 patients who underwent decompressive craniectomy and subsequent autologous bone cranioplasty between April 2005 and October 2014. BFR was defined as : 1) decrement ratio ([the ratio of initial BF size/craniectomy size]-[the ratio of last BF/craniectomy size]) >0.1; and 2) bone flap thinning or geometrical irregularity of bone flap shape on computed tomographic scan or skull plain X-ray. The minimal interval between craniectomy and cranioplasty was one month and the minimal follow-up period was one year. Clinical factors were compared between the BFR and no-BFR groups. Results : The time interval between craniectomy and cranioplasty was $175.7{\pm}258.2$ days and the mean period of follow up was $1364{\pm}886.8$ days. Among the 29 patients (mean age 48.1 years, male : female ratio 20 : 9), BFR occurred in 8 patients (27.6%). In one patient, removal of the bone flap was carried out due to severe BFR. The overall rate of BFR was $0.10{\pm}0.11$ over 3.7 years. Following univariate analysis, younger age ($30.5{\pm}23.2$ vs. $54.9{\pm}13.4$) and longer follow-up period ($2204.5{\pm}897.3$ vs. $1044.1{\pm}655.1$) were significantly associated with BFR (p=0.008 and 0.003, respectively). Conclusion : The degree of BFR following autologous bone cranioplasty was 2.7%/year and was associated with younger age and longer follow-up period.

• The Korean Journal of Physiology and Pharmacology
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• 제26권3호
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• pp.207-218
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• 2022

Aging in mammals, including humans, is accompanied by loss of bone and muscular function and mass, characterized by osteoporosis and sarcopenia. Although resistance exercise training (RET) is considered an effective intervention, its effect is blunted in some elderly individuals. Fibroblast growth factor (FGF) and its receptor, FGFR, can modulate bone and muscle quality during aging and physical performance. To elucidate this possibility, the FGFR inhibitor NVP-BGJ398 was administrated to C57BL/6n mice for 8 weeks with or without RET. Treatment with NVPBGJ398 decreased grip strength, muscular endurance, running capacity and bone quality in the mice. FGFR inhibition elevated bone resorption and relevant gene expression, indicating altered bone formation and resorption. RET attenuated tibial bone resorption, accompanied by changes in the expression of relevant genes. However, RET did not overcome the detrimental effect of NVP-BGJ398 on muscular function. Taken together, these findings provide evidence that FGFR signaling may have a potential role in the maintenance of physical performance and quality of bone and muscles.

• The Journal of Advanced Prosthodontics
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• 제13권2호
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• pp.117-125
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• 2021

PURPSE. The aim of this study was to evaluate the labio-lingual alterations of the alveolar bone where the implant was placed immediately after tooth extraction. MATERIALS AND METHODS. Implants were placed immediately after tooth extraction on anterior alveolar ridges in the maxilla and mandible. The pinguide system was used to help determine the location and path of implants during the surgical process. The horizontal distance from implants to the outer border of alveolar bone was measured at the rim and middle of the implants in the cone beam computed tomography images. The alteration of alveolar bone was evaluated comparing the horizontal distances measured immediately after surgery and 3 months after surgery. RESULTS. The results show that more resorption occurred towards the labial bone than the lingual bone in the maxilla. A similar amount of labial and lingual bone resorption was observed in the mandible. CONCLUSION. Considering the horizontal alteration of alveolar bone, labio-lingual positioning of the implant towards the lingual bone in the maxilla and at the center of the alveolar ridge in the mandible is recommended when it is placed immediately after tooth extraction.

• 한국전산구조공학회논문집
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• 제26권6호
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• pp.471-474
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• 2013

본 논문에서는 치조골의 흡수 유형에 따른 치근단 절제술의 수술적 평가를 수행하였다. 유한요소해석이 사용되었으며 CT 이미지를 통하여 동양 성인 여성의 상악 중절치의 3D 모델을 사용하였다. 연구에는 상악중절치의 정상저작하중조건이 적용되었다. 치조골 흡수 유형에 따른 치근 절제술의 평가를 위해 정상모델과 함께 치조골의 전체적 흡수 모델, 순측 흡수 모델 및 설측 흡수 모델을 비교하였다. 이에 따라 설측 치조골 흡수의 영향은 순측 치조골의 흡수에 비해 치아의 유지 안정성에 미치는 영향이 작음을 확인하고, 설측 치조골 흡수로 인해 치근이 노출된 환자를 대상으로 한 치근 절제술의 위험 가능성을 제시하였다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2009년도 춘계학술대회 논문집
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• pp.55-56
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• 2009

• Journal of Cancer Prevention
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• 제21권2호
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• pp.88-94
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• 2016

Background: Breast cancer is the most common malignant disease in women. The patients with advanced breast cancer develop metastasis to bone. Bone metastasis and skeletal-related events by breast cancer are frequently associated with the invasiveness of breast cancer cells and osteoclasts-mediated bone resorption. Forsythia koreana is used in oriental traditional medicine to treat asthma, atopy, and allergic diseases. The aim of this study was to evaluate the inhibitory effects of F. koreana extracts on the invasion of breast cancer cells and bone resorption by osteoclasts. Methods: Cell viability was measured by an MTT assay and the migration and invasion of MDA-MB-231 cells were detected by a Boyden chamber assay. The formation of osteoclasts and pit was detected using tartrate-resistant acid phosphatase staining and calcium phosphate-coated plates, respectively. The activities of matrix metalloproteinases (MMPs) and cathepsin K were evaluated by gelatin zymography and a cathepsin K detection kit. Results: The fruit and leaf extracts of F. koreana significantly inhibited the invasion of MDA-MB-231 cells at noncytotoxic concentrations. The fruit extract of F. koreana reduced the transforming growth factor ${\beta}1-induced$ migration, invasion and MMPs activities of MDA-MB-231 cells. In addition, the fruit, branch, and leaf extracts of F. koreana also inhibited the receptor activator of nuclear factor kappa-B ligand-induced osteoclast formation and osteoclast-mediated bone-resorbing activity by reducing the activities of MMPs and cathepsin K. Conclusions: The extracts of F. koreana may possess the potential to inhibit the breast cancer-induced bone destruction through blocking invasion of breast cancer cells, osteoclastogenesis, and the activity of mature osteoclasts.